Incidental Mutation 'R4662:Mcm9'
ID 352938
Institutional Source Beutler Lab
Gene Symbol Mcm9
Ensembl Gene ENSMUSG00000058298
Gene Name minichromosome maintenance 9 homologous recombination repair factor
Synonyms 9030408O17Rik, Mcmdc1
MMRRC Submission 042011-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4662 (G1)
Quality Score 225
Status Not validated
Chromosome 10
Chromosomal Location 53412411-53506535 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 53424623 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 656 (I656V)
Ref Sequence ENSEMBL: ENSMUSP00000074978 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075540] [ENSMUST00000219547] [ENSMUST00000220007]
AlphaFold Q2KHI9
Predicted Effect probably benign
Transcript: ENSMUST00000075540
AA Change: I656V

PolyPhen 2 Score 0.099 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000074978
Gene: ENSMUSG00000058298
AA Change: I656V

DomainStartEndE-ValueType
low complexity region 22 44 N/A INTRINSIC
low complexity region 62 79 N/A INTRINSIC
low complexity region 81 111 N/A INTRINSIC
MCM 268 761 9.44e-116 SMART
AAA 500 649 2.43e-6 SMART
coiled coil region 789 817 N/A INTRINSIC
low complexity region 884 895 N/A INTRINSIC
low complexity region 1004 1028 N/A INTRINSIC
low complexity region 1045 1056 N/A INTRINSIC
low complexity region 1199 1216 N/A INTRINSIC
low complexity region 1219 1232 N/A INTRINSIC
low complexity region 1246 1255 N/A INTRINSIC
low complexity region 1262 1276 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000219547
Predicted Effect probably benign
Transcript: ENSMUST00000220007
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220260
Meta Mutation Damage Score 0.0743 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.2%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. [provided by RefSeq, Nov 2010]
PHENOTYPE: Mice homozygous for gene trap alleles display germ cell loss with reduced fertility or infertility and increased tumor incidence, particulary of hepatocellular carcinomas. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930590J08Rik A T 6: 91,891,939 (GRCm39) Q67L probably benign Het
Adam34l T A 8: 44,080,116 (GRCm39) Y36F probably benign Het
Adrb1 A G 19: 56,711,206 (GRCm39) T135A probably damaging Het
Ark2n T A 18: 77,762,186 (GRCm39) Q42L probably benign Het
Asxl2 G T 12: 3,477,193 (GRCm39) W13L probably damaging Het
Atp4a G A 7: 30,419,650 (GRCm39) R671Q probably benign Het
Brsk1 T C 7: 4,710,298 (GRCm39) S436P possibly damaging Het
Calb2 A G 8: 110,894,709 (GRCm39) F21L probably benign Het
Camk2a T C 18: 61,074,411 (GRCm39) Y39H probably damaging Het
Cavin2 T C 1: 51,340,510 (GRCm39) S396P probably benign Het
Cfdp1 A G 8: 112,557,577 (GRCm39) F188S probably benign Het
Chek2 T A 5: 111,014,908 (GRCm39) V459D probably damaging Het
Cldn8 G A 16: 88,359,296 (GRCm39) H210Y probably benign Het
Cobl A G 11: 12,203,672 (GRCm39) V1003A probably benign Het
Ctsll3 A G 13: 60,947,416 (GRCm39) F257L possibly damaging Het
Dnajc13 A C 9: 104,084,957 (GRCm39) F819V probably damaging Het
Dram1 C A 10: 88,161,246 (GRCm39) V208L probably damaging Het
Dynlt1b A G 17: 6,699,279 (GRCm39) T10A probably benign Het
Eml6 A T 11: 29,727,390 (GRCm39) V1244E probably damaging Het
Ethe1 G A 7: 24,293,405 (GRCm39) S17N probably benign Het
Foxi1 T C 11: 34,157,578 (GRCm39) D149G probably damaging Het
Fzd9 T C 5: 135,278,475 (GRCm39) E470G probably damaging Het
Ggnbp2 A G 11: 84,753,072 (GRCm39) F56L probably damaging Het
Hao1 G A 2: 134,364,947 (GRCm39) R227* probably null Het
Hyal1 G A 9: 107,456,420 (GRCm39) R369H probably damaging Het
Jam2 G A 16: 84,609,840 (GRCm39) V151M probably damaging Het
Kcna2 T A 3: 107,012,733 (GRCm39) I438N probably benign Het
Lrp1 A T 10: 127,388,054 (GRCm39) C3331* probably null Het
Mroh9 C T 1: 162,883,162 (GRCm39) C439Y probably damaging Het
N4bp2l2 T C 5: 150,574,160 (GRCm39) D85G probably damaging Het
Nr1h2 A G 7: 44,199,855 (GRCm39) Y355H probably damaging Het
Nr5a2 T C 1: 136,868,167 (GRCm39) I322V probably benign Het
Nup153 A C 13: 46,840,750 (GRCm39) L273V possibly damaging Het
Obscn A G 11: 58,890,422 (GRCm39) L7370P unknown Het
Or1a1 T C 11: 74,086,542 (GRCm39) I71T probably damaging Het
Or4b1 T A 2: 89,980,222 (GRCm39) I43F probably damaging Het
Or5k15 A G 16: 58,710,287 (GRCm39) C99R probably damaging Het
Prkdc G A 16: 15,551,916 (GRCm39) D2041N probably damaging Het
Ptdss1 A G 13: 67,081,675 (GRCm39) D35G possibly damaging Het
Ptprs G T 17: 56,724,666 (GRCm39) T1118K probably damaging Het
Pygb C T 2: 150,657,036 (GRCm39) T329I probably benign Het
Rhoh T A 5: 66,050,157 (GRCm39) D142E probably benign Het
Saraf C A 8: 34,635,616 (GRCm39) A306E probably damaging Het
Scn1a T C 2: 66,181,332 (GRCm39) I64V probably benign Het
Sec16a A G 2: 26,320,582 (GRCm39) W1333R probably damaging Het
Shroom1 A T 11: 53,357,289 (GRCm39) T651S possibly damaging Het
Skint3 C A 4: 112,134,863 (GRCm39) Y345* probably null Het
Slc1a7 T A 4: 107,864,751 (GRCm39) N263K probably damaging Het
Sptbn2 C T 19: 4,789,267 (GRCm39) R1236C probably damaging Het
Tbx21 T C 11: 96,992,393 (GRCm39) N226S probably benign Het
Thada A G 17: 84,743,078 (GRCm39) L782P probably damaging Het
Tle1 T G 4: 72,055,335 (GRCm39) I446L possibly damaging Het
Trgv1 T A 13: 19,524,503 (GRCm39) L76I possibly damaging Het
Triobp A G 15: 78,877,469 (GRCm39) D1621G probably damaging Het
Trpm2 G C 10: 77,773,972 (GRCm39) A481G probably benign Het
Unc80 A T 1: 66,685,595 (GRCm39) M2240L probably benign Het
Usp9x A G X: 12,989,747 (GRCm39) R776G possibly damaging Homo
Vangl1 T C 3: 102,074,238 (GRCm39) T290A probably benign Het
Vmn1r233 T A 17: 21,214,393 (GRCm39) I186F probably benign Het
Vmn2r102 G A 17: 19,901,424 (GRCm39) C517Y probably damaging Het
Vrk2 G A 11: 26,421,611 (GRCm39) T449M possibly damaging Het
Zfp518a A G 19: 40,900,304 (GRCm39) S78G probably benign Het
Zscan25 T C 5: 145,223,120 (GRCm39) S131P unknown Het
Zscan29 G A 2: 120,997,096 (GRCm39) T140I probably benign Het
Other mutations in Mcm9
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00660:Mcm9 APN 10 53,499,069 (GRCm39) missense probably damaging 0.97
IGL00904:Mcm9 APN 10 53,499,017 (GRCm39) missense possibly damaging 0.89
IGL00943:Mcm9 APN 10 53,424,685 (GRCm39) missense probably damaging 1.00
IGL01019:Mcm9 APN 10 53,506,041 (GRCm39) missense probably damaging 1.00
IGL02452:Mcm9 APN 10 53,417,653 (GRCm39) missense probably damaging 1.00
IGL02481:Mcm9 APN 10 53,502,033 (GRCm39) missense probably damaging 1.00
IGL02982:Mcm9 APN 10 53,501,922 (GRCm39) missense probably damaging 0.99
IGL03300:Mcm9 APN 10 53,487,523 (GRCm39) missense probably damaging 1.00
R0021:Mcm9 UTSW 10 53,413,997 (GRCm39) missense possibly damaging 0.94
R0117:Mcm9 UTSW 10 53,413,832 (GRCm39) missense possibly damaging 0.49
R0137:Mcm9 UTSW 10 53,439,526 (GRCm39) missense possibly damaging 0.95
R0420:Mcm9 UTSW 10 53,424,623 (GRCm39) missense probably benign 0.10
R0499:Mcm9 UTSW 10 53,414,250 (GRCm39) missense probably benign 0.01
R0543:Mcm9 UTSW 10 53,417,694 (GRCm39) missense probably damaging 0.97
R0947:Mcm9 UTSW 10 53,413,597 (GRCm39) small deletion probably benign
R0975:Mcm9 UTSW 10 53,414,742 (GRCm39) nonsense probably null
R1573:Mcm9 UTSW 10 53,424,752 (GRCm39) missense probably damaging 0.97
R1726:Mcm9 UTSW 10 53,413,977 (GRCm39) missense possibly damaging 0.67
R1839:Mcm9 UTSW 10 53,417,649 (GRCm39) missense probably damaging 0.99
R2050:Mcm9 UTSW 10 53,488,921 (GRCm39) critical splice donor site probably null
R2113:Mcm9 UTSW 10 53,491,943 (GRCm39) splice site probably null
R2172:Mcm9 UTSW 10 53,424,670 (GRCm39) missense probably damaging 1.00
R3417:Mcm9 UTSW 10 53,413,503 (GRCm39) missense possibly damaging 0.83
R3755:Mcm9 UTSW 10 53,502,048 (GRCm39) missense probably benign 0.08
R3787:Mcm9 UTSW 10 53,492,076 (GRCm39) missense possibly damaging 0.78
R3789:Mcm9 UTSW 10 53,492,113 (GRCm39) missense probably damaging 1.00
R3953:Mcm9 UTSW 10 53,439,440 (GRCm39) missense probably damaging 1.00
R4291:Mcm9 UTSW 10 53,423,668 (GRCm39) missense probably benign 0.22
R4358:Mcm9 UTSW 10 53,413,749 (GRCm39) missense probably benign 0.03
R4660:Mcm9 UTSW 10 53,424,623 (GRCm39) missense probably benign 0.10
R5082:Mcm9 UTSW 10 53,414,156 (GRCm39) missense possibly damaging 0.94
R5130:Mcm9 UTSW 10 53,506,495 (GRCm39) missense possibly damaging 0.90
R5193:Mcm9 UTSW 10 53,492,134 (GRCm39) missense probably damaging 0.99
R5238:Mcm9 UTSW 10 53,506,093 (GRCm39) missense possibly damaging 0.83
R5317:Mcm9 UTSW 10 53,414,330 (GRCm39) missense probably damaging 1.00
R5395:Mcm9 UTSW 10 53,414,788 (GRCm39) missense possibly damaging 0.93
R5524:Mcm9 UTSW 10 53,424,786 (GRCm39) nonsense probably null
R5593:Mcm9 UTSW 10 53,414,393 (GRCm39) missense probably damaging 0.99
R5748:Mcm9 UTSW 10 53,501,825 (GRCm39) missense probably damaging 1.00
R6025:Mcm9 UTSW 10 53,492,073 (GRCm39) missense possibly damaging 0.93
R6299:Mcm9 UTSW 10 53,413,777 (GRCm39) missense probably damaging 1.00
R6344:Mcm9 UTSW 10 53,414,033 (GRCm39) missense probably benign 0.03
R6502:Mcm9 UTSW 10 53,488,935 (GRCm39) missense probably damaging 1.00
R6621:Mcm9 UTSW 10 53,439,409 (GRCm39) missense probably damaging 1.00
R6883:Mcm9 UTSW 10 53,492,110 (GRCm39) missense probably damaging 1.00
R6932:Mcm9 UTSW 10 53,496,299 (GRCm39) missense probably benign 0.06
R6963:Mcm9 UTSW 10 53,424,713 (GRCm39) missense probably damaging 1.00
R7094:Mcm9 UTSW 10 53,496,253 (GRCm39) missense probably damaging 1.00
R7114:Mcm9 UTSW 10 53,414,669 (GRCm39) missense possibly damaging 0.55
R7200:Mcm9 UTSW 10 53,492,019 (GRCm39) missense
R7593:Mcm9 UTSW 10 53,506,088 (GRCm39) missense probably benign 0.04
R7671:Mcm9 UTSW 10 53,413,665 (GRCm39) missense probably benign 0.01
R7697:Mcm9 UTSW 10 53,491,990 (GRCm39) missense
R7997:Mcm9 UTSW 10 53,473,502 (GRCm39) start gained probably benign
R8136:Mcm9 UTSW 10 53,487,439 (GRCm39) makesense probably null
R8137:Mcm9 UTSW 10 53,499,076 (GRCm39) missense
R8494:Mcm9 UTSW 10 53,501,856 (GRCm39) missense possibly damaging 0.48
R8526:Mcm9 UTSW 10 53,506,221 (GRCm39) unclassified probably benign
R8558:Mcm9 UTSW 10 53,492,068 (GRCm39) missense probably benign 0.07
R8703:Mcm9 UTSW 10 53,506,073 (GRCm39) missense probably damaging 0.96
R8836:Mcm9 UTSW 10 53,502,130 (GRCm39) missense
R8994:Mcm9 UTSW 10 53,424,620 (GRCm39) missense probably benign 0.31
R9150:Mcm9 UTSW 10 53,502,110 (GRCm39) missense
R9564:Mcm9 UTSW 10 53,506,104 (GRCm39) missense possibly damaging 0.90
Z1176:Mcm9 UTSW 10 53,505,884 (GRCm39) frame shift probably null
Z1176:Mcm9 UTSW 10 53,413,603 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- ATACCTGGCTTCTCAGCTGC -3'
(R):5'- GTGTTCAAGGGACAATTACATCC -3'

Sequencing Primer
(F):5'- AGCTGCCTTCTGTCTAAGC -3'
(R):5'- TGAATCTCAGTCAATGAATTTTTCCC -3'
Posted On 2015-10-08