Incidental Mutation 'R4662:Mroh9'
| ID |
352909 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mroh9
|
| Ensembl Gene |
ENSMUSG00000071890 |
| Gene Name |
maestro heat-like repeat family member 9 |
| Synonyms |
4921528O07Rik, Armc11 |
| MMRRC Submission |
042011-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4662 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
162851871-162913239 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 162883162 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Tyrosine
at position 439
(C439Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000094365
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000096608]
|
| AlphaFold |
G5E8L9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000096608
AA Change: C439Y
PolyPhen 2
Score 0.968 (Sensitivity: 0.77; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000094365
Gene: ENSMUSG00000071890
AA Change: C439Y
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1gw5b_
|
231 |
716 |
2e-8 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000104420
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000195132
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.1%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4930590J08Rik |
A |
T |
6: 91,891,939 (GRCm39) |
Q67L |
probably benign |
Het |
| Adam34l |
T |
A |
8: 44,080,116 (GRCm39) |
Y36F |
probably benign |
Het |
| Adrb1 |
A |
G |
19: 56,711,206 (GRCm39) |
T135A |
probably damaging |
Het |
| Ark2n |
T |
A |
18: 77,762,186 (GRCm39) |
Q42L |
probably benign |
Het |
| Asxl2 |
G |
T |
12: 3,477,193 (GRCm39) |
W13L |
probably damaging |
Het |
| Atp4a |
G |
A |
7: 30,419,650 (GRCm39) |
R671Q |
probably benign |
Het |
| Brsk1 |
T |
C |
7: 4,710,298 (GRCm39) |
S436P |
possibly damaging |
Het |
| Calb2 |
A |
G |
8: 110,894,709 (GRCm39) |
F21L |
probably benign |
Het |
| Camk2a |
T |
C |
18: 61,074,411 (GRCm39) |
Y39H |
probably damaging |
Het |
| Cavin2 |
T |
C |
1: 51,340,510 (GRCm39) |
S396P |
probably benign |
Het |
| Cfdp1 |
A |
G |
8: 112,557,577 (GRCm39) |
F188S |
probably benign |
Het |
| Chek2 |
T |
A |
5: 111,014,908 (GRCm39) |
V459D |
probably damaging |
Het |
| Cldn8 |
G |
A |
16: 88,359,296 (GRCm39) |
H210Y |
probably benign |
Het |
| Cobl |
A |
G |
11: 12,203,672 (GRCm39) |
V1003A |
probably benign |
Het |
| Ctsll3 |
A |
G |
13: 60,947,416 (GRCm39) |
F257L |
possibly damaging |
Het |
| Dnajc13 |
A |
C |
9: 104,084,957 (GRCm39) |
F819V |
probably damaging |
Het |
| Dram1 |
C |
A |
10: 88,161,246 (GRCm39) |
V208L |
probably damaging |
Het |
| Dynlt1b |
A |
G |
17: 6,699,279 (GRCm39) |
T10A |
probably benign |
Het |
| Eml6 |
A |
T |
11: 29,727,390 (GRCm39) |
V1244E |
probably damaging |
Het |
| Ethe1 |
G |
A |
7: 24,293,405 (GRCm39) |
S17N |
probably benign |
Het |
| Foxi1 |
T |
C |
11: 34,157,578 (GRCm39) |
D149G |
probably damaging |
Het |
| Fzd9 |
T |
C |
5: 135,278,475 (GRCm39) |
E470G |
probably damaging |
Het |
| Ggnbp2 |
A |
G |
11: 84,753,072 (GRCm39) |
F56L |
probably damaging |
Het |
| Hao1 |
G |
A |
2: 134,364,947 (GRCm39) |
R227* |
probably null |
Het |
| Hyal1 |
G |
A |
9: 107,456,420 (GRCm39) |
R369H |
probably damaging |
Het |
| Jam2 |
G |
A |
16: 84,609,840 (GRCm39) |
V151M |
probably damaging |
Het |
| Kcna2 |
T |
A |
3: 107,012,733 (GRCm39) |
I438N |
probably benign |
Het |
| Lrp1 |
A |
T |
10: 127,388,054 (GRCm39) |
C3331* |
probably null |
Het |
| Mcm9 |
T |
C |
10: 53,424,623 (GRCm39) |
I656V |
probably benign |
Het |
| N4bp2l2 |
T |
C |
5: 150,574,160 (GRCm39) |
D85G |
probably damaging |
Het |
| Nr1h2 |
A |
G |
7: 44,199,855 (GRCm39) |
Y355H |
probably damaging |
Het |
| Nr5a2 |
T |
C |
1: 136,868,167 (GRCm39) |
I322V |
probably benign |
Het |
| Nup153 |
A |
C |
13: 46,840,750 (GRCm39) |
L273V |
possibly damaging |
Het |
| Obscn |
A |
G |
11: 58,890,422 (GRCm39) |
L7370P |
unknown |
Het |
| Or1a1 |
T |
C |
11: 74,086,542 (GRCm39) |
I71T |
probably damaging |
Het |
| Or4b1 |
T |
A |
2: 89,980,222 (GRCm39) |
I43F |
probably damaging |
Het |
| Or5k15 |
A |
G |
16: 58,710,287 (GRCm39) |
C99R |
probably damaging |
Het |
| Prkdc |
G |
A |
16: 15,551,916 (GRCm39) |
D2041N |
probably damaging |
Het |
| Ptdss1 |
A |
G |
13: 67,081,675 (GRCm39) |
D35G |
possibly damaging |
Het |
| Ptprs |
G |
T |
17: 56,724,666 (GRCm39) |
T1118K |
probably damaging |
Het |
| Pygb |
C |
T |
2: 150,657,036 (GRCm39) |
T329I |
probably benign |
Het |
| Rhoh |
T |
A |
5: 66,050,157 (GRCm39) |
D142E |
probably benign |
Het |
| Saraf |
C |
A |
8: 34,635,616 (GRCm39) |
A306E |
probably damaging |
Het |
| Scn1a |
T |
C |
2: 66,181,332 (GRCm39) |
I64V |
probably benign |
Het |
| Sec16a |
A |
G |
2: 26,320,582 (GRCm39) |
W1333R |
probably damaging |
Het |
| Shroom1 |
A |
T |
11: 53,357,289 (GRCm39) |
T651S |
possibly damaging |
Het |
| Skint3 |
C |
A |
4: 112,134,863 (GRCm39) |
Y345* |
probably null |
Het |
| Slc1a7 |
T |
A |
4: 107,864,751 (GRCm39) |
N263K |
probably damaging |
Het |
| Sptbn2 |
C |
T |
19: 4,789,267 (GRCm39) |
R1236C |
probably damaging |
Het |
| Tbx21 |
T |
C |
11: 96,992,393 (GRCm39) |
N226S |
probably benign |
Het |
| Thada |
A |
G |
17: 84,743,078 (GRCm39) |
L782P |
probably damaging |
Het |
| Tle1 |
T |
G |
4: 72,055,335 (GRCm39) |
I446L |
possibly damaging |
Het |
| Trgv1 |
T |
A |
13: 19,524,503 (GRCm39) |
L76I |
possibly damaging |
Het |
| Triobp |
A |
G |
15: 78,877,469 (GRCm39) |
D1621G |
probably damaging |
Het |
| Trpm2 |
G |
C |
10: 77,773,972 (GRCm39) |
A481G |
probably benign |
Het |
| Unc80 |
A |
T |
1: 66,685,595 (GRCm39) |
M2240L |
probably benign |
Het |
| Usp9x |
A |
G |
X: 12,989,747 (GRCm39) |
R776G |
possibly damaging |
Homo |
| Vangl1 |
T |
C |
3: 102,074,238 (GRCm39) |
T290A |
probably benign |
Het |
| Vmn1r233 |
T |
A |
17: 21,214,393 (GRCm39) |
I186F |
probably benign |
Het |
| Vmn2r102 |
G |
A |
17: 19,901,424 (GRCm39) |
C517Y |
probably damaging |
Het |
| Vrk2 |
G |
A |
11: 26,421,611 (GRCm39) |
T449M |
possibly damaging |
Het |
| Zfp518a |
A |
G |
19: 40,900,304 (GRCm39) |
S78G |
probably benign |
Het |
| Zscan25 |
T |
C |
5: 145,223,120 (GRCm39) |
S131P |
unknown |
Het |
| Zscan29 |
G |
A |
2: 120,997,096 (GRCm39) |
T140I |
probably benign |
Het |
|
| Other mutations in Mroh9 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00593:Mroh9
|
APN |
1 |
162,873,350 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL00705:Mroh9
|
APN |
1 |
162,907,072 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00788:Mroh9
|
APN |
1 |
162,852,227 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL00795:Mroh9
|
APN |
1 |
162,888,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00815:Mroh9
|
APN |
1 |
162,866,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01025:Mroh9
|
APN |
1 |
162,875,435 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL01303:Mroh9
|
APN |
1 |
162,908,144 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01526:Mroh9
|
APN |
1 |
162,883,172 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01680:Mroh9
|
APN |
1 |
162,875,551 (GRCm39) |
splice site |
probably null |
|
|
IGL01823:Mroh9
|
APN |
1 |
162,883,178 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02024:Mroh9
|
APN |
1 |
162,890,071 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL02213:Mroh9
|
APN |
1 |
162,885,648 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02455:Mroh9
|
APN |
1 |
162,903,149 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02546:Mroh9
|
APN |
1 |
162,908,145 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03059:Mroh9
|
APN |
1 |
162,852,205 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03061:Mroh9
|
APN |
1 |
162,854,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03071:Mroh9
|
APN |
1 |
162,866,766 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0048:Mroh9
|
UTSW |
1 |
162,890,056 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0048:Mroh9
|
UTSW |
1 |
162,890,056 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0441:Mroh9
|
UTSW |
1 |
162,888,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0506:Mroh9
|
UTSW |
1 |
162,888,205 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0629:Mroh9
|
UTSW |
1 |
162,888,205 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0751:Mroh9
|
UTSW |
1 |
162,893,693 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R1301:Mroh9
|
UTSW |
1 |
162,871,552 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1481:Mroh9
|
UTSW |
1 |
162,854,078 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1618:Mroh9
|
UTSW |
1 |
162,852,110 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1647:Mroh9
|
UTSW |
1 |
162,873,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1648:Mroh9
|
UTSW |
1 |
162,873,625 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1668:Mroh9
|
UTSW |
1 |
162,852,161 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R1795:Mroh9
|
UTSW |
1 |
162,884,347 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1796:Mroh9
|
UTSW |
1 |
162,873,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1857:Mroh9
|
UTSW |
1 |
162,866,714 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1869:Mroh9
|
UTSW |
1 |
162,854,082 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1923:Mroh9
|
UTSW |
1 |
162,903,860 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2325:Mroh9
|
UTSW |
1 |
162,854,099 (GRCm39) |
splice site |
probably null |
|
|
R2511:Mroh9
|
UTSW |
1 |
162,866,514 (GRCm39) |
missense |
probably benign |
0.13 |
|
R2912:Mroh9
|
UTSW |
1 |
162,871,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2913:Mroh9
|
UTSW |
1 |
162,871,572 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2919:Mroh9
|
UTSW |
1 |
162,884,341 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2973:Mroh9
|
UTSW |
1 |
162,884,338 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3912:Mroh9
|
UTSW |
1 |
162,893,638 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4034:Mroh9
|
UTSW |
1 |
162,908,122 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4551:Mroh9
|
UTSW |
1 |
162,871,662 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4656:Mroh9
|
UTSW |
1 |
162,893,593 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4743:Mroh9
|
UTSW |
1 |
162,852,061 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4890:Mroh9
|
UTSW |
1 |
162,854,093 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5128:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5129:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5147:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5157:Mroh9
|
UTSW |
1 |
162,871,690 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5324:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5325:Mroh9
|
UTSW |
1 |
162,888,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5340:Mroh9
|
UTSW |
1 |
162,908,156 (GRCm39) |
start gained |
probably benign |
|
|
R6005:Mroh9
|
UTSW |
1 |
162,903,246 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6182:Mroh9
|
UTSW |
1 |
162,893,612 (GRCm39) |
nonsense |
probably null |
|
|
R6414:Mroh9
|
UTSW |
1 |
162,902,271 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6477:Mroh9
|
UTSW |
1 |
162,903,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6540:Mroh9
|
UTSW |
1 |
162,866,541 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R6541:Mroh9
|
UTSW |
1 |
162,885,607 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6643:Mroh9
|
UTSW |
1 |
162,903,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6811:Mroh9
|
UTSW |
1 |
162,873,610 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R6830:Mroh9
|
UTSW |
1 |
162,903,935 (GRCm39) |
missense |
probably benign |
|
|
R7026:Mroh9
|
UTSW |
1 |
162,888,251 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7052:Mroh9
|
UTSW |
1 |
162,866,525 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7068:Mroh9
|
UTSW |
1 |
162,866,750 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Mroh9
|
UTSW |
1 |
162,903,858 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7545:Mroh9
|
UTSW |
1 |
162,902,277 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7615:Mroh9
|
UTSW |
1 |
162,873,601 (GRCm39) |
missense |
probably benign |
0.40 |
|
R7743:Mroh9
|
UTSW |
1 |
162,852,122 (GRCm39) |
missense |
probably benign |
|
|
R7808:Mroh9
|
UTSW |
1 |
162,866,678 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8024:Mroh9
|
UTSW |
1 |
162,866,802 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8062:Mroh9
|
UTSW |
1 |
162,866,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8145:Mroh9
|
UTSW |
1 |
162,890,096 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8426:Mroh9
|
UTSW |
1 |
162,852,294 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8458:Mroh9
|
UTSW |
1 |
162,883,250 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8555:Mroh9
|
UTSW |
1 |
162,899,595 (GRCm39) |
splice site |
probably null |
|
|
R8960:Mroh9
|
UTSW |
1 |
162,883,196 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9040:Mroh9
|
UTSW |
1 |
162,890,069 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9125:Mroh9
|
UTSW |
1 |
162,875,412 (GRCm39) |
missense |
probably benign |
0.19 |
|
R9154:Mroh9
|
UTSW |
1 |
162,890,030 (GRCm39) |
missense |
|
|
|
R9596:Mroh9
|
UTSW |
1 |
162,893,576 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9612:Mroh9
|
UTSW |
1 |
162,866,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
RF003:Mroh9
|
UTSW |
1 |
162,885,630 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGTGAACACTCATAGCCTCAGG -3'
(R):5'- AGCCATTCTAGCCCTCTGTATG -3'
Sequencing Primer
(F):5'- TCATAGCCTCAGGAGGATTACTC -3'
(R):5'- CCTCTGTATGACTGACAATCATTGG -3'
|
| Posted On |
2015-10-08 |
Incidental Mutation