Mutagenetix > Incidental Mutation

Incidental Mutation 'R4659:Dync1h1'

352701

Institutional Source

Beutler Lab

Gene Symbol

Dync1h1

Ensembl Gene

ENSMUSG00000018707

Gene Name

dynein cytoplasmic 1 heavy chain 1

Synonyms

9930018I23Rik, Dnchc1, dynein heavy chain, retrograde transport, Swl, MAP1C, Loa, Dnec1

MMRRC Submission

041919-MU

Accession Numbers

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R4659 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

110601452-110666945 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 110628767 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 1371 (F1371S)

Ref Sequence

ENSEMBL: ENSMUSP00000018851 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000018851]

AlphaFold

no structure available at present

PDB Structure

Microtubule binding domain from mouse cytoplasmic dynein as a fusion with seryl-tRNA synthetase [X-RAY DIFFRACTION]
High affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Low affinity dynein microtubule binding domain - tubulin complex [ELECTRON MICROSCOPY]
Structure of the entire stalk region of the dynein motor domain [X-RAY DIFFRACTION]

Predicted Effect

possibly damaging
Transcript: ENSMUST00000018851
AA Change: F1371S

PolyPhen 2 Score 0.499 (Sensitivity: 0.88; Specificity: 0.90)

SMART Domains

Protein: ENSMUSP00000018851
Gene: ENSMUSG00000018707
AA Change: F1371S

Domain	Start	End	E-Value	Type
low complexity region	46	61	N/A	INTRINSIC
low complexity region	83	95	N/A	INTRINSIC
Pfam:DHC_N1	237	830	1.9e-145	PFAM
coiled coil region	1171	1198	N/A	INTRINSIC
Pfam:DHC_N2	1317	1721	3.3e-116	PFAM
AAA	1899	2043	5.39e-2	SMART
low complexity region	2102	2116	N/A	INTRINSIC
AAA	2214	2365	2.13e0	SMART
low complexity region	2394	2405	N/A	INTRINSIC
AAA	2585	2735	8.6e-7	SMART
Blast:AAA	2777	2811	2e-13	BLAST
AAA	2927	3093	4.79e-5	SMART
Pfam:MT	3197	3534	1.1e-44	PFAM
Pfam:AAA_9	3554	3778	8.5e-75	PFAM
Pfam:Dynein_heavy	3919	4642	4.3e-163	PFAM

Meta Mutation Damage Score

0.2356

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.3%
20x: 95.4%

Validation Efficiency

96% (74/77)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008]
PHENOTYPE: Mice homozygous for either the Cra1 or Loa ENU mutation exhibit neonatal lethality with reduced anterior horn cell number, abnormal motor neuron innervation, neuronal inclusions, and abnormal axonal transport. Heterozygotes display motor neuron degeneration and muscle spasms. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2410089E03Rik	G	T	15: 8,216,276 (GRCm38)		probably benign	Het
Abcc9	C	A	6: 142,672,595 (GRCm38)		probably null	Het
Ankrd22	C	T	19: 34,125,568 (GRCm38)	V118I	probably damaging	Het
Aoc1	A	T	6: 48,906,076 (GRCm38)	E295D	probably benign	Het
Arap2	T	C	5: 62,654,126 (GRCm38)	N1114S	possibly damaging	Het
AU021092	C	G	16: 5,212,147 (GRCm38)	A335P	probably damaging	Het
Carhsp1	T	C	16: 8,664,265 (GRCm38)	T51A	probably benign	Het
Ccdc144b	T	C	3: 36,025,954 (GRCm38)	D218G	possibly damaging	Het
Cdc42bpb	T	C	12: 111,339,891 (GRCm38)	D152G	probably damaging	Het
Cep70	T	A	9: 99,296,341 (GRCm38)	D497E	possibly damaging	Het
Chrm5	T	C	2: 112,479,757 (GRCm38)	N338S	probably benign	Het
Cldn8	G	A	16: 88,562,408 (GRCm38)	H210Y	probably benign	Het
Clhc1	T	A	11: 29,578,229 (GRCm38)	*586K	probably null	Het
Dopey1	T	A	9: 86,502,032 (GRCm38)		probably benign	Het
Eif6	A	G	2: 155,826,181 (GRCm38)	I46T	probably damaging	Het
Esco2	G	A	14: 65,826,586 (GRCm38)	T383M	possibly damaging	Het
Exoc8	T	C	8: 124,897,532 (GRCm38)	D32G	probably damaging	Het
Fam149b	G	T	14: 20,367,873 (GRCm38)	S216I	probably benign	Het
Fam219a	T	C	4: 41,521,645 (GRCm38)	D87G	probably null	Het
Fbxw26	A	T	9: 109,744,871 (GRCm38)	V71D	probably damaging	Het
Gabra4	T	A	5: 71,641,144 (GRCm38)	K164M	probably damaging	Het
Gm8603	G	A	17: 13,517,028 (GRCm38)		noncoding transcript	Het
Gnmt	A	G	17: 46,725,966 (GRCm38)	F239S	probably damaging	Het
Gpsm1	G	A	2: 26,319,831 (GRCm38)		probably benign	Het
Jam2	G	A	16: 84,812,952 (GRCm38)	V151M	probably damaging	Het
Kcnj1	A	T	9: 32,394,148 (GRCm38)	D2V	probably benign	Het
Limch1	C	T	5: 67,027,557 (GRCm38)	R797C	probably damaging	Het
Lrrc9	T	A	12: 72,470,264 (GRCm38)	F597I	probably damaging	Het
Lrriq3	T	A	3: 155,129,453 (GRCm38)	I275N	possibly damaging	Het
Mcoln1	T	A	8: 3,510,840 (GRCm38)	S387R	probably damaging	Het
Mgst3	T	A	1: 167,377,279 (GRCm38)	Q58L	probably damaging	Het
Mical1	G	A	10: 41,486,936 (GRCm38)		probably benign	Het
Mmp3	C	A	9: 7,453,673 (GRCm38)	D431E	probably benign	Het
Mx1	T	C	16: 97,455,239 (GRCm38)		probably null	Het
Myo7a	A	G	7: 98,085,466 (GRCm38)	L607P	probably damaging	Het
Myt1l	A	G	12: 29,849,457 (GRCm38)	N153D	probably damaging	Het
Nfu1	A	T	6: 87,019,426 (GRCm38)	T120S	probably damaging	Het
Nhlrc2	T	C	19: 56,576,267 (GRCm38)	V341A	possibly damaging	Het
Notch1	T	C	2: 26,470,889 (GRCm38)	E1148G	probably damaging	Het
Nqo1	C	T	8: 107,391,044 (GRCm38)		probably null	Het
Nwd1	T	A	8: 72,695,321 (GRCm38)	D998E	probably benign	Het
Olfr1049	G	A	2: 86,255,013 (GRCm38)	Q227*	probably null	Het
Oxct2a	T	C	4: 123,322,680 (GRCm38)	I303V	probably benign	Het
Parp10	A	T	15: 76,242,985 (GRCm38)	D58E	probably damaging	Het
Pcdha6	T	A	18: 36,969,239 (GRCm38)	V495E	probably damaging	Het
Pitrm1	T	A	13: 6,553,182 (GRCm38)	S88R	probably benign	Het
Pxdn	T	C	12: 29,994,553 (GRCm38)	V510A	probably benign	Het
Ranbp17	T	A	11: 33,266,288 (GRCm38)	D820V	probably damaging	Het
Sec24c	G	T	14: 20,683,144 (GRCm38)	G180C	probably damaging	Het
Serpina3n	T	C	12: 104,413,493 (GRCm38)	S382P	probably benign	Het
Sestd1	A	T	2: 77,212,499 (GRCm38)	M237K	probably null	Het
Sf3a2	T	C	10: 80,803,584 (GRCm38)	I136T	probably damaging	Het
Sh3tc2	A	G	18: 61,974,509 (GRCm38)	Y197C	probably benign	Het
Speer4b	T	C	5: 27,497,895 (GRCm38)	K204E	probably benign	Het
Speer4f1	A	C	5: 17,476,223 (GRCm38)	E33A	possibly damaging	Het
Sspo	T	A	6: 48,484,213 (GRCm38)	D3529E	probably damaging	Het
Stard13	T	C	5: 151,062,788 (GRCm38)	D419G	probably benign	Het
Tg	A	G	15: 66,673,920 (GRCm38)	S164G	possibly damaging	Het
Thap12	A	G	7: 98,710,091 (GRCm38)		probably benign	Het
Thsd1	C	A	8: 22,259,298 (GRCm38)	Y667*	probably null	Het
Tnks	A	C	8: 34,849,311 (GRCm38)	Y885D	possibly damaging	Het
Ttll3	A	G	6: 113,414,141 (GRCm38)	I896V	probably benign	Het
Txnip	T	G	3: 96,559,427 (GRCm38)	F190C	probably damaging	Het
Urb1	T	C	16: 90,776,129 (GRCm38)	D1005G	probably damaging	Het
Usp3	T	C	9: 66,527,070 (GRCm38)		probably null	Het
Usp54	G	T	14: 20,564,992 (GRCm38)	Q794K	probably damaging	Het
Xrn2	A	G	2: 147,061,474 (GRCm38)	Q798R	probably benign	Het
Zfp189	A	G	4: 49,530,342 (GRCm38)	I482V	probably benign	Het
Zfp28	A	G	7: 6,393,507 (GRCm38)	N314D	probably benign	Het
Zmym4	A	G	4: 126,948,428 (GRCm38)		probably null	Het

