Incidental Mutation 'R0271:Or5m12'
ID 35281
Institutional Source Beutler Lab
Gene Symbol Or5m12
Ensembl Gene ENSMUSG00000075206
Gene Name olfactory receptor family 5 subfamily M member 12
Synonyms Olfr1024, GA_x6K02T2Q125-47384320-47383337, MOR197-1
MMRRC Submission 038497-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.153) question?
Stock # R0271 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 85734413-85735396 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 85734633 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Lysine at position 255 (M255K)
Ref Sequence ENSEMBL: ENSMUSP00000097496 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099912]
AlphaFold A2ASU7
Predicted Effect possibly damaging
Transcript: ENSMUST00000099912
AA Change: M255K

PolyPhen 2 Score 0.683 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000097496
Gene: ENSMUSG00000075206
AA Change: M255K

DomainStartEndE-ValueType
Pfam:7tm_4 36 313 7.6e-52 PFAM
Pfam:7tm_1 46 295 4.1e-25 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000215677
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 98.5%
  • 3x: 97.4%
  • 10x: 95.2%
  • 20x: 90.6%
Validation Efficiency 100% (65/65)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 63 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930544D05Rik A G 11: 70,507,474 (GRCm39) Q173R possibly damaging Het
Ampd2 C T 3: 107,994,032 (GRCm39) probably benign Het
Ankrd17 T C 5: 90,402,658 (GRCm39) S1467G possibly damaging Het
Arhgap31 T G 16: 38,422,872 (GRCm39) S1065R possibly damaging Het
Arhgef19 G T 4: 140,977,918 (GRCm39) M542I probably benign Het
C7 T C 15: 5,044,862 (GRCm39) D392G possibly damaging Het
Ccdc138 G A 10: 58,411,645 (GRCm39) C671Y probably damaging Het
Cdh8 A G 8: 99,838,347 (GRCm39) S498P possibly damaging Het
Cpb2 T A 14: 75,495,149 (GRCm39) probably null Het
Cwc22 A C 2: 77,751,202 (GRCm39) N389K probably benign Het
Dgkb T A 12: 38,278,025 (GRCm39) L550Q probably damaging Het
Dip2c A G 13: 9,665,811 (GRCm39) R950G probably damaging Het
Eml6 A G 11: 29,798,949 (GRCm39) V437A possibly damaging Het
Fanca T C 8: 123,999,180 (GRCm39) probably benign Het
Fgd2 C G 17: 29,585,982 (GRCm39) L189V possibly damaging Het
Foxred2 A C 15: 77,827,590 (GRCm39) S590A possibly damaging Het
Gm1110 A G 9: 26,831,962 (GRCm39) F63S probably damaging Het
Gm14496 A T 2: 181,637,747 (GRCm39) M274L probably benign Het
Gm7008 T A 12: 40,273,559 (GRCm39) probably benign Het
Gm9922 T A 14: 101,966,989 (GRCm39) probably benign Het
Gtf3c3 A T 1: 54,467,971 (GRCm39) M222K possibly damaging Het
Hspa1b A G 17: 35,177,808 (GRCm39) V59A probably benign Het
Impg1 T C 9: 80,294,161 (GRCm39) probably benign Het
Khdc4 T C 3: 88,593,636 (GRCm39) probably benign Het
Lpcat4 T A 2: 112,073,590 (GRCm39) probably null Het
Mipol1 T C 12: 57,507,740 (GRCm39) probably benign Het
Mrpl37 C A 4: 106,923,658 (GRCm39) R112L possibly damaging Het
Myo18b T C 5: 112,957,551 (GRCm39) N1471D possibly damaging Het
Nes G A 3: 87,885,949 (GRCm39) E1359K possibly damaging Het
Nipbl A T 15: 8,391,221 (GRCm39) V251E possibly damaging Het
Nlrp1b T C 11: 71,052,591 (GRCm39) I946V possibly damaging Het
Obscn T G 11: 58,947,568 (GRCm39) probably benign Het
Or10q1b A T 19: 13,682,499 (GRCm39) T103S probably benign Het
Or4a2 T A 2: 89,248,502 (GRCm39) Y85F probably benign Het
Or51q1 T A 7: 103,628,837 (GRCm39) I146K possibly damaging Het
Pck2 T C 14: 55,782,041 (GRCm39) probably null Het
Pcsk9 A G 4: 106,306,246 (GRCm39) probably benign Het
Phyhd1 A T 2: 30,159,834 (GRCm39) Q56L probably benign Het
Plxnc1 C T 10: 94,673,780 (GRCm39) G1001S probably null Het
Prss52 T C 14: 64,351,127 (GRCm39) V304A probably benign Het
Prss55 C T 14: 64,313,056 (GRCm39) G276D probably benign Het
Pzp A T 6: 128,496,477 (GRCm39) Y252N probably damaging Het
Rad1 T C 15: 10,490,543 (GRCm39) probably null Het
Ripply3 A T 16: 94,136,616 (GRCm39) E92D possibly damaging Het
Rpp30 T A 19: 36,081,803 (GRCm39) D255E probably benign Het
Rsad1 T C 11: 94,439,290 (GRCm39) probably benign Het
Serpini2 A G 3: 75,153,885 (GRCm39) M358T probably damaging Het
Slc35a1 T A 4: 34,664,125 (GRCm39) E331V probably benign Het
Slc38a7 A G 8: 96,572,506 (GRCm39) F179L probably damaging Het
Stmn4 C T 14: 66,593,732 (GRCm39) Q42* probably null Het
Sytl2 T C 7: 90,052,228 (GRCm39) probably benign Het
Tab2 G A 10: 7,794,922 (GRCm39) A520V probably benign Het
Tcp10a A G 17: 7,598,555 (GRCm39) I162M probably benign Het
Tmprss13 A G 9: 45,244,986 (GRCm39) probably benign Het
Tnfrsf14 A G 4: 155,011,054 (GRCm39) probably null Het
Tpx2 A G 2: 152,709,287 (GRCm39) probably benign Het
Vmn2r105 T A 17: 20,454,965 (GRCm39) N57I probably damaging Het
Wars1 C T 12: 108,841,119 (GRCm39) V220I probably benign Het
Washc1 T A 17: 66,423,714 (GRCm39) D212E possibly damaging Het
Wdr17 C T 8: 55,146,131 (GRCm39) A90T possibly damaging Het
Wdr43 A G 17: 71,933,820 (GRCm39) D139G probably benign Het
Zfp235 A T 7: 23,836,556 (GRCm39) H34L possibly damaging Het
Zkscan16 G A 4: 58,952,391 (GRCm39) V230I probably benign Het
Other mutations in Or5m12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01632:Or5m12 APN 2 85,734,714 (GRCm39) missense probably benign
IGL02108:Or5m12 APN 2 85,734,494 (GRCm39) missense possibly damaging 0.67
IGL02738:Or5m12 APN 2 85,735,293 (GRCm39) missense probably benign 0.06
IGL03343:Or5m12 APN 2 85,735,285 (GRCm39) missense probably benign
IGL02802:Or5m12 UTSW 2 85,734,733 (GRCm39) missense probably damaging 1.00
R0265:Or5m12 UTSW 2 85,734,591 (GRCm39) missense probably benign 0.01
R0432:Or5m12 UTSW 2 85,734,501 (GRCm39) missense probably damaging 1.00
R0501:Or5m12 UTSW 2 85,735,348 (GRCm39) missense probably damaging 1.00
R0504:Or5m12 UTSW 2 85,735,030 (GRCm39) missense possibly damaging 0.95
R1513:Or5m12 UTSW 2 85,735,015 (GRCm39) missense probably damaging 1.00
R2224:Or5m12 UTSW 2 85,735,099 (GRCm39) missense probably benign 0.11
R2516:Or5m12 UTSW 2 85,734,900 (GRCm39) missense probably benign 0.01
R3845:Or5m12 UTSW 2 85,735,081 (GRCm39) missense probably damaging 0.99
R4871:Or5m12 UTSW 2 85,734,715 (GRCm39) missense probably benign
R4889:Or5m12 UTSW 2 85,735,092 (GRCm39) missense possibly damaging 0.48
R4890:Or5m12 UTSW 2 85,735,092 (GRCm39) missense possibly damaging 0.48
R5543:Or5m12 UTSW 2 85,734,672 (GRCm39) missense probably damaging 1.00
R5865:Or5m12 UTSW 2 85,734,865 (GRCm39) missense probably benign 0.00
R6254:Or5m12 UTSW 2 85,734,849 (GRCm39) missense probably damaging 1.00
R6331:Or5m12 UTSW 2 85,734,560 (GRCm39) missense probably benign 0.32
R6465:Or5m12 UTSW 2 85,734,883 (GRCm39) missense probably benign 0.05
R7183:Or5m12 UTSW 2 85,734,486 (GRCm39) missense probably benign 0.00
R7427:Or5m12 UTSW 2 85,734,475 (GRCm39) nonsense probably null
R7428:Or5m12 UTSW 2 85,734,475 (GRCm39) nonsense probably null
R7552:Or5m12 UTSW 2 85,734,447 (GRCm39) missense probably benign 0.01
R7654:Or5m12 UTSW 2 85,734,663 (GRCm39) missense possibly damaging 0.95
R7674:Or5m12 UTSW 2 85,734,880 (GRCm39) missense probably damaging 1.00
R7980:Or5m12 UTSW 2 85,734,942 (GRCm39) missense probably benign 0.22
R8209:Or5m12 UTSW 2 85,734,547 (GRCm39) missense probably benign 0.14
R8226:Or5m12 UTSW 2 85,734,547 (GRCm39) missense probably benign 0.14
Z1177:Or5m12 UTSW 2 85,735,389 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- AAACACTCTTCTCAGAGCCTGCTTC -3'
(R):5'- GCCAGTTTGCATTTGCCTGGTTAC -3'

Sequencing Primer
(F):5'- AGAGCCTGCTTCACATCCTTG -3'
(R):5'- CAGGTGATATTGACTTCACGTC -3'
Posted On 2013-05-09