Mutagenetix > Incidental Mutation

Incidental Mutation 'R4666:Celsr1'

351970

Institutional Source

Beutler Lab

Gene Symbol

Celsr1

Ensembl Gene

ENSMUSG00000016028

Gene Name

cadherin, EGF LAG seven-pass G-type receptor 1

Synonyms

crash, Crsh, Scy

MMRRC Submission

041924-MU

Accession Numbers

Essential gene?

Possibly essential (E-score: 0.630) question?

Stock #

R4666 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

85898929-86033777 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 86030494 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 1093 (S1093P)

Ref Sequence

ENSEMBL: ENSMUSP00000016172 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000016172]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000016172
AA Change: S1093P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000016172
Gene: ENSMUSG00000016028
AA Change: S1093P

Domain	Start	End	E-Value	Type
signal peptide	1	29	N/A	INTRINSIC
low complexity region	65	93	N/A	INTRINSIC
low complexity region	221	240	N/A	INTRINSIC
low complexity region	243	257	N/A	INTRINSIC
CA	282	366	9.51e-26	SMART
CA	390	472	1.59e-27	SMART
CA	496	578	3.8e-25	SMART
CA	602	700	2.25e-27	SMART
CA	724	802	3.14e-17	SMART
CA	826	905	2.67e-29	SMART
CA	929	1012	3.23e-28	SMART
CA	1036	1114	4.17e-22	SMART
CA	1142	1218	6.89e-1	SMART
EGF	1321	1376	3.38e-3	SMART
EGF	1381	1414	5.49e-3	SMART
EGF	1421	1456	9.7e-4	SMART
LamG	1477	1644	2.53e-33	SMART
EGF	1667	1700	6.4e-4	SMART
LamG	1726	1864	1.13e-21	SMART
EGF	1890	1923	1.84e-4	SMART
EGF	1925	1961	5.49e-3	SMART
EGF_Lam	2018	2063	7.12e-11	SMART
HormR	2066	2128	2.55e-20	SMART
Pfam:GAIN	2140	2396	1.1e-64	PFAM
GPS	2422	2475	5.03e-22	SMART
Pfam:7tm_2	2480	2712	2.6e-60	PFAM
low complexity region	2738	2753	N/A	INTRINSIC
low complexity region	2819	2852	N/A	INTRINSIC
low complexity region	2976	2988	N/A	INTRINSIC

Coding Region Coverage

1x: 99.3%
3x: 98.7%
10x: 97.5%
20x: 95.8%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Nullizygous mice exhibit kinky tails, variable neural tube defects, abnormal hair follicle orientation, whorl-like hair patterns, and partial prenatal lethality. ENU-induced mutants show defects in planar polarity of inner ear hair cells and complete perinatal lethality due to craniorachischisis. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 100 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410137M14Rik	G	A	17: 36,978,902 (GRCm38)	S12L	probably benign	Het
Abce1	A	G	8: 79,687,486 (GRCm38)	V532A	probably damaging	Het
Adamts12	T	A	15: 11,311,492 (GRCm38)	N1278K	probably benign	Het
Adipor1	T	A	1: 134,424,905 (GRCm38)	I138N	probably damaging	Het
Aox2	C	T	1: 58,304,597 (GRCm38)	Q480*	probably null	Het
Arhgef38	C	T	3: 133,140,772 (GRCm38)		probably null	Het
Atmin	A	G	8: 116,957,959 (GRCm38)	D786G	probably damaging	Het
Bltp3a	G	T	17: 27,893,503 (GRCm38)	W1222L	possibly damaging	Het
Capn1	A	T	19: 6,011,015 (GRCm38)	N253K	probably benign	Het
Cdh8	T	C	8: 99,024,902 (GRCm38)	T728A	possibly damaging	Het
Cep135	C	A	5: 76,616,854 (GRCm38)	P560T	probably benign	Het
Chfr	C	T	5: 110,144,867 (GRCm38)	Q167*	probably null	Het
Chrna4	A	G	2: 181,037,493 (GRCm38)	S54P	probably damaging	Het
Cntln	A	G	4: 84,971,216 (GRCm38)	N312S	probably benign	Het
Cntn6	A	G	6: 104,728,284 (GRCm38)	E154G	probably benign	Het
Col6a6	T	A	9: 105,767,342 (GRCm38)	Y1249F	possibly damaging	Het
Cpsf2	T	C	12: 101,983,207 (GRCm38)	S61P	probably damaging	Het
Cpvl	C	T	6: 53,931,933 (GRCm38)	E282K	probably benign	Het
Cryba2	C	T	1: 74,890,048 (GRCm38)	D179N	probably benign	Het
Daglb	A	T	5: 143,503,349 (GRCm38)	R654W	probably damaging	Het
Dennd3	A	G	15: 73,570,860 (GRCm38)	D1244G	probably damaging	Het
Dhx57	T	C	17: 80,274,961 (GRCm38)	E405G	probably damaging	Het
Dnah10	T	C	5: 124,828,472 (GRCm38)	M4060T	possibly damaging	Het
Dph1	A	G	11: 75,181,330 (GRCm38)	S238P	probably damaging	Het
Duox1	C	T	2: 122,319,475 (GRCm38)	P116S	probably benign	Het
Ebf1	A	G	11: 44,991,557 (GRCm38)	N447D	probably damaging	Het
Epg5	A	G	18: 78,012,864 (GRCm38)	N1751S	probably benign	Het
Exoc6	A	G	19: 37,570,505 (GRCm38)	D75G	probably damaging	Het
Extl2	T	A	3: 116,024,207 (GRCm38)	I70N	probably damaging	Het
Fanca	T	C	8: 123,268,972 (GRCm38)	T1364A	probably damaging	Het
Fbln7	T	A	2: 128,894,910 (GRCm38)		probably null	Het
Foxa3	G	T	7: 19,014,372 (GRCm38)	C275*	probably null	Het
Foxred1	C	T	9: 35,210,855 (GRCm38)		probably benign	Het
Galr2	A	G	11: 116,283,629 (GRCm38)	T362A	probably benign	Het
Garem2	C	A	5: 30,114,667 (GRCm38)	R376S	probably damaging	Het
Garre1	T	C	7: 34,284,773 (GRCm38)	M142V	probably damaging	Het
Gatc	T	A	5: 115,335,547 (GRCm38)	N111I	probably benign	Het
Gjb4	C	A	4: 127,351,778 (GRCm38)	K123N	probably damaging	Het
Gm9894	T	C	13: 67,765,094 (GRCm38)		noncoding transcript	Het
Gtdc1	T	C	2: 44,591,925 (GRCm38)	N301S	probably benign	Het
Gtf2ird1	T	A	5: 134,383,902 (GRCm38)	E55V	probably damaging	Het
Gtsf1	T	C	15: 103,421,205 (GRCm38)	I96V	probably benign	Het
Homer1	T	A	13: 93,402,159 (GRCm38)	I170N	probably damaging	Het
Homer3	G	A	8: 70,290,143 (GRCm38)		probably null	Het
Hoxb9	A	G	11: 96,274,831 (GRCm38)	K242R	possibly damaging	Het
Ifna14	T	C	4: 88,571,336 (GRCm38)	R155G	probably benign	Het
Lrrc7	GAAGTTGTTTGGAGATTCTTATCTTA	GA	3: 158,318,408 (GRCm38)		probably benign	Het
Lsm11	A	G	11: 45,933,813 (GRCm38)	S296P	probably damaging	Het
Macrod2	T	C	2: 142,217,599 (GRCm38)	L265P	probably damaging	Het
Mcu	G	A	10: 59,456,699 (GRCm38)	L53F	probably damaging	Het
Mpv17l2	A	G	8: 70,760,415 (GRCm38)	V104A	possibly damaging	Het
Myh10	G	A	11: 68,801,730 (GRCm38)		probably null	Het
Nemf	T	C	12: 69,312,280 (GRCm38)	E1031G	probably damaging	Het
Nhsl1	G	A	10: 18,531,405 (GRCm38)	S1395N	probably damaging	Het
Niban3	G	T	8: 71,603,825 (GRCm38)	E390*	probably null	Het
Nlrp2	T	A	7: 5,319,189 (GRCm38)	I82F	probably benign	Het
Nlrp4e	T	A	7: 23,336,780 (GRCm38)	L686*	probably null	Het
Nudt12os	T	A	17: 59,024,551 (GRCm38)		noncoding transcript	Het
Or10ag57	T	A	2: 87,387,876 (GRCm38)	I57K	probably damaging	Het
Or10j5	G	A	1: 172,957,590 (GRCm38)	S265N	probably benign	Het
Or2h1b	A	T	17: 37,151,379 (GRCm38)	S44T	possibly damaging	Het
Or5ac23	A	G	16: 59,329,210 (GRCm38)	Y100H	possibly damaging	Het
Or5k16	T	C	16: 58,916,584 (GRCm38)	D19G	probably benign	Het
Or8g27	T	A	9: 39,217,846 (GRCm38)	M163K	probably damaging	Het
Pde7a	T	C	3: 19,260,256 (GRCm38)	T59A	probably damaging	Het
Pde7b	A	C	10: 20,438,750 (GRCm38)	D203E	probably damaging	Het
Phkg2	T	A	7: 127,577,984 (GRCm38)	I94N	possibly damaging	Het
Pik3r2	G	A	8: 70,768,859 (GRCm38)	T667I	possibly damaging	Het
Pitx3	T	A	19: 46,137,101 (GRCm38)	H68L	possibly damaging	Het
Prcd	A	G	11: 116,668,164 (GRCm38)		probably benign	Het
Prune2	C	T	19: 17,120,188 (GRCm38)	R1019*	probably null	Het
Psap	A	G	10: 60,300,545 (GRCm38)	D486G	probably benign	Het
Purb	A	T	11: 6,475,615 (GRCm38)	V91E	probably damaging	Het
Recql	C	A	6: 142,376,841 (GRCm38)	V112F	probably damaging	Het
Rptor	A	T	11: 119,743,882 (GRCm38)	I175F	probably damaging	Het
Sbf1	C	T	15: 89,295,246 (GRCm38)	V1385M	probably damaging	Het
Serpinb13	C	T	1: 106,982,844 (GRCm38)	S66L	probably damaging	Het
Slc35f6	T	C	5: 30,655,613 (GRCm38)	L37P	probably damaging	Het
Slc6a3	T	A	13: 73,538,581 (GRCm38)	N22K	possibly damaging	Het
Sorl1	A	T	9: 42,004,051 (GRCm38)	M1294K	probably damaging	Het
Sp6	C	A	11: 97,021,875 (GRCm38)	A138E	probably benign	Het
Spag8	G	T	4: 43,653,408 (GRCm38)		probably benign	Het
Spmip4	G	T	6: 50,595,828 (GRCm38)	T35K	possibly damaging	Het
Spon1	T	A	7: 114,028,969 (GRCm38)	M320K	probably benign	Het
Tceanc2	A	T	4: 107,165,560 (GRCm38)	S77T	probably damaging	Het
Thsd7a	T	A	6: 12,504,013 (GRCm38)	I381F	possibly damaging	Het
Thsd7a	T	A	6: 12,337,314 (GRCm38)	T1235S	possibly damaging	Het
Tmc4	T	C	7: 3,671,271 (GRCm38)		probably null	Het
Tmprss11d	T	C	5: 86,309,401 (GRCm38)	D133G	probably damaging	Het
Trav13n-3	T	A	14: 53,337,496 (GRCm38)	V65D	probably damaging	Het
Trpm1	G	T	7: 64,203,034 (GRCm38)	L65F	probably damaging	Het
Tyk2	C	T	9: 21,114,207 (GRCm38)	A741T	probably damaging	Het
Ube2v1	T	A	2: 167,610,377 (GRCm38)	Y102F	probably damaging	Het
Uckl1	A	T	2: 181,574,868 (GRCm38)	S95T	possibly damaging	Het
Vcan	C	A	13: 89,679,934 (GRCm38)	W2171L	probably damaging	Het
Vinac1	T	C	2: 129,038,230 (GRCm38)	H592R	probably benign	Het
Vmn1r64	T	C	7: 5,884,358 (GRCm38)	N62S	probably damaging	Het
Vmn2r67	T	C	7: 85,150,623 (GRCm38)	D469G	probably benign	Het
Vps13b	A	G	15: 35,640,544 (GRCm38)	S1352G	probably benign	Het
Zbtb38	C	T	9: 96,688,383 (GRCm38)	R216H	probably damaging	Het

Other mutations in Celsr1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00392:Celsr1	APN	15	85,931,345 (GRCm38)	missense	probably benign	0.04
IGL00519:Celsr1	APN	15	86,030,836 (GRCm38)	missense	probably damaging	1.00
IGL00909:Celsr1	APN	15	85,922,235 (GRCm38)	missense	probably damaging	1.00
IGL01303:Celsr1	APN	15	86,030,491 (GRCm38)	missense	probably damaging	0.97
IGL01726:Celsr1	APN	15	85,926,190 (GRCm38)	missense	probably benign	0.35
IGL01910:Celsr1	APN	15	85,929,895 (GRCm38)	missense	probably benign
IGL01931:Celsr1	APN	15	85,907,660 (GRCm38)	missense	probably damaging	1.00
IGL01952:Celsr1	APN	15	85,963,223 (GRCm38)	missense	probably benign	0.35
IGL02090:Celsr1	APN	15	85,907,721 (GRCm38)	missense	possibly damaging	0.49
IGL02191:Celsr1	APN	15	85,979,004 (GRCm38)	missense	possibly damaging	0.69
IGL02372:Celsr1	APN	15	85,929,907 (GRCm38)	missense	probably benign	0.01
IGL02413:Celsr1	APN	15	86,031,226 (GRCm38)	missense	possibly damaging	0.96
IGL02478:Celsr1	APN	15	85,941,136 (GRCm38)	missense	possibly damaging	0.68
IGL02507:Celsr1	APN	15	85,900,688 (GRCm38)	utr 3 prime	probably benign
IGL02508:Celsr1	APN	15	86,030,617 (GRCm38)	nonsense	probably null
IGL02899:Celsr1	APN	15	86,031,726 (GRCm38)	missense	probably damaging	0.98
IGL02939:Celsr1	APN	15	85,901,472 (GRCm38)	missense	probably benign
IGL03212:Celsr1	APN	15	85,930,677 (GRCm38)	missense	probably benign	0.04
P0028:Celsr1	UTSW	15	85,922,235 (GRCm38)	missense	probably damaging	1.00
PIT4305001:Celsr1	UTSW	15	85,900,937 (GRCm38)	missense	possibly damaging	0.87
PIT4480001:Celsr1	UTSW	15	86,032,414 (GRCm38)	missense	probably damaging	0.99
R0018:Celsr1	UTSW	15	86,031,042 (GRCm38)	missense	possibly damaging	0.47
R0018:Celsr1	UTSW	15	86,031,042 (GRCm38)	missense	possibly damaging	0.47
R0038:Celsr1	UTSW	15	85,929,419 (GRCm38)	missense	possibly damaging	0.65
R0057:Celsr1	UTSW	15	86,030,762 (GRCm38)	missense	probably benign	0.02
R0060:Celsr1	UTSW	15	85,922,198 (GRCm38)	missense	probably damaging	0.98
R0060:Celsr1	UTSW	15	85,922,198 (GRCm38)	missense	probably damaging	0.98
R0279:Celsr1	UTSW	15	85,902,864 (GRCm38)	missense	probably benign	0.00
R0570:Celsr1	UTSW	15	85,903,365 (GRCm38)	missense	probably benign	0.18
R0611:Celsr1	UTSW	15	85,932,323 (GRCm38)	missense	possibly damaging	0.91
R0731:Celsr1	UTSW	15	85,901,597 (GRCm38)	missense	probably benign
R0792:Celsr1	UTSW	15	85,931,276 (GRCm38)	missense	probably benign	0.02
R0943:Celsr1	UTSW	15	85,903,288 (GRCm38)	missense	probably damaging	1.00
R0989:Celsr1	UTSW	15	86,031,279 (GRCm38)	missense	probably benign	0.39
R1118:Celsr1	UTSW	15	86,032,047 (GRCm38)	missense	probably damaging	1.00
R1237:Celsr1	UTSW	15	85,903,974 (GRCm38)	missense	probably benign	0.01
R1239:Celsr1	UTSW	15	85,979,146 (GRCm38)	missense	probably damaging	0.99
R1405:Celsr1	UTSW	15	85,905,434 (GRCm38)	splice site	probably null
R1405:Celsr1	UTSW	15	85,905,434 (GRCm38)	splice site	probably null
R1522:Celsr1	UTSW	15	85,931,276 (GRCm38)	missense	probably benign	0.02
R1662:Celsr1	UTSW	15	86,031,062 (GRCm38)	missense	probably damaging	1.00
R1673:Celsr1	UTSW	15	85,932,457 (GRCm38)	missense	probably benign	0.00
R1795:Celsr1	UTSW	15	86,030,323 (GRCm38)	missense	probably damaging	0.99
R1799:Celsr1	UTSW	15	86,032,685 (GRCm38)	missense	probably damaging	1.00
R1858:Celsr1	UTSW	15	86,032,759 (GRCm38)	missense	probably damaging	1.00
R2040:Celsr1	UTSW	15	86,032,887 (GRCm38)	missense	probably damaging	1.00
R2050:Celsr1	UTSW	15	86,030,547 (GRCm38)	missense	probably benign	0.02
R2131:Celsr1	UTSW	15	85,963,223 (GRCm38)	missense	probably benign	0.35
R2132:Celsr1	UTSW	15	86,031,967 (GRCm38)	missense	possibly damaging	0.91
R2189:Celsr1	UTSW	15	85,979,230 (GRCm38)	missense	possibly damaging	0.93
R2192:Celsr1	UTSW	15	85,916,723 (GRCm38)	missense	possibly damaging	0.93
R4213:Celsr1	UTSW	15	86,031,807 (GRCm38)	missense	probably damaging	1.00
R4356:Celsr1	UTSW	15	85,978,827 (GRCm38)	missense	probably damaging	1.00
R4414:Celsr1	UTSW	15	85,927,999 (GRCm38)	missense	probably damaging	1.00
R4414:Celsr1	UTSW	15	85,963,133 (GRCm38)	missense	probably benign	0.00
R4416:Celsr1	UTSW	15	85,927,999 (GRCm38)	missense	probably damaging	1.00
R4645:Celsr1	UTSW	15	85,916,756 (GRCm38)	missense	probably benign	0.35
R4687:Celsr1	UTSW	15	85,932,460 (GRCm38)	missense	possibly damaging	0.94
R4735:Celsr1	UTSW	15	85,906,029 (GRCm38)	critical splice acceptor site	probably null
R4804:Celsr1	UTSW	15	85,937,953 (GRCm38)	missense	possibly damaging	0.49
R4995:Celsr1	UTSW	15	85,937,911 (GRCm38)	missense	probably damaging	0.99
R5070:Celsr1	UTSW	15	85,939,134 (GRCm38)	missense	possibly damaging	0.89
R5218:Celsr1	UTSW	15	85,932,384 (GRCm38)	missense	probably damaging	1.00
R5280:Celsr1	UTSW	15	85,930,546 (GRCm38)	missense	probably benign
R5310:Celsr1	UTSW	15	85,926,222 (GRCm38)	missense	possibly damaging	0.88
R5388:Celsr1	UTSW	15	85,925,518 (GRCm38)	missense	probably damaging	0.99
R5484:Celsr1	UTSW	15	85,931,282 (GRCm38)	missense	probably benign	0.00
R5639:Celsr1	UTSW	15	86,030,767 (GRCm38)	missense	probably damaging	1.00
R5758:Celsr1	UTSW	15	85,941,264 (GRCm38)	missense	probably benign	0.27
R5778:Celsr1	UTSW	15	86,032,955 (GRCm38)	missense	probably damaging	1.00
R5893:Celsr1	UTSW	15	85,904,014 (GRCm38)	missense	probably benign	0.02
R5915:Celsr1	UTSW	15	86,030,349 (GRCm38)	missense	probably damaging	0.96
R5915:Celsr1	UTSW	15	85,937,975 (GRCm38)	missense	probably benign
R5932:Celsr1	UTSW	15	86,032,704 (GRCm38)	missense	probably damaging	1.00
R5950:Celsr1	UTSW	15	86,032,500 (GRCm38)	missense	probably damaging	1.00
R5975:Celsr1	UTSW	15	85,919,038 (GRCm38)	splice site	probably null
R6050:Celsr1	UTSW	15	85,930,611 (GRCm38)	missense	probably benign	0.00
R6117:Celsr1	UTSW	15	85,932,411 (GRCm38)	missense	probably benign	0.04
R6178:Celsr1	UTSW	15	85,901,021 (GRCm38)	missense	probably benign	0.08
R6186:Celsr1	UTSW	15	85,921,193 (GRCm38)	missense	possibly damaging	0.84
R6212:Celsr1	UTSW	15	85,916,687 (GRCm38)	missense	probably benign	0.25
R6307:Celsr1	UTSW	15	85,928,330 (GRCm38)	missense	probably benign
R6320:Celsr1	UTSW	15	85,900,959 (GRCm38)	missense	probably benign	0.13
R6349:Celsr1	UTSW	15	86,031,684 (GRCm38)	missense	probably damaging	1.00
R6478:Celsr1	UTSW	15	85,925,518 (GRCm38)	missense	probably damaging	0.99
R6504:Celsr1	UTSW	15	85,978,920 (GRCm38)	missense	probably benign	0.07
R6607:Celsr1	UTSW	15	85,963,285 (GRCm38)	missense	probably benign
R6615:Celsr1	UTSW	15	85,902,114 (GRCm38)	critical splice donor site	probably null
R6661:Celsr1	UTSW	15	85,918,934 (GRCm38)	missense	probably damaging	1.00
R6722:Celsr1	UTSW	15	85,905,914 (GRCm38)	critical splice donor site	probably null
R6743:Celsr1	UTSW	15	85,907,598 (GRCm38)	missense	probably damaging	0.96
R6746:Celsr1	UTSW	15	86,031,495 (GRCm38)	missense	probably damaging	1.00
R6772:Celsr1	UTSW	15	86,030,782 (GRCm38)	missense	probably benign
R6838:Celsr1	UTSW	15	85,939,194 (GRCm38)	missense	probably benign
R6886:Celsr1	UTSW	15	86,031,654 (GRCm38)	missense	probably benign	0.00
R7030:Celsr1	UTSW	15	85,905,478 (GRCm38)	missense	probably damaging	0.99
R7060:Celsr1	UTSW	15	86,032,655 (GRCm38)	missense	probably benign	0.07
R7080:Celsr1	UTSW	15	85,932,451 (GRCm38)	missense	possibly damaging	0.87
R7325:Celsr1	UTSW	15	86,033,008 (GRCm38)	missense	probably damaging	0.99
R7357:Celsr1	UTSW	15	86,030,514 (GRCm38)	missense	probably benign	0.00
R7371:Celsr1	UTSW	15	86,030,674 (GRCm38)	missense	possibly damaging	0.91
R7446:Celsr1	UTSW	15	85,907,673 (GRCm38)	missense	possibly damaging	0.95
R7465:Celsr1	UTSW	15	86,033,392 (GRCm38)	missense	probably benign
R7491:Celsr1	UTSW	15	86,032,518 (GRCm38)	missense	possibly damaging	0.78
R7639:Celsr1	UTSW	15	85,929,872 (GRCm38)	missense	probably benign	0.00
R7685:Celsr1	UTSW	15	85,978,732 (GRCm38)	nonsense	probably null
R7741:Celsr1	UTSW	15	85,979,102 (GRCm38)	missense	possibly damaging	0.94
R7768:Celsr1	UTSW	15	85,932,409 (GRCm38)	missense	probably benign
R7974:Celsr1	UTSW	15	86,031,030 (GRCm38)	missense	probably damaging	1.00
R7977:Celsr1	UTSW	15	86,032,993 (GRCm38)	missense	probably damaging	1.00
R7987:Celsr1	UTSW	15	86,032,993 (GRCm38)	missense	probably damaging	1.00
R8073:Celsr1	UTSW	15	85,939,155 (GRCm38)	missense	probably benign	0.00
R8099:Celsr1	UTSW	15	86,031,600 (GRCm38)	missense	probably damaging	0.99
R8190:Celsr1	UTSW	15	85,902,889 (GRCm38)	missense	probably damaging	0.99
R8210:Celsr1	UTSW	15	85,979,235 (GRCm38)	missense	probably benign	0.00
R8289:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R8290:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R8292:Celsr1	UTSW	15	85,907,618 (GRCm38)	missense	possibly damaging	0.90
R8328:Celsr1	UTSW	15	85,922,244 (GRCm38)	missense	probably benign	0.00
R8330:Celsr1	UTSW	15	85,932,300 (GRCm38)	missense	probably damaging	0.99
R8333:Celsr1	UTSW	15	86,031,414 (GRCm38)	missense	possibly damaging	0.65
R8352:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R8384:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R8452:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R8463:Celsr1	UTSW	15	86,030,214 (GRCm38)	missense	probably damaging	1.00
R8479:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R8480:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R8493:Celsr1	UTSW	15	85,938,006 (GRCm38)	missense	possibly damaging	0.67
R8498:Celsr1	UTSW	15	85,939,105 (GRCm38)	missense	probably benign	0.01
R8506:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R8771:Celsr1	UTSW	15	85,903,974 (GRCm38)	missense	probably benign	0.01
R8891:Celsr1	UTSW	15	85,937,993 (GRCm38)	missense	probably benign	0.01
R8905:Celsr1	UTSW	15	85,904,068 (GRCm38)	intron	probably benign
R8924:Celsr1	UTSW	15	86,032,470 (GRCm38)	missense	possibly damaging	0.94
R8979:Celsr1	UTSW	15	85,963,139 (GRCm38)	missense	probably damaging	0.96
R9069:Celsr1	UTSW	15	86,030,571 (GRCm38)	missense	possibly damaging	0.53
R9115:Celsr1	UTSW	15	85,919,016 (GRCm38)	missense	probably damaging	1.00
R9194:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R9196:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R9198:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R9200:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R9201:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R9202:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R9203:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R9222:Celsr1	UTSW	15	85,931,270 (GRCm38)	missense	possibly damaging	0.68
R9236:Celsr1	UTSW	15	86,030,850 (GRCm38)	missense	probably damaging	1.00
R9384:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R9386:Celsr1	UTSW	15	85,979,030 (GRCm38)	missense	probably damaging	1.00
R9400:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R9401:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R9415:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R9428:Celsr1	UTSW	15	85,931,348 (GRCm38)	missense	possibly damaging	0.64
R9435:Celsr1	UTSW	15	85,922,334 (GRCm38)	splice site	probably benign
R9493:Celsr1	UTSW	15	85,901,145 (GRCm38)	missense	probably damaging	0.98
R9495:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R9499:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
R9607:Celsr1	UTSW	15	86,031,028 (GRCm38)	missense
R9673:Celsr1	UTSW	15	86,033,085 (GRCm38)	nonsense	probably null
Z1176:Celsr1	UTSW	15	85,963,100 (GRCm38)	missense	probably damaging	0.96
Z1177:Celsr1	UTSW	15	85,978,851 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TGAGGCTGTCAGATAGGTCAGG -3'
(R):5'- CTGTTTGTGGAAGAGAACAGC -3'

Sequencing Primer
(F):5'- CAGATAGGTCAGGGTCGTGG -3'
(R):5'- AGAGAACAGCCCTGTGGGTTC -3'

Posted On

2015-10-08