Incidental Mutation 'R4669:Wdr17'
| ID |
352270 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Wdr17
|
| Ensembl Gene |
ENSMUSG00000039375 |
| Gene Name |
WD repeat domain 17 |
| Synonyms |
B230207L18Rik, 3010002I12Rik |
| MMRRC Submission |
041925-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4669 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
8 |
| Chromosomal Location |
55082316-55180014 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 55143083 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 189
(V189A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115550
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000127511]
[ENSMUST00000129132]
[ENSMUST00000144482]
[ENSMUST00000144711]
[ENSMUST00000150488]
[ENSMUST00000175915]
[ENSMUST00000176866]
|
| AlphaFold |
E9Q271 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000126316
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000127511
AA Change: V189A
PolyPhen 2
Score 0.718 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000115550
Gene: ENSMUSG00000039375
AA Change: V189A
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
72 |
112 |
8.55e-8 |
SMART |
|
WD40
|
162 |
202 |
1.58e2 |
SMART |
|
WD40
|
205 |
252 |
4.26e1 |
SMART |
|
WD40
|
255 |
298 |
1.15e0 |
SMART |
|
WD40
|
383 |
422 |
1.59e-7 |
SMART |
|
WD40
|
425 |
465 |
2.39e0 |
SMART |
|
WD40
|
468 |
509 |
5.52e-2 |
SMART |
|
WD40
|
511 |
550 |
4.14e-6 |
SMART |
|
WD40
|
555 |
595 |
5.14e-11 |
SMART |
|
WD40
|
598 |
638 |
6.58e-9 |
SMART |
|
WD40
|
641 |
681 |
6.28e-6 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000129132
AA Change: V165A
PolyPhen 2
Score 0.460 (Sensitivity: 0.89; Specificity: 0.90)
|
| SMART Domains |
Protein: ENSMUSP00000134935
Gene: ENSMUSG00000039375
AA Change: V165A
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
Blast:WD40
|
91 |
131 |
1e-12 |
BLAST |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
271 |
9.86e1 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144482
AA Change: V1A
PolyPhen 2
Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000134950
Gene: ENSMUSG00000039375
AA Change: V1A
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:WD40
|
16 |
65 |
2e-24 |
BLAST |
|
WD40
|
70 |
109 |
1.59e-7 |
SMART |
|
WD40
|
112 |
152 |
2.39e0 |
SMART |
|
WD40
|
155 |
196 |
5.52e-2 |
SMART |
|
WD40
|
198 |
237 |
4.14e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144711
AA Change: V189A
PolyPhen 2
Score 0.209 (Sensitivity: 0.92; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000117710
Gene: ENSMUSG00000039375
AA Change: V189A
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
72 |
112 |
8.55e-8 |
SMART |
|
WD40
|
194 |
235 |
7.64e1 |
SMART |
|
WD40
|
238 |
281 |
1.15e0 |
SMART |
|
WD40
|
366 |
405 |
1.59e-7 |
SMART |
|
WD40
|
408 |
448 |
2.39e0 |
SMART |
|
WD40
|
451 |
492 |
5.52e-2 |
SMART |
|
WD40
|
494 |
533 |
4.14e-6 |
SMART |
|
WD40
|
538 |
578 |
5.14e-11 |
SMART |
|
WD40
|
581 |
621 |
6.58e-9 |
SMART |
|
WD40
|
624 |
664 |
6.28e-6 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000148806
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000150488
AA Change: V165A
PolyPhen 2
Score 0.282 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000122326
Gene: ENSMUSG00000039375
AA Change: V165A
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
274 |
1.15e0 |
SMART |
|
WD40
|
359 |
398 |
1.59e-7 |
SMART |
|
WD40
|
401 |
441 |
2.39e0 |
SMART |
|
WD40
|
444 |
485 |
5.52e-2 |
SMART |
|
WD40
|
487 |
526 |
4.14e-6 |
SMART |
|
WD40
|
531 |
571 |
5.14e-11 |
SMART |
|
WD40
|
574 |
614 |
6.58e-9 |
SMART |
|
WD40
|
617 |
657 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000175915
AA Change: V165A
PolyPhen 2
Score 0.326 (Sensitivity: 0.90; Specificity: 0.89)
|
| SMART Domains |
Protein: ENSMUSP00000135805
Gene: ENSMUSG00000039375
AA Change: V165A
| Domain | Start | End | E-Value | Type |
|---|
|
WD40
|
48 |
88 |
8.55e-8 |
SMART |
|
WD40
|
138 |
178 |
1.58e2 |
SMART |
|
WD40
|
181 |
228 |
4.26e1 |
SMART |
|
WD40
|
231 |
274 |
1.15e0 |
SMART |
|
WD40
|
359 |
398 |
1.59e-7 |
SMART |
|
WD40
|
401 |
441 |
2.39e0 |
SMART |
|
WD40
|
444 |
485 |
5.52e-2 |
SMART |
|
WD40
|
487 |
526 |
4.14e-6 |
SMART |
|
WD40
|
531 |
571 |
5.14e-11 |
SMART |
|
WD40
|
574 |
614 |
6.58e-9 |
SMART |
|
WD40
|
617 |
657 |
6.28e-6 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176866
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.4%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a WD repeat-containing protein. It is abundantly expressed in retina and testis, and is thought to be a candidate gene for retinal disease. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2009]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 98 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acad8 |
A |
G |
9: 26,901,923 (GRCm39) |
L147P |
probably damaging |
Het |
| Acan |
A |
G |
7: 78,750,890 (GRCm39) |
E464G |
probably benign |
Het |
| Agap1 |
A |
G |
1: 89,765,528 (GRCm39) |
|
probably null |
Het |
| Akap13 |
A |
G |
7: 75,378,842 (GRCm39) |
T2128A |
probably damaging |
Het |
| Ap2a1 |
A |
T |
7: 44,552,343 (GRCm39) |
|
probably benign |
Het |
| Arap3 |
T |
C |
18: 38,129,307 (GRCm39) |
D217G |
probably benign |
Het |
| Arl2 |
C |
A |
19: 6,184,716 (GRCm39) |
R179L |
probably damaging |
Het |
| Atg2a |
T |
A |
19: 6,309,017 (GRCm39) |
|
probably null |
Het |
| B3gat1 |
T |
A |
9: 26,663,052 (GRCm39) |
L6Q |
probably benign |
Het |
| Bcl10 |
A |
G |
3: 145,636,327 (GRCm39) |
N75S |
probably damaging |
Het |
| Bmpr2 |
T |
C |
1: 59,906,875 (GRCm39) |
L656S |
probably damaging |
Het |
| Brms1l |
A |
G |
12: 55,888,356 (GRCm39) |
E48G |
possibly damaging |
Het |
| C2cd2l |
A |
T |
9: 44,226,322 (GRCm39) |
N414K |
possibly damaging |
Het |
| Capn2 |
C |
T |
1: 182,298,345 (GRCm39) |
C640Y |
probably benign |
Het |
| Ccdc153 |
G |
T |
9: 44,157,021 (GRCm39) |
R99M |
probably damaging |
Het |
| Ccdc51 |
A |
G |
9: 108,920,030 (GRCm39) |
N142S |
probably benign |
Het |
| Cdipt |
A |
G |
7: 126,577,578 (GRCm39) |
H108R |
possibly damaging |
Het |
| Ceacam20 |
T |
C |
7: 19,719,952 (GRCm39) |
Y495H |
probably damaging |
Het |
| Celf2 |
T |
C |
2: 6,726,339 (GRCm39) |
I47V |
probably benign |
Het |
| Cts3 |
C |
T |
13: 61,714,637 (GRCm39) |
E223K |
probably benign |
Het |
| Cyp2a22 |
T |
C |
7: 26,637,280 (GRCm39) |
D168G |
possibly damaging |
Het |
| Cyp2c67 |
T |
A |
19: 39,632,098 (GRCm39) |
H90L |
probably benign |
Het |
| Ddx4 |
T |
C |
13: 112,758,778 (GRCm39) |
Y261C |
probably damaging |
Het |
| Dnah17 |
T |
C |
11: 117,965,119 (GRCm39) |
T2308A |
probably benign |
Het |
| Dnah6 |
T |
C |
6: 73,014,671 (GRCm39) |
T3587A |
probably damaging |
Het |
| Dpy19l1 |
C |
T |
9: 24,343,664 (GRCm39) |
V494I |
possibly damaging |
Het |
| Dse |
T |
G |
10: 34,029,008 (GRCm39) |
Y694S |
probably damaging |
Het |
| Emilin3 |
T |
C |
2: 160,752,717 (GRCm39) |
I78V |
probably benign |
Het |
| Esam |
T |
A |
9: 37,447,952 (GRCm39) |
Y195* |
probably null |
Het |
| Extl3 |
T |
A |
14: 65,313,745 (GRCm39) |
N479I |
possibly damaging |
Het |
| Fat2 |
A |
G |
11: 55,202,441 (GRCm39) |
V211A |
probably benign |
Het |
| Ganc |
G |
T |
2: 120,261,548 (GRCm39) |
V343F |
probably benign |
Het |
| Ggt5 |
T |
C |
10: 75,438,865 (GRCm39) |
L121P |
probably damaging |
Het |
| Gnmt |
A |
T |
17: 47,037,225 (GRCm39) |
C186* |
probably null |
Het |
| Gpr75 |
A |
T |
11: 30,842,072 (GRCm39) |
I326F |
probably damaging |
Het |
| Gsdme |
C |
T |
6: 50,185,102 (GRCm39) |
V451M |
probably damaging |
Het |
| H2-T23 |
G |
T |
17: 36,342,690 (GRCm39) |
D149E |
probably damaging |
Het |
| Hmcn2 |
G |
T |
2: 31,325,804 (GRCm39) |
R4277L |
probably benign |
Het |
| Irf9 |
C |
A |
14: 55,843,223 (GRCm39) |
H94N |
probably benign |
Het |
| Jhy |
T |
C |
9: 40,872,449 (GRCm39) |
N20S |
probably benign |
Het |
| Klf17 |
C |
A |
4: 117,617,568 (GRCm39) |
C263F |
probably damaging |
Het |
| Lama5 |
T |
C |
2: 179,822,430 (GRCm39) |
Y2881C |
probably damaging |
Het |
| Lig1 |
T |
G |
7: 13,044,953 (GRCm39) |
I882S |
probably damaging |
Het |
| Ltn1 |
A |
T |
16: 87,215,375 (GRCm39) |
M420K |
possibly damaging |
Het |
| Mael |
T |
C |
1: 166,063,077 (GRCm39) |
E125G |
probably damaging |
Het |
| Mib2 |
C |
T |
4: 155,741,872 (GRCm39) |
D275N |
possibly damaging |
Het |
| Mical3 |
C |
T |
6: 120,934,664 (GRCm39) |
R1805Q |
probably damaging |
Het |
| Mix23 |
A |
G |
16: 35,903,089 (GRCm39) |
D27G |
probably damaging |
Het |
| Mllt10 |
A |
G |
2: 18,208,444 (GRCm39) |
D158G |
probably damaging |
Het |
| Mocs1 |
A |
G |
17: 49,761,613 (GRCm39) |
D569G |
possibly damaging |
Het |
| Msh6 |
T |
C |
17: 88,292,234 (GRCm39) |
S330P |
possibly damaging |
Het |
| Mtmr2 |
T |
C |
9: 13,707,260 (GRCm39) |
S199P |
probably damaging |
Het |
| Ndufaf5 |
T |
C |
2: 140,029,675 (GRCm39) |
V164A |
probably benign |
Het |
| Nek9 |
T |
C |
12: 85,360,978 (GRCm39) |
E518G |
probably benign |
Het |
| Nfatc2 |
T |
C |
2: 168,413,410 (GRCm39) |
I72V |
probably benign |
Het |
| Nlrp9c |
C |
T |
7: 26,074,793 (GRCm39) |
A746T |
possibly damaging |
Het |
| Nup42 |
A |
G |
5: 24,387,415 (GRCm39) |
R402G |
probably benign |
Het |
| Ogdh |
G |
T |
11: 6,290,600 (GRCm39) |
C406F |
probably benign |
Het |
| Or3a1d |
A |
G |
11: 74,237,789 (GRCm39) |
V207A |
probably benign |
Het |
| Or4c120 |
G |
A |
2: 89,001,245 (GRCm39) |
H104Y |
probably damaging |
Het |
| Or8b35 |
A |
T |
9: 37,904,381 (GRCm39) |
I198F |
possibly damaging |
Het |
| Or8g17 |
T |
A |
9: 38,930,675 (GRCm39) |
Y54F |
probably benign |
Het |
| Or8j3 |
A |
T |
2: 86,028,277 (GRCm39) |
M273K |
possibly damaging |
Het |
| Otof |
A |
G |
5: 30,578,318 (GRCm39) |
|
probably null |
Het |
| Pcdhb17 |
T |
C |
18: 37,619,259 (GRCm39) |
S350P |
probably damaging |
Het |
| Phf3 |
T |
C |
1: 30,869,027 (GRCm39) |
T674A |
probably damaging |
Het |
| Pikfyve |
T |
A |
1: 65,289,432 (GRCm39) |
C1235S |
probably damaging |
Het |
| Ppfia3 |
T |
C |
7: 45,001,517 (GRCm39) |
E465G |
probably damaging |
Het |
| Prkg1 |
T |
A |
19: 31,641,639 (GRCm39) |
I15F |
probably damaging |
Het |
| Rab5c |
A |
G |
11: 100,610,843 (GRCm39) |
F22L |
probably damaging |
Het |
| Raf1 |
A |
G |
6: 115,609,880 (GRCm39) |
S220P |
probably damaging |
Het |
| Rgl1 |
T |
G |
1: 152,397,122 (GRCm39) |
R716S |
probably damaging |
Het |
| Rhbg |
C |
A |
3: 88,153,273 (GRCm39) |
W205L |
probably damaging |
Het |
| Rimbp3 |
A |
G |
16: 17,027,053 (GRCm39) |
E159G |
possibly damaging |
Het |
| Ryr1 |
T |
C |
7: 28,759,256 (GRCm39) |
D3338G |
probably null |
Het |
| Sash1 |
T |
C |
10: 8,606,149 (GRCm39) |
N747S |
probably benign |
Het |
| Serpina3g |
A |
T |
12: 104,205,479 (GRCm39) |
I73F |
probably damaging |
Het |
| Sfxn2 |
C |
A |
19: 46,574,213 (GRCm39) |
N134K |
probably damaging |
Het |
| Slc12a6 |
A |
G |
2: 112,184,640 (GRCm39) |
H853R |
probably damaging |
Het |
| Slc16a12 |
C |
T |
19: 34,649,965 (GRCm39) |
D357N |
probably damaging |
Het |
| Slc39a8 |
T |
C |
3: 135,561,772 (GRCm39) |
Y164H |
probably benign |
Het |
| Snx9 |
A |
G |
17: 5,977,499 (GRCm39) |
K518E |
probably damaging |
Het |
| Spdye4c |
G |
A |
2: 128,434,273 (GRCm39) |
V5I |
possibly damaging |
Het |
| Spef2 |
A |
G |
15: 9,676,459 (GRCm39) |
V704A |
probably benign |
Het |
| Stard3nl |
T |
A |
13: 19,560,689 (GRCm39) |
N29Y |
probably damaging |
Het |
| Strap |
C |
A |
6: 137,712,384 (GRCm39) |
S11* |
probably null |
Het |
| Synpo2 |
A |
G |
3: 122,906,712 (GRCm39) |
L868P |
probably damaging |
Het |
| Tenm2 |
A |
G |
11: 35,901,314 (GRCm39) |
V2474A |
probably damaging |
Het |
| Tm9sf4 |
T |
A |
2: 153,029,228 (GRCm39) |
V92D |
probably damaging |
Het |
| Tmf1 |
A |
T |
6: 97,147,388 (GRCm39) |
M526K |
probably benign |
Het |
| Top2b |
T |
G |
14: 16,409,189 (GRCm38) |
I777M |
probably damaging |
Het |
| Ttc39d |
A |
G |
17: 80,525,068 (GRCm39) |
I576V |
probably benign |
Het |
| Upk1a |
T |
G |
7: 30,304,554 (GRCm39) |
T193P |
probably benign |
Het |
| Vmn2r67 |
A |
T |
7: 84,799,732 (GRCm39) |
V502E |
probably benign |
Het |
| Wrap73 |
A |
T |
4: 154,236,153 (GRCm39) |
S161C |
probably benign |
Het |
| Zfp568 |
A |
G |
7: 29,722,702 (GRCm39) |
H549R |
probably damaging |
Het |
| Zfp605 |
T |
A |
5: 110,275,227 (GRCm39) |
M115K |
possibly damaging |
Het |
| Zp1 |
T |
A |
19: 10,896,269 (GRCm39) |
H152L |
probably benign |
Het |
|
| Other mutations in Wdr17 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00309:Wdr17
|
APN |
8 |
55,140,746 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00496:Wdr17
|
APN |
8 |
55,112,614 (GRCm39) |
splice site |
probably benign |
|
|
IGL01318:Wdr17
|
APN |
8 |
55,125,585 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01347:Wdr17
|
APN |
8 |
55,104,380 (GRCm39) |
missense |
probably benign |
|
|
IGL01654:Wdr17
|
APN |
8 |
55,115,914 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02010:Wdr17
|
APN |
8 |
55,112,738 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02085:Wdr17
|
APN |
8 |
55,140,771 (GRCm39) |
nonsense |
probably null |
|
|
IGL02205:Wdr17
|
APN |
8 |
55,149,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02375:Wdr17
|
APN |
8 |
55,149,423 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02705:Wdr17
|
APN |
8 |
55,101,250 (GRCm39) |
splice site |
probably null |
|
|
IGL02719:Wdr17
|
APN |
8 |
55,146,089 (GRCm39) |
splice site |
probably null |
|
|
IGL03051:Wdr17
|
APN |
8 |
55,104,349 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03131:Wdr17
|
APN |
8 |
55,149,302 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03172:Wdr17
|
APN |
8 |
55,114,515 (GRCm39) |
missense |
probably damaging |
0.96 |
|
enthralled
|
UTSW |
8 |
55,112,716 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
riveted
|
UTSW |
8 |
55,085,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
thrilled
|
UTSW |
8 |
55,149,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03138:Wdr17
|
UTSW |
8 |
55,102,178 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4458001:Wdr17
|
UTSW |
8 |
55,126,614 (GRCm39) |
nonsense |
probably null |
|
|
R0011:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0011:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R0124:Wdr17
|
UTSW |
8 |
55,088,526 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0226:Wdr17
|
UTSW |
8 |
55,116,043 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0270:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0271:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0288:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0321:Wdr17
|
UTSW |
8 |
55,149,303 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0464:Wdr17
|
UTSW |
8 |
55,123,427 (GRCm39) |
splice site |
probably benign |
|
|
R0479:Wdr17
|
UTSW |
8 |
55,104,456 (GRCm39) |
splice site |
probably null |
|
|
R0488:Wdr17
|
UTSW |
8 |
55,146,087 (GRCm39) |
unclassified |
probably benign |
|
|
R0552:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0553:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0600:Wdr17
|
UTSW |
8 |
55,114,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0621:Wdr17
|
UTSW |
8 |
55,096,226 (GRCm39) |
missense |
probably benign |
0.18 |
|
R0655:Wdr17
|
UTSW |
8 |
55,102,233 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0730:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0789:Wdr17
|
UTSW |
8 |
55,112,607 (GRCm39) |
splice site |
probably benign |
|
|
R0854:Wdr17
|
UTSW |
8 |
55,156,916 (GRCm39) |
missense |
probably benign |
|
|
R0879:Wdr17
|
UTSW |
8 |
55,114,516 (GRCm39) |
missense |
probably benign |
0.08 |
|
R1462:Wdr17
|
UTSW |
8 |
55,123,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1462:Wdr17
|
UTSW |
8 |
55,123,363 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1497:Wdr17
|
UTSW |
8 |
55,125,536 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1589:Wdr17
|
UTSW |
8 |
55,156,942 (GRCm39) |
intron |
probably benign |
|
|
R1618:Wdr17
|
UTSW |
8 |
55,092,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1768:Wdr17
|
UTSW |
8 |
55,126,689 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1778:Wdr17
|
UTSW |
8 |
55,143,249 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1819:Wdr17
|
UTSW |
8 |
55,143,159 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1913:Wdr17
|
UTSW |
8 |
55,140,761 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2129:Wdr17
|
UTSW |
8 |
55,085,416 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2132:Wdr17
|
UTSW |
8 |
55,125,541 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2309:Wdr17
|
UTSW |
8 |
55,096,283 (GRCm39) |
missense |
probably benign |
|
|
R3882:Wdr17
|
UTSW |
8 |
55,092,536 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4097:Wdr17
|
UTSW |
8 |
55,088,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4372:Wdr17
|
UTSW |
8 |
55,092,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4380:Wdr17
|
UTSW |
8 |
55,101,442 (GRCm39) |
intron |
probably benign |
|
|
R4480:Wdr17
|
UTSW |
8 |
55,117,999 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4654:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4656:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4719:Wdr17
|
UTSW |
8 |
55,092,911 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4912:Wdr17
|
UTSW |
8 |
55,082,896 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5000:Wdr17
|
UTSW |
8 |
55,118,161 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R5073:Wdr17
|
UTSW |
8 |
55,143,271 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5176:Wdr17
|
UTSW |
8 |
55,106,913 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5194:Wdr17
|
UTSW |
8 |
55,140,639 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5270:Wdr17
|
UTSW |
8 |
55,096,221 (GRCm39) |
missense |
probably benign |
0.20 |
|
R5300:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5325:Wdr17
|
UTSW |
8 |
55,112,716 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5336:Wdr17
|
UTSW |
8 |
55,085,353 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5394:Wdr17
|
UTSW |
8 |
55,092,524 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5424:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5425:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5426:Wdr17
|
UTSW |
8 |
55,134,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5548:Wdr17
|
UTSW |
8 |
55,156,886 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5681:Wdr17
|
UTSW |
8 |
55,115,904 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5722:Wdr17
|
UTSW |
8 |
55,113,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5894:Wdr17
|
UTSW |
8 |
55,149,335 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5906:Wdr17
|
UTSW |
8 |
55,092,503 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6038:Wdr17
|
UTSW |
8 |
55,085,346 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6038:Wdr17
|
UTSW |
8 |
55,085,346 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6391:Wdr17
|
UTSW |
8 |
55,114,495 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6605:Wdr17
|
UTSW |
8 |
55,134,559 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6892:Wdr17
|
UTSW |
8 |
55,126,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7019:Wdr17
|
UTSW |
8 |
55,134,488 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7257:Wdr17
|
UTSW |
8 |
55,085,522 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7481:Wdr17
|
UTSW |
8 |
55,114,371 (GRCm39) |
missense |
probably benign |
|
|
R7868:Wdr17
|
UTSW |
8 |
55,149,302 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7939:Wdr17
|
UTSW |
8 |
55,140,677 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7962:Wdr17
|
UTSW |
8 |
55,113,806 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8017:Wdr17
|
UTSW |
8 |
55,091,403 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8122:Wdr17
|
UTSW |
8 |
55,118,011 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8226:Wdr17
|
UTSW |
8 |
55,146,155 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R8251:Wdr17
|
UTSW |
8 |
55,110,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8413:Wdr17
|
UTSW |
8 |
55,115,953 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8534:Wdr17
|
UTSW |
8 |
55,101,265 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8708:Wdr17
|
UTSW |
8 |
55,093,127 (GRCm39) |
intron |
probably benign |
|
|
R9116:Wdr17
|
UTSW |
8 |
55,114,605 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9258:Wdr17
|
UTSW |
8 |
55,112,654 (GRCm39) |
nonsense |
probably null |
|
|
R9351:Wdr17
|
UTSW |
8 |
55,143,057 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9475:Wdr17
|
UTSW |
8 |
55,088,512 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9546:Wdr17
|
UTSW |
8 |
55,112,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9547:Wdr17
|
UTSW |
8 |
55,112,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9635:Wdr17
|
UTSW |
8 |
55,101,375 (GRCm39) |
missense |
probably damaging |
0.98 |
|
V5088:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
V5622:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
V5622:Wdr17
|
UTSW |
8 |
55,146,131 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
X0022:Wdr17
|
UTSW |
8 |
55,092,529 (GRCm39) |
missense |
probably benign |
0.04 |
|
X0066:Wdr17
|
UTSW |
8 |
55,126,595 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Wdr17
|
UTSW |
8 |
55,123,414 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Wdr17
|
UTSW |
8 |
55,096,220 (GRCm39) |
missense |
probably benign |
0.03 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTCTGAAATTAACTTTCCTTCCGC -3'
(R):5'- CTGGTGCTGGAACACACATG -3'
Sequencing Primer
(F):5'- TTGATCAGAGACTGAAACCTCC -3'
(R):5'- ACACACATGATGCTGTGGC -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation