Incidental Mutation 'R4652:Ptprk'
| ID |
351409 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ptprk
|
| Ensembl Gene |
ENSMUSG00000019889 |
| Gene Name |
protein tyrosine phosphatase receptor type K |
| Synonyms |
RPTPkappa, PTPk |
| MMRRC Submission |
041912-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4652 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
27950816-28473393 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 28139686 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Threonine
at position 137
(I137T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126279
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166468]
[ENSMUST00000218276]
[ENSMUST00000218359]
|
| AlphaFold |
P35822 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000166468
AA Change: I137T
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000126279
Gene: ENSMUSG00000019889
AA Change: I137T
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
28 |
N/A |
INTRINSIC |
|
MAM
|
30 |
193 |
1.61e-73 |
SMART |
|
IG
|
200 |
288 |
2.16e-8 |
SMART |
|
FN3
|
290 |
373 |
1.48e-4 |
SMART |
|
FN3
|
389 |
475 |
4.24e1 |
SMART |
|
FN3
|
491 |
579 |
3.32e-7 |
SMART |
|
transmembrane domain
|
753 |
774 |
N/A |
INTRINSIC |
|
PTPc
|
898 |
1161 |
3.56e-132 |
SMART |
|
PTPc
|
1190 |
1455 |
2.68e-86 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000218276
AA Change: I137T
PolyPhen 2
Score 0.988 (Sensitivity: 0.73; Specificity: 0.96)
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000218359
AA Change: I137T
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000218584
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000218633
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219478
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000219761
|
| Meta Mutation Damage Score |
0.3152 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.7%
|
| Validation Efficiency |
95% (111/117) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310022B05Rik |
T |
A |
8: 125,366,350 (GRCm39) |
Q131L |
probably damaging |
Het |
| 2700049A03Rik |
G |
T |
12: 71,211,320 (GRCm39) |
E685* |
probably null |
Het |
| 2700049A03Rik |
A |
T |
12: 71,211,321 (GRCm39) |
E685V |
possibly damaging |
Het |
| 4933409G03Rik |
G |
A |
2: 68,436,559 (GRCm39) |
E168K |
unknown |
Het |
| A830018L16Rik |
C |
A |
1: 11,607,566 (GRCm39) |
|
probably benign |
Het |
| Adam26b |
A |
G |
8: 43,974,375 (GRCm39) |
V209A |
possibly damaging |
Het |
| Adh6a |
T |
A |
3: 138,031,876 (GRCm39) |
M256K |
probably benign |
Het |
| Ahnak2 |
T |
G |
12: 112,741,271 (GRCm39) |
S128R |
possibly damaging |
Het |
| Angptl2 |
G |
T |
2: 33,133,895 (GRCm39) |
D406Y |
probably damaging |
Het |
| Ano10 |
A |
T |
9: 122,090,181 (GRCm39) |
Y377* |
probably null |
Het |
| Arfgef1 |
C |
T |
1: 10,243,487 (GRCm39) |
D1021N |
probably damaging |
Het |
| Arhgap17 |
G |
A |
7: 122,885,841 (GRCm39) |
|
probably benign |
Het |
| Arsi |
G |
A |
18: 61,049,723 (GRCm39) |
G202E |
probably benign |
Het |
| Atp10b |
G |
A |
11: 43,085,472 (GRCm39) |
G284S |
probably damaging |
Het |
| Atp13a4 |
A |
T |
16: 29,271,421 (GRCm39) |
D498E |
probably damaging |
Het |
| C4a |
T |
A |
17: 35,029,108 (GRCm39) |
|
noncoding transcript |
Het |
| Cacna1d |
C |
T |
14: 29,817,365 (GRCm39) |
M1232I |
probably benign |
Het |
| Camsap3 |
A |
C |
8: 3,650,689 (GRCm39) |
K223T |
possibly damaging |
Het |
| Cast |
A |
G |
13: 74,894,133 (GRCm39) |
S171P |
probably benign |
Het |
| Cdh8 |
T |
A |
8: 99,751,491 (GRCm39) |
D742V |
probably benign |
Het |
| Ceacam12 |
A |
G |
7: 17,801,359 (GRCm39) |
T113A |
probably damaging |
Het |
| Cers3 |
G |
A |
7: 66,431,604 (GRCm39) |
|
probably null |
Het |
| Cipc |
T |
C |
12: 87,008,864 (GRCm39) |
V241A |
probably benign |
Het |
| Cntn5 |
C |
A |
9: 9,704,917 (GRCm39) |
K832N |
possibly damaging |
Het |
| Col12a1 |
A |
T |
9: 79,520,228 (GRCm39) |
D2815E |
probably damaging |
Het |
| Ctf2 |
T |
C |
7: 127,318,556 (GRCm39) |
T148A |
probably benign |
Het |
| Cttnbp2 |
A |
G |
6: 18,434,037 (GRCm39) |
I607T |
possibly damaging |
Het |
| Cux1 |
A |
T |
5: 136,596,083 (GRCm39) |
N4K |
probably damaging |
Het |
| Dhx36 |
A |
T |
3: 62,408,419 (GRCm39) |
L140M |
probably benign |
Het |
| Dhx58 |
T |
A |
11: 100,592,185 (GRCm39) |
N288Y |
probably damaging |
Het |
| Dlgap1 |
T |
A |
17: 71,068,090 (GRCm39) |
Y554N |
probably damaging |
Het |
| Dnah10 |
T |
C |
5: 124,806,207 (GRCm39) |
Y127H |
probably benign |
Het |
| Dnah6 |
T |
C |
6: 73,047,580 (GRCm39) |
M3140V |
probably benign |
Het |
| Dnd1 |
G |
A |
18: 36,898,114 (GRCm39) |
|
probably benign |
Het |
| Dpy19l1 |
A |
C |
9: 24,393,350 (GRCm39) |
S140A |
possibly damaging |
Het |
| Dyrk1a |
C |
T |
16: 94,492,924 (GRCm39) |
T719I |
probably benign |
Het |
| Erlin1 |
T |
A |
19: 44,029,231 (GRCm39) |
K234* |
probably null |
Het |
| Fndc7 |
T |
C |
3: 108,770,135 (GRCm39) |
N597S |
probably benign |
Het |
| Folh1 |
C |
A |
7: 86,393,633 (GRCm39) |
G360* |
probably null |
Het |
| Frmd4b |
T |
C |
6: 97,272,716 (GRCm39) |
H846R |
probably benign |
Het |
| Gm10375 |
C |
A |
14: 43,844,326 (GRCm39) |
|
probably null |
Het |
| Gm27047 |
T |
C |
6: 130,607,479 (GRCm39) |
|
noncoding transcript |
Het |
| Gm7168 |
A |
G |
17: 14,170,069 (GRCm39) |
R479G |
possibly damaging |
Het |
| Gm9996 |
T |
A |
10: 29,019,754 (GRCm39) |
|
probably benign |
Het |
| Gnat3 |
T |
A |
5: 18,220,568 (GRCm39) |
L247H |
probably damaging |
Het |
| H2-D1 |
T |
G |
17: 35,485,492 (GRCm39) |
|
probably null |
Het |
| Hpf1 |
T |
G |
8: 61,346,764 (GRCm39) |
S26R |
possibly damaging |
Het |
| Ift80 |
T |
A |
3: 68,822,273 (GRCm39) |
N627I |
probably benign |
Het |
| Inpp5d |
A |
G |
1: 87,593,173 (GRCm39) |
K91R |
probably benign |
Het |
| Irgc |
C |
A |
7: 24,132,238 (GRCm39) |
R193L |
probably damaging |
Het |
| Kirrel1 |
C |
T |
3: 86,996,458 (GRCm39) |
M380I |
probably null |
Het |
| Lamc1 |
T |
G |
1: 153,104,523 (GRCm39) |
S59R |
probably damaging |
Het |
| Lrrc9 |
T |
C |
12: 72,524,160 (GRCm39) |
W790R |
probably damaging |
Het |
| Man1a2 |
A |
G |
3: 100,539,877 (GRCm39) |
L188P |
probably damaging |
Het |
| Med8 |
A |
T |
4: 118,268,089 (GRCm39) |
E5V |
probably damaging |
Het |
| Mefv |
A |
G |
16: 3,535,682 (GRCm39) |
L82P |
probably damaging |
Het |
| Mettl25 |
A |
T |
10: 105,615,509 (GRCm39) |
C498* |
probably null |
Het |
| Mettl3 |
T |
A |
14: 52,532,549 (GRCm39) |
I545F |
probably damaging |
Het |
| Mvp |
T |
A |
7: 126,592,721 (GRCm39) |
I397F |
probably damaging |
Het |
| Nlrp14 |
A |
T |
7: 106,781,024 (GRCm39) |
I74F |
probably benign |
Het |
| Nudt5 |
G |
A |
2: 5,860,876 (GRCm39) |
|
probably benign |
Het |
| Nyap2 |
T |
A |
1: 81,314,444 (GRCm39) |
D713E |
probably damaging |
Het |
| Obscn |
G |
A |
11: 58,929,703 (GRCm39) |
R5824C |
probably damaging |
Het |
| Or4f6 |
G |
T |
2: 111,838,595 (GRCm39) |
S312Y |
probably damaging |
Het |
| Or6c214 |
T |
C |
10: 129,591,287 (GRCm39) |
I11V |
probably benign |
Het |
| Orc4 |
A |
T |
2: 48,826,762 (GRCm39) |
|
probably benign |
Het |
| Pde10a |
T |
A |
17: 8,975,885 (GRCm39) |
N3K |
possibly damaging |
Het |
| Pgm3 |
T |
A |
9: 86,440,523 (GRCm39) |
R389S |
probably benign |
Het |
| Piwil4 |
G |
A |
9: 14,623,604 (GRCm39) |
R529* |
probably null |
Het |
| Pkd2l2 |
A |
T |
18: 34,542,889 (GRCm39) |
R20* |
probably null |
Het |
| Ppp4r3a |
T |
A |
12: 101,049,170 (GRCm39) |
|
probably benign |
Het |
| Prkcq |
T |
C |
2: 11,284,333 (GRCm39) |
V501A |
possibly damaging |
Het |
| Prkg1 |
T |
C |
19: 30,572,412 (GRCm39) |
T400A |
probably damaging |
Het |
| Prps2 |
T |
C |
X: 166,135,288 (GRCm39) |
D183G |
probably damaging |
Het |
| Prrc2c |
A |
T |
1: 162,550,843 (GRCm39) |
H40Q |
probably damaging |
Het |
| Ptcd1 |
A |
T |
5: 145,091,985 (GRCm39) |
H371Q |
probably benign |
Het |
| R3hdm1 |
T |
C |
1: 128,112,181 (GRCm39) |
S422P |
probably damaging |
Het |
| Rapgef5 |
G |
A |
12: 117,677,863 (GRCm39) |
G366E |
probably damaging |
Het |
| Rsf1 |
GCGGCGGCG |
GCGGCGGCGTCGGCGGCG |
7: 97,229,126 (GRCm39) |
|
probably benign |
Het |
| Setd2 |
A |
G |
9: 110,423,200 (GRCm39) |
D2085G |
possibly damaging |
Het |
| Sfxn3 |
A |
G |
19: 45,039,313 (GRCm39) |
|
probably null |
Het |
| Sgce |
T |
C |
6: 4,689,560 (GRCm39) |
|
probably benign |
Het |
| Sipa1l1 |
T |
A |
12: 82,469,245 (GRCm39) |
L1248* |
probably null |
Het |
| Skint7 |
T |
G |
4: 111,839,309 (GRCm39) |
M201R |
probably damaging |
Het |
| Slc18a1 |
A |
G |
8: 69,496,583 (GRCm39) |
M360T |
possibly damaging |
Het |
| Srp68 |
A |
T |
11: 116,164,840 (GRCm39) |
S31R |
probably benign |
Het |
| Stag1 |
T |
A |
9: 100,678,769 (GRCm39) |
M230K |
probably damaging |
Het |
| Strc |
A |
T |
2: 121,204,829 (GRCm39) |
D985E |
possibly damaging |
Het |
| Tars3 |
T |
A |
7: 65,339,717 (GRCm39) |
V704E |
probably damaging |
Het |
| Tbc1d2b |
A |
G |
9: 90,089,940 (GRCm39) |
F863S |
probably damaging |
Het |
| Tek |
T |
C |
4: 94,669,121 (GRCm39) |
S41P |
probably damaging |
Het |
| Top1 |
T |
C |
2: 160,554,637 (GRCm39) |
Y463H |
probably damaging |
Het |
| Trim24 |
T |
G |
6: 37,934,774 (GRCm39) |
|
probably null |
Het |
| Ttn |
A |
G |
2: 76,576,979 (GRCm39) |
V24638A |
possibly damaging |
Het |
| Ttn |
A |
G |
2: 76,701,213 (GRCm39) |
|
probably benign |
Het |
| Txndc11 |
A |
G |
16: 10,892,986 (GRCm39) |
S915P |
probably benign |
Het |
| Tyro3 |
G |
C |
2: 119,647,349 (GRCm39) |
G826A |
probably benign |
Het |
| Ubxn4 |
T |
A |
1: 128,202,587 (GRCm39) |
W410R |
probably benign |
Het |
| Vmn1r193 |
C |
T |
13: 22,403,695 (GRCm39) |
G99D |
probably damaging |
Het |
| Vmn2r109 |
T |
A |
17: 20,761,656 (GRCm39) |
K567M |
probably damaging |
Het |
| Vmn2r23 |
T |
C |
6: 123,718,689 (GRCm39) |
F681L |
probably damaging |
Het |
| Vrk2 |
T |
C |
11: 26,439,803 (GRCm39) |
D256G |
probably damaging |
Het |
| Vwa3a |
T |
A |
7: 120,378,138 (GRCm39) |
I476N |
probably damaging |
Het |
| Wdr81 |
A |
G |
11: 75,342,066 (GRCm39) |
V1067A |
probably damaging |
Het |
| Zcwpw2 |
A |
G |
9: 117,843,119 (GRCm39) |
|
noncoding transcript |
Het |
|
| Other mutations in Ptprk |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00310:Ptprk
|
APN |
10 |
28,212,506 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL00533:Ptprk
|
APN |
10 |
28,461,971 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01062:Ptprk
|
APN |
10 |
28,456,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01295:Ptprk
|
APN |
10 |
28,351,174 (GRCm39) |
missense |
probably benign |
0.14 |
|
IGL01372:Ptprk
|
APN |
10 |
28,445,923 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01452:Ptprk
|
APN |
10 |
28,450,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01829:Ptprk
|
APN |
10 |
28,449,383 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01861:Ptprk
|
APN |
10 |
28,259,441 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL01955:Ptprk
|
APN |
10 |
28,471,861 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02263:Ptprk
|
APN |
10 |
27,951,110 (GRCm39) |
missense |
unknown |
|
|
IGL02489:Ptprk
|
APN |
10 |
28,259,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02697:Ptprk
|
APN |
10 |
28,451,614 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL02713:Ptprk
|
APN |
10 |
28,468,807 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
IGL02943:Ptprk
|
APN |
10 |
28,351,172 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL03240:Ptprk
|
APN |
10 |
28,368,957 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03373:Ptprk
|
APN |
10 |
28,442,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
LCD18:Ptprk
|
UTSW |
10 |
28,450,983 (GRCm39) |
intron |
probably benign |
|
|
PIT4366001:Ptprk
|
UTSW |
10 |
28,462,015 (GRCm39) |
missense |
probably benign |
|
|
R0010:Ptprk
|
UTSW |
10 |
28,461,965 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0021:Ptprk
|
UTSW |
10 |
28,468,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0021:Ptprk
|
UTSW |
10 |
28,468,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0035:Ptprk
|
UTSW |
10 |
28,139,504 (GRCm39) |
nonsense |
probably null |
|
|
R0035:Ptprk
|
UTSW |
10 |
28,139,504 (GRCm39) |
nonsense |
probably null |
|
|
R0053:Ptprk
|
UTSW |
10 |
28,351,105 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0063:Ptprk
|
UTSW |
10 |
28,139,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0063:Ptprk
|
UTSW |
10 |
28,139,763 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0244:Ptprk
|
UTSW |
10 |
28,082,221 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0281:Ptprk
|
UTSW |
10 |
28,449,388 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0387:Ptprk
|
UTSW |
10 |
28,230,625 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0480:Ptprk
|
UTSW |
10 |
28,461,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0480:Ptprk
|
UTSW |
10 |
28,461,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0585:Ptprk
|
UTSW |
10 |
28,451,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0614:Ptprk
|
UTSW |
10 |
27,951,132 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0684:Ptprk
|
UTSW |
10 |
28,359,294 (GRCm39) |
splice site |
probably benign |
|
|
R1073:Ptprk
|
UTSW |
10 |
28,372,943 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1377:Ptprk
|
UTSW |
10 |
28,462,022 (GRCm39) |
missense |
probably benign |
0.42 |
|
R1422:Ptprk
|
UTSW |
10 |
28,351,276 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R1482:Ptprk
|
UTSW |
10 |
28,139,512 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1532:Ptprk
|
UTSW |
10 |
28,461,626 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1576:Ptprk
|
UTSW |
10 |
28,427,647 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1618:Ptprk
|
UTSW |
10 |
28,369,166 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1654:Ptprk
|
UTSW |
10 |
28,259,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1701:Ptprk
|
UTSW |
10 |
28,342,054 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1747:Ptprk
|
UTSW |
10 |
28,230,688 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R2033:Ptprk
|
UTSW |
10 |
28,468,763 (GRCm39) |
unclassified |
probably benign |
|
|
R2059:Ptprk
|
UTSW |
10 |
