Incidental Mutation 'R4665:Or10ag57'
ID 351805
Institutional Source Beutler Lab
Gene Symbol Or10ag57
Ensembl Gene ENSMUSG00000047594
Gene Name olfactory receptor family 10 subfamily AG member 57
Synonyms GA_x6K02T2Q125-48880078-48881058, Olfr1122, MOR264-1
MMRRC Submission 041923-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.101) question?
Stock # R4665 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 87218051-87219031 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 87218220 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Lysine at position 57 (I57K)
Ref Sequence ENSEMBL: ENSMUSP00000149403 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000056435] [ENSMUST00000215371]
AlphaFold Q8VGT9
Predicted Effect probably damaging
Transcript: ENSMUST00000056435
AA Change: I57K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000052190
Gene: ENSMUSG00000047594
AA Change: I57K

DomainStartEndE-ValueType
Pfam:7tm_4 43 319 6.3e-51 PFAM
Pfam:7tm_1 53 302 5.8e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000215371
AA Change: I57K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.4961 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.3%
  • 20x: 95.4%
Validation Efficiency 99% (89/90)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aak1 T A 6: 86,902,059 (GRCm39) M76K probably null Het
Abcc4 A G 14: 118,766,414 (GRCm39) I886T probably benign Het
Adam6a T C 12: 113,507,992 (GRCm39) Y122H possibly damaging Het
Adgre1 A G 17: 57,787,947 (GRCm39) T905A probably benign Het
Arap2 A G 5: 62,827,312 (GRCm39) F969L possibly damaging Het
Arhgef4 G T 1: 34,845,113 (GRCm39) G1439V possibly damaging Het
Atm A G 9: 53,375,529 (GRCm39) W2097R probably benign Het
Atmin A G 8: 117,684,698 (GRCm39) D786G probably damaging Het
AU016765 T A 17: 64,826,916 (GRCm39) noncoding transcript Het
Capn1 A T 19: 6,061,045 (GRCm39) N253K probably benign Het
Cdc42bpa A G 1: 179,972,130 (GRCm39) T527A probably damaging Het
Chmp7 A T 14: 69,958,404 (GRCm39) V255D probably damaging Het
Cldn12 A G 5: 5,558,385 (GRCm39) F14S probably damaging Het
Cpsf2 T C 12: 101,949,466 (GRCm39) S61P probably damaging Het
Cpvl C T 6: 53,908,918 (GRCm39) E282K probably benign Het
Crygn T A 5: 24,956,019 (GRCm39) probably benign Het
Csde1 C T 3: 102,954,388 (GRCm39) T386M probably damaging Het
Cux1 G A 5: 136,315,653 (GRCm39) T1129I probably damaging Het
Dcaf10 G A 4: 45,372,769 (GRCm39) R394Q possibly damaging Het
Dhx16 T C 17: 36,190,835 (GRCm39) V11A probably damaging Het
Dnah10 T C 5: 124,905,536 (GRCm39) M4060T possibly damaging Het
Duox1 C T 2: 122,149,956 (GRCm39) P116S probably benign Het
Eif5b A G 1: 38,084,793 (GRCm39) E880G probably damaging Het
Eml6 A T 11: 29,769,007 (GRCm39) Y67* probably null Het
Faim2 C A 15: 99,422,581 (GRCm39) probably null Het
Faim2 T G 15: 99,422,582 (GRCm39) S72R probably benign Het
Fanca T C 8: 123,995,711 (GRCm39) T1364A probably damaging Het
Fhip1a A T 3: 85,637,988 (GRCm39) W104R probably damaging Het
Gak A G 5: 108,730,826 (GRCm39) I860T probably benign Het
Garem2 C A 5: 30,319,665 (GRCm39) R376S probably damaging Het
Gdf2 A G 14: 33,667,408 (GRCm39) T377A probably damaging Het
Gm2431 A T 7: 141,811,440 (GRCm39) C155S unknown Het
Gm5814 A G 17: 47,721,288 (GRCm39) M1V probably null Het
Gm5901 C G 7: 105,026,438 (GRCm39) Q69E possibly damaging Het
Gm9945 A G 11: 53,371,202 (GRCm39) probably benign Het
Gmps T C 3: 63,908,956 (GRCm39) V486A probably benign Het
Gtf2ird1 T A 5: 134,412,756 (GRCm39) E55V probably damaging Het
Hoxa11 T A 6: 52,220,483 (GRCm39) N267Y probably damaging Het
Ifngr2 C A 16: 91,356,926 (GRCm39) H153Q possibly damaging Het
Ift172 G T 5: 31,442,598 (GRCm39) Q190K possibly damaging Het
Iqch A G 9: 63,352,853 (GRCm39) V899A probably damaging Het
Lactb2 T C 1: 13,717,624 (GRCm39) E133G probably damaging Het
Lig3 G A 11: 82,691,076 (GRCm39) V110M probably damaging Het
Lin54 C A 5: 100,600,943 (GRCm39) Q262H possibly damaging Het
Lingo3 G A 10: 80,671,372 (GRCm39) T186I probably damaging Het
Lrrc7 GAAGTTGTTTGGAGATTCTTATCTTA GA 3: 158,024,045 (GRCm39) probably benign Het
Ly86 T A 13: 37,559,010 (GRCm39) F70I probably damaging Het
Mospd2 A T X: 163,730,329 (GRCm39) S301T probably benign Het
Mroh2a A C 1: 88,169,340 (GRCm39) I672L probably benign Het
Myo15a A T 11: 60,395,705 (GRCm39) probably null Het
Nme8 C G 13: 19,858,605 (GRCm39) A78P probably damaging Het
Obscn C T 11: 59,015,578 (GRCm39) V965M probably damaging Het
Parn T C 16: 13,358,967 (GRCm39) K592E probably benign Het
Pax6 C A 2: 105,514,343 (GRCm39) probably benign Het
Pdcd6 A T 13: 74,465,325 (GRCm39) M1K probably null Het
Pex11b T C 3: 96,551,151 (GRCm39) L198P possibly damaging Het
Phldb3 C T 7: 24,310,852 (GRCm39) A28V probably benign Het
Pkn3 C A 2: 29,975,469 (GRCm39) probably benign Het
Pknox1 T C 17: 31,814,300 (GRCm39) probably null Het
Ptprg A C 14: 12,215,288 (GRCm38) I1092L possibly damaging Het
Pxylp1 A C 9: 96,707,338 (GRCm39) I281M probably damaging Het
Ramac C T 7: 81,418,178 (GRCm39) R78W probably damaging Het
Retreg2 G T 1: 75,121,310 (GRCm39) L195F probably damaging Het
Rgs20 G C 1: 5,091,231 (GRCm39) F66L probably benign Het
Ripk4 C T 16: 97,556,273 (GRCm39) V157I probably damaging Het
Ryr2 T C 13: 11,765,571 (GRCm39) probably null Het
Scaper A T 9: 55,819,339 (GRCm39) S125R probably damaging Het
Sec16a C T 2: 26,302,970 (GRCm39) probably benign Het
Slc35f6 T C 5: 30,812,957 (GRCm39) L37P probably damaging Het
Slc6a12 T A 6: 121,335,972 (GRCm39) probably benign Het
Slc9a5 A G 8: 106,094,760 (GRCm39) K784E probably damaging Het
Snd1 T C 6: 28,707,053 (GRCm39) V455A probably damaging Het
Ssbp2 A T 13: 91,687,454 (GRCm39) I46L possibly damaging Het
Stil A G 4: 114,898,841 (GRCm39) D1157G probably benign Het
Tax1bp1 T A 6: 52,714,116 (GRCm39) C271S probably benign Het
Tdpoz6 G A 3: 93,599,776 (GRCm39) H198Y probably damaging Het
Tdrd6 T A 17: 43,935,007 (GRCm39) M2014L probably benign Het
Thsd7a T A 6: 12,504,012 (GRCm39) I381F possibly damaging Het
Thsd7a T A 6: 12,337,313 (GRCm39) T1235S possibly damaging Het
Tmprss11d T C 5: 86,457,260 (GRCm39) D133G probably damaging Het
Tpr C T 1: 150,320,150 (GRCm39) R2233W probably damaging Het
Ugt1a1 CAGAGAGAGAGAGA CAGAGAGAGAGA 1: 88,139,706 (GRCm39) probably benign Het
Vgll1 A G X: 56,137,792 (GRCm39) R54G possibly damaging Het
Wdr72 A G 9: 74,117,306 (GRCm39) T673A probably benign Het
Zfp169 C T 13: 48,644,339 (GRCm39) probably benign Het
Zfp319 G A 8: 96,052,201 (GRCm39) probably benign Het
Other mutations in Or10ag57
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01783:Or10ag57 APN 2 87,218,182 (GRCm39) missense probably benign 0.39
IGL01783:Or10ag57 APN 2 87,218,187 (GRCm39) missense possibly damaging 0.91
IGL02396:Or10ag57 APN 2 87,218,049 (GRCm39) utr 5 prime probably benign
IGL03338:Or10ag57 APN 2 87,218,470 (GRCm39) missense probably benign 0.05
IGL03373:Or10ag57 APN 2 87,218,577 (GRCm39) missense probably damaging 1.00
R0594:Or10ag57 UTSW 2 87,218,298 (GRCm39) missense probably damaging 1.00
R1245:Or10ag57 UTSW 2 87,218,553 (GRCm39) missense probably benign 0.00
R1376:Or10ag57 UTSW 2 87,218,162 (GRCm39) missense probably benign 0.00
R1376:Or10ag57 UTSW 2 87,218,162 (GRCm39) missense probably benign 0.00
R1471:Or10ag57 UTSW 2 87,218,862 (GRCm39) missense probably damaging 1.00
R1681:Or10ag57 UTSW 2 87,218,964 (GRCm39) missense possibly damaging 0.95
R1995:Or10ag57 UTSW 2 87,218,175 (GRCm39) missense probably damaging 0.97
R2246:Or10ag57 UTSW 2 87,218,195 (GRCm39) missense probably benign 0.00
R2341:Or10ag57 UTSW 2 87,218,084 (GRCm39) missense probably benign
R4008:Or10ag57 UTSW 2 87,218,924 (GRCm39) missense possibly damaging 0.67
R4009:Or10ag57 UTSW 2 87,218,924 (GRCm39) missense possibly damaging 0.67
R4011:Or10ag57 UTSW 2 87,218,924 (GRCm39) missense possibly damaging 0.67
R4119:Or10ag57 UTSW 2 87,218,187 (GRCm39) missense possibly damaging 0.91
R4547:Or10ag57 UTSW 2 87,218,504 (GRCm39) missense probably benign 0.07
R4666:Or10ag57 UTSW 2 87,218,220 (GRCm39) missense probably damaging 1.00
R4801:Or10ag57 UTSW 2 87,218,553 (GRCm39) missense probably benign 0.00
R4802:Or10ag57 UTSW 2 87,218,553 (GRCm39) missense probably benign 0.00
R5049:Or10ag57 UTSW 2 87,219,002 (GRCm39) missense probably benign 0.00
R5070:Or10ag57 UTSW 2 87,218,507 (GRCm39) missense probably damaging 1.00
R7594:Or10ag57 UTSW 2 87,218,613 (GRCm39) missense probably damaging 1.00
R7684:Or10ag57 UTSW 2 87,218,372 (GRCm39) missense probably damaging 0.99
R8064:Or10ag57 UTSW 2 87,218,853 (GRCm39) missense probably benign 0.00
R8218:Or10ag57 UTSW 2 87,218,922 (GRCm39) missense probably damaging 0.99
R8282:Or10ag57 UTSW 2 87,218,852 (GRCm39) missense probably benign 0.01
R8335:Or10ag57 UTSW 2 87,218,204 (GRCm39) missense probably benign 0.02
R9800:Or10ag57 UTSW 2 87,218,508 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TTCATCTCATCAGGCCAGC -3'
(R):5'- AGGAACTCCATGCCTCCAAG -3'

Sequencing Primer
(F):5'- TCTCATCAGGCCAGCAAAGAAG -3'
(R):5'- TGCCTCCAAGCATGATGAC -3'
Posted On 2015-10-08