Incidental Mutation 'R4642:Ly86'
ID 351692
Institutional Source Beutler Lab
Gene Symbol Ly86
Ensembl Gene ENSMUSG00000021423
Gene Name lymphocyte antigen 86
Synonyms MD-1, MD1
MMRRC Submission 041904-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.054) question?
Stock # R4642 (G1)
Quality Score 225
Status Validated
Chromosome 13
Chromosomal Location 37529276-37603012 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 37560877 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Serine at position 79 (R79S)
Ref Sequence ENSEMBL: ENSMUSP00000021860 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021860]
AlphaFold O88188
PDB Structure Crystal structure of mouse MD-1 in complex with phosphatidylcholine [X-RAY DIFFRACTION]
Crystal structure of mouse RP105/MD-1 complex [X-RAY DIFFRACTION]
Predicted Effect possibly damaging
Transcript: ENSMUST00000021860
AA Change: R79S

PolyPhen 2 Score 0.526 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000021860
Gene: ENSMUSG00000021423
AA Change: R79S

DomainStartEndE-ValueType
ML 42 159 4.29e-26 SMART
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.3%
Validation Efficiency 96% (46/48)
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele display impaired LPS-induced B-cell proliferation and antibody production. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abce1 T C 8: 80,415,982 (GRCm39) T387A probably damaging Het
Acaca A T 11: 84,171,287 (GRCm39) T3S probably damaging Het
Adamts16 G A 13: 70,927,637 (GRCm39) probably benign Het
Cacna1g A G 11: 94,308,920 (GRCm39) I1631T probably damaging Het
Camk1g T A 1: 193,038,667 (GRCm39) D85V probably damaging Het
Caskin1 G A 17: 24,725,602 (GRCm39) S1296N probably benign Het
Ccbe1 A T 18: 66,424,654 (GRCm39) probably benign Het
Ccdc184 T G 15: 98,066,537 (GRCm39) V114G probably benign Het
Cpxm2 C T 7: 131,672,610 (GRCm39) R313H probably benign Het
Crebrf G T 17: 26,962,035 (GRCm39) E377D probably benign Het
Dcstamp T C 15: 39,618,118 (GRCm39) F176L probably benign Het
Dnah2 T C 11: 69,387,385 (GRCm39) D947G probably benign Het
Erbb4 A G 1: 68,289,791 (GRCm39) I750T probably damaging Het
Gas2l3 CACTCGTCATACT CACT 10: 89,266,820 (GRCm39) probably benign Het
Gm16391 T G 17: 76,591,826 (GRCm39) noncoding transcript Het
Gm973 A T 1: 59,597,273 (GRCm39) E434D probably damaging Het
Hdac7 T C 15: 97,704,397 (GRCm39) E491G probably damaging Het
Hyal5 A G 6: 24,876,621 (GRCm39) N165D probably benign Het
Mapk7 A G 11: 61,381,727 (GRCm39) I13T probably damaging Het
Medag T A 5: 149,335,444 (GRCm39) M1K probably null Het
Myh9 T C 15: 77,646,151 (GRCm39) D1944G probably benign Het
Nadk2 T C 15: 9,092,810 (GRCm39) W206R possibly damaging Het
Or7g18 T A 9: 18,787,463 (GRCm39) M280K probably damaging Het
Pcdhb11 T A 18: 37,555,021 (GRCm39) F117Y probably benign Het
Pdzd8 C T 19: 59,293,662 (GRCm39) E396K probably damaging Het
Piezo1 T A 8: 123,222,193 (GRCm39) Y541F probably damaging Het
Polr3h T C 15: 81,806,667 (GRCm39) I51V probably benign Het
Prune2 T C 19: 16,998,019 (GRCm39) probably null Het
Pyroxd1 C G 6: 142,300,467 (GRCm39) S199* probably null Het
Rars2 T G 4: 34,656,229 (GRCm39) V461G probably damaging Het
Rasgrp3 T C 17: 75,805,443 (GRCm39) C145R possibly damaging Het
Ryr1 T C 7: 28,785,463 (GRCm39) T1743A possibly damaging Het
Sac3d1 G A 19: 6,166,434 (GRCm39) A325V possibly damaging Het
Shank1 A T 7: 43,962,565 (GRCm39) D93V unknown Het
Smg1 T C 7: 117,753,487 (GRCm39) probably benign Het
Tbl1xr1 A T 3: 22,242,584 (GRCm39) N38I probably damaging Het
Ufc1 A G 1: 171,117,467 (GRCm39) I82T probably benign Het
Uggt2 A T 14: 119,272,347 (GRCm39) M434K probably benign Het
Unc80 G A 1: 66,710,873 (GRCm39) probably null Het
Zan T A 5: 137,462,450 (GRCm39) T910S unknown Het
Zfp64 A G 2: 168,776,851 (GRCm39) C256R probably benign Het
Other mutations in Ly86
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02693:Ly86 APN 13 37,559,005 (GRCm39) missense probably damaging 1.00
R0082:Ly86 UTSW 13 37,602,513 (GRCm39) critical splice acceptor site probably null
R4605:Ly86 UTSW 13 37,558,987 (GRCm39) missense possibly damaging 0.81
R4665:Ly86 UTSW 13 37,559,010 (GRCm39) missense probably damaging 0.98
R4904:Ly86 UTSW 13 37,599,496 (GRCm39) missense possibly damaging 0.94
R5112:Ly86 UTSW 13 37,559,013 (GRCm39) missense probably damaging 1.00
R5300:Ly86 UTSW 13 37,602,588 (GRCm39) missense probably benign 0.00
R7145:Ly86 UTSW 13 37,560,986 (GRCm39) missense probably damaging 1.00
R7258:Ly86 UTSW 13 37,529,473 (GRCm39) missense probably benign
R8524:Ly86 UTSW 13 37,560,869 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GGCAGAGTGCTGAGAGTATC -3'
(R):5'- GGAAGAGTCAGGACTTTGACCC -3'

Sequencing Primer
(F):5'- AAGATAGCCAGTGAGCTGCCTC -3'
(R):5'- TCAGGACTTTGACCCCTGGG -3'
Posted On 2015-10-08