28,442,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2076:Ptprk
|
UTSW |
10 |
28,465,364 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2164:Ptprk
|
UTSW |
10 |
28,436,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2260:Ptprk
|
UTSW |
10 |
28,082,145 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2394:Ptprk
|
UTSW |
10 |
28,427,713 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2432:Ptprk
|
UTSW |
10 |
28,468,840 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2437:Ptprk
|
UTSW |
10 |
28,230,709 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2495:Ptprk
|
UTSW |
10 |
28,351,074 (GRCm39) |
splice site |
probably benign |
|
|
R3037:Ptprk
|
UTSW |
10 |
28,456,474 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3162:Ptprk
|
UTSW |
10 |
28,468,822 (GRCm39) |
missense |
probably benign |
|
|
R3162:Ptprk
|
UTSW |
10 |
28,468,822 (GRCm39) |
missense |
probably benign |
|
|
R3687:Ptprk
|
UTSW |
10 |
28,349,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3722:Ptprk
|
UTSW |
10 |
28,259,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3892:Ptprk
|
UTSW |
10 |
28,139,617 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3963:Ptprk
|
UTSW |
10 |
28,427,661 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4077:Ptprk
|
UTSW |
10 |
28,139,508 (GRCm39) |
missense |
probably benign |
|
|
R4079:Ptprk
|
UTSW |
10 |
28,139,508 (GRCm39) |
missense |
probably benign |
|
|
R4112:Ptprk
|
UTSW |
10 |
28,351,284 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4255:Ptprk
|
UTSW |
10 |
28,082,241 (GRCm39) |
missense |
probably benign |
0.14 |
|
R4523:Ptprk
|
UTSW |
10 |
28,342,048 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4651:Ptprk
|
UTSW |
10 |
28,139,686 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4828:Ptprk
|
UTSW |
10 |
28,436,050 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4829:Ptprk
|
UTSW |
10 |
28,456,480 (GRCm39) |
nonsense |
probably null |
|
|
R4883:Ptprk
|
UTSW |
10 |
28,464,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5004:Ptprk
|
UTSW |
10 |
28,462,059 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5013:Ptprk
|
UTSW |
10 |
28,427,713 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5092:Ptprk
|
UTSW |
10 |
28,468,769 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5126:Ptprk
|
UTSW |
10 |
28,451,640 (GRCm39) |
splice site |
probably null |
|
|
R5183:Ptprk
|
UTSW |
10 |
28,351,232 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5264:Ptprk
|
UTSW |
10 |
28,461,582 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5304:Ptprk
|
UTSW |
10 |
28,468,050 (GRCm39) |
splice site |
probably null |
|
|
R5330:Ptprk
|
UTSW |
10 |
28,463,076 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5474:Ptprk
|
UTSW |
10 |
28,372,926 (GRCm39) |
nonsense |
probably null |
|
|
R5516:Ptprk
|
UTSW |
10 |
28,372,926 (GRCm39) |
nonsense |
probably null |
|
|
R5796:Ptprk
|
UTSW |
10 |
28,259,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5843:Ptprk
|
UTSW |
10 |
28,369,060 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5952:Ptprk
|
UTSW |
10 |
28,461,671 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6065:Ptprk
|
UTSW |
10 |
28,351,166 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6226:Ptprk
|
UTSW |
10 |
28,440,099 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6264:Ptprk
|
UTSW |
10 |
28,442,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6638:Ptprk
|
UTSW |
10 |
28,471,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6843:Ptprk
|
UTSW |
10 |
28,467,978 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6860:Ptprk
|
UTSW |
10 |
28,210,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6869:Ptprk
|
UTSW |
10 |
28,349,055 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7214:Ptprk
|
UTSW |
10 |
28,450,905 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7307:Ptprk
|
UTSW |
10 |
28,465,004 (GRCm39) |
nonsense |
probably null |
|
|
R7349:Ptprk
|
UTSW |
10 |
28,468,834 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R7442:Ptprk
|
UTSW |
10 |
28,450,815 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7585:Ptprk
|
UTSW |
10 |
28,436,084 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7661:Ptprk
|
UTSW |
10 |
28,342,036 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7694:Ptprk
|
UTSW |
10 |
28,465,366 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7740:Ptprk
|
UTSW |
10 |
28,372,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7810:Ptprk
|
UTSW |
10 |
28,468,853 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7831:Ptprk
|
UTSW |
10 |
28,444,404 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7836:Ptprk
|
UTSW |
10 |
28,449,385 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8049:Ptprk
|
UTSW |
10 |
28,259,565 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R8235:Ptprk
|
UTSW |
10 |
28,465,037 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R8274:Ptprk
|
UTSW |
10 |
28,456,408 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8286:Ptprk
|
UTSW |
10 |
28,444,323 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8372:Ptprk
|
UTSW |
10 |
28,230,688 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R8727:Ptprk
|
UTSW |
10 |
28,442,541 (GRCm39) |
unclassified |
probably benign |
|
|
R8794:Ptprk
|
UTSW |
10 |
28,139,504 (GRCm39) |
nonsense |
probably null |
|
|
R8842:Ptprk
|
UTSW |
10 |
28,442,497 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8861:Ptprk
|
UTSW |
10 |
28,446,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8897:Ptprk
|
UTSW |
10 |
28,467,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8910:Ptprk
|
UTSW |
10 |
28,368,993 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R8919:Ptprk
|
UTSW |
10 |
28,359,203 (GRCm39) |
nonsense |
probably null |
|
|
R8976:Ptprk
|
UTSW |
10 |
28,461,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8982:Ptprk
|
UTSW |
10 |
28,436,138 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9036:Ptprk
|
UTSW |
10 |
28,461,928 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9135:Ptprk
|
UTSW |
10 |
28,456,413 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9308:Ptprk
|
UTSW |
10 |
28,450,850 (GRCm39) |
missense |
probably benign |
0.15 |
|
R9317:Ptprk
|
UTSW |
10 |
28,230,731 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9475:Ptprk
|
UTSW |
10 |
28,210,476 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9585:Ptprk
|
UTSW |
10 |
28,369,147 (GRCm39) |
nonsense |
probably null |
|
|
R9625:Ptprk
|
UTSW |
10 |
28,462,006 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9700:Ptprk
|
UTSW |
10 |
28,456,495 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9745:Ptprk
|
UTSW |
10 |
28,139,608 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
Z1177:Ptprk
|
UTSW |
10 |
28,369,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACTCCTCAAATCATGATCCTGGAG -3'
(R):5'- GTGTCAAGGCACTCAAACTCC -3'
Sequencing Primer
(F):5'- TCATGATCCTGGAGAAAAAGCC -3'
(R):5'- GGCACTCAAACTCCTCCTCAAG -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation