Incidental Mutation 'R4660:Clip1'
| ID |
352759 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Clip1
|
| Ensembl Gene |
ENSMUSG00000049550 |
| Gene Name |
CAP-GLY domain containing linker protein 1 |
| Synonyms |
Rsn, CLIP-170, 4631429H07Rik, restin, Clip 170, 1110007I12Rik, Clip50, cytoplasmic linker protein 50 |
| MMRRC Submission |
041920-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4660 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
123715857-123822527 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 123717437 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Isoleucine
at position 1284
(T1284I)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000107190
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000031382]
[ENSMUST00000063905]
[ENSMUST00000111561]
[ENSMUST00000111564]
[ENSMUST00000111566]
|
| AlphaFold |
Q922J3 |
| PDB Structure |
Solution structure of the 1st CAP-Gly domain in mouse CLIP-170/restin [SOLUTION NMR]
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000031382
AA Change: T1406I
PolyPhen 2
Score 0.971 (Sensitivity: 0.77; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000031382
Gene: ENSMUSG00000049550
AA Change: T1406I
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
2.28e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
2.28e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
451 |
N/A |
INTRINSIC |
|
coiled coil region
|
474 |
535 |
N/A |
INTRINSIC |
|
coiled coil region
|
581 |
620 |
N/A |
INTRINSIC |
|
coiled coil region
|
652 |
1352 |
N/A |
INTRINSIC |
|
low complexity region
|
1362 |
1373 |
N/A |
INTRINSIC |
|
Pfam:CLIP1_ZNF
|
1375 |
1392 |
5.8e-9 |
PFAM |
|
ZnF_C2HC
|
1417 |
1433 |
1.45e0 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000063905
AA Change: T1289I
PolyPhen 2
Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000068241
Gene: ENSMUSG00000049550
AA Change: T1289I
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
3.3e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
3.3e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
524 |
N/A |
INTRINSIC |
|
coiled coil region
|
570 |
609 |
N/A |
INTRINSIC |
|
coiled coil region
|
641 |
1075 |
N/A |
INTRINSIC |
|
coiled coil region
|
1115 |
1235 |
N/A |
INTRINSIC |
|
low complexity region
|
1245 |
1256 |
N/A |
INTRINSIC |
|
ZnF_C2HC
|
1300 |
1316 |
1.45e0 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000111561
AA Change: T1395I
PolyPhen 2
Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000107186
Gene: ENSMUSG00000049550
AA Change: T1395I
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
1.93e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
1.93e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
524 |
N/A |
INTRINSIC |
|
coiled coil region
|
570 |
609 |
N/A |
INTRINSIC |
|
coiled coil region
|
641 |
1341 |
N/A |
INTRINSIC |
|
low complexity region
|
1351 |
1362 |
N/A |
INTRINSIC |
|
ZnF_C2HC
|
1406 |
1422 |
1.45e0 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000111564
AA Change: T1284I
PolyPhen 2
Score 0.980 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000107190
Gene: ENSMUSG00000049550
AA Change: T1284I
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
2.5e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
2.5e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
489 |
N/A |
INTRINSIC |
|
coiled coil region
|
535 |
574 |
N/A |
INTRINSIC |
|
coiled coil region
|
606 |
1230 |
N/A |
INTRINSIC |
|
low complexity region
|
1240 |
1251 |
N/A |
INTRINSIC |
|
ZnF_C2HC
|
1295 |
1311 |
1.45e0 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000111566
AA Change: T1360I
PolyPhen 2
Score 0.966 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000107192
Gene: ENSMUSG00000049550
AA Change: T1360I
| Domain | Start | End | E-Value | Type |
|---|
|
internal_repeat_2
|
11 |
53 |
2e-5 |
PROSPERO |
|
CAP_GLY
|
60 |
125 |
1.05e-31 |
SMART |
|
internal_repeat_2
|
140 |
177 |
2e-5 |
PROSPERO |
|
CAP_GLY
|
213 |
278 |
4.69e-34 |
SMART |
|
low complexity region
|
286 |
304 |
N/A |
INTRINSIC |
|
low complexity region
|
305 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
349 |
489 |
N/A |
INTRINSIC |
|
coiled coil region
|
535 |
574 |
N/A |
INTRINSIC |
|
coiled coil region
|
606 |
1306 |
N/A |
INTRINSIC |
|
low complexity region
|
1316 |
1327 |
N/A |
INTRINSIC |
|
ZnF_C2HC
|
1371 |
1387 |
1.45e0 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125340
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000137363
AA Change: T1034I
|
| SMART Domains |
Protein: ENSMUSP00000121425
Gene: ENSMUSG00000049550
AA Change: T1034I
| Domain | Start | End | E-Value | Type |
|---|
|
CAP_GLY
|
2 |
31 |
2.59e0 |
SMART |
|
low complexity region
|
39 |
57 |
N/A |
INTRINSIC |
|
low complexity region
|
58 |
84 |
N/A |
INTRINSIC |
|
coiled coil region
|
101 |
276 |
N/A |
INTRINSIC |
|
coiled coil region
|
322 |
361 |
N/A |
INTRINSIC |
|
coiled coil region
|
393 |
980 |
N/A |
INTRINSIC |
|
low complexity region
|
991 |
1002 |
N/A |
INTRINSIC |
|
Pfam:CLIP1_ZNF
|
1004 |
1021 |
4.2e-9 |
PFAM |
|
ZnF_C2HC
|
1046 |
1062 |
1.45e0 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137602
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000198833
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000154672
|
| SMART Domains |
Protein: ENSMUSP00000122064
Gene: ENSMUSG00000049550
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
59 |
N/A |
INTRINSIC |
|
low complexity region
|
165 |
176 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
352 |
375 |
1.56e-8 |
PROSPERO |
|
internal_repeat_3
|
358 |
377 |
5.32e-6 |
PROSPERO |
|
internal_repeat_1
|
450 |
473 |
1.56e-8 |
PROSPERO |
|
internal_repeat_3
|
544 |
563 |
5.32e-6 |
PROSPERO |
|
internal_repeat_2
|
553 |
575 |
2.88e-7 |
PROSPERO |
|
low complexity region
|
735 |
744 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
781 |
803 |
2.88e-7 |
PROSPERO |
|
low complexity region
|
819 |
830 |
N/A |
INTRINSIC |
|
low complexity region
|
962 |
977 |
N/A |
INTRINSIC |
|
low complexity region
|
1081 |
1099 |
N/A |
INTRINSIC |
|
low complexity region
|
1110 |
1121 |
N/A |
INTRINSIC |
|
low complexity region
|
1164 |
1175 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.1032 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 95.0%
|
| Validation Efficiency |
96% (102/106) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PHENOTYPE: Mice homozygous for a targeted allele display reduced male fertility and teratozoospermia. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adra1d |
T |
C |
2: 131,403,062 (GRCm39) |
T343A |
probably damaging |
Het |
| Angptl4 |
A |
T |
17: 33,996,249 (GRCm39) |
|
probably benign |
Het |
| Antxr2 |
A |
T |
5: 98,151,913 (GRCm39) |
|
probably null |
Het |
| Ap1b1 |
T |
A |
11: 4,966,760 (GRCm39) |
V145E |
probably damaging |
Het |
| Asns |
G |
T |
6: 7,678,012 (GRCm39) |
N355K |
probably benign |
Het |
| Asxl3 |
A |
G |
18: 22,649,534 (GRCm39) |
T508A |
probably benign |
Het |
| B4galt7 |
T |
A |
13: 55,752,111 (GRCm39) |
V54D |
possibly damaging |
Het |
| Bach2 |
C |
T |
4: 32,562,777 (GRCm39) |
P415S |
probably benign |
Het |
| Bbs9 |
G |
A |
9: 22,490,063 (GRCm39) |
R278Q |
probably benign |
Het |
| Blzf1 |
C |
T |
1: 164,134,062 (GRCm39) |
|
probably benign |
Het |
| Btd |
A |
T |
14: 31,389,760 (GRCm39) |
T494S |
probably benign |
Het |
| Casp9 |
C |
T |
4: 141,540,934 (GRCm39) |
T434I |
probably benign |
Het |
| Cavin2 |
T |
C |
1: 51,340,510 (GRCm39) |
S396P |
probably benign |
Het |
| Ccnk |
C |
T |
12: 108,168,575 (GRCm39) |
|
probably benign |
Het |
| Cldn8 |
G |
A |
16: 88,359,296 (GRCm39) |
H210Y |
probably benign |
Het |
| Coch |
T |
C |
12: 51,642,268 (GRCm39) |
V80A |
probably benign |
Het |
| Cttnbp2 |
A |
G |
6: 18,406,536 (GRCm39) |
S1052P |
probably benign |
Het |
| Cyp2j7 |
C |
T |
4: 96,083,579 (GRCm39) |
R457K |
probably benign |
Het |
| Dalrd3 |
T |
C |
9: 108,447,568 (GRCm39) |
S129P |
probably benign |
Het |
| Ddx10 |
A |
G |
9: 53,147,698 (GRCm39) |
|
probably null |
Het |
| Dnah7b |
A |
T |
1: 46,328,696 (GRCm39) |
T3143S |
probably damaging |
Het |
| Dynlt1b |
A |
G |
17: 6,699,279 (GRCm39) |
T10A |
probably benign |
Het |
| Eif2s2 |
G |
A |
2: 154,730,189 (GRCm39) |
T36I |
probably benign |
Het |
| Fam118b |
A |
T |
9: 35,146,551 (GRCm39) |
H105Q |
possibly damaging |
Het |
| Galntl5 |
T |
A |
5: 25,408,377 (GRCm39) |
I250N |
probably damaging |
Het |
| Gm11544 |
C |
T |
11: 94,736,306 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5709 |
C |
T |
3: 59,526,124 (GRCm39) |
|
noncoding transcript |
Het |
| Golgb1 |
T |
A |
16: 36,707,980 (GRCm39) |
I107N |
probably damaging |
Het |
| Gpld1 |
T |
C |
13: 25,166,586 (GRCm39) |
|
probably null |
Het |
| Grik1 |
T |
A |
16: 87,720,019 (GRCm39) |
T768S |
probably damaging |
Het |
| H2-T23 |
T |
G |
17: 36,341,108 (GRCm39) |
Q349P |
probably damaging |
Het |
| Ing3 |
A |
T |
6: 21,973,710 (GRCm39) |
|
probably benign |
Het |
| Iqgap3 |
T |
G |
3: 88,027,483 (GRCm39) |
L702R |
probably damaging |
Het |
| Itga8 |
A |
G |
2: 12,270,069 (GRCm39) |
V139A |
probably damaging |
Het |
| Jam2 |
G |
A |
16: 84,609,840 (GRCm39) |
V151M |
probably damaging |
Het |
| Kbtbd12 |
T |
C |
6: 88,594,772 (GRCm39) |
I353V |
probably benign |
Het |
| Kif27 |
T |
C |
13: 58,471,730 (GRCm39) |
E786G |
probably damaging |
Het |
| Lingo4 |
T |
A |
3: 94,310,672 (GRCm39) |
S537T |
probably benign |
Het |
| Lipo3 |
C |
T |
19: 33,598,360 (GRCm39) |
|
probably benign |
Het |
| Lrrc3 |
G |
T |
10: 77,729,866 (GRCm39) |
|
probably benign |
Het |
| Ltbp3 |
T |
A |
19: 5,798,814 (GRCm39) |
|
probably null |
Het |
| Lyg1 |
T |
A |
1: 37,985,942 (GRCm39) |
|
probably benign |
Het |
| Mcm9 |
T |
C |
10: 53,424,623 (GRCm39) |
I656V |
probably benign |
Het |
| Mfsd8 |
T |
A |
3: 40,776,372 (GRCm39) |
I427F |
probably benign |
Het |
| Mga |
T |
A |
2: 119,769,104 (GRCm39) |
|
probably benign |
Het |
| Miga1 |
A |
G |
3: 151,993,155 (GRCm39) |
L422P |
probably damaging |
Het |
| Msantd3 |
A |
G |
4: 48,552,536 (GRCm39) |
I42V |
probably benign |
Het |
| Mybbp1a |
T |
C |
11: 72,336,538 (GRCm39) |
V510A |
probably benign |
Het |
| Nccrp1 |
G |
T |
7: 28,245,760 (GRCm39) |
P135T |
probably damaging |
Het |
| Neb |
T |
A |
2: 52,145,600 (GRCm39) |
M2975L |
possibly damaging |
Het |
| Nfxl1 |
A |
T |
5: 72,710,011 (GRCm39) |
I171N |
probably damaging |
Het |
| Odad2 |
A |
G |
18: 7,211,609 (GRCm39) |
V755A |
possibly damaging |
Het |
| Or10q3 |
T |
C |
19: 11,848,412 (GRCm39) |
H56R |
possibly damaging |
Het |
| Or12j5 |
A |
T |
7: 140,083,933 (GRCm39) |
F146L |
probably benign |
Het |
| Or13a19 |
T |
C |
7: 139,903,325 (GRCm39) |
F238L |
possibly damaging |
Het |
| Otop1 |
T |
G |
5: 38,457,368 (GRCm39) |
S376A |
possibly damaging |
Het |
| Pdgfra |
T |
C |
5: 75,322,932 (GRCm39) |
V10A |
possibly damaging |
Het |
| Pgs1 |
T |
C |
11: 117,910,503 (GRCm39) |
V538A |
probably damaging |
Het |
| Ppa2 |
A |
T |
3: 133,032,445 (GRCm39) |
T97S |
probably damaging |
Het |
| Pramel22 |
T |
A |
4: 143,380,847 (GRCm39) |
Y392F |
probably benign |
Het |
| Pramel26 |
A |
G |
4: 143,538,435 (GRCm39) |
S179P |
probably benign |
Het |
| Prdm10 |
G |
A |
9: 31,238,624 (GRCm39) |
C172Y |
probably damaging |
Het |
| Prrc2c |
G |
A |
1: 162,508,464 (GRCm39) |
P1091L |
probably damaging |
Het |
| Pthlh |
G |
A |
6: 147,158,796 (GRCm39) |
R55C |
probably damaging |
Het |
| Ptpn9 |
A |
T |
9: 56,943,782 (GRCm39) |
T105S |
probably benign |
Het |
| Rundc1 |
T |
A |
11: 101,324,830 (GRCm39) |
V512E |
possibly damaging |
Het |
| Scrib |
G |
A |
15: 75,937,185 (GRCm39) |
S307L |
probably damaging |
Het |
| Sec23ip |
A |
G |
7: 128,352,010 (GRCm39) |
S26G |
probably null |
Het |
| Sec61a2 |
A |
G |
2: 5,878,504 (GRCm39) |
|
probably benign |
Het |
| Sema3c |
T |
C |
5: 17,877,511 (GRCm39) |
V206A |
probably damaging |
Het |
| Sgk2 |
C |
T |
2: 162,839,763 (GRCm39) |
H124Y |
possibly damaging |
Het |
| Slc26a6 |
C |
T |
9: 108,738,540 (GRCm39) |
T592I |
probably damaging |
Het |
| Slc5a11 |
T |
C |
7: 122,864,486 (GRCm39) |
Y361H |
probably damaging |
Het |
| Smc6 |
T |
C |
12: 11,324,008 (GRCm39) |
V51A |
probably damaging |
Het |
| Stab1 |
A |
T |
14: 30,876,872 (GRCm39) |
N817K |
possibly damaging |
Het |
| Swt1 |
A |
T |
1: 151,283,348 (GRCm39) |
D336E |
probably benign |
Het |
| Taf13 |
T |
A |
3: 108,480,293 (GRCm39) |
|
probably benign |
Het |
| Tmub2 |
T |
C |
11: 102,175,845 (GRCm39) |
|
probably benign |
Het |
| Tnf |
A |
G |
17: 35,419,156 (GRCm39) |
S209P |
probably benign |
Het |
| Try10 |
A |
G |
6: 41,334,761 (GRCm39) |
Y229C |
probably damaging |
Het |
| Ttbk1 |
G |
T |
17: 46,788,714 (GRCm39) |
Y183* |
probably null |
Het |
| Ttc17 |
A |
T |
2: 94,194,774 (GRCm39) |
I533N |
possibly damaging |
Het |
| Tubb6 |
C |
T |
18: 67,535,016 (GRCm39) |
P305L |
probably damaging |
Het |
| Tulp3 |
G |
A |
6: 128,300,017 (GRCm39) |
|
probably benign |
Het |
| Usp9x |
A |
G |
X: 12,989,747 (GRCm39) |
R776G |
possibly damaging |
Het |
| Virma |
T |
C |
4: 11,513,505 (GRCm39) |
V453A |
probably damaging |
Het |
| Vmn2r103 |
A |
T |
17: 20,032,077 (GRCm39) |
N617I |
probably damaging |
Het |
| Xirp1 |
G |
T |
9: 119,846,058 (GRCm39) |
L942M |
probably damaging |
Het |
| Zc3h7b |
T |
G |
15: 81,676,451 (GRCm39) |
V731G |
probably benign |
Het |
| Zfp534 |
C |
T |
4: 147,759,175 (GRCm39) |
G498D |
probably benign |
Het |
| Zfp639 |
T |
C |
3: 32,574,679 (GRCm39) |
Y435H |
probably damaging |
Het |
| Zxdc |
A |
G |
6: 90,355,820 (GRCm39) |
H443R |
probably damaging |
Het |
|
| Other mutations in Clip1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00159:Clip1
|
APN |
5 |
123,741,717 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL01067:Clip1
|
APN |
5 |
123,768,867 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01524:Clip1
|
APN |
5 |
123,717,442 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01632:Clip1
|
APN |
5 |
123,755,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01798:Clip1
|
APN |
5 |
123,721,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01874:Clip1
|
APN |
5 |
123,741,729 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01908:Clip1
|
APN |
5 |
123,761,270 (GRCm39) |
splice site |
probably benign |
|
|
IGL02120:Clip1
|
APN |
5 |
123,785,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02309:Clip1
|
APN |
5 |
123,755,763 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02555:Clip1
|
APN |
5 |
123,759,857 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03027:Clip1
|
APN |
5 |
123,759,919 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03336:Clip1
|
APN |
5 |
123,791,633 (GRCm39) |
nonsense |
probably null |
|
|
IGL03365:Clip1
|
APN |
5 |
123,721,649 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02802:Clip1
|
UTSW |
5 |
123,769,186 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4812001:Clip1
|
UTSW |
5 |
123,768,738 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0254:Clip1
|
UTSW |
5 |
123,755,395 (GRCm39) |
splice site |
probably benign |
|
|
R0401:Clip1
|
UTSW |
5 |
123,791,852 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0530:Clip1
|
UTSW |
5 |
123,778,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0744:Clip1
|
UTSW |
5 |
123,768,784 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0833:Clip1
|
UTSW |
5 |
123,768,784 (GRCm39) |
missense |
probably benign |
0.05 |
|
R1116:Clip1
|
UTSW |
5 |
123,717,554 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1182:Clip1
|
UTSW |
5 |
123,785,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1656:Clip1
|
UTSW |
5 |
123,768,466 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R1700:Clip1
|
UTSW |
5 |
123,768,433 (GRCm39) |
missense |
probably benign |
|
|
R1889:Clip1
|
UTSW |
5 |
123,791,559 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1975:Clip1
|
UTSW |
5 |
123,761,281 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R2406:Clip1
|
UTSW |
5 |
123,741,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3545:Clip1
|
UTSW |
5 |
123,769,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3547:Clip1
|
UTSW |
5 |
123,769,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3548:Clip1
|
UTSW |
5 |
123,769,141 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3911:Clip1
|
UTSW |
5 |
123,728,897 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3944:Clip1
|
UTSW |
5 |
123,755,892 (GRCm39) |
unclassified |
probably benign |
|
|
R4784:Clip1
|
UTSW |
5 |
123,717,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4785:Clip1
|
UTSW |
5 |
123,717,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4824:Clip1
|
UTSW |
5 |
123,769,086 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4831:Clip1
|
UTSW |
5 |
123,721,664 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4951:Clip1
|
UTSW |
5 |
123,768,408 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4960:Clip1
|
UTSW |
5 |
123,792,066 (GRCm39) |
nonsense |
probably null |
|
|
R5014:Clip1
|
UTSW |
5 |
123,755,793 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5116:Clip1
|
UTSW |
5 |
123,768,770 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5212:Clip1
|
UTSW |
5 |
123,768,744 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5238:Clip1
|
UTSW |
5 |
123,785,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5318:Clip1
|
UTSW |
5 |
123,751,147 (GRCm39) |
unclassified |
probably benign |
|
|
R5372:Clip1
|
UTSW |
5 |
123,768,303 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5701:Clip1
|
UTSW |
5 |
123,751,366 (GRCm39) |
unclassified |
probably benign |
|
|
R5734:Clip1
|
UTSW |
5 |
123,753,217 (GRCm39) |
unclassified |
probably benign |
|
|
R5757:Clip1
|
UTSW |
5 |
123,765,460 (GRCm39) |
missense |
probably benign |
0.21 |
|
R6024:Clip1
|
UTSW |
5 |
123,753,152 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6160:Clip1
|
UTSW |
5 |
123,751,604 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R6177:Clip1
|
UTSW |
5 |
123,751,897 (GRCm39) |
unclassified |
probably benign |
|
|
R6183:Clip1
|
UTSW |
5 |
123,780,667 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6377:Clip1
|
UTSW |
5 |
123,741,717 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6436:Clip1
|
UTSW |
5 |
123,779,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6471:Clip1
|
UTSW |
5 |
123,778,612 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6766:Clip1
|
UTSW |
5 |
123,752,827 (GRCm39) |
unclassified |
probably benign |
|
|
R7015:Clip1
|
UTSW |
5 |
123,751,675 (GRCm39) |
unclassified |
probably benign |
|
|
R7094:Clip1
|
UTSW |
5 |
123,761,333 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7143:Clip1
|
UTSW |
5 |
123,791,673 (GRCm39) |
missense |
probably benign |
|
|
R7222:Clip1
|
UTSW |
5 |
123,749,904 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7233:Clip1
|
UTSW |
5 |
123,749,922 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7238:Clip1
|
UTSW |
5 |
123,751,328 (GRCm39) |
missense |
|
|
|
R7249:Clip1
|
UTSW |
5 |
123,741,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7283:Clip1
|
UTSW |
5 |
123,751,857 (GRCm39) |
missense |
|
|
|
R7295:Clip1
|
UTSW |
5 |
123,765,419 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7447:Clip1
|
UTSW |
5 |
123,791,696 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7458:Clip1
|
UTSW |
5 |
123,778,609 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7483:Clip1
|
UTSW |
5 |
123,755,447 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7516:Clip1
|
UTSW |
5 |
123,721,448 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7619:Clip1
|
UTSW |
5 |
123,752,342 (GRCm39) |
missense |
|
|
|
R7831:Clip1
|
UTSW |
5 |
123,751,342 (GRCm39) |
missense |
|
|
|
R7897:Clip1
|
UTSW |
5 |
123,760,861 (GRCm39) |
missense |
probably benign |
|
|
R8155:Clip1
|
UTSW |
5 |
123,751,699 (GRCm39) |
missense |
|
|
|
R8157:Clip1
|
UTSW |
5 |
123,768,782 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8232:Clip1
|
UTSW |
5 |
123,785,981 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8396:Clip1
|
UTSW |
5 |
123,780,627 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8446:Clip1
|
UTSW |
5 |
123,794,008 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8486:Clip1
|
UTSW |
5 |
123,752,770 (GRCm39) |
unclassified |
probably benign |
|
|
R8511:Clip1
|
UTSW |
5 |
123,791,969 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R8731:Clip1
|
UTSW |
5 |
123,752,756 (GRCm39) |
missense |
|
|
|
R8889:Clip1
|
UTSW |
5 |
123,717,565 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8892:Clip1
|
UTSW |
5 |
123,717,565 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9058:Clip1
|
UTSW |
5 |
123,752,645 (GRCm39) |
missense |
|
|
|
R9106:Clip1
|
UTSW |
5 |
123,753,223 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9212:Clip1
|
UTSW |
5 |
123,721,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9217:Clip1
|
UTSW |
5 |
123,717,441 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9223:Clip1
|
UTSW |
5 |
123,784,337 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9325:Clip1
|
UTSW |
5 |
123,751,186 (GRCm39) |
missense |
|
|
|
R9752:Clip1
|
UTSW |
5 |
123,760,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Clip1
|
UTSW |
5 |
123,755,413 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAAGTTGCACACCAATGCTG -3'
(R):5'- GTGGCTATTGTTAGTCCCAAGGC -3'
Sequencing Primer
(F):5'- TCATTGCAGTTGGTTGCC -3'
(R):5'- CTCTAGGAGTTCTGTCACCTGAG -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation