Incidental Mutation 'R4667:Sipa1l2'
| ID |
352048 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Sipa1l2
|
| Ensembl Gene |
ENSMUSG00000001995 |
| Gene Name |
signal-induced proliferation-associated 1 like 2 |
| Synonyms |
|
| MMRRC Submission |
042012-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.324)
|
| Stock # |
R4667 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
125418063-125569808 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 125453470 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Arginine to Glycine
at position 1063
(R1063G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000148557
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000108775]
[ENSMUST00000212168]
[ENSMUST00000212987]
|
| AlphaFold |
Q80TE4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000108775
AA Change: R1063G
PolyPhen 2
Score 0.888 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000104405
Gene: ENSMUSG00000001995
AA Change: R1063G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
53 |
64 |
N/A |
INTRINSIC |
|
low complexity region
|
163 |
172 |
N/A |
INTRINSIC |
|
low complexity region
|
261 |
272 |
N/A |
INTRINSIC |
|
low complexity region
|
427 |
449 |
N/A |
INTRINSIC |
|
Pfam:Rap_GAP
|
625 |
807 |
2.6e-67 |
PFAM |
|
PDZ
|
960 |
1026 |
6.47e-9 |
SMART |
|
low complexity region
|
1091 |
1103 |
N/A |
INTRINSIC |
|
low complexity region
|
1120 |
1138 |
N/A |
INTRINSIC |
|
low complexity region
|
1220 |
1238 |
N/A |
INTRINSIC |
|
low complexity region
|
1299 |
1312 |
N/A |
INTRINSIC |
|
low complexity region
|
1321 |
1329 |
N/A |
INTRINSIC |
|
low complexity region
|
1334 |
1355 |
N/A |
INTRINSIC |
|
low complexity region
|
1404 |
1418 |
N/A |
INTRINSIC |
|
Pfam:SPAR_C
|
1421 |
1666 |
2.5e-76 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000212168
AA Change: R1063G
PolyPhen 2
Score 0.932 (Sensitivity: 0.80; Specificity: 0.94)
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000212987
AA Change: R1063G
PolyPhen 2
Score 0.888 (Sensitivity: 0.82; Specificity: 0.94)
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 95.1%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the signal-induced proliferation-associated 1 like family. Members of this family contain a GTPase activating domain, a PDZ domain and a C-terminal coiled-coil domain with a leucine zipper. A similar protein in rat acts as a GTPases for the small GTPase Rap. [provided by RefSeq, Sep 2015]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 109 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930539E08Rik |
G |
T |
17: 28,908,313 (GRCm38) |
Q241K |
possibly damaging |
Het |
| Acad8 |
A |
G |
9: 26,990,627 (GRCm38) |
L147P |
probably damaging |
Het |
| Adgra3 |
T |
A |
5: 49,978,956 (GRCm38) |
Y729F |
possibly damaging |
Het |
| Ago2 |
A |
G |
15: 73,146,416 (GRCm38) |
Y58H |
probably damaging |
Het |
| Akap13 |
A |
G |
7: 75,729,094 (GRCm38) |
T2128A |
probably damaging |
Het |
| Akap2 |
A |
T |
4: 57,855,655 (GRCm38) |
D328V |
possibly damaging |
Het |
| Ankhd1 |
C |
A |
18: 36,648,021 (GRCm38) |
P2042Q |
possibly damaging |
Het |
| Arhgef15 |
T |
C |
11: 68,954,561 (GRCm38) |
K155R |
probably benign |
Het |
| Atp10b |
T |
C |
11: 43,247,518 (GRCm38) |
F1209L |
probably damaging |
Het |
| B130006D01Rik |
A |
T |
11: 95,726,509 (GRCm38) |
|
probably benign |
Het |
| Bmpr2 |
T |
C |
1: 59,867,716 (GRCm38) |
L656S |
probably damaging |
Het |
| Btbd17 |
A |
G |
11: 114,793,857 (GRCm38) |
F119L |
possibly damaging |
Het |
| Ccdc191 |
G |
T |
16: 43,931,283 (GRCm38) |
K267N |
probably damaging |
Het |
| Ceacam20 |
T |
C |
7: 19,986,027 (GRCm38) |
Y495H |
probably damaging |
Het |
| Celf2 |
T |
C |
2: 6,721,528 (GRCm38) |
I47V |
probably benign |
Het |
| Chd9 |
T |
C |
8: 91,033,800 (GRCm38) |
S2058P |
possibly damaging |
Het |
| Clcn6 |
T |
C |
4: 148,024,167 (GRCm38) |
E135G |
possibly damaging |
Het |
| Cntn1 |
T |
A |
15: 92,295,079 (GRCm38) |
N687K |
probably damaging |
Het |
| Col1a2 |
A |
T |
6: 4,512,412 (GRCm38) |
M99L |
unknown |
Het |
| Cpeb2 |
T |
C |
5: 43,233,892 (GRCm38) |
|
probably benign |
Het |
| Csn1s2b |
A |
G |
5: 87,822,311 (GRCm38) |
T134A |
possibly damaging |
Het |
| Cst13 |
A |
T |
2: 148,823,081 (GRCm38) |
|
probably benign |
Het |
| Cyp2c66 |
T |
A |
19: 39,176,656 (GRCm38) |
D360E |
probably damaging |
Het |
| Dhx8 |
A |
G |
11: 101,738,161 (GRCm38) |
S179G |
unknown |
Het |
| Dip2b |
A |
G |
15: 100,151,360 (GRCm38) |
I212V |
probably benign |
Het |
| Dnah9 |
G |
A |
11: 66,155,531 (GRCm38) |
H64Y |
probably benign |
Het |
| Dnal1 |
T |
C |
12: 84,136,700 (GRCm38) |
|
probably benign |
Het |
| Dse |
T |
G |
10: 34,153,012 (GRCm38) |
Y694S |
probably damaging |
Het |
| Dync2h1 |
T |
C |
9: 7,051,411 (GRCm38) |
I3175V |
probably benign |
Het |
| Elf5 |
A |
G |
2: 103,449,060 (GRCm38) |
N209D |
probably damaging |
Het |
| Elovl1 |
A |
G |
4: 118,430,787 (GRCm38) |
Y40C |
probably damaging |
Het |
| Erp27 |
T |
C |
6: 136,908,152 (GRCm38) |
E216G |
possibly damaging |
Het |
| F5 |
G |
A |
1: 164,174,186 (GRCm38) |
V153I |
probably benign |
Het |
| Fam186a |
G |
A |
15: 99,944,532 (GRCm38) |
T1277I |
possibly damaging |
Het |
| Fam90a1a |
A |
T |
8: 21,963,346 (GRCm38) |
H239L |
possibly damaging |
Het |
| Fchsd2 |
G |
T |
7: 101,250,449 (GRCm38) |
R334L |
probably damaging |
Het |
| Fermt3 |
T |
C |
19: 7,002,920 (GRCm38) |
Y369C |
probably damaging |
Het |
| Fhod3 |
C |
T |
18: 25,066,338 (GRCm38) |
P689S |
probably benign |
Het |
| Fnbp1l |
G |
T |
3: 122,556,567 (GRCm38) |
Q332K |
probably benign |
Het |
| Frem3 |
T |
C |
8: 80,663,420 (GRCm38) |
S1767P |
probably damaging |
Het |
| Ggt5 |
T |
C |
10: 75,603,031 (GRCm38) |
L121P |
probably damaging |
Het |
| Gm609 |
A |
G |
16: 45,444,163 (GRCm38) |
S11P |
probably benign |
Het |
| Gphn |
T |
C |
12: 78,454,817 (GRCm38) |
S119P |
probably damaging |
Het |
| Herc2 |
A |
G |
7: 56,131,253 (GRCm38) |
D1222G |
probably damaging |
Het |
| Hmx3 |
T |
C |
7: 131,544,382 (GRCm38) |
I273T |
possibly damaging |
Het |
| Hnrnpu |
A |
G |
1: 178,332,181 (GRCm38) |
|
probably benign |
Het |
| Hspg2 |
C |
T |
4: 137,539,645 (GRCm38) |
T1987I |
possibly damaging |
Het |
| Ighv1-22 |
T |
A |
12: 114,746,451 (GRCm38) |
Q58L |
probably damaging |
Het |
| Ighv14-3 |
T |
A |
12: 114,060,255 (GRCm38) |
I7F |
probably benign |
Het |
| Kcns3 |
C |
A |
12: 11,091,783 (GRCm38) |
R305L |
probably damaging |
Het |
| Kcnu1 |
C |
T |
8: 25,910,921 (GRCm38) |
A699V |
possibly damaging |
Het |
| Kif22 |
A |
C |
7: 127,033,328 (GRCm38) |
L270W |
probably damaging |
Het |
| Lrp2 |
G |
T |
2: 69,489,298 (GRCm38) |
H1960Q |
probably benign |
Het |
| March7 |
C |
T |
2: 60,241,050 (GRCm38) |
Q94* |
probably null |
Het |
| Mcoln3 |
A |
T |
3: 146,131,204 (GRCm38) |
I264F |
probably benign |
Het |
| Mdn1 |
A |
C |
4: 32,679,572 (GRCm38) |
T706P |
probably damaging |
Het |
| Mfsd2b |
A |
G |
12: 4,867,636 (GRCm38) |
C137R |
probably benign |
Het |
| Mmp25 |
A |
G |
17: 23,644,607 (GRCm38) |
V83A |
probably benign |
Het |
| Mocos |
T |
C |
18: 24,666,434 (GRCm38) |
Y242H |
probably benign |
Het |
| Msh6 |
T |
C |
17: 87,984,806 (GRCm38) |
S330P |
possibly damaging |
Het |
| Mtus2 |
T |
C |
5: 148,298,260 (GRCm38) |
S1156P |
possibly damaging |
Het |
| Muc5b |
G |
A |
7: 141,842,379 (GRCm38) |
R124H |
unknown |
Het |
| Mybbp1a |
G |
A |
11: 72,447,971 (GRCm38) |
E775K |
possibly damaging |
Het |
| Myo10 |
A |
G |
15: 25,793,153 (GRCm38) |
E1272G |
possibly damaging |
Het |
| Nars |
A |
G |
18: 64,505,231 (GRCm38) |
S254P |
possibly damaging |
Het |
| Ncapd2 |
A |
G |
6: 125,184,518 (GRCm38) |
I211T |
possibly damaging |
Het |
| Ncoa7 |
A |
T |
10: 30,690,790 (GRCm38) |
W582R |
probably damaging |
Het |
| Npr3 |
T |
A |
15: 11,905,467 (GRCm38) |
D58V |
possibly damaging |
Het |
| Nr3c1 |
G |
T |
18: 39,428,727 (GRCm38) |
T430K |
probably benign |
Het |
| Odf2l |
A |
G |
3: 145,128,040 (GRCm38) |
T111A |
probably benign |
Het |
| Ogdh |
G |
T |
11: 6,340,600 (GRCm38) |
C406F |
probably benign |
Het |
| Olfml2a |
T |
G |
2: 38,949,010 (GRCm38) |
S190A |
probably damaging |
Het |
| Olfr148 |
T |
C |
9: 39,613,738 (GRCm38) |
M57T |
probably damaging |
Het |
| Olfr243 |
A |
G |
7: 103,716,638 (GRCm38) |
T15A |
probably benign |
Het |
| Olfr870 |
T |
C |
9: 20,171,098 (GRCm38) |
I158V |
probably benign |
Het |
| Olfr965 |
G |
T |
9: 39,719,709 (GRCm38) |
V161F |
probably benign |
Het |
| Optn |
T |
C |
2: 5,033,139 (GRCm38) |
K415E |
probably benign |
Het |
| Perm1 |
C |
A |
4: 156,220,206 (GRCm38) |
S803* |
probably null |
Het |
| Pex14 |
T |
C |
4: 148,984,085 (GRCm38) |
T84A |
probably benign |
Het |
| Pih1d2 |
T |
A |
9: 50,620,952 (GRCm38) |
Y103* |
probably null |
Het |
| Pikfyve |
T |
A |
1: 65,250,273 (GRCm38) |
C1235S |
probably damaging |
Het |
| Polr1a |
A |
G |
6: 71,917,821 (GRCm38) |
N171S |
probably benign |
Het |
| Prrx1 |
A |
G |
1: 163,254,047 (GRCm38) |
S201P |
probably benign |
Het |
| Psme2b |
A |
T |
11: 48,945,666 (GRCm38) |
N151K |
probably benign |
Het |
| Serpinb5 |
A |
T |
1: 106,872,295 (GRCm38) |
T72S |
probably benign |
Het |
| Sgsm1 |
A |
G |
5: 113,260,047 (GRCm38) |
|
probably null |
Het |
| Slc19a3 |
T |
C |
1: 83,022,799 (GRCm38) |
T166A |
probably benign |
Het |
| Slc5a4b |
T |
C |
10: 76,075,045 (GRCm38) |
Y319C |
possibly damaging |
Het |
| Stard3nl |
T |
A |
13: 19,376,519 (GRCm38) |
N29Y |
probably damaging |
Het |
| Sult6b2 |
G |
T |
6: 142,801,695 (GRCm38) |
C109* |
probably null |
Het |
| Tcf25 |
A |
G |
8: 123,397,025 (GRCm38) |
E467G |
possibly damaging |
Het |
| Tmem177 |
A |
T |
1: 119,910,220 (GRCm38) |
V243D |
probably benign |
Het |
| Tmem2 |
C |
T |
19: 21,844,781 (GRCm38) |
A1180V |
probably benign |
Het |
| Tmem2 |
G |
A |
19: 21,797,351 (GRCm38) |
R119H |
probably benign |
Het |
| Top2b |
T |
G |
14: 16,409,189 (GRCm38) |
I777M |
probably damaging |
Het |
| Tspan11 |
T |
A |
6: 127,943,715 (GRCm38) |
C208* |
probably null |
Het |
| Ttc1 |
A |
G |
11: 43,745,317 (GRCm38) |
V33A |
probably benign |
Het |
| Uck1 |
T |
A |
2: 32,256,034 (GRCm38) |
H283L |
probably damaging |
Het |
| Utrn |
A |
C |
10: 12,698,053 (GRCm38) |
V1091G |
probably benign |
Het |
| Vmn1r11 |
A |
T |
6: 57,137,498 (GRCm38) |
H49L |
probably damaging |
Het |
| Vmn1r160 |
G |
T |
7: 22,872,053 (GRCm38) |
S277I |
probably benign |
Het |
| Vmn1r18 |
A |
T |
6: 57,390,084 (GRCm38) |
S162T |
probably benign |
Het |
| Vps37b |
A |
G |
5: 124,010,732 (GRCm38) |
L80P |
probably damaging |
Het |
| Wfdc3 |
T |
C |
2: 164,743,086 (GRCm38) |
M1V |
probably null |
Het |
| Wrn |
A |
T |
8: 33,324,338 (GRCm38) |
N116K |
probably benign |
Het |
| Wscd2 |
G |
T |
5: 113,577,272 (GRCm38) |
G391V |
probably damaging |
Het |
| Zcchc11 |
G |
A |
4: 108,495,159 (GRCm38) |
E357K |
probably damaging |
Het |
| Zfp286 |
A |
G |
11: 62,780,602 (GRCm38) |
V215A |
probably benign |
Het |
| Zfp568 |
A |
G |
7: 30,023,277 (GRCm38) |
H549R |
probably damaging |
Het |
|
| Other mutations in Sipa1l2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00534:Sipa1l2
|
APN |
8 |
125,491,806 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00939:Sipa1l2
|
APN |
8 |
125,464,435 (GRCm38) |
splice site |
probably benign |
|
|
IGL00965:Sipa1l2
|
APN |
8 |
125,447,874 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL01321:Sipa1l2
|
APN |
8 |
125,491,518 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01450:Sipa1l2
|
APN |
8 |
125,422,577 (GRCm38) |
critical splice donor site |
probably null |
|
|
IGL01753:Sipa1l2
|
APN |
8 |
125,453,292 (GRCm38) |
splice site |
probably benign |
|
|
IGL01930:Sipa1l2
|
APN |
8 |
125,419,239 (GRCm38) |
missense |
probably damaging |
0.99 |
|
IGL02041:Sipa1l2
|
APN |
8 |
125,491,819 (GRCm38) |
missense |
probably benign |
0.03 |
|
IGL02215:Sipa1l2
|
APN |
8 |
125,447,837 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
IGL02272:Sipa1l2
|
APN |
8 |
125,492,011 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02370:Sipa1l2
|
APN |
8 |
125,480,269 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02538:Sipa1l2
|
APN |
8 |
125,451,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02633:Sipa1l2
|
APN |
8 |
125,447,768 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03394:Sipa1l2
|
APN |
8 |
125,491,659 (GRCm38) |
missense |
possibly damaging |
0.67 |
|
Rebellious
|
UTSW |
8 |
125,468,339 (GRCm38) |
missense |
probably benign |
0.01 |
|
R0144:Sipa1l2
|
UTSW |
8 |
125,449,876 (GRCm38) |
splice site |
probably null |
|
|
R0153:Sipa1l2
|
UTSW |
8 |
125,421,898 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0276:Sipa1l2
|
UTSW |
8 |
125,421,940 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0318:Sipa1l2
|
UTSW |
8 |
125,447,697 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
R0373:Sipa1l2
|
UTSW |
8 |
125,464,410 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0427:Sipa1l2
|
UTSW |
8 |
125,480,332 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0634:Sipa1l2
|
UTSW |
8 |
125,422,624 (GRCm38) |
nonsense |
probably null |
|
|
R1377:Sipa1l2
|
UTSW |
8 |
125,491,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1404:Sipa1l2
|
UTSW |
8 |
125,449,973 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1404:Sipa1l2
|
UTSW |
8 |
125,449,973 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1435:Sipa1l2
|
UTSW |
8 |
125,468,725 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1523:Sipa1l2
|
UTSW |
8 |
125,447,613 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R1577:Sipa1l2
|
UTSW |
8 |
125,492,262 (GRCm38) |
missense |
probably benign |
0.00 |
|
R1581:Sipa1l2
|
UTSW |
8 |
125,491,617 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R1583:Sipa1l2
|
UTSW |
8 |
125,421,895 (GRCm38) |
missense |
probably damaging |
0.97 |
|
R1719:Sipa1l2
|
UTSW |
8 |
125,444,535 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R1730:Sipa1l2
|
UTSW |
8 |
125,480,141 (GRCm38) |
splice site |
probably null |
|
|
R1940:Sipa1l2
|
UTSW |
8 |
125,480,148 (GRCm38) |
splice site |
probably benign |
|
|
R2007:Sipa1l2
|
UTSW |
8 |
125,439,437 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2141:Sipa1l2
|
UTSW |
8 |
125,491,491 (GRCm38) |
missense |
probably benign |
0.07 |
|
R2203:Sipa1l2
|
UTSW |
8 |
125,491,627 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2764:Sipa1l2
|
UTSW |
8 |
125,492,374 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R3722:Sipa1l2
|
UTSW |
8 |
125,473,584 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3787:Sipa1l2
|
UTSW |
8 |
125,450,383 (GRCm38) |
missense |
possibly damaging |
0.52 |
|
R3787:Sipa1l2
|
UTSW |
8 |
125,423,205 (GRCm38) |
missense |
probably benign |
|
|
R4106:Sipa1l2
|
UTSW |
8 |
125,492,308 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4117:Sipa1l2
|
UTSW |
8 |
125,468,510 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4194:Sipa1l2
|
UTSW |
8 |
125,491,672 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4237:Sipa1l2
|
UTSW |
8 |
125,491,656 (GRCm38) |
missense |
probably benign |
0.44 |
|
R4240:Sipa1l2
|
UTSW |
8 |
125,491,656 (GRCm38) |
missense |
probably benign |
0.44 |
|
R4448:Sipa1l2
|
UTSW |
8 |
125,492,355 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4515:Sipa1l2
|
UTSW |
8 |
125,492,226 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4519:Sipa1l2
|
UTSW |
8 |
125,492,226 (GRCm38) |
missense |
probably benign |
0.00 |
|
R4523:Sipa1l2
|
UTSW |
8 |
125,492,424 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4557:Sipa1l2
|
UTSW |
8 |
125,464,415 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R4687:Sipa1l2
|
UTSW |
8 |
125,491,245 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4854:Sipa1l2
|
UTSW |
8 |
125,473,601 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4890:Sipa1l2
|
UTSW |
8 |
125,491,867 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5065:Sipa1l2
|
UTSW |
8 |
125,491,585 (GRCm38) |
missense |
probably benign |
0.19 |
|
R5194:Sipa1l2
|
UTSW |
8 |
125,439,273 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R5266:Sipa1l2
|
UTSW |
8 |
125,492,126 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R5475:Sipa1l2
|
UTSW |
8 |
125,491,595 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5718:Sipa1l2
|
UTSW |
8 |
125,491,248 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5910:Sipa1l2
|
UTSW |
8 |
125,491,684 (GRCm38) |
missense |
probably benign |
0.42 |
|
R5916:Sipa1l2
|
UTSW |
8 |
125,468,573 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5941:Sipa1l2
|
UTSW |
8 |
125,473,536 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R6083:Sipa1l2
|
UTSW |
8 |
125,468,473 (GRCm38) |
missense |
possibly damaging |
0.87 |
|
R6185:Sipa1l2
|
UTSW |
8 |
125,468,253 (GRCm38) |
nonsense |
probably null |
|
|
R6235:Sipa1l2
|
UTSW |
8 |
125,474,871 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6274:Sipa1l2
|
UTSW |
8 |
125,469,872 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6299:Sipa1l2
|
UTSW |
8 |
125,453,464 (GRCm38) |
missense |
possibly damaging |
0.75 |
|
R6374:Sipa1l2
|
UTSW |
8 |
125,444,630 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6459:Sipa1l2
|
UTSW |
8 |
125,444,484 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6462:Sipa1l2
|
UTSW |
8 |
125,491,230 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6496:Sipa1l2
|
UTSW |
8 |
125,449,894 (GRCm38) |
missense |
probably benign |
0.00 |
|
R6543:Sipa1l2
|
UTSW |
8 |
125,450,362 (GRCm38) |
missense |
possibly damaging |
0.50 |
|
R7154:Sipa1l2
|
UTSW |
8 |
125,468,339 (GRCm38) |
missense |
probably benign |
0.01 |
|
R7192:Sipa1l2
|
UTSW |
8 |
125,422,609 (GRCm38) |
missense |
probably benign |
0.09 |
|
R7240:Sipa1l2
|
UTSW |
8 |
125,469,860 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7361:Sipa1l2
|
UTSW |
8 |
125,453,332 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7383:Sipa1l2
|
UTSW |
8 |
125,447,646 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7417:Sipa1l2
|
UTSW |
8 |
125,482,106 (GRCm38) |
missense |
possibly damaging |
0.93 |
|
R7604:Sipa1l2
|
UTSW |
8 |
125,419,272 (GRCm38) |
missense |
probably benign |
0.45 |
|
R7658:Sipa1l2
|
UTSW |
8 |
125,492,290 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7743:Sipa1l2
|
UTSW |
8 |
125,464,233 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7781:Sipa1l2
|
UTSW |
8 |
125,491,827 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R7812:Sipa1l2
|
UTSW |
8 |
125,491,595 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7829:Sipa1l2
|
UTSW |
8 |
125,451,988 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7880:Sipa1l2
|
UTSW |
8 |
125,464,393 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7884:Sipa1l2
|
UTSW |
8 |
125,447,598 (GRCm38) |
missense |
probably benign |
|
|
R8057:Sipa1l2
|
UTSW |
8 |
125,468,530 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8082:Sipa1l2
|
UTSW |
8 |
125,491,809 (GRCm38) |
missense |
possibly damaging |
0.82 |
|
R8092:Sipa1l2
|
UTSW |
8 |
125,419,168 (GRCm38) |
missense |
probably benign |
0.03 |
|
R8247:Sipa1l2
|
UTSW |
8 |
125,422,633 (GRCm38) |
missense |
probably benign |
0.29 |
|
R8252:Sipa1l2
|
UTSW |
8 |
125,468,671 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8386:Sipa1l2
|
UTSW |
8 |
125,492,093 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8466:Sipa1l2
|
UTSW |
8 |
125,492,246 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8697:Sipa1l2
|
UTSW |
8 |
125,482,116 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8725:Sipa1l2
|
UTSW |
8 |
125,450,386 (GRCm38) |
missense |
probably benign |
0.28 |
|
R8727:Sipa1l2
|
UTSW |
8 |
125,450,386 (GRCm38) |
missense |
probably benign |
0.28 |
|
R9048:Sipa1l2
|
UTSW |
8 |
125,447,726 (GRCm38) |
missense |
possibly damaging |
0.59 |
|
R9224:Sipa1l2
|
UTSW |
8 |
125,491,977 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9279:Sipa1l2
|
UTSW |
8 |
125,482,157 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9392:Sipa1l2
|
UTSW |
8 |
125,468,221 (GRCm38) |
missense |
probably benign |
|
|
R9574:Sipa1l2
|
UTSW |
8 |
125,442,714 (GRCm38) |
missense |
probably benign |
|
|
R9591:Sipa1l2
|
UTSW |
8 |
125,492,373 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9614:Sipa1l2
|
UTSW |
8 |
125,469,826 (GRCm38) |
missense |
probably null |
0.01 |
|
R9690:Sipa1l2
|
UTSW |
8 |
125,492,257 (GRCm38) |
missense |
probably benign |
|
|
X0027:Sipa1l2
|
UTSW |
8 |
125,492,136 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Sipa1l2
|
UTSW |
8 |
125,447,556 (GRCm38) |
missense |
possibly damaging |
0.72 |
|
| Predicted Primers |
PCR Primer
(F):5'- GTGTTACCTGGTGCCATCAG -3'
(R):5'- GTAAGGTGCCATCCTGTTAGG -3'
Sequencing Primer
(F):5'- TCAGGCAGCTTCCTATCAAAG -3'
(R):5'- AGAGTCTGCTCCGCCATGAG -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation