Mutagenetix > Incidental Mutations

Incidental Mutation 'R4660:Vmn2r103'

352806

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r103

Ensembl Gene

ENSMUSG00000091771

Gene Name

vomeronasal 2, receptor 103

Synonyms

EG627636

MMRRC Submission

041920-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

R4660 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

19773363-19812536 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 19811815 bp

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Isoleucine at position 617 (N617I)

Ref Sequence

ENSEMBL: ENSMUSP00000126756 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000172203]

Predicted Effect

probably damaging
Transcript: ENSMUST00000172203
AA Change: N617I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000126756
Gene: ENSMUSG00000091771
AA Change: N617I

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	82	449	1.3e-37	PFAM
Pfam:NCD3G	509	562	3.5e-22	PFAM
Pfam:7tm_3	595	830	1.1e-51	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.1%
20x: 95.0%

Validation Efficiency

96% (102/106)

Allele List at MGI

Other mutations in this stock

Total: 92 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adra1d	T	C	2: 131,561,142	T343A	probably damaging	Het
Angptl4	A	T	17: 33,777,275		probably benign	Het
Antxr2	A	T	5: 98,004,054		probably null	Het
Ap1b1	T	A	11: 5,016,760	V145E	probably damaging	Het
Armc4	A	G	18: 7,211,609	V755A	possibly damaging	Het
Asns	G	T	6: 7,678,012	N355K	probably benign	Het
Asxl3	A	G	18: 22,516,477	T508A	probably benign	Het
B4galt7	T	A	13: 55,604,298	V54D	possibly damaging	Het
Bach2	C	T	4: 32,562,777	P415S	probably benign	Het
Bbs9	G	A	9: 22,578,767	R278Q	probably benign	Het
Blzf1	C	T	1: 164,306,493		probably benign	Het
Btd	A	T	14: 31,667,803	T494S	probably benign	Het
Casp9	C	T	4: 141,813,623	T434I	probably benign	Het
Cavin2	T	C	1: 51,301,351	S396P	probably benign	Het
Ccnk	C	T	12: 108,202,316		probably benign	Het
Cldn8	G	A	16: 88,562,408	H210Y	probably benign	Het
Clip1	G	A	5: 123,579,374	T1284I	probably damaging	Het
Coch	T	C	12: 51,595,485	V80A	probably benign	Het
Cttnbp2	A	G	6: 18,406,537	S1052P	probably benign	Het
Cyp2j7	C	T	4: 96,195,342	R457K	probably benign	Het
Dalrd3	T	C	9: 108,570,369	S129P	probably benign	Het
Ddx10	A	G	9: 53,236,398		probably null	Het
Dnah7b	A	T	1: 46,289,536	T3143S	probably damaging	Het
Dynlt1b	A	G	17: 6,431,880	T10A	probably benign	Het
Eif2s2	G	A	2: 154,888,269	T36I	probably benign	Het
Fam118b	A	T	9: 35,235,255	H105Q	possibly damaging	Het
Galntl5	T	A	5: 25,203,379	I250N	probably damaging	Het
Gm11544	C	T	11: 94,845,480		noncoding transcript	Het
Gm13084	A	G	4: 143,811,865	S179P	probably benign	Het
Gm13088	T	A	4: 143,654,277	Y392F	probably benign	Het
Gm5709	C	T	3: 59,618,703		noncoding transcript	Het
Golgb1	T	A	16: 36,887,618	I107N	probably damaging	Het
Gpld1	T	C	13: 24,982,603		probably null	Het
Grik1	T	A	16: 87,923,131	T768S	probably damaging	Het
H2-T23	T	G	17: 36,030,216	Q349P	probably damaging	Het
Ing3	A	T	6: 21,973,711		probably benign	Het
Iqgap3	T	G	3: 88,120,176	L702R	probably damaging	Het
Itga8	A	G	2: 12,265,258	V139A	probably damaging	Het
Jam2	G	A	16: 84,812,952	V151M	probably damaging	Het
Kbtbd12	T	C	6: 88,617,790	I353V	probably benign	Het
Kif27	T	C	13: 58,323,916	E786G	probably damaging	Het
Lingo4	T	A	3: 94,403,365	S537T	probably benign	Het
Lipo3	C	T	19: 33,620,960		probably benign	Het
Lrrc3	G	T	10: 77,894,032		probably benign	Het
Ltbp3	T	A	19: 5,748,786		probably null	Het
Lyg1	T	A	1: 37,946,861		probably benign	Het
Mcm9	T	C	10: 53,548,527	I656V	probably benign	Het
Mfsd8	T	A	3: 40,821,937	I427F	probably benign	Het
Mga	T	A	2: 119,938,623		probably benign	Het
Miga1	A	G	3: 152,287,518	L422P	probably damaging	Het
Msantd3	A	G	4: 48,552,536	I42V	probably benign	Het
Mybbp1a	T	C	11: 72,445,712	V510A	probably benign	Het
Nccrp1	G	T	7: 28,546,335	P135T	probably damaging	Het
Neb	T	A	2: 52,255,588	M2975L	possibly damaging	Het
Nfxl1	A	T	5: 72,552,668	I171N	probably damaging	Het
Olfr1419	T	C	19: 11,871,048	H56R	possibly damaging	Het
Olfr525	T	C	7: 140,323,412	F238L	possibly damaging	Het
Olfr536	A	T	7: 140,504,020	F146L	probably benign	Het
Otop1	T	G	5: 38,300,024	S376A	possibly damaging	Het
Pdgfra	T	C	5: 75,162,271	V10A	possibly damaging	Het
Pgs1	T	C	11: 118,019,677	V538A	probably damaging	Het
Ppa2	A	T	3: 133,326,684	T97S	probably damaging	Het
Prdm10	G	A	9: 31,327,328	C172Y	probably damaging	Het
Prrc2c	G	A	1: 162,680,895	P1091L	probably damaging	Het
Pthlh	G	A	6: 147,257,298	R55C	probably damaging	Het
Ptpn9	A	T	9: 57,036,498	T105S	probably benign	Het
Rundc1	T	A	11: 101,434,004	V512E	possibly damaging	Het
Scrib	G	A	15: 76,065,336	S307L	probably damaging	Het
Sec23ip	A	G	7: 128,750,286	S26G	probably null	Het
Sec61a2	A	G	2: 5,873,693		probably benign	Het
Sema3c	T	C	5: 17,672,513	V206A	probably damaging	Het
Sgk2	C	T	2: 162,997,843	H124Y	possibly damaging	Het
Slc26a6	C	T	9: 108,861,341	T592I	probably damaging	Het
Slc5a11	T	C	7: 123,265,263	Y361H	probably damaging	Het
Smc6	T	C	12: 11,274,007	V51A	probably damaging	Het
Stab1	A	T	14: 31,154,915	N817K	possibly damaging	Het
Swt1	A	T	1: 151,407,597	D336E	probably benign	Het
Taf13	T	A	3: 108,572,977		probably benign	Het
Tmub2	T	C	11: 102,285,019		probably benign	Het
Tnf	A	G	17: 35,200,180	S209P	probably benign	Het
Try10	A	G	6: 41,357,827	Y229C	probably damaging	Het
Ttbk1	G	T	17: 46,477,788	Y183*	probably null	Het
Ttc17	A	T	2: 94,364,429	I533N	possibly damaging	Het
Tubb6	C	T	18: 67,401,946	P305L	probably damaging	Het
Tulp3	G	A	6: 128,323,054		probably benign	Het
Usp9x	A	G	X: 13,123,508	R776G	possibly damaging	Het
Virma	T	C	4: 11,513,505	V453A	probably damaging	Het
Xirp1	G	T	9: 120,016,992	L942M	probably damaging	Het
Zc3h7b	T	G	15: 81,792,250	V731G	probably benign	Het
Zfp534	C	T	4: 147,674,718	G498D	probably benign	Het
Zfp639	T	C	3: 32,520,530	Y435H	probably damaging	Het
Zxdc	A	G	6: 90,378,838	H443R	probably damaging	Het

Other mutations in Vmn2r103

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00333:Vmn2r103	APN	17	19793102	missense	probably damaging	0.98
IGL00939:Vmn2r103	APN	17	19794965	missense	probably benign	0.00
IGL01120:Vmn2r103	APN	17	19792997	missense	probably benign	0.06
IGL01403:Vmn2r103	APN	17	19792967	missense	probably benign
IGL01404:Vmn2r103	APN	17	19812434	missense	probably damaging	1.00
IGL01713:Vmn2r103	APN	17	19794068	missense	probably damaging	1.00
IGL01802:Vmn2r103	APN	17	19799208	missense	probably benign
IGL02251:Vmn2r103	APN	17	19793969	missense	possibly damaging	0.84
IGL02466:Vmn2r103	APN	17	19773369	missense	probably benign
IGL02555:Vmn2r103	APN	17	19811611	missense	probably damaging	1.00
IGL02668:Vmn2r103	APN	17	19794127	missense	probably benign	0.03
IGL02715:Vmn2r103	APN	17	19793956	missense	probably damaging	0.97
IGL02735:Vmn2r103	APN	17	19812248	missense	probably benign	0.27
IGL03101:Vmn2r103	APN	17	19773520	missense	probably damaging	0.98
R0003:Vmn2r103	UTSW	17	19811979	missense	probably damaging	0.99
R0052:Vmn2r103	UTSW	17	19811641	missense	probably benign	0.01
R0375:Vmn2r103	UTSW	17	19792859	missense	probably benign	0.06
R0375:Vmn2r103	UTSW	17	19793464	missense	probably benign	0.12
R0755:Vmn2r103	UTSW	17	19773568	missense	probably benign	0.01
R0837:Vmn2r103	UTSW	17	19793927	missense	probably damaging	0.99
R1345:Vmn2r103	UTSW	17	19794247	missense	probably damaging	1.00
R1396:Vmn2r103	UTSW	17	19792968	missense	probably benign
R1488:Vmn2r103	UTSW	17	19793660	missense	probably damaging	0.97
R1533:Vmn2r103	UTSW	17	19773400	missense	probably benign	0.01
R1590:Vmn2r103	UTSW	17	19794234	missense	probably benign
R1928:Vmn2r103	UTSW	17	19811767	missense	possibly damaging	0.95
R1942:Vmn2r103	UTSW	17	19812300	missense	probably benign	0.02
R2071:Vmn2r103	UTSW	17	19793794	missense	probably benign
R2219:Vmn2r103	UTSW	17	19793647	missense	probably damaging	1.00
R2442:Vmn2r103	UTSW	17	19773531	missense	probably benign	0.00
R2889:Vmn2r103	UTSW	17	19793600	missense	probably damaging	1.00
R3762:Vmn2r103	UTSW	17	19812149	missense	probably damaging	0.98
R4014:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R4331:Vmn2r103	UTSW	17	19794233	missense	probably benign	0.00
R4630:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4631:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4632:Vmn2r103	UTSW	17	19793696	missense	probably benign	0.04
R4801:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4802:Vmn2r103	UTSW	17	19795076	missense	probably benign	0.06
R4931:Vmn2r103	UTSW	17	19811769	missense	probably benign	0.01
R4995:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R5309:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5312:Vmn2r103	UTSW	17	19793034	missense	probably benign	0.01
R5329:Vmn2r103	UTSW	17	19812171	missense	probably damaging	1.00
R5611:Vmn2r103	UTSW	17	19793642	missense	probably damaging	0.99
R5684:Vmn2r103	UTSW	17	19792989	missense	probably benign	0.02
R5715:Vmn2r103	UTSW	17	19794939	missense	probably benign	0.17
R5907:Vmn2r103	UTSW	17	19812453	missense	possibly damaging	0.67
R6029:Vmn2r103	UTSW	17	19794216	nonsense	probably null
R6114:Vmn2r103	UTSW	17	19812325	missense	probably damaging	0.99
R6285:Vmn2r103	UTSW	17	19812144	missense	probably benign
R6292:Vmn2r103	UTSW	17	19793604	missense	possibly damaging	0.67
R6334:Vmn2r103	UTSW	17	19794082	missense	probably damaging	0.97
R6501:Vmn2r103	UTSW	17	19811904	missense	probably benign	0.29
R6710:Vmn2r103	UTSW	17	19811977	missense	probably damaging	1.00
R6774:Vmn2r103	UTSW	17	19773511	missense	probably benign	0.14
R6981:Vmn2r103	UTSW	17	19793477	missense	probably benign	0.00
R7768:Vmn2r103	UTSW	17	19812052	missense	probably damaging	0.99
R7816:Vmn2r103	UTSW	17	19794214	missense	probably benign	0.06
R7885:Vmn2r103	UTSW	17	19793123	missense	probably benign	0.25
R7968:Vmn2r103	UTSW	17	19793123	missense	probably benign	0.25
R8002:Vmn2r103	UTSW	17	19799249
R8031:Vmn2r103	UTSW	17	19793497
Z1088:Vmn2r103	UTSW	17	19795047	missense	probably benign	0.08

Predicted Primers

PCR Primer
(F):5'- TATACCAGTGTGTGAAGTGTCC -3'
(R):5'- CCTGGAAAACTGACCTTAAAGGC -3'

Sequencing Primer
(F):5'- AGTGTCCAGAAGGTCATTATGC -3'
(R):5'- CAAGGACCACAGTAATAGCTTTGGC -3'

Posted On

2015-10-08