Mutagenetix > Incidental Mutation

Incidental Mutation 'R4658:Vmn2r117'

352637

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r117

Ensembl Gene

ENSMUSG00000091407

Gene Name

vomeronasal 2, receptor 117

Synonyms

EG619788

MMRRC Submission

041918-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.099) question?

Stock #

R4658 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

23459675-23479597 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 23478416 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Leucine at position 101 (F101L)

Ref Sequence

ENSEMBL: ENSMUSP00000126885 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000171996]

AlphaFold

K7N6V1

Predicted Effect

probably benign
Transcript: ENSMUST00000171996
AA Change: F101L

PolyPhen 2 Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)

SMART Domains

Protein: ENSMUSP00000126885
Gene: ENSMUSG00000091407
AA Change: F101L

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	471	2.6e-28	PFAM
Pfam:NCD3G	512	565	5e-20	PFAM
Pfam:7tm_3	595	833	8.2e-54	PFAM

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.5%

Validation Efficiency

99% (88/89)

Allele List at MGI

Other mutations in this stock

Total: 78 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acacb	A	T	5: 114,200,564 (GRCm38)	R778S	probably damaging	Het
Adam17	A	G	12: 21,332,160 (GRCm38)	C567R	probably damaging	Het
Ankrd28	G	A	14: 31,710,868 (GRCm38)	A758V	probably damaging	Het
Atrn	T	C	2: 130,933,429 (GRCm38)	Y151H	probably damaging	Het
B3gat3	A	G	19: 8,925,632 (GRCm38)	T118A	possibly damaging	Het
Camta1	A	G	4: 151,143,910 (GRCm38)	C822R	probably damaging	Het
Capn15	G	T	17: 25,960,768 (GRCm38)	Q807K	probably benign	Het
Clec12a	T	C	6: 129,354,530 (GRCm38)	Y145H	probably damaging	Het
Clk1	T	C	1: 58,412,987 (GRCm38)	I393V	probably benign	Het
Cpm	A	G	10: 117,668,051 (GRCm38)	I121V	probably benign	Het
Cux1	A	G	5: 136,250,594 (GRCm38)	I405T	possibly damaging	Het
Dnah3	A	G	7: 119,950,651 (GRCm38)	S3471P	probably damaging	Het
Dok6	A	G	18: 89,473,847 (GRCm38)		probably benign	Het
Eif4g1	A	T	16: 20,685,934 (GRCm38)	D1124V	possibly damaging	Het
Eif4g3	A	G	4: 138,206,132 (GRCm38)	E1756G	probably damaging	Het
Exo5	A	G	4: 120,922,551 (GRCm38)	V39A	probably benign	Het
Fmnl1	A	T	11: 103,197,694 (GRCm38)	I90F	probably damaging	Het
Fryl	G	T	5: 73,081,053 (GRCm38)	T1450K	probably damaging	Het
Gde1	T	C	7: 118,694,528 (GRCm38)	M91V	probably benign	Het
Gimd1	T	C	3: 132,644,582 (GRCm38)	I84T	probably damaging	Het
Gm13889	C	T	2: 93,957,108 (GRCm38)		probably benign	Het
Gm6445	T	A	19: 9,608,197 (GRCm38)		noncoding transcript	Het
Gm8113	T	C	14: 43,932,410 (GRCm38)	S483P	probably damaging	Het
Grik2	T	C	10: 49,523,792 (GRCm38)	I281V	possibly damaging	Het
Grik5	T	C	7: 25,060,727 (GRCm38)		probably benign	Het
Herc1	A	T	9: 66,479,491 (GRCm38)	I3796F	possibly damaging	Het
Hoxb13	A	T	11: 96,194,483 (GRCm38)	D14V	probably benign	Het
Hspg2	A	G	4: 137,533,730 (GRCm38)	Y1645C	probably damaging	Het
Igkv8-16	G	T	6: 70,386,778 (GRCm38)	R87S	probably damaging	Het
Ints1	A	T	5: 139,774,299 (GRCm38)	V140E	possibly damaging	Het
Kbtbd11	C	A	8: 15,028,917 (GRCm38)	D505E	possibly damaging	Het
Kcnu1	G	A	8: 25,937,555 (GRCm38)	C300Y	probably damaging	Het
Kmt2d	G	C	15: 98,852,529 (GRCm38)		probably benign	Het
Lats1	T	C	10: 7,702,729 (GRCm38)	V539A	probably benign	Het
Lipo5	C	T	19: 33,464,522 (GRCm38)	G200D	unknown	Het
Lmo7	C	A	14: 101,886,957 (GRCm38)	A284D	probably damaging	Het
Lyst	G	A	13: 13,635,383 (GRCm38)	R546H	probably damaging	Het
Mcpt8	T	C	14: 56,083,828 (GRCm38)	M60V	possibly damaging	Het
Mdn1	A	G	4: 32,730,749 (GRCm38)		probably null	Het
Mphosph10	A	G	7: 64,388,974 (GRCm38)		probably null	Het
Muc5b	G	A	7: 141,841,398 (GRCm38)	S47N	unknown	Het
Notch3	A	T	17: 32,154,763 (GRCm38)	N490K	probably damaging	Het
Nr1d1	G	A	11: 98,771,912 (GRCm38)	S85L	possibly damaging	Het
Obscn	T	A	11: 59,054,288 (GRCm38)	R4635*	probably null	Het
Olfr121	G	T	17: 37,752,163 (GRCm38)	C103F	probably damaging	Het
Olfr1504	T	C	19: 13,887,548 (GRCm38)	I221V	probably benign	Het
Olfr275	T	C	4: 52,826,240 (GRCm38)	L281P	probably damaging	Het
Pappa	G	A	4: 65,314,796 (GRCm38)		probably null	Het
Pcdhb17	G	A	18: 37,486,599 (GRCm38)	G481S	probably damaging	Het
Pde1a	TCC	TC	2: 79,898,181 (GRCm38)		probably benign	Het
Phf3	A	T	1: 30,863,088 (GRCm38)	M48K	probably damaging	Het
Pira2	A	T	7: 3,840,934 (GRCm38)	V613E	probably damaging	Het
Poc1a	T	C	9: 106,349,688 (GRCm38)	S327P	possibly damaging	Het
Ptpn9	A	G	9: 57,020,037 (GRCm38)	H66R	probably benign	Het
Rabgap1	C	T	2: 37,487,549 (GRCm38)	R353*	probably null	Het
Rcc1l	G	T	5: 134,171,890 (GRCm38)	N134K	probably damaging	Het
Rims1	G	A	1: 22,427,543 (GRCm38)	T787I	probably damaging	Het
Rreb1	T	G	13: 37,948,801 (GRCm38)	S1651A	probably damaging	Het
Rsl1d1	T	C	16: 11,201,374 (GRCm38)	D100G	probably damaging	Het
Samd4	C	T	14: 47,064,246 (GRCm38)	R147C	probably damaging	Het
Serpinb6e	T	C	13: 33,841,316 (GRCm38)		probably benign	Het
Ska1	T	C	18: 74,197,040 (GRCm38)	I210V	probably benign	Het
Slc17a1	A	G	13: 23,878,560 (GRCm38)	I237V	probably benign	Het
Slc22a4	A	T	11: 53,997,510 (GRCm38)	S231T	probably benign	Het
Slc7a4	T	A	16: 17,575,933 (GRCm38)	M66L	probably damaging	Het
Snapc1	A	G	12: 73,983,868 (GRCm38)	T381A	possibly damaging	Het
St6galnac2	C	T	11: 116,684,525 (GRCm38)		probably benign	Het
Taar2	C	T	10: 23,941,503 (GRCm38)	L314F	probably benign	Het
Tmem74b	A	G	2: 151,706,641 (GRCm38)	D96G	probably damaging	Het
Tnfrsf17	T	C	16: 11,313,969 (GRCm38)	F6S	probably benign	Het
Tpp2	G	T	1: 43,954,710 (GRCm38)	G252W	probably damaging	Het
Trf	A	G	9: 103,223,608 (GRCm38)	F209L	probably damaging	Het
Ttn	T	C	2: 76,898,591 (GRCm38)		probably benign	Het
Uhmk1	A	T	1: 170,207,205 (GRCm38)	H311Q	probably damaging	Het
Unc13c	G	T	9: 73,932,826 (GRCm38)	Q248K	probably damaging	Het
Uqcrc2	A	G	7: 120,650,921 (GRCm38)	Y253C	probably damaging	Het
Vmn2r43	T	C	7: 8,255,071 (GRCm38)	N381S	probably benign	Het
Zfp879	T	A	11: 50,833,197 (GRCm38)	Y271F	probably damaging	Het

Other mutations in Vmn2r117

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Vmn2r117	APN	17	23,479,546 (GRCm38)	missense	probably benign
IGL00990:Vmn2r117	APN	17	23,477,840 (GRCm38)	missense	probably damaging	1.00
IGL00990:Vmn2r117	APN	17	23,475,429 (GRCm38)	missense	probably damaging	1.00
IGL01078:Vmn2r117	APN	17	23,477,804 (GRCm38)	missense	probably damaging	1.00
IGL01139:Vmn2r117	APN	17	23,477,804 (GRCm38)	missense	probably damaging	1.00
IGL01374:Vmn2r117	APN	17	23,478,382 (GRCm38)	missense	possibly damaging	0.46
IGL01779:Vmn2r117	APN	17	23,477,241 (GRCm38)	missense	probably benign	0.00
IGL02283:Vmn2r117	APN	17	23,475,382 (GRCm38)	missense	probably damaging	0.99
IGL02527:Vmn2r117	APN	17	23,477,225 (GRCm38)	missense	possibly damaging	0.65
IGL02612:Vmn2r117	APN	17	23,459,784 (GRCm38)	missense	possibly damaging	0.91
IGL02887:Vmn2r117	APN	17	23,475,578 (GRCm38)	splice site	probably benign
IGL03167:Vmn2r117	APN	17	23,477,707 (GRCm38)	missense	probably damaging	1.00
R0315:Vmn2r117	UTSW	17	23,460,165 (GRCm38)	missense	probably benign	0.11
R0610:Vmn2r117	UTSW	17	23,475,514 (GRCm38)	missense	probably benign	0.00
R0747:Vmn2r117	UTSW	17	23,475,503 (GRCm38)	nonsense	probably null
R1411:Vmn2r117	UTSW	17	23,460,553 (GRCm38)	missense	probably damaging	1.00
R1471:Vmn2r117	UTSW	17	23,478,473 (GRCm38)	missense	probably benign	0.00
R1853:Vmn2r117	UTSW	17	23,477,455 (GRCm38)	missense	probably damaging	0.99
R1925:Vmn2r117	UTSW	17	23,478,389 (GRCm38)	missense	probably benign	0.00
R1940:Vmn2r117	UTSW	17	23,477,480 (GRCm38)	missense	probably damaging	1.00
R2005:Vmn2r117	UTSW	17	23,477,644 (GRCm38)	missense	probably damaging	1.00
R2082:Vmn2r117	UTSW	17	23,460,256 (GRCm38)	missense	possibly damaging	0.55
R2698:Vmn2r117	UTSW	17	23,459,911 (GRCm38)	missense	probably damaging	0.98
R2972:Vmn2r117	UTSW	17	23,459,856 (GRCm38)	missense	probably damaging	1.00
R2973:Vmn2r117	UTSW	17	23,459,856 (GRCm38)	missense	probably damaging	1.00
R2974:Vmn2r117	UTSW	17	23,459,856 (GRCm38)	missense	probably damaging	1.00
R3160:Vmn2r117	UTSW	17	23,460,378 (GRCm38)	missense	probably damaging	1.00
R3161:Vmn2r117	UTSW	17	23,460,378 (GRCm38)	missense	probably damaging	1.00
R3162:Vmn2r117	UTSW	17	23,460,378 (GRCm38)	missense	probably damaging	1.00
R3847:Vmn2r117	UTSW	17	23,460,415 (GRCm38)	missense	probably damaging	0.97
R3848:Vmn2r117	UTSW	17	23,460,415 (GRCm38)	missense	probably damaging	0.97
R4082:Vmn2r117	UTSW	17	23,460,106 (GRCm38)	missense	probably benign	0.00
R4320:Vmn2r117	UTSW	17	23,479,513 (GRCm38)	frame shift	probably null
R4560:Vmn2r117	UTSW	17	23,459,877 (GRCm38)	missense	probably damaging	1.00
R4881:Vmn2r117	UTSW	17	23,477,885 (GRCm38)	missense	probably damaging	1.00
R4908:Vmn2r117	UTSW	17	23,459,838 (GRCm38)	missense	probably damaging	1.00
R4910:Vmn2r117	UTSW	17	23,479,513 (GRCm38)	frame shift	probably null
R5078:Vmn2r117	UTSW	17	23,460,148 (GRCm38)	missense	probably damaging	1.00
R5327:Vmn2r117	UTSW	17	23,477,874 (GRCm38)	nonsense	probably null
R5774:Vmn2r117	UTSW	17	23,477,202 (GRCm38)	missense	probably damaging	0.98
R6014:Vmn2r117	UTSW	17	23,479,561 (GRCm38)	missense	probably damaging	0.97
R6390:Vmn2r117	UTSW	17	23,460,114 (GRCm38)	missense	possibly damaging	0.95
R6520:Vmn2r117	UTSW	17	23,460,219 (GRCm38)	missense	probably damaging	0.99
R6674:Vmn2r117	UTSW	17	23,460,049 (GRCm38)	nonsense	probably null
R6736:Vmn2r117	UTSW	17	23,478,308 (GRCm38)	missense	probably damaging	0.99
R6909:Vmn2r117	UTSW	17	23,479,505 (GRCm38)	missense	possibly damaging	0.67
R6913:Vmn2r117	UTSW	17	23,479,563 (GRCm38)	missense	probably damaging	0.99
R7220:Vmn2r117	UTSW	17	23,477,203 (GRCm38)	missense	probably damaging	1.00
R7260:Vmn2r117	UTSW	17	23,475,385 (GRCm38)	missense	probably benign	0.06
R7440:Vmn2r117	UTSW	17	23,475,565 (GRCm38)	missense	probably benign	0.26
R7443:Vmn2r117	UTSW	17	23,460,345 (GRCm38)	missense	probably damaging	1.00
R7443:Vmn2r117	UTSW	17	23,460,133 (GRCm38)	missense	probably benign	0.25
R7449:Vmn2r117	UTSW	17	23,459,895 (GRCm38)	missense	probably damaging	1.00
R7644:Vmn2r117	UTSW	17	23,477,291 (GRCm38)	missense	probably damaging	0.98
R7914:Vmn2r117	UTSW	17	23,460,126 (GRCm38)	missense	possibly damaging	0.95
R8001:Vmn2r117	UTSW	17	23,479,407 (GRCm38)	missense	possibly damaging	0.89
R8029:Vmn2r117	UTSW	17	23,477,770 (GRCm38)	missense	probably benign	0.00
R8340:Vmn2r117	UTSW	17	23,460,537 (GRCm38)	missense	probably benign	0.01
R8519:Vmn2r117	UTSW	17	23,479,468 (GRCm38)	missense	probably benign
R8723:Vmn2r117	UTSW	17	23,477,369 (GRCm38)	missense	probably damaging	1.00
R8914:Vmn2r117	UTSW	17	23,460,169 (GRCm38)	missense	probably benign	0.02
R9010:Vmn2r117	UTSW	17	23,460,471 (GRCm38)	missense	probably benign	0.10
R9129:Vmn2r117	UTSW	17	23,459,944 (GRCm38)	nonsense	probably null
R9244:Vmn2r117	UTSW	17	23,477,615 (GRCm38)	missense	probably damaging	0.98
R9464:Vmn2r117	UTSW	17	23,477,604 (GRCm38)	missense	probably benign	0.23
R9620:Vmn2r117	UTSW	17	23,478,476 (GRCm38)	missense	probably damaging	0.97
V5622:Vmn2r117	UTSW	17	23,479,505 (GRCm38)	missense	possibly damaging	0.67
V5622:Vmn2r117	UTSW	17	23,477,840 (GRCm38)	missense	probably damaging	1.00
Z1176:Vmn2r117	UTSW	17	23,459,766 (GRCm38)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- ACCTGCTGAGACATGAAGTTG -3'
(R):5'- TTTATGGGGTGGGGACAATAAAATCC -3'

Sequencing Primer
(F):5'- ACCTGCTGAGACATGAAGTTGTTTAG -3'
(R):5'- CCACTGGAGAATTGTCCTTTTATTG -3'

Posted On

2015-10-08