Incidental Mutation 'R0270:Wdr17'
| ID |
35226 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Wdr17
|
| Ensembl Gene |
ENSMUSG00000039375 |
| Gene Name |
WD repeat domain 17 |
| Synonyms |
B230207L18Rik, 3010002I12Rik |
| MMRRC Submission |
038496-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0270 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
8 |
| Chromosomal Location |
55082316-55180014 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 55146131 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Alanine to Threonine
at position 90
(A90T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135805
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000127511]
[ENSMUST00000129132]
[ENSMUST00000144482]
[ENSMUST00000144711]
[ENSMUST00000148408]
[ENSMUST00000175915]
[ENSMUST00000150488]
[ENSMUST00000176866]
|
| AlphaFold |
E9Q271 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126316
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000127511
AA Change: A114T
PolyPhen 2
Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
|
| SMART Domains |
Protein: ENSMUSP00000115550
Gene: ENSMUSG00000039375
AA Change: A114T
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
72 |
112 |
8.55e-8 |
SMART |
|
WD40
|
162 |
202 |
1.58e2 |
SMART |
|
WD40
|
205 |
252 |
4.26e1 |
SMART |
|
WD40
|
255 |
298 |
1.15e0 |
SMART |
|
WD40
|
383 |
422 |
1.59e-7 |
SMART |
|
WD40
|
425 |
465 |
2.39e0 |
SMART |
|
WD40
|
468 |
509 |
5.52e-2 |
SMART |
|
WD40
|
511 |
550 |
4.14e-6 |
SMART |
|
WD40
|
555 |
595 |
5.14e-11 |
SMART |
|
WD40
|
598 |
638 |
6.58e-9 |
SMART |
|
WD40
|
641 |
681 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000129132
AA Change: A90T
PolyPhen 2
Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000134935
Gene: ENSMUSG00000039375
AA Change: A90T
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
Blast:WD40
|
91 |
131 |
1e-12 |
BLAST |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
271 |
9.86e1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144482
|
| SMART Domains |
Protein: ENSMUSP00000134950
Gene: ENSMUSG00000039375
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:WD40
|
16 |
65 |
2e-24 |
BLAST |
|
WD40
|
70 |
109 |
1.59e-7 |
SMART |
|
WD40
|
112 |
152 |
2.39e0 |
SMART |
|
WD40
|
155 |
196 |
5.52e-2 |
SMART |
|
WD40
|
198 |
237 |
4.14e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144711
AA Change: A114T
PolyPhen 2
Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000117710
Gene: ENSMUSG00000039375
AA Change: A114T
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
72 |
112 |
8.55e-8 |
SMART |
|
WD40
|
194 |
235 |
7.64e1 |
SMART |
|
WD40
|
238 |
281 |
1.15e0 |
SMART |
|
WD40
|
366 |
405 |
1.59e-7 |
SMART |
|
WD40
|
408 |
448 |
2.39e0 |
SMART |
|
WD40
|
451 |
492 |
5.52e-2 |
SMART |
|
WD40
|
494 |
533 |
4.14e-6 |
SMART |
|
WD40
|
538 |
578 |
5.14e-11 |
SMART |
|
WD40
|
581 |
621 |
6.58e-9 |
SMART |
|
WD40
|
624 |
664 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000148408
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148806
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000175915
AA Change: A90T
PolyPhen 2
Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000135805
Gene: ENSMUSG00000039375
AA Change: A90T
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
274 |
1.15e0 |
SMART |
|
WD40
|
359 |
398 |
1.59e-7 |
SMART |
|
WD40
|
401 |
441 |
2.39e0 |
SMART |
|
WD40
|
444 |
485 |
5.52e-2 |
SMART |
|
WD40
|
487 |
526 |
4.14e-6 |
SMART |
|
WD40
|
531 |
571 |
5.14e-11 |
SMART |
|
WD40
|
574 |
614 |
6.58e-9 |
SMART |
|
WD40
|
617 |
657 |
6.28e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000150488
AA Change: A90T
PolyPhen 2
Score 0.740 (Sensitivity: 0.85; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000122326
Gene: ENSMUSG00000039375
AA Change: A90T
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
274 |
1.15e0 |
SMART |
|
WD40
|
359 |
398 |
1.59e-7 |
SMART |
|
WD40
|
401 |
441 |
2.39e0 |
SMART |
|
WD40
|
444 |
485 |
5.52e-2 |
SMART |
|
WD40
|
487 |
526 |
4.14e-6 |
SMART |
|
WD40
|
531 |
571 |
5.14e-11 |
SMART |
|
WD40
|
574 |
614 |
6.58e-9 |
SMART |
|
WD40
|
617 |
657 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176866
|
| Meta Mutation Damage Score |
0.0614 |
| Coding Region Coverage |
- 1x: 98.7%
- 3x: 97.7%
- 10x: 96.0%
- 20x: 93.2%
|
| Validation Efficiency |
99% (113/114) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 109 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 3110009E18Rik |
T |
A |
1: 120,093,906 (GRCm39) |
|
probably benign |
Het |
| Aadacl2fm3 |
T |
A |
3: 59,784,440 (GRCm39) |
N304K |
probably benign |
Het |
| Abcf3 |
T |
A |
16: 20,378,918 (GRCm39) |
|
probably null |
Het |
| Acadm |
C |
T |
3: 153,641,961 (GRCm39) |
M190I |
possibly damaging |
Het |
| Adamtsl3 |
G |
A |
7: 82,206,032 (GRCm39) |
R739Q |
probably damaging |
Het |
| Ank1 |
T |
A |
8: 23,578,941 (GRCm39) |
|
probably benign |
Het |
| Ap3b1 |
T |
A |
13: 94,540,626 (GRCm39) |
|
probably benign |
Het |
| Arhgdib |
A |
G |
6: 136,903,732 (GRCm39) |
V31A |
probably damaging |
Het |
| Arid4a |
A |
G |
12: 71,119,406 (GRCm39) |
R342G |
probably damaging |
Het |
| Asic3 |
C |
T |
5: 24,622,700 (GRCm39) |
L517F |
probably benign |
Het |
| Atxn7l1 |
C |
T |
12: 33,392,150 (GRCm39) |
P242L |
possibly damaging |
Het |
| AY761185 |
T |
A |
8: 21,434,616 (GRCm39) |
E37D |
possibly damaging |
Het |
| Babam1 |
T |
A |
8: 71,851,050 (GRCm39) |
D104E |
probably damaging |
Het |
| Batf |
A |
T |
12: 85,755,446 (GRCm39) |
T100S |
probably benign |
Het |
| Blcap |
A |
T |
2: 157,399,897 (GRCm39) |
Y59* |
probably null |
Het |
| Cacnb3 |
G |
A |
15: 98,540,440 (GRCm39) |
A350T |
probably damaging |
Het |
| Cdk15 |
T |
A |
1: 59,349,965 (GRCm39) |
V319D |
probably damaging |
Het |
| Cenpf |
T |
C |
1: 189,382,911 (GRCm39) |
H2661R |
probably benign |
Het |
| Cenpq |
T |
C |
17: 41,240,941 (GRCm39) |
E106G |
probably damaging |
Het |
| Cfap43 |
A |
G |
19: 47,785,642 (GRCm39) |
|
probably benign |
Het |
| Cfb |
G |
A |
17: 35,079,362 (GRCm39) |
S778L |
possibly damaging |
Het |
| Clec2m |
A |
T |
6: 129,302,571 (GRCm39) |
L152* |
probably null |
Het |
| Clspn |
T |
A |
4: 126,467,029 (GRCm39) |
N631K |
probably damaging |
Het |
| Cntn2 |
T |
A |
1: 132,449,462 (GRCm39) |
T660S |
probably damaging |
Het |
| Cntrob |
T |
A |
11: 69,202,167 (GRCm39) |
H475L |
possibly damaging |
Het |
| Ddx46 |
T |
C |
13: 55,821,917 (GRCm39) |
I863T |
probably benign |
Het |
| Dnah11 |
G |
A |
12: 118,004,748 (GRCm39) |
T2191I |
probably damaging |
Het |
| Dock9 |
T |
C |
14: 121,813,411 (GRCm39) |
T1703A |
probably benign |
Het |
| Fam13c |
C |
T |
10: 70,380,343 (GRCm39) |
P424S |
probably benign |
Het |
| Fan1 |
T |
C |
7: 63,998,619 (GRCm39) |
N968D |
probably benign |
Het |
| Fbxl20 |
A |
T |
11: 97,989,329 (GRCm39) |
|
probably benign |
Het |
| Fkbp1b |
A |
T |
12: 4,888,229 (GRCm39) |
|
probably benign |
Het |
| G930045G22Rik |
T |
A |
6: 50,824,039 (GRCm39) |
|
noncoding transcript |
Het |
| Gm28042 |
C |
A |
2: 119,872,073 (GRCm39) |
R1008S |
probably benign |
Het |
| Gon4l |
G |
A |
3: 88,765,707 (GRCm39) |
S376N |
probably damaging |
Het |
| Gstt3 |
C |
A |
10: 75,616,749 (GRCm39) |
R15L |
probably damaging |
Het |
| Gtdc1 |
A |
T |
2: 44,642,186 (GRCm39) |
S73T |
possibly damaging |
Het |
| Hhatl |
A |
G |
9: 121,613,786 (GRCm39) |
S419P |
probably benign |
Het |
| Hirip3 |
T |
G |
7: 126,462,363 (GRCm39) |
S46R |
probably damaging |
Het |
| Hsf2 |
A |
G |
10: 57,378,735 (GRCm39) |
T204A |
probably benign |
Het |
| Impg2 |
G |
A |
16: 56,089,378 (GRCm39) |
E1108K |
possibly damaging |
Het |
| Itgb2l |
G |
T |
16: 96,224,130 (GRCm39) |
|
probably benign |
Het |
| Itih5 |
A |
T |
2: 10,256,075 (GRCm39) |
N847I |
probably benign |
Het |
| Kif1a |
T |
C |
1: 92,982,164 (GRCm39) |
|
probably benign |
Het |
| Klhl1 |
T |
A |
14: 96,755,780 (GRCm39) |
|
probably benign |
Het |
| Ktn1 |
T |
A |
14: 47,952,119 (GRCm39) |
D963E |
probably benign |
Het |
| Lclat1 |
T |
A |
17: 73,547,022 (GRCm39) |
V313E |
probably benign |
Het |
| Lrrn4 |
T |
C |
2: 132,712,639 (GRCm39) |
S395G |
probably benign |
Het |
| Macroh2a1 |
G |
A |
13: 56,243,927 (GRCm39) |
|
probably benign |
Het |
| Mbtps1 |
G |
A |
8: 120,264,856 (GRCm39) |
|
probably benign |
Het |
| Me1 |
A |
G |
9: 86,478,257 (GRCm39) |
|
probably benign |
Het |
| Mov10 |
C |
A |
3: 104,702,721 (GRCm39) |
C948F |
probably benign |
Het |
| Mterf1a |
G |
A |
5: 3,940,990 (GRCm39) |
Q293* |
probably null |
Het |
| Nfkb2 |
A |
T |
19: 46,300,065 (GRCm39) |
M838L |
possibly damaging |
Het |
| Nhlrc2 |
T |
A |
19: 56,540,302 (GRCm39) |
L97Q |
probably damaging |
Het |
| Nr6a1 |
A |
T |
2: 38,629,032 (GRCm39) |
Y331N |
possibly damaging |
Het |
| Nup214 |
C |
T |
2: 31,924,826 (GRCm39) |
A1785V |
probably damaging |
Het |
| Ogg1 |
C |
T |
6: 113,306,217 (GRCm39) |
T138I |
probably benign |
Het |
| Or5ac20 |
A |
G |
16: 59,104,116 (GRCm39) |
V248A |
probably damaging |
Het |
| Or5b107 |
A |
G |
19: 13,143,251 (GRCm39) |
Y291C |
probably damaging |
Het |
| Or5b124 |
A |
G |
19: 13,611,048 (GRCm39) |
Y191C |
probably damaging |
Het |
| Or7g17 |
T |
A |
9: 18,768,127 (GRCm39) |
Y60N |
probably damaging |
Het |
| Plod2 |
G |
T |
9: 92,466,574 (GRCm39) |
R178L |
probably benign |
Het |
| Polr3b |
T |
A |
10: 84,554,339 (GRCm39) |
L1017Q |
probably benign |
Het |
| Postn |
C |
A |
3: 54,291,971 (GRCm39) |
T724N |
probably damaging |
Het |
| Ppm1l |
T |
G |
3: 69,225,309 (GRCm39) |
|
probably benign |
Het |
| Prpf8 |
T |
G |
11: 75,396,075 (GRCm39) |
L1983R |
probably damaging |
Het |
| Psma7 |
A |
G |
2: 179,681,193 (GRCm39) |
V59A |
probably benign |
Het |
| Qser1 |
T |
A |
2: 104,619,306 (GRCm39) |
Y502F |
probably benign |
Het |
| Rad50 |
T |
C |
11: 53,558,852 (GRCm39) |
D1129G |
probably damaging |
Het |
| Rasal1 |
C |
A |
5: 120,812,794 (GRCm39) |
P606Q |
probably damaging |
Het |
| Rgs6 |
A |
G |
12: 83,180,463 (GRCm39) |
Y438C |
probably damaging |
Het |
| Rnf180 |
A |
G |
13: 105,388,774 (GRCm39) |
C73R |
probably benign |
Het |
| Rnf216 |
T |
A |
5: 143,065,996 (GRCm39) |
I474F |
possibly damaging |
Het |
| Sdha |
A |
T |
13: 74,480,366 (GRCm39) |
L371Q |
probably damaging |
Het |
| Sdk1 |
T |
G |
5: 142,070,321 (GRCm39) |
L1162R |
possibly damaging |
Het |
| Sh3rf2 |
T |
C |
18: 42,237,146 (GRCm39) |
I223T |
probably damaging |
Het |
| Sirpb1a |
A |
G |
3: 15,475,587 (GRCm39) |
V316A |
probably damaging |
Het |
| Slc12a4 |
A |
T |
8: 106,672,021 (GRCm39) |
I897N |
probably benign |
Het |
| Slc35d1 |
A |
T |
4: 103,048,035 (GRCm39) |
V243E |
probably damaging |
Het |
| Slc4a11 |
T |
A |
2: 130,532,852 (GRCm39) |
K200N |
possibly damaging |
Het |
| Slc9a8 |
T |
A |
2: 167,293,216 (GRCm39) |
M188K |
probably damaging |
Het |
| Slco1a8 |
T |
A |
6: 141,918,137 (GRCm39) |
I580F |
possibly damaging |
Het |
| Snrnp200 |
T |
C |
2: 127,074,902 (GRCm39) |
S1492P |
probably damaging |
Het |
| Sphk2 |
T |
C |
7: 45,360,149 (GRCm39) |
*618W |
probably null |
Het |
| Sytl2 |
T |
C |
7: 90,052,228 (GRCm39) |
|
probably benign |
Het |
| Tdpoz3 |
A |
G |
3: 93,734,231 (GRCm39) |
N302S |
probably benign |
Het |
| Tdrd6 |
T |
C |
17: 43,935,199 (GRCm39) |
M1950V |
probably benign |
Het |
| Tmem39a |
A |
G |
16: 38,384,675 (GRCm39) |
|
probably benign |
Het |
| Trip4 |
A |
T |
9: 65,765,640 (GRCm39) |
I353K |
probably damaging |
Het |
| Trip6 |
A |
T |
5: 137,311,103 (GRCm39) |
F204L |
probably benign |
Het |
| Trpm4 |
T |
A |
7: 44,968,677 (GRCm39) |
I419F |
possibly damaging |
Het |
| Ttn |
C |
A |
2: 76,775,140 (GRCm39) |
E1967D |
probably damaging |
Het |
| Uba2 |
C |
T |
7: 33,850,281 (GRCm39) |
V391M |
possibly damaging |
Het |
| Ubr4 |
T |
G |
4: 139,206,746 (GRCm39) |
|
probably benign |
Het |
| Upf1 |
G |
A |
8: 70,788,295 (GRCm39) |
|
probably benign |
Het |
| Vmn1r228 |
A |
C |
17: 20,996,858 (GRCm39) |
V220G |
possibly damaging |
Het |
| Vmn2r79 |
A |
G |
7: 86,652,594 (GRCm39) |
M429V |
probably benign |
Het |
| Vps36 |
C |
T |
8: 22,700,472 (GRCm39) |
T210I |
possibly damaging |
Het |
| Ybx1 |
C |
T |
4: 119,138,788 (GRCm39) |
G126D |
probably benign |
Het |
| Yipf5 |
C |
A |
18: 40,339,460 (GRCm39) |
|
probably benign |
Het |
| Zbtb47 |
A |
G |
9: 121,596,641 (GRCm39) |
T666A |
probably benign |
Het |
| Zdhhc5 |
A |
C |
2: 84,520,459 (GRCm39) |
S573A |
probably benign |
Het |
| Zfp457 |
A |
T |
13: 67,441,991 (GRCm39) |
C99S |
probably damaging |
Het |
| Zfp52 |
T |
A |
17: 21,781,564 (GRCm39) |
C471S |
probably damaging |
Het |
| Zfp558 |
C |
T |
9: 18,379,252 (GRCm39) |
V71I |
probably damaging |
Het |
| Zfp655 |
A |
G |
5: 145,181,267 (GRCm39) |
Y375C |
probably damaging |
Het |
| Zfp882 |
A |
T |
8: 72,668,459 (GRCm39) |
T429S |
probably benign |
Het |
| Zmym2 |
T |
C |
14: 57,187,141 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Wdr17 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00309:Wdr17
|
APN |
8 |
55,140,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00496:Wdr17
|
APN |
8 |
55,112,614 (GRCm39) |
splice site |
probably benign |
|
|
IGL01318:Wdr17
|
APN |
8 |
55,125,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01347:Wdr17
|
APN |
8 |
55,104,380 (GRCm39) |
missense |
probably benign |
|
|
IGL01654:Wdr17
|
APN |
8 |
55,115,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02010:Wdr17
|
APN |
8 |
55,112,738 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02085:Wdr17
|
APN |
8 |
55,140,771 (GRCm39) |
nonsense |
probably null |
|
|
IGL02205:Wdr17
|
APN |
8 |
55,149,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02375:Wdr17
|
APN |
8 |
55,149,423 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02705:Wdr17
|
APN |
8 |
55,101,250 (GRCm39) |
splice site |
probably null |
|
|
IGL02719:Wdr17
|
APN |
8 |
55,146,089 (GRCm39) |
splice site |
probably null |
|
|
IGL03051:Wdr17
|
APN |
8 |
55,104,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03131:Wdr17
|
APN |
8 |
55,149,302 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03172:Wdr17
|
APN |
8 |
55,114,515 (GRCm39) |
missense |
probably damaging |
0.96 |
|
enthralled
|
UTSW |
8 |
55,112,716 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
riveted
|
UTSW |
8 |
55,085,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
thrilled
|
UTSW |
8 |
55,149,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03138:Wdr17
|
UTSW |
8 |
55,102,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4458001:Wdr17
|
UTSW |
8 |
55,126,614 (GRCm39) |
nonsense |
probably null |
|
|
R0011:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0011:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0124:Wdr17
|
UTSW |
8 |
55,088,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0226:Wdr17
|
UTSW |
8 |
55,116,043 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0271:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0288:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0321:Wdr17
|
UTSW |
8 |
55,149,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0464:Wdr17
|
UTSW |
8 |
55,123,427 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Wdr17
|
UTSW |
8 |
55,104,456 (GRCm39) |
splice site |
probably null |
|
|
R0488:Wdr17
|
UTSW |
8 |
55,146,087 (GRCm39) |
unclassified |
probably benign |
|
|
R0552:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0553:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0600:Wdr17
|
UTSW |
8 |
55,114,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0621:Wdr17
|
UTSW |
8 |
55,096,226 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0655:Wdr17
|
UTSW |
8 |
55,102,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0730:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0789:Wdr17
|
UTSW |
8 |
55,112,607 (GRCm39) |
splice site |
probably benign |
|
|
R0854:Wdr17
|
UTSW |
8 |
55,156,916 (GRCm39) |
missense |
probably benign |
|
|
R0879:Wdr17
|
UTSW |
8 |
55,114,516 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1462:Wdr17
|
UTSW |
8 |
55,123,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1462:Wdr17
|
UTSW |
8 |
55,123,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1497:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1589:Wdr17
|
UTSW |
8 |
55,156,942 (GRCm39) |
intron |
probably benign |
|
|
R1618:Wdr17
|
UTSW |
8 |
55,092,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1768:Wdr17
|
UTSW |
8 |
55,126,689 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1778:Wdr17
|
UTSW |
8 |
55,143,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1819:Wdr17
|
UTSW |
8 |
55,143,159 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1913:Wdr17
|
UTSW |
8 |
55,140,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2129:Wdr17
|
UTSW |
8 |
55,085,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Wdr17
|
UTSW |
8 |
55,125,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2309:Wdr17
|
UTSW |
8 |
55,096,283 (GRCm39) |
missense |
probably benign |
|
|
R3882:Wdr17
|
UTSW |
8 |
55,092,536 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4097:Wdr17
|
UTSW |
8 |
55,088,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4372:Wdr17
|
UTSW |
8 |
55,092,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4380:Wdr17
|
UTSW |
8 |
55,101,442 (GRCm39) |
intron |
probably benign |
|
|
R4480:Wdr17
|
UTSW |
8 |
55,117,999 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4654:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4656:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4669:Wdr17
|
UTSW |
8 |
55,143,083 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R4719:Wdr17
|
UTSW |
8 |
55,092,911 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4912:Wdr17
|
UTSW |
8 |
55,082,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5000:Wdr17
|
UTSW |
8 |
55,118,161 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5073:Wdr17
|
UTSW |
8 |
55,143,271 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5176:Wdr17
|
UTSW |
8 |
55,106,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5194:Wdr17
|
UTSW |
8 |
55,140,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5270:Wdr17
|
UTSW |
8 |
55,096,221 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5300:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5325:Wdr17
|
UTSW |
8 |
55,112,716 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5336:Wdr17
|
UTSW |
8 |
55,085,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5394:Wdr17
|
UTSW |
8 |
55,092,524 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5424:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5425:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5426:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5548:Wdr17
|
UTSW |
8 |
55,156,886 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5681:Wdr17
|
UTSW |
8 |
55,115,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5722:Wdr17
|
UTSW |
8 |
55,113,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5894:Wdr17
|
UTSW |
8 |
55,149,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5906:Wdr17
|
UTSW |
8 |
55,092,503 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6038:Wdr17
|
UTSW |
8 |
55,085,346 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6038:Wdr17
|
UTSW |
8 |
55,085,346 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6391:Wdr17
|
UTSW |
8 |
55,114,495 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6605:Wdr17
|
UTSW |
8 |
55,134,559 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6892:Wdr17
|
UTSW |
8 |
55,126,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7019:Wdr17
|
UTSW |
8 |
55,134,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7257:Wdr17
|
UTSW |
8 |
55,085,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7481:Wdr17
|
UTSW |
8 |
55,114,371 (GRCm39) |
missense |
probably benign |
|
|
R7868:Wdr17
|
UTSW |
8 |
55,149,302 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7939:Wdr17
|
UTSW |
8 |
55,140,677 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7962:Wdr17
|
UTSW |
8 |
55,113,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8017:Wdr17
|
UTSW |
8 |
55,091,403 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8122:Wdr17
|
UTSW |
8 |
55,118,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8226:Wdr17
|
UTSW |
8 |
55,146,155 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8251:Wdr17
|
UTSW |
8 |
55,110,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8413:Wdr17
|
UTSW |
8 |
55,115,953 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8534:Wdr17
|
UTSW |
8 |
55,101,265 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8708:Wdr17
|
UTSW |
8 |
55,093,127 (GRCm39) |
intron |
probably benign |
|
|
R9116:Wdr17
|
UTSW |
8 |
55,114,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9258:Wdr17
|
UTSW |
8 |
55,112,654 (GRCm39) |
nonsense |
probably null |
|
|
R9351:Wdr17
|
UTSW |
8 |
55,143,057 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9475:Wdr17
|
UTSW |
8 |
55,088,512 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9546:Wdr17
|
UTSW |
8 |
55,112,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9547:Wdr17
|
UTSW |
8 |
55,112,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9635:Wdr17
|
UTSW |
8 |
55,101,375 (GRCm39) |
missense |
probably damaging |
0.98 |
|
V5088:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
V5622:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
V5622:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
X0022:Wdr17
|
UTSW |
8 |
55,092,529 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0066:Wdr17
|
UTSW |
8 |
55,126,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Wdr17
|
UTSW |
8 |
55,123,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Wdr17
|
UTSW |
8 |
55,096,220 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGCTAATAgtaatggcatacctttaatcccag -3'
(R):5'- GGTTGAATGAAAACCAAGGCATAACATGA -3'
Sequencing Primer
(F):5'- agaacacataaatgaacaggcaag -3'
(R):5'- GGTTGCTAACTGAGAGCATATTACG -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation