Incidental Mutation 'R4655:Vmn2r74'
ID |
352358 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r74
|
Ensembl Gene |
ENSMUSG00000090774 |
Gene Name |
vomeronasal 2, receptor 74 |
Synonyms |
EG546980 |
MMRRC Submission |
041915-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.105)
|
Stock # |
R4655 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
85601075-85610690 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 85610555 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Threonine to Alanine
at position 46
(T46A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000126917
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000166355]
|
AlphaFold |
E9PW21 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000166355
AA Change: T46A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000126917 Gene: ENSMUSG00000090774 AA Change: T46A
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
467 |
7.3e-28 |
PFAM |
Pfam:NCD3G
|
510 |
562 |
4.7e-20 |
PFAM |
Pfam:7tm_3
|
592 |
830 |
1.3e-52 |
PFAM |
|
Meta Mutation Damage Score |
0.0898 |
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.4%
- 20x: 95.7%
|
Validation Efficiency |
96% (79/82) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 75 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4921509C19Rik |
A |
G |
2: 151,314,778 (GRCm39) |
V300A |
probably benign |
Het |
Aadacl4fm2 |
A |
T |
4: 144,281,645 (GRCm39) |
F382L |
probably benign |
Het |
Abca4 |
A |
G |
3: 121,941,147 (GRCm39) |
N405S |
possibly damaging |
Het |
Acsl3 |
A |
G |
1: 78,668,063 (GRCm39) |
T212A |
probably damaging |
Het |
Ahnak |
A |
G |
19: 8,986,065 (GRCm39) |
K2450E |
probably damaging |
Het |
Akap9 |
G |
A |
5: 4,096,403 (GRCm39) |
R2426H |
probably benign |
Het |
Akr1c6 |
T |
C |
13: 4,499,428 (GRCm39) |
V266A |
probably damaging |
Het |
Ccs |
A |
G |
19: 4,889,232 (GRCm39) |
V11A |
probably benign |
Het |
Cdc14a |
T |
A |
3: 116,122,136 (GRCm39) |
H228L |
probably damaging |
Het |
Cgn |
G |
A |
3: 94,686,559 (GRCm39) |
Q248* |
probably null |
Het |
Cux2 |
G |
A |
5: 122,023,997 (GRCm39) |
T92M |
possibly damaging |
Het |
Cyb5r4 |
A |
G |
9: 86,941,482 (GRCm39) |
K68E |
probably benign |
Het |
Dcaf10 |
G |
A |
4: 45,372,769 (GRCm39) |
R394Q |
possibly damaging |
Het |
Dnah9 |
T |
C |
11: 65,846,558 (GRCm39) |
N2918S |
probably benign |
Het |
Dyrk1b |
T |
C |
7: 27,885,176 (GRCm39) |
V438A |
probably damaging |
Het |
Eml1 |
G |
A |
12: 108,500,972 (GRCm39) |
D625N |
probably damaging |
Het |
Eno2 |
T |
C |
6: 124,740,889 (GRCm39) |
|
probably null |
Het |
Ephb3 |
G |
A |
16: 21,040,958 (GRCm39) |
G672D |
probably damaging |
Het |
Evx1 |
A |
T |
6: 52,291,182 (GRCm39) |
D118V |
probably damaging |
Het |
Fbxl13 |
A |
G |
5: 21,787,037 (GRCm39) |
L300S |
probably damaging |
Het |
Fbxo30 |
T |
C |
10: 11,166,837 (GRCm39) |
F520L |
probably damaging |
Het |
Flt3 |
G |
A |
5: 147,286,403 (GRCm39) |
P728S |
possibly damaging |
Het |
Gas2l2 |
T |
C |
11: 83,314,001 (GRCm39) |
E437G |
possibly damaging |
Het |
Gldc |
A |
T |
19: 30,138,102 (GRCm39) |
|
probably benign |
Het |
Gm18856 |
T |
C |
13: 14,140,232 (GRCm39) |
|
probably benign |
Het |
Gm7358 |
A |
T |
17: 14,279,410 (GRCm39) |
|
noncoding transcript |
Het |
Grifin |
A |
G |
5: 140,550,300 (GRCm39) |
V47A |
possibly damaging |
Het |
H3c7 |
T |
C |
13: 23,728,923 (GRCm39) |
V90A |
probably benign |
Het |
Hddc2 |
G |
T |
10: 31,204,016 (GRCm39) |
|
probably benign |
Het |
Hkdc1 |
T |
A |
10: 62,236,242 (GRCm39) |
R433S |
probably benign |
Het |
Htt |
A |
G |
5: 35,063,476 (GRCm39) |
D2918G |
probably benign |
Het |
Itga2 |
A |
C |
13: 115,009,805 (GRCm39) |
D383E |
probably benign |
Het |
Itpr1 |
G |
A |
6: 108,458,254 (GRCm39) |
C2007Y |
probably damaging |
Het |
Krt42 |
C |
A |
11: 100,160,671 (GRCm39) |
Q9H |
probably damaging |
Het |
Lyrm7 |
T |
C |
11: 54,739,434 (GRCm39) |
Q72R |
probably damaging |
Het |
Mmp9 |
A |
G |
2: 164,793,122 (GRCm39) |
S424G |
probably benign |
Het |
Mtr |
A |
G |
13: 12,242,679 (GRCm39) |
V457A |
probably damaging |
Het |
Myo15b |
T |
C |
11: 115,781,523 (GRCm39) |
L1359P |
probably damaging |
Het |
Neb |
A |
G |
2: 52,117,311 (GRCm39) |
L4087P |
probably damaging |
Het |
Npl |
T |
C |
1: 153,391,152 (GRCm39) |
D201G |
probably damaging |
Het |
Or1af1 |
A |
G |
2: 37,109,885 (GRCm39) |
N128S |
probably benign |
Het |
Or8b1c |
C |
A |
9: 38,384,120 (GRCm39) |
P26T |
probably damaging |
Het |
Or8k3 |
A |
G |
2: 86,059,037 (GRCm39) |
S93P |
probably benign |
Het |
Pclo |
T |
C |
5: 14,732,397 (GRCm39) |
|
probably benign |
Het |
Pdp2 |
A |
G |
8: 105,321,168 (GRCm39) |
D339G |
probably benign |
Het |
Pfdn6 |
A |
T |
17: 34,159,014 (GRCm39) |
Y16* |
probably null |
Het |
Pilra |
C |
T |
5: 137,833,588 (GRCm39) |
|
probably null |
Het |
Prrc2a |
A |
T |
17: 35,374,590 (GRCm39) |
N1353K |
probably benign |
Het |
Prss3l |
T |
A |
6: 41,422,984 (GRCm39) |
I6F |
probably benign |
Het |
Ptger4 |
C |
A |
15: 5,272,545 (GRCm39) |
A50S |
probably benign |
Het |
Pus10 |
T |
C |
11: 23,622,707 (GRCm39) |
V109A |
probably benign |
Het |
Pus3 |
A |
C |
9: 35,476,228 (GRCm39) |
D39A |
probably benign |
Het |
Rab44 |
A |
G |
17: 29,358,168 (GRCm39) |
N119D |
probably benign |
Het |
Rasgrp2 |
T |
C |
19: 6,454,876 (GRCm39) |
|
probably benign |
Het |
Rhobtb2 |
T |
A |
14: 70,033,438 (GRCm39) |
I511F |
probably damaging |
Het |
Sfxn1 |
C |
A |
13: 54,246,457 (GRCm39) |
A167D |
probably benign |
Het |
Slc12a6 |
A |
G |
2: 112,188,111 (GRCm39) |
|
probably null |
Het |
Smyd4 |
C |
T |
11: 75,281,558 (GRCm39) |
L344F |
probably damaging |
Het |
Srsf11 |
A |
G |
3: 157,728,972 (GRCm39) |
V93A |
probably benign |
Het |
Tle1 |
A |
G |
4: 72,063,581 (GRCm39) |
I224T |
possibly damaging |
Het |
Tmc6 |
A |
T |
11: 117,663,868 (GRCm39) |
S479R |
possibly damaging |
Het |
Tmprss4 |
T |
C |
9: 45,087,702 (GRCm39) |
M296V |
probably benign |
Het |
Togaram1 |
A |
G |
12: 65,013,894 (GRCm39) |
N382D |
possibly damaging |
Het |
Tpcn1 |
A |
G |
5: 120,677,322 (GRCm39) |
S662P |
probably damaging |
Het |
Tppp |
G |
T |
13: 74,178,983 (GRCm39) |
R141S |
probably benign |
Het |
Ttc21a |
A |
G |
9: 119,790,828 (GRCm39) |
D858G |
possibly damaging |
Het |
Tuba3a |
A |
G |
6: 125,258,130 (GRCm39) |
S287P |
possibly damaging |
Het |
Unc80 |
T |
G |
1: 66,710,821 (GRCm39) |
S2697A |
probably benign |
Het |
Vmn1r69 |
A |
G |
7: 10,314,026 (GRCm39) |
V235A |
probably benign |
Het |
Vmn2r26 |
T |
A |
6: 124,038,375 (GRCm39) |
I650N |
probably damaging |
Het |
Vmn2r53 |
G |
A |
7: 12,315,932 (GRCm39) |
T629I |
possibly damaging |
Het |
Vmn2r84 |
A |
T |
10: 130,229,973 (GRCm39) |
C46* |
probably null |
Het |
Vps13b |
T |
C |
15: 35,770,835 (GRCm39) |
S2093P |
probably benign |
Het |
Wdfy4 |
T |
C |
14: 32,711,893 (GRCm39) |
R2375G |
probably damaging |
Het |
Wnk2 |
T |
G |
13: 49,210,359 (GRCm39) |
E1820A |
probably damaging |
Het |
|
Other mutations in Vmn2r74 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00899:Vmn2r74
|
APN |
7 |
85,606,338 (GRCm39) |
missense |
probably benign |
0.03 |
IGL00904:Vmn2r74
|
APN |
7 |
85,606,788 (GRCm39) |
missense |
probably benign |
0.05 |
IGL01285:Vmn2r74
|
APN |
7 |
85,606,692 (GRCm39) |
missense |
possibly damaging |
0.54 |
IGL01300:Vmn2r74
|
APN |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
0.00 |
IGL01410:Vmn2r74
|
APN |
7 |
85,610,500 (GRCm39) |
missense |
possibly damaging |
0.83 |
IGL01827:Vmn2r74
|
APN |
7 |
85,606,800 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02094:Vmn2r74
|
APN |
7 |
85,610,669 (GRCm39) |
missense |
probably benign |
0.01 |
IGL02252:Vmn2r74
|
APN |
7 |
85,606,531 (GRCm39) |
missense |
probably benign |
0.41 |
IGL02349:Vmn2r74
|
APN |
7 |
85,601,724 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02438:Vmn2r74
|
APN |
7 |
85,601,824 (GRCm39) |
missense |
probably damaging |
0.98 |
IGL02554:Vmn2r74
|
APN |
7 |
85,606,581 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03036:Vmn2r74
|
APN |
7 |
85,601,900 (GRCm39) |
nonsense |
probably null |
|
IGL03370:Vmn2r74
|
APN |
7 |
85,607,265 (GRCm39) |
missense |
probably benign |
|
R0115:Vmn2r74
|
UTSW |
7 |
85,606,564 (GRCm39) |
missense |
probably benign |
0.00 |
R0333:Vmn2r74
|
UTSW |
7 |
85,601,491 (GRCm39) |
missense |
probably benign |
0.06 |
R0415:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
R0571:Vmn2r74
|
UTSW |
7 |
85,601,629 (GRCm39) |
missense |
probably damaging |
1.00 |
R0626:Vmn2r74
|
UTSW |
7 |
85,610,517 (GRCm39) |
nonsense |
probably null |
|
R0659:Vmn2r74
|
UTSW |
7 |
85,605,122 (GRCm39) |
splice site |
probably benign |
|
R1202:Vmn2r74
|
UTSW |
7 |
85,610,545 (GRCm39) |
missense |
possibly damaging |
0.83 |
R1473:Vmn2r74
|
UTSW |
7 |
85,610,618 (GRCm39) |
missense |
probably damaging |
1.00 |
R1908:Vmn2r74
|
UTSW |
7 |
85,601,650 (GRCm39) |
missense |
probably benign |
|
R2079:Vmn2r74
|
UTSW |
7 |
85,606,383 (GRCm39) |
missense |
probably benign |
0.00 |
R2368:Vmn2r74
|
UTSW |
7 |
85,610,522 (GRCm39) |
missense |
probably benign |
0.39 |
R3782:Vmn2r74
|
UTSW |
7 |
85,605,322 (GRCm39) |
missense |
probably benign |
0.01 |
R3824:Vmn2r74
|
UTSW |
7 |
85,607,466 (GRCm39) |
missense |
probably damaging |
1.00 |
R3977:Vmn2r74
|
UTSW |
7 |
85,607,345 (GRCm39) |
missense |
probably benign |
0.01 |
R4182:Vmn2r74
|
UTSW |
7 |
85,606,395 (GRCm39) |
missense |
possibly damaging |
0.87 |
R4289:Vmn2r74
|
UTSW |
7 |
85,606,562 (GRCm39) |
missense |
probably benign |
|
R4294:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
R4645:Vmn2r74
|
UTSW |
7 |
85,606,317 (GRCm39) |
missense |
probably benign |
|
R4646:Vmn2r74
|
UTSW |
7 |
85,606,782 (GRCm39) |
missense |
probably benign |
0.42 |
R4901:Vmn2r74
|
UTSW |
7 |
85,605,199 (GRCm39) |
nonsense |
probably null |
|
R5532:Vmn2r74
|
UTSW |
7 |
85,601,197 (GRCm39) |
missense |
probably benign |
0.32 |
R5642:Vmn2r74
|
UTSW |
7 |
85,606,588 (GRCm39) |
missense |
probably benign |
0.00 |
R5913:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
R6035:Vmn2r74
|
UTSW |
7 |
85,601,098 (GRCm39) |
missense |
probably damaging |
0.98 |
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
R6039:Vmn2r74
|
UTSW |
7 |
85,607,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
R6170:Vmn2r74
|
UTSW |
7 |
85,606,348 (GRCm39) |
missense |
probably benign |
0.03 |
R6232:Vmn2r74
|
UTSW |
7 |
85,607,498 (GRCm39) |
missense |
possibly damaging |
0.82 |
R6238:Vmn2r74
|
UTSW |
7 |
85,601,280 (GRCm39) |
missense |
probably damaging |
1.00 |
R6255:Vmn2r74
|
UTSW |
7 |
85,601,659 (GRCm39) |
missense |
possibly damaging |
0.90 |
R6468:Vmn2r74
|
UTSW |
7 |
85,610,599 (GRCm39) |
missense |
probably benign |
0.34 |
R6732:Vmn2r74
|
UTSW |
7 |
85,606,758 (GRCm39) |
missense |
probably damaging |
1.00 |
R6816:Vmn2r74
|
UTSW |
7 |
85,610,621 (GRCm39) |
nonsense |
probably null |
|
R6836:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.00 |
R6995:Vmn2r74
|
UTSW |
7 |
85,606,860 (GRCm39) |
critical splice acceptor site |
probably null |
|
R6995:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
R7186:Vmn2r74
|
UTSW |
7 |
85,601,150 (GRCm39) |
nonsense |
probably null |
|
R7246:Vmn2r74
|
UTSW |
7 |
85,605,173 (GRCm39) |
missense |
probably benign |
|
R7374:Vmn2r74
|
UTSW |
7 |
85,606,630 (GRCm39) |
missense |
probably benign |
0.02 |
R7505:Vmn2r74
|
UTSW |
7 |
85,606,279 (GRCm39) |
nonsense |
probably null |
|
R7525:Vmn2r74
|
UTSW |
7 |
85,610,510 (GRCm39) |
missense |
probably benign |
|
R7569:Vmn2r74
|
UTSW |
7 |
85,601,544 (GRCm39) |
missense |
probably damaging |
0.99 |
R7644:Vmn2r74
|
UTSW |
7 |
85,606,746 (GRCm39) |
missense |
probably benign |
0.11 |
R7956:Vmn2r74
|
UTSW |
7 |
85,605,166 (GRCm39) |
missense |
probably benign |
0.09 |
R8119:Vmn2r74
|
UTSW |
7 |
85,610,690 (GRCm39) |
start codon destroyed |
probably null |
0.08 |
R8131:Vmn2r74
|
UTSW |
7 |
85,601,943 (GRCm39) |
missense |
probably benign |
0.01 |
R8147:Vmn2r74
|
UTSW |
7 |
85,605,227 (GRCm39) |
nonsense |
probably null |
|
R8181:Vmn2r74
|
UTSW |
7 |
85,605,324 (GRCm39) |
missense |
probably damaging |
1.00 |
R8184:Vmn2r74
|
UTSW |
7 |
85,601,454 (GRCm39) |
missense |
probably benign |
0.00 |
R8375:Vmn2r74
|
UTSW |
7 |
85,601,914 (GRCm39) |
missense |
possibly damaging |
0.64 |
R8948:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
R8950:Vmn2r74
|
UTSW |
7 |
85,606,569 (GRCm39) |
missense |
probably damaging |
1.00 |
R9033:Vmn2r74
|
UTSW |
7 |
85,606,414 (GRCm39) |
missense |
probably benign |
|
R9342:Vmn2r74
|
UTSW |
7 |
85,606,624 (GRCm39) |
missense |
probably benign |
0.14 |
R9578:Vmn2r74
|
UTSW |
7 |
85,606,101 (GRCm39) |
missense |
probably benign |
0.01 |
R9607:Vmn2r74
|
UTSW |
7 |
85,610,619 (GRCm39) |
missense |
probably benign |
0.02 |
R9776:Vmn2r74
|
UTSW |
7 |
85,605,212 (GRCm39) |
missense |
possibly damaging |
0.70 |
Z1176:Vmn2r74
|
UTSW |
7 |
85,604,835 (GRCm39) |
missense |
probably damaging |
1.00 |
Z31818:Vmn2r74
|
UTSW |
7 |
85,604,729 (GRCm39) |
splice site |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- CACCATGGTTCATTCATTCAGC -3'
(R):5'- ACTCAGGCAGATATCTTGCTG -3'
Sequencing Primer
(F):5'- CAATTTTGGTTATCTCCTAGCAAGGG -3'
(R):5'- CTCAGGCAGATATCTTGCTGACAGG -3'
|
Posted On |
2015-10-08 |