Other mutations in Dync1h1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01291:Dync1h1	APN	12	110,649,104 (GRCm38)	missense	probably benign	0.31
IGL01299:Dync1h1	APN	12	110,614,107 (GRCm38)	missense	probably benign	0.04
IGL01321:Dync1h1	APN	12	110,625,607 (GRCm38)	splice site	probably benign
IGL01324:Dync1h1	APN	12	110,626,865 (GRCm38)	missense	probably damaging	0.99
IGL01327:Dync1h1	APN	12	110,616,692 (GRCm38)	splice site	probably benign
IGL01371:Dync1h1	APN	12	110,638,851 (GRCm38)	missense	probably benign	0.05
IGL01598:Dync1h1	APN	12	110,658,128 (GRCm38)	missense	probably damaging	0.99
IGL01782:Dync1h1	APN	12	110,614,940 (GRCm38)	missense	probably damaging	1.00
IGL01791:Dync1h1	APN	12	110,658,930 (GRCm38)	missense	probably damaging	0.99
IGL01797:Dync1h1	APN	12	110,652,196 (GRCm38)	critical splice donor site	probably null
IGL02040:Dync1h1	APN	12	110,637,124 (GRCm38)	missense	probably benign	0.21
IGL02096:Dync1h1	APN	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
IGL02164:Dync1h1	APN	12	110,662,559 (GRCm38)	missense	probably damaging	1.00
IGL02216:Dync1h1	APN	12	110,663,002 (GRCm38)	missense	probably damaging	0.98
IGL02298:Dync1h1	APN	12	110,640,888 (GRCm38)	missense	probably damaging	1.00
IGL02422:Dync1h1	APN	12	110,640,210 (GRCm38)	missense	possibly damaging	0.68
IGL02610:Dync1h1	APN	12	110,659,232 (GRCm38)	nonsense	probably null
IGL02643:Dync1h1	APN	12	110,659,272 (GRCm38)	unclassified	probably benign
IGL03076:Dync1h1	APN	12	110,657,893 (GRCm38)	missense	probably damaging	1.00
IGL03292:Dync1h1	APN	12	110,666,555 (GRCm38)	splice site	probably null
IGL03293:Dync1h1	APN	12	110,628,734 (GRCm38)	missense	probably benign	0.12
IGL03299:Dync1h1	APN	12	110,619,210 (GRCm38)	missense	possibly damaging	0.49
chinashop	UTSW	12	110,658,134 (GRCm38)	missense	probably damaging	1.00
Gesund	UTSW	12	110,616,404 (GRCm38)	missense	probably benign	0.35
gymnast	UTSW	12	110,618,368 (GRCm38)	missense	probably damaging	1.00
Lightfoot	UTSW	12	110,617,920 (GRCm38)	missense	probably damaging	1.00
Lissom	UTSW	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
Strong	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
waters	UTSW	12	110,629,679 (GRCm38)	missense	probably damaging	1.00
ANU05:Dync1h1	UTSW	12	110,649,104 (GRCm38)	missense	probably benign	0.31
H8562:Dync1h1	UTSW	12	110,616,807 (GRCm38)	missense	probably benign	0.01
R0082:Dync1h1	UTSW	12	110,636,446 (GRCm38)	missense	probably benign
R0110:Dync1h1	UTSW	12	110,639,944 (GRCm38)	missense	probably benign	0.42
R0130:Dync1h1	UTSW	12	110,618,674 (GRCm38)	missense	probably benign	0.16
R0233:Dync1h1	UTSW	12	110,640,980 (GRCm38)	missense	probably benign	0.45
R0233:Dync1h1	UTSW	12	110,640,980 (GRCm38)	missense	probably benign	0.45
R0242:Dync1h1	UTSW	12	110,649,851 (GRCm38)	missense	possibly damaging	0.67
R0242:Dync1h1	UTSW	12	110,649,851 (GRCm38)	missense	possibly damaging	0.67
R0408:Dync1h1	UTSW	12	110,631,692 (GRCm38)	missense	probably benign
R0450:Dync1h1	UTSW	12	110,639,944 (GRCm38)	missense	probably benign	0.42
R0611:Dync1h1	UTSW	12	110,632,788 (GRCm38)	missense	probably damaging	0.97
R0612:Dync1h1	UTSW	12	110,616,496 (GRCm38)	missense	probably damaging	1.00
R0624:Dync1h1	UTSW	12	110,651,747 (GRCm38)	unclassified	probably benign
R0685:Dync1h1	UTSW	12	110,657,192 (GRCm38)	missense	probably damaging	1.00
R0747:Dync1h1	UTSW	12	110,629,284 (GRCm38)	missense	probably damaging	0.99
R0747:Dync1h1	UTSW	12	110,612,411 (GRCm38)	missense	probably benign
R0843:Dync1h1	UTSW	12	110,665,213 (GRCm38)	missense	possibly damaging	0.81
R0970:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1161:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1211:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1214:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1215:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1227:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1230:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1232:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1237:Dync1h1	UTSW	12	110,665,959 (GRCm38)	missense	probably benign	0.00
R1274:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1275:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1289:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1290:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1331:Dync1h1	UTSW	12	110,649,264 (GRCm38)	missense	probably damaging	0.98
R1340:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1383:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1394:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1396:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1397:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1413:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1432:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1500:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1661:Dync1h1	UTSW	12	110,656,357 (GRCm38)	missense	probably damaging	1.00
R1678:Dync1h1	UTSW	12	110,665,662 (GRCm38)	critical splice acceptor site	probably null
R1698:Dync1h1	UTSW	12	110,626,992 (GRCm38)	missense	possibly damaging	0.88
R1767:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1776:Dync1h1	UTSW	12	110,632,928 (GRCm38)	splice site	probably benign
R1812:Dync1h1	UTSW	12	110,662,900 (GRCm38)	missense	possibly damaging	0.46
R1831:Dync1h1	UTSW	12	110,614,059 (GRCm38)	missense	probably damaging	1.00
R1832:Dync1h1	UTSW	12	110,614,059 (GRCm38)	missense	probably damaging	1.00
R1856:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1857:Dync1h1	UTSW	12	110,662,625 (GRCm38)	missense	probably damaging	0.96
R1879:Dync1h1	UTSW	12	110,624,636 (GRCm38)	missense	probably benign	0.04
R1892:Dync1h1	UTSW	12	110,646,304 (GRCm38)	missense	probably damaging	1.00
R1909:Dync1h1	UTSW	12	110,662,629 (GRCm38)	missense	probably damaging	1.00
R1962:Dync1h1	UTSW	12	110,636,509 (GRCm38)	missense	probably benign	0.04
R1974:Dync1h1	UTSW	12	110,625,732 (GRCm38)	missense	possibly damaging	0.80
R1999:Dync1h1	UTSW	12	110,666,423 (GRCm38)	critical splice donor site	probably null
R2073:Dync1h1	UTSW	12	110,614,592 (GRCm38)	missense	probably damaging	1.00
R2091:Dync1h1	UTSW	12	110,649,588 (GRCm38)	missense	probably benign	0.07
R2113:Dync1h1	UTSW	12	110,629,986 (GRCm38)	missense	probably damaging	1.00
R2128:Dync1h1	UTSW	12	110,640,882 (GRCm38)	missense	probably damaging	1.00
R2134:Dync1h1	UTSW	12	110,656,631 (GRCm38)	missense	possibly damaging	0.68
R2496:Dync1h1	UTSW	12	110,641,220 (GRCm38)	missense	possibly damaging	0.65
R2680:Dync1h1	UTSW	12	110,643,247 (GRCm38)	missense	probably damaging	1.00
R2890:Dync1h1	UTSW	12	110,616,891 (GRCm38)	missense	probably damaging	1.00
R2964:Dync1h1	UTSW	12	110,641,026 (GRCm38)	critical splice donor site	probably null
R3705:Dync1h1	UTSW	12	110,640,586 (GRCm38)	missense	possibly damaging	0.80
R3708:Dync1h1	UTSW	12	110,643,129 (GRCm38)	missense	probably damaging	0.96
R3735:Dync1h1	UTSW	12	110,631,675 (GRCm38)	missense	probably benign
R3736:Dync1h1	UTSW	12	110,631,675 (GRCm38)	missense	probably benign
R3882:Dync1h1	UTSW	12	110,629,058 (GRCm38)	missense	probably benign	0.41
R3971:Dync1h1	UTSW	12	110,665,965 (GRCm38)	missense	probably benign	0.00
R4017:Dync1h1	UTSW	12	110,643,190 (GRCm38)	missense	probably damaging	1.00
R4032:Dync1h1	UTSW	12	110,618,049 (GRCm38)	nonsense	probably null
R4355:Dync1h1	UTSW	12	110,632,899 (GRCm38)	missense	possibly damaging	0.55
R4514:Dync1h1	UTSW	12	110,657,139 (GRCm38)	missense	possibly damaging	0.76
R4586:Dync1h1	UTSW	12	110,649,483 (GRCm38)	missense	probably benign	0.30
R4619:Dync1h1	UTSW	12	110,638,844 (GRCm38)	missense	probably benign	0.09
R4676:Dync1h1	UTSW	12	110,662,541 (GRCm38)	missense	probably damaging	0.99
R4688:Dync1h1	UTSW	12	110,655,528 (GRCm38)	missense	probably damaging	0.99
R4732:Dync1h1	UTSW	12	110,649,507 (GRCm38)	nonsense	probably null
R4733:Dync1h1	UTSW	12	110,649,507 (GRCm38)	nonsense	probably null
R4780:Dync1h1	UTSW	12	110,661,196 (GRCm38)	missense	probably damaging	1.00
R4846:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4861:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4865:Dync1h1	UTSW	12	110,639,801 (GRCm38)	missense	possibly damaging	0.84
R4872:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4873:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4874:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4875:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4927:Dync1h1	UTSW	12	110,662,855 (GRCm38)	missense	possibly damaging	0.82
R4949:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4954:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4956:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4957:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4958:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4984:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4985:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R4988:Dync1h1	UTSW	12	110,658,126 (GRCm38)	missense	probably damaging	1.00
R5029:Dync1h1	UTSW	12	110,618,010 (GRCm38)	missense	possibly damaging	0.46
R5032:Dync1h1	UTSW	12	110,626,892 (GRCm38)	nonsense	probably null
R5036:Dync1h1	UTSW	12	110,630,535 (GRCm38)	missense	probably damaging	1.00
R5037:Dync1h1	UTSW	12	110,640,907 (GRCm38)	missense	probably benign	0.09
R5105:Dync1h1	UTSW	12	110,617,932 (GRCm38)	missense	probably damaging	0.99
R5122:Dync1h1	UTSW	12	110,629,680 (GRCm38)	missense	probably damaging	1.00
R5156:Dync1h1	UTSW	12	110,628,830 (GRCm38)	missense	probably benign	0.00
R5290:Dync1h1	UTSW	12	110,615,068 (GRCm38)	missense	probably benign	0.03
R5453:Dync1h1	UTSW	12	110,632,665 (GRCm38)	missense	probably benign	0.12
R5540:Dync1h1	UTSW	12	110,660,950 (GRCm38)	missense	probably benign	0.00
R5613:Dync1h1	UTSW	12	110,632,820 (GRCm38)	missense	possibly damaging	0.68
R5626:Dync1h1	UTSW	12	110,641,141 (GRCm38)	missense	probably benign	0.01
R5652:Dync1h1	UTSW	12	110,665,988 (GRCm38)	missense	possibly damaging	0.70
R5655:Dync1h1	UTSW	12	110,629,062 (GRCm38)	missense	probably benign	0.03
R5686:Dync1h1	UTSW	12	110,616,404 (GRCm38)	missense	probably benign	0.35
R5772:Dync1h1	UTSW	12	110,646,273 (GRCm38)	nonsense	probably null
R5806:Dync1h1	UTSW	12	110,651,653 (GRCm38)	missense	probably damaging	1.00
R5891:Dync1h1	UTSW	12	110,614,220 (GRCm38)	critical splice donor site	probably null
R5921:Dync1h1	UTSW	12	110,618,368 (GRCm38)	missense	probably damaging	1.00
R5965:Dync1h1	UTSW	12	110,632,778 (GRCm38)	missense	probably benign
R6113:Dync1h1	UTSW	12	110,620,414 (GRCm38)	missense	probably benign
R6119:Dync1h1	UTSW	12	110,628,006 (GRCm38)	missense	possibly damaging	0.82
R6154:Dync1h1	UTSW	12	110,617,993 (GRCm38)	missense	probably damaging	1.00
R6339:Dync1h1	UTSW	12	110,646,205 (GRCm38)	missense	probably damaging	0.97
R6522:Dync1h1	UTSW	12	110,616,737 (GRCm38)	missense	probably damaging	0.99
R6531:Dync1h1	UTSW	12	110,617,920 (GRCm38)	missense	probably damaging	1.00
R6554:Dync1h1	UTSW	12	110,649,848 (GRCm38)	missense	probably benign	0.06
R6672:Dync1h1	UTSW	12	110,658,134 (GRCm38)	missense	probably damaging	1.00
R6746:Dync1h1	UTSW	12	110,651,653 (GRCm38)	missense	probably damaging	1.00
R6785:Dync1h1	UTSW	12	110,629,679 (GRCm38)	missense	probably damaging	1.00
R6857:Dync1h1	UTSW	12	110,658,547 (GRCm38)	missense	possibly damaging	0.94
R6863:Dync1h1	UTSW	12	110,652,180 (GRCm38)	missense	probably benign	0.07
R6881:Dync1h1	UTSW	12	110,624,561 (GRCm38)	missense	probably damaging	1.00
R6892:Dync1h1	UTSW	12	110,638,901 (GRCm38)	missense	probably benign	0.00
R7015:Dync1h1	UTSW	12	110,666,087 (GRCm38)	nonsense	probably null
R7096:Dync1h1	UTSW	12	110,657,078 (GRCm38)	missense	probably damaging	0.99
R7173:Dync1h1	UTSW	12	110,601,739 (GRCm38)	missense	probably benign
R7224:Dync1h1	UTSW	12	110,617,762 (GRCm38)	missense	possibly damaging	0.93
R7295:Dync1h1	UTSW	12	110,664,749 (GRCm38)	critical splice donor site	probably null
R7308:Dync1h1	UTSW	12	110,665,162 (GRCm38)	missense	possibly damaging	0.91
R7346:Dync1h1	UTSW	12	110,635,642 (GRCm38)	missense	probably damaging	1.00
R7359:Dync1h1	UTSW	12	110,624,602 (GRCm38)	missense	probably benign	0.00
R7405:Dync1h1	UTSW	12	110,634,220 (GRCm38)	missense	probably damaging	1.00
R7439:Dync1h1	UTSW	12	110,636,453 (GRCm38)	missense	probably damaging	1.00
R7441:Dync1h1	UTSW	12	110,636,453 (GRCm38)	missense	probably damaging	1.00
R7472:Dync1h1	UTSW	12	110,665,675 (GRCm38)	missense	probably damaging	0.99
R7532:Dync1h1	UTSW	12	110,651,577 (GRCm38)	missense	probably benign	0.00
R7543:Dync1h1	UTSW	12	110,614,107 (GRCm38)	missense	probably benign	0.04
R7555:Dync1h1	UTSW	12	110,630,625 (GRCm38)	missense	probably benign	0.03
R7632:Dync1h1	UTSW	12	110,660,893 (GRCm38)	missense	probably benign	0.10
R7701:Dync1h1	UTSW	12	110,618,646 (GRCm38)	missense	probably damaging	1.00
R7704:Dync1h1	UTSW	12	110,665,766 (GRCm38)	missense	probably damaging	1.00
R7808:Dync1h1	UTSW	12	110,655,459 (GRCm38)	missense	possibly damaging	0.53
R7891:Dync1h1	UTSW	12	110,643,156 (GRCm38)	missense	probably benign	0.02
R7895:Dync1h1	UTSW	12	110,616,457 (GRCm38)	missense	probably damaging	1.00
R7913:Dync1h1	UTSW	12	110,628,734 (GRCm38)	missense	probably benign	0.12
R8164:Dync1h1	UTSW	12	110,616,360 (GRCm38)	missense	possibly damaging	0.91
R8257:Dync1h1	UTSW	12	110,636,474 (GRCm38)	missense	probably damaging	1.00
R8346:Dync1h1	UTSW	12	110,665,792 (GRCm38)	missense	probably benign	0.21
R8432:Dync1h1	UTSW	12	110,618,142 (GRCm38)	missense	probably benign	0.00
R8510:Dync1h1	UTSW	12	110,616,743 (GRCm38)	missense	possibly damaging	0.94
R8731:Dync1h1	UTSW	12	110,640,584 (GRCm38)	missense	possibly damaging	0.93
R8739:Dync1h1	UTSW	12	110,614,580 (GRCm38)	missense	probably damaging	1.00
R8756:Dync1h1	UTSW	12	110,616,827 (GRCm38)	missense	probably benign	0.06
R8855:Dync1h1	UTSW	12	110,635,899 (GRCm38)	missense	probably damaging	1.00
R8866:Dync1h1	UTSW	12	110,635,899 (GRCm38)	missense	probably damaging	1.00
R8885:Dync1h1	UTSW	12	110,616,738 (GRCm38)	missense	probably damaging	1.00
R8893:Dync1h1	UTSW	12	110,642,043 (GRCm38)	missense	probably damaging	1.00
R8913:Dync1h1	UTSW	12	110,658,168 (GRCm38)	missense	probably benign	0.14
R8937:Dync1h1	UTSW	12	110,618,037 (GRCm38)	missense	probably damaging	1.00
R8958:Dync1h1	UTSW	12	110,620,371 (GRCm38)	missense	probably benign	0.00
R9000:Dync1h1	UTSW	12	110,639,963 (GRCm38)	missense	probably benign
R9036:Dync1h1	UTSW	12	110,639,752 (GRCm38)	missense	probably benign
R9090:Dync1h1	UTSW	12	110,616,876 (GRCm38)	missense	probably benign	0.06
R9108:Dync1h1	UTSW	12	110,656,272 (GRCm38)	intron	probably benign
R9161:Dync1h1	UTSW	12	110,658,589 (GRCm38)	missense	probably benign	0.01
R9185:Dync1h1	UTSW	12	110,635,503 (GRCm38)	missense	probably benign	0.33
R9271:Dync1h1	UTSW	12	110,616,876 (GRCm38)	missense	probably benign	0.06
R9436:Dync1h1	UTSW	12	110,616,541 (GRCm38)	missense	probably damaging	1.00
R9478:Dync1h1	UTSW	12	110,658,703 (GRCm38)	missense	probably benign	0.02
R9547:Dync1h1	UTSW	12	110,658,371 (GRCm38)	missense	probably damaging	1.00
R9561:Dync1h1	UTSW	12	110,649,099 (GRCm38)	missense	probably damaging	0.99
R9586:Dync1h1	UTSW	12	110,616,541 (GRCm38)	missense	probably damaging	1.00
R9609:Dync1h1	UTSW	12	110,640,928 (GRCm38)	missense	probably benign	0.01
Z1088:Dync1h1	UTSW	12	110,629,917 (GRCm38)	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110,658,517 (GRCm38)	nonsense	probably null
Z1177:Dync1h1	UTSW	12	110,641,177 (GRCm38)	frame shift	probably null
Z1177:Dync1h1	UTSW	12	110,637,554 (GRCm38)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTGTAACGTCAAAGCTAGCCTTG -3'
(R):5'- TGAAGCCTCTTCATCAGCTG -3'

Sequencing Primer
(F):5'- GCTAGCCTTGGATAAATTCATGACTG -3'
(R):5'- AGCTGTTTCCAGTGCCG -3'

Posted On

2015-10-08