Incidental Mutation 'R4668:Top2b'
| ID |
352193 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Top2b
|
| Ensembl Gene |
ENSMUSG00000017485 |
| Gene Name |
topoisomerase (DNA) II beta |
| Synonyms |
D230016L12Rik, Top-2 |
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.888)
|
| Stock # |
R4668 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
14 |
| Chromosomal Location |
16365179-16435462 bp(+) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to G
at 16409189 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Methionine
at position 777
(I777M)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000017629
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000017629]
[ENSMUST00000161693]
|
| AlphaFold |
Q64511 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000017629
AA Change: I777M
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000017629
Gene: ENSMUSG00000017485
AA Change: I777M
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TOP2c
|
32 |
70 |
7e-10 |
BLAST |
|
HATPase_c
|
85 |
234 |
1.91e-2 |
SMART |
|
TOP2c
|
89 |
679 |
N/A |
SMART |
|
TOP4c
|
702 |
1175 |
2.55e-230 |
SMART |
|
low complexity region
|
1201 |
1215 |
N/A |
INTRINSIC |
|
low complexity region
|
1287 |
1299 |
N/A |
INTRINSIC |
|
low complexity region
|
1324 |
1336 |
N/A |
INTRINSIC |
|
low complexity region
|
1360 |
1382 |
N/A |
INTRINSIC |
|
Pfam:DTHCT
|
1495 |
1597 |
4.6e-31 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159302
|
| SMART Domains |
Protein: ENSMUSP00000123789
Gene: ENSMUSG00000017485
| Domain | Start | End | E-Value | Type |
|---|
|
TOP4c
|
1 |
177 |
4.06e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160501
|
| SMART Domains |
Protein: ENSMUSP00000124889
Gene: ENSMUSG00000017485
| Domain | Start | End | E-Value | Type |
|---|
|
TOP4c
|
2 |
222 |
3.97e-12 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000161693
|
| SMART Domains |
Protein: ENSMUSP00000123992
Gene: ENSMUSG00000017485
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:DNA_topoisoIV
|
1 |
117 |
1.2e-12 |
PFAM |
|
low complexity region
|
161 |
173 |
N/A |
INTRINSIC |
|
low complexity region
|
198 |
210 |
N/A |
INTRINSIC |
|
low complexity region
|
234 |
256 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.8018 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
PHENOTYPE: Homozygous null mice exhibit abnormal innervation. Offspring die shortly after birth due to respiratory failure. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4921528I07Rik |
A |
T |
9: 114,304,711 (GRCm38) |
|
noncoding transcript |
Het |
| 6430548M08Rik |
T |
C |
8: 120,160,414 (GRCm38) |
|
probably null |
Het |
| Abca4 |
G |
A |
3: 122,155,299 (GRCm38) |
G531E |
possibly damaging |
Het |
| Acad8 |
A |
G |
9: 26,990,627 (GRCm38) |
L147P |
probably damaging |
Het |
| Acot10 |
T |
C |
15: 20,665,942 (GRCm38) |
S238G |
probably benign |
Het |
| Adamtsl2 |
A |
T |
2: 27,095,475 (GRCm38) |
H457L |
probably benign |
Het |
| Ankrd35 |
A |
T |
3: 96,679,208 (GRCm38) |
T67S |
probably damaging |
Het |
| Aox2 |
T |
G |
1: 58,334,694 (GRCm38) |
I838S |
possibly damaging |
Het |
| Arnt2 |
T |
C |
7: 84,275,386 (GRCm38) |
N411S |
probably damaging |
Het |
| Bmpr2 |
T |
C |
1: 59,867,716 (GRCm38) |
L656S |
probably damaging |
Het |
| Carns1 |
A |
T |
19: 4,165,476 (GRCm38) |
Y902* |
probably null |
Het |
| Cavin1 |
T |
C |
11: 100,958,796 (GRCm38) |
E336G |
probably damaging |
Het |
| Cbl |
A |
T |
9: 44,153,848 (GRCm38) |
C728S |
probably benign |
Het |
| Ccdc136 |
C |
A |
6: 29,411,281 (GRCm38) |
Q218K |
probably damaging |
Het |
| Cdk19 |
C |
A |
10: 40,466,710 (GRCm38) |
T196K |
probably damaging |
Het |
| Ceacam20 |
T |
C |
7: 19,986,027 (GRCm38) |
Y495H |
probably damaging |
Het |
| Celf2 |
T |
C |
2: 6,721,528 (GRCm38) |
I47V |
probably benign |
Het |
| Ces3a |
A |
C |
8: 105,053,423 (GRCm38) |
K299T |
probably damaging |
Het |
| Cfap61 |
A |
T |
2: 146,143,136 (GRCm38) |
I967F |
probably damaging |
Het |
| Cnksr1 |
C |
T |
4: 134,232,971 (GRCm38) |
|
probably benign |
Het |
| Cped1 |
T |
C |
6: 22,237,653 (GRCm38) |
Y923H |
probably benign |
Het |
| Crip3 |
T |
C |
17: 46,429,364 (GRCm38) |
L30P |
probably damaging |
Het |
| Csmd1 |
A |
G |
8: 16,023,891 (GRCm38) |
I2030T |
possibly damaging |
Het |
| Ctse |
C |
A |
1: 131,662,749 (GRCm38) |
P70T |
probably damaging |
Het |
| Cyp2b23 |
A |
G |
7: 26,672,734 (GRCm38) |
F429L |
probably damaging |
Het |
| Cyp2c66 |
T |
A |
19: 39,176,656 (GRCm38) |
D360E |
probably damaging |
Het |
| D8Ertd738e |
A |
T |
8: 84,249,481 (GRCm38) |
L46* |
probably null |
Het |
| Dcp2 |
T |
A |
18: 44,415,362 (GRCm38) |
|
probably null |
Het |
| Ddx10 |
C |
A |
9: 53,099,213 (GRCm38) |
D834Y |
possibly damaging |
Het |
| Ddx19a |
A |
T |
8: 110,979,084 (GRCm38) |
V245E |
probably damaging |
Het |
| Dpf2 |
A |
C |
19: 5,904,487 (GRCm38) |
D130E |
probably benign |
Het |
| Emc8 |
A |
T |
8: 120,667,779 (GRCm38) |
M67K |
probably damaging |
Het |
| Ephb6 |
T |
C |
6: 41,614,602 (GRCm38) |
L231P |
possibly damaging |
Het |
| Erp27 |
T |
C |
6: 136,908,152 (GRCm38) |
E216G |
possibly damaging |
Het |
| Esco1 |
A |
T |
18: 10,594,734 (GRCm38) |
I184N |
possibly damaging |
Het |
| Fam205c |
A |
G |
4: 42,871,608 (GRCm38) |
F256L |
probably benign |
Het |
| Fdxacb1 |
T |
A |
9: 50,770,260 (GRCm38) |
D11E |
possibly damaging |
Het |
| Fhod3 |
C |
T |
18: 25,066,338 (GRCm38) |
P689S |
probably benign |
Het |
| Fnip1 |
T |
A |
11: 54,503,559 (GRCm38) |
S940R |
probably damaging |
Het |
| Ganc |
G |
T |
2: 120,431,067 (GRCm38) |
V343F |
probably benign |
Het |
| Gldn |
T |
A |
9: 54,332,018 (GRCm38) |
L228* |
probably null |
Het |
| Gm1123 |
C |
T |
9: 99,009,373 (GRCm38) |
R341H |
probably damaging |
Het |
| Gtf2f2 |
T |
C |
14: 75,917,638 (GRCm38) |
Y161C |
probably benign |
Het |
| Gtf3c1 |
T |
C |
7: 125,667,338 (GRCm38) |
T979A |
probably damaging |
Het |
| Hist1h4a |
A |
G |
13: 23,760,976 (GRCm38) |
V61A |
probably benign |
Het |
| Hmcn2 |
G |
T |
2: 31,435,792 (GRCm38) |
R4277L |
probably benign |
Het |
| Hsd17b6 |
T |
A |
10: 127,994,426 (GRCm38) |
|
probably null |
Het |
| Igkv12-46 |
T |
C |
6: 69,764,797 (GRCm38) |
T25A |
probably damaging |
Het |
| Inpp5e |
G |
A |
2: 26,400,994 (GRCm38) |
R354C |
probably damaging |
Het |
| Jcad |
T |
A |
18: 4,680,221 (GRCm38) |
|
probably null |
Het |
| Kcna10 |
G |
T |
3: 107,194,694 (GRCm38) |
A214S |
possibly damaging |
Het |
| Kit |
T |
C |
5: 75,641,220 (GRCm38) |
|
probably null |
Het |
| Kmt2a |
G |
A |
9: 44,824,572 (GRCm38) |
|
probably benign |
Het |
| Lama1 |
T |
C |
17: 67,752,434 (GRCm38) |
V604A |
probably benign |
Het |
| Mesd |
T |
C |
7: 83,895,756 (GRCm38) |
V138A |
probably damaging |
Het |
| Mmp13 |
T |
C |
9: 7,272,580 (GRCm38) |
F9S |
possibly damaging |
Het |
| Mocos |
T |
C |
18: 24,666,434 (GRCm38) |
Y242H |
probably benign |
Het |
| Mrc1 |
A |
C |
2: 14,293,486 (GRCm38) |
T718P |
probably damaging |
Het |
| Msh6 |
T |
C |
17: 87,984,806 (GRCm38) |
S330P |
possibly damaging |
Het |
| Myh10 |
A |
G |
11: 68,804,642 (GRCm38) |
K1532E |
probably damaging |
Het |
| Nat9 |
T |
C |
11: 115,184,542 (GRCm38) |
N91S |
probably damaging |
Het |
| Neto2 |
A |
T |
8: 85,641,062 (GRCm38) |
I351N |
probably damaging |
Het |
| Nfx1 |
A |
G |
4: 40,976,367 (GRCm38) |
N14D |
possibly damaging |
Het |
| Nlrp4b |
A |
G |
7: 10,714,733 (GRCm38) |
T288A |
possibly damaging |
Het |
| Nutm2 |
C |
A |
13: 50,472,997 (GRCm38) |
T396K |
probably benign |
Het |
| Ogdhl |
A |
G |
14: 32,332,536 (GRCm38) |
T196A |
probably benign |
Het |
| Olfr1453 |
A |
T |
19: 13,028,081 (GRCm38) |
F83I |
probably benign |
Het |
| Olfr548-ps1 |
A |
G |
7: 102,542,604 (GRCm38) |
I223V |
possibly damaging |
Het |
| Olfr582 |
A |
T |
7: 103,041,851 (GRCm38) |
D119V |
probably benign |
Het |
| Omg |
T |
A |
11: 79,502,423 (GRCm38) |
N203I |
probably damaging |
Het |
| Pdgfrb |
A |
G |
18: 61,064,113 (GRCm38) |
Y207C |
probably damaging |
Het |
| Pdzd7 |
T |
A |
19: 45,045,687 (GRCm38) |
|
probably benign |
Het |
| Pgs1 |
C |
A |
11: 118,003,507 (GRCm38) |
H157N |
probably damaging |
Het |
| Pik3c2a |
A |
G |
7: 116,358,688 (GRCm38) |
V1121A |
probably benign |
Het |
| Pikfyve |
T |
A |
1: 65,250,273 (GRCm38) |
C1235S |
probably damaging |
Het |
| Pms1 |
G |
A |
1: 53,189,474 (GRCm38) |
Q872* |
probably null |
Het |
| Ptgs2 |
A |
G |
1: 150,101,084 (GRCm38) |
T23A |
probably benign |
Het |
| Rgl1 |
T |
G |
1: 152,521,371 (GRCm38) |
R716S |
probably damaging |
Het |
| Rif1 |
A |
G |
2: 52,111,952 (GRCm38) |
E1806G |
probably benign |
Het |
| Ripor1 |
T |
C |
8: 105,614,652 (GRCm38) |
V39A |
probably benign |
Het |
| Ryr2 |
G |
T |
13: 11,593,117 (GRCm38) |
T868N |
probably benign |
Het |
| Sec22b |
A |
T |
3: 97,921,122 (GRCm38) |
D167V |
probably damaging |
Het |
| Sec24d |
T |
C |
3: 123,355,774 (GRCm38) |
V810A |
probably damaging |
Het |
| Shh |
T |
C |
5: 28,457,855 (GRCm38) |
*438W |
probably null |
Het |
| Slc25a12 |
G |
A |
2: 71,315,062 (GRCm38) |
S178L |
probably benign |
Het |
| Sorl1 |
A |
T |
9: 41,984,508 (GRCm38) |
W1784R |
probably damaging |
Het |
| Sp3 |
A |
T |
2: 72,970,981 (GRCm38) |
S229R |
probably damaging |
Het |
| Spdye4c |
G |
A |
2: 128,592,353 (GRCm38) |
V5I |
possibly damaging |
Het |
| Spint2 |
A |
T |
7: 29,260,379 (GRCm38) |
V53D |
probably damaging |
Het |
| Stard3nl |
T |
A |
13: 19,376,519 (GRCm38) |
N29Y |
probably damaging |
Het |
| Stk25 |
A |
G |
1: 93,625,483 (GRCm38) |
S299P |
probably damaging |
Het |
| Sult2a3 |
A |
G |
7: 14,122,861 (GRCm38) |
S45P |
probably damaging |
Het |
| Thsd7a |
A |
T |
6: 12,408,968 (GRCm38) |
V685E |
probably damaging |
Het |
| Tm9sf4 |
T |
A |
2: 153,187,308 (GRCm38) |
V92D |
probably damaging |
Het |
| Topors |
G |
A |
4: 40,262,669 (GRCm38) |
T205I |
probably damaging |
Het |
| Tpo |
T |
A |
12: 30,103,290 (GRCm38) |
Y355F |
probably benign |
Het |
| Uba1y |
T |
A |
Y: 826,032 (GRCm38) |
M396K |
possibly damaging |
Het |
| Vmn1r50 |
A |
T |
6: 90,107,531 (GRCm38) |
Q86L |
probably benign |
Het |
| Vmn1r77 |
A |
G |
7: 12,041,431 (GRCm38) |
K45E |
probably damaging |
Het |
| Vmn2r114 |
A |
C |
17: 23,310,473 (GRCm38) |
N218K |
possibly damaging |
Het |
| Vmn2r66 |
T |
A |
7: 84,994,697 (GRCm38) |
N835I |
probably damaging |
Het |
| Vps54 |
T |
G |
11: 21,299,989 (GRCm38) |
N458K |
probably benign |
Het |
| Zcchc7 |
G |
T |
4: 44,895,964 (GRCm38) |
C304F |
probably damaging |
Het |
| Zfp335 |
A |
T |
2: 164,900,286 (GRCm38) |
C593S |
probably damaging |
Het |
| Zmynd15 |
C |
G |
11: 70,462,588 (GRCm38) |
P214R |
probably damaging |
Het |
|
| Other mutations in Top2b |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00430:Top2b
|
APN |
14 |
16,422,692 (GRCm38) |
missense |
probably benign |
0.00 |
|
IGL00730:Top2b
|
APN |
14 |
16,389,831 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL00917:Top2b
|
APN |
14 |
16,407,354 (GRCm38) |
missense |
probably benign |
0.05 |
|
IGL01959:Top2b
|
APN |
14 |
16,422,695 (GRCm38) |
missense |
probably benign |
0.19 |
|
IGL02019:Top2b
|
APN |
14 |
16,409,965 (GRCm38) |
missense |
probably benign |
0.44 |
|
IGL02119:Top2b
|
APN |
14 |
16,406,733 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02136:Top2b
|
APN |
14 |
16,407,103 (GRCm38) |
unclassified |
probably benign |
|
|
IGL02148:Top2b
|
APN |
14 |
16,400,488 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02496:Top2b
|
APN |
14 |
16,387,335 (GRCm38) |
missense |
probably benign |
|
|
IGL02503:Top2b
|
APN |
14 |
16,407,163 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
IGL02672:Top2b
|
APN |
14 |
16,409,166 (GRCm38) |
unclassified |
probably benign |
|
|
IGL02721:Top2b
|
APN |
14 |
16,409,236 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02886:Top2b
|
APN |
14 |
16,365,688 (GRCm38) |
missense |
possibly damaging |
0.73 |
|
IGL03252:Top2b
|
APN |
14 |
16,393,163 (GRCm38) |
missense |
possibly damaging |
0.60 |
|
PIT4434001:Top2b
|
UTSW |
14 |
16,423,780 (GRCm38) |
critical splice donor site |
probably null |
|
|
R0092:Top2b
|
UTSW |
14 |
16,409,263 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0201:Top2b
|
UTSW |
14 |
16,383,174 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0390:Top2b
|
UTSW |
14 |
16,418,442 (GRCm38) |
missense |
probably benign |
0.00 |
|
R0394:Top2b
|
UTSW |
14 |
16,413,556 (GRCm38) |
splice site |
probably null |
|
|
R1159:Top2b
|
UTSW |
14 |
16,430,329 (GRCm38) |
missense |
possibly damaging |
0.81 |
|
R1424:Top2b
|
UTSW |
14 |
16,383,177 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1519:Top2b
|
UTSW |
14 |
16,408,953 (GRCm38) |
splice site |
probably null |
|
|
R1561:Top2b
|
UTSW |
14 |
16,398,993 (GRCm38) |
missense |
possibly damaging |
0.80 |
|
R1713:Top2b
|
UTSW |
14 |
16,409,823 (GRCm38) |
missense |
probably benign |
0.05 |
|
R1987:Top2b
|
UTSW |
14 |
16,398,916 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R2219:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2287:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2422:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2679:Top2b
|
UTSW |
14 |
16,413,947 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3687:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3707:Top2b
|
UTSW |
14 |
16,388,447 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3810:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3812:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3815:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3816:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3818:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4023:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4025:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4026:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4133:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4157:Top2b
|
UTSW |
14 |
16,384,491 (GRCm38) |
missense |
probably benign |
0.42 |
|
R4179:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4180:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4300:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4376:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4377:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4492:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4549:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4550:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4581:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4582:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4628:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4630:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4667:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4669:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4698:Top2b
|
UTSW |
14 |
16,387,331 (GRCm38) |
nonsense |
probably null |
|
|
R4769:Top2b
|
UTSW |
14 |
16,398,991 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4809:Top2b
|
UTSW |
14 |
16,383,125 (GRCm38) |
missense |
probably benign |
0.06 |
|
R4899:Top2b
|
UTSW |
14 |
16,387,313 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5035:Top2b
|
UTSW |
14 |
16,409,966 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5621:Top2b
|
UTSW |
14 |
16,387,280 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5631:Top2b
|
UTSW |
14 |
16,409,882 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5685:Top2b
|
UTSW |
14 |
16,413,666 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5732:Top2b
|
UTSW |
14 |
16,400,106 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R5939:Top2b
|
UTSW |
14 |
16,422,786 (GRCm38) |
missense |
probably damaging |
0.96 |
|
R6007:Top2b
|
UTSW |
14 |
16,423,779 (GRCm38) |
critical splice donor site |
probably null |
|
|
R6087:Top2b
|
UTSW |
14 |
16,409,864 (GRCm38) |
missense |
probably benign |
0.14 |
|
R6144:Top2b
|
UTSW |
14 |
16,423,740 (GRCm38) |
missense |
possibly damaging |
0.48 |
|
R6196:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6218:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6229:Top2b
|
UTSW |
14 |
16,409,838 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6249:Top2b
|
UTSW |
14 |
16,399,006 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6337:Top2b
|
UTSW |
14 |
16,399,026 (GRCm38) |
missense |
possibly damaging |
0.77 |
|
R6353:Top2b
|
UTSW |
14 |
16,416,671 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6512:Top2b
|
UTSW |
14 |
16,409,854 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R6573:Top2b
|
UTSW |
14 |
16,398,991 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6614:Top2b
|
UTSW |
14 |
16,407,142 (GRCm38) |
nonsense |
probably null |
|
|
R6844:Top2b
|
UTSW |
14 |
16,429,383 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R6848:Top2b
|
UTSW |
14 |
16,409,958 (GRCm38) |
missense |
possibly damaging |
0.89 |
|
R6871:Top2b
|
UTSW |
14 |
16,409,189 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6895:Top2b
|
UTSW |
14 |
16,413,604 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7162:Top2b
|
UTSW |
14 |
16,416,653 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7247:Top2b
|
UTSW |
14 |
16,416,962 (GRCm38) |
missense |
probably benign |
0.08 |
|
R7250:Top2b
|
UTSW |
14 |
16,420,411 (GRCm38) |
missense |
probably benign |
|
|
R7359:Top2b
|
UTSW |
14 |
16,407,376 (GRCm38) |
missense |
probably null |
1.00 |
|
R7365:Top2b
|
UTSW |
14 |
16,416,649 (GRCm38) |
missense |
probably benign |
0.04 |
|
R7493:Top2b
|
UTSW |
14 |
16,416,605 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7528:Top2b
|
UTSW |
14 |
16,395,427 (GRCm38) |
nonsense |
probably null |
|
|
R7562:Top2b
|
UTSW |
14 |
16,412,946 (GRCm38) |
missense |
probably benign |
0.04 |
|
R7594:Top2b
|
UTSW |
14 |
16,428,587 (GRCm38) |
missense |
probably benign |
|
|
R7670:Top2b
|
UTSW |
14 |
16,416,620 (GRCm38) |
missense |
possibly damaging |
0.61 |
|
R7894:Top2b
|
UTSW |
14 |
16,413,081 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R8031:Top2b
|
UTSW |
14 |
16,412,986 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8150:Top2b
|
UTSW |
14 |
16,393,291 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R8214:Top2b
|
UTSW |
14 |
16,383,177 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8299:Top2b
|
UTSW |
14 |
16,386,123 (GRCm38) |
missense |
possibly damaging |
0.68 |
|
R8977:Top2b
|
UTSW |
14 |
16,393,239 (GRCm38) |
missense |
probably benign |
0.36 |
|
R9562:Top2b
|
UTSW |
14 |
16,365,718 (GRCm38) |
missense |
probably benign |
0.09 |
|
R9565:Top2b
|
UTSW |
14 |
16,365,718 (GRCm38) |
missense |
probably benign |
0.09 |
|
R9798:Top2b
|
UTSW |
14 |
16,389,845 (GRCm38) |
missense |
probably damaging |
1.00 |
|
X0028:Top2b
|
UTSW |
14 |
16,384,499 (GRCm38) |
nonsense |
probably null |
|
|
Z1176:Top2b
|
UTSW |
14 |
16,395,434 (GRCm38) |
missense |
probably damaging |
1.00 |
|
Z1177:Top2b
|
UTSW |
14 |
16,416,953 (GRCm38) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCACTGAAGATGGGATCAACTG -3'
(R):5'- ATTTGAAGTACTCTCCCTGAGC -3'
Sequencing Primer
(F):5'- CTGAAGATGGGATCAACTGAGAACTG -3'
(R):5'- TCTCCCTGAGCAGAAAAACTAAATG -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation