Mutagenetix > Incidental Mutation

Incidental Mutation 'R4710:Lrrk2'

353232

Institutional Source

Beutler Lab

Gene Symbol

Lrrk2

Ensembl Gene

ENSMUSG00000036273

Gene Name

leucine-rich repeat kinase 2

Synonyms

9330188B09Rik, 4921513O20Rik, LOC381026, cI-46, D630001M17Rik

MMRRC Submission

042019-MU

Accession Numbers

Genbank: NM_025730; MGI: 1913975

Essential gene?

Possibly essential (E-score: 0.520) question?

Stock #

R4710 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

91673175-91816120 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 91699927 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Valine to Methionine at position 297 (V297M)

Ref Sequence

ENSEMBL: ENSMUSP00000052584 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000060642]

AlphaFold

Q5S006

Predicted Effect

possibly damaging
Transcript: ENSMUST00000060642
AA Change: V297M

PolyPhen 2 Score 0.881 (Sensitivity: 0.82; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000052584
Gene: ENSMUSG00000036273
AA Change: V297M

Domain	Start	End	E-Value	Type
low complexity region	138	156	N/A	INTRINSIC
low complexity region	332	347	N/A	INTRINSIC
ANK	708	737	3.95e1	SMART
ANK	770	800	4.58e2	SMART
low complexity region	890	901	N/A	INTRINSIC
low complexity region	953	966	N/A	INTRINSIC
low complexity region	971	979	N/A	INTRINSIC
LRR	1010	1033	9.96e-1	SMART
LRR	1034	1057	8.01e0	SMART
LRR	1082	1105	2.45e0	SMART
LRR	1128	1151	9.3e-1	SMART
LRR	1195	1219	3.24e0	SMART
LRR	1244	1266	3.87e1	SMART
LRR	1267	1291	4.98e1	SMART
Pfam:Roc	1336	1456	4.9e-32	PFAM
Pfam:Ras	1336	1489	3.3e-17	PFAM
Pfam:COR	1524	1740	4e-28	PFAM
Pfam:Pkinase	1881	2132	4.7e-40	PFAM
Pfam:Pkinase_Tyr	1882	2132	6.8e-39	PFAM
WD40	2231	2276	3.09e-1	SMART
WD40	2401	2438	1.37e2	SMART

Meta Mutation Damage Score

0.1100

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 96.9%
20x: 94.5%

Validation Efficiency

99% (75/76)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-in allele exhibit impaired response to dopamine, amphetamine, and quinpirole. Mice homozygous for one knock-out allele exhibit increased neurite growth. Mice homozygous for different knock-out alleles exhibit alopecia due to excessive grooming or kdiney atrophy. [provided by MGI curators]

Allele List at MGI

All alleles(7) : Targeted, knock-out(6) Targeted, other(1)

Other mutations in this stock

Total: 72 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
A2m	A	T	6: 121,641,303 (GRCm38)	Q185L	probably benign	Het
Acaca	T	A	11: 84,392,337 (GRCm38)	I2243N	possibly damaging	Het
Adamts18	A	G	8: 113,706,926 (GRCm38)	S1059P	probably damaging	Het
Aox4	A	T	1: 58,255,638 (GRCm38)	K1002M	probably damaging	Het
Ap1b1	A	G	11: 5,031,664 (GRCm38)	Y524C	probably damaging	Het
Bag4	C	T	8: 25,769,488 (GRCm38)	A228T	probably benign	Het
Bpifb6	T	A	2: 153,908,516 (GRCm38)	I309N	possibly damaging	Het
Cd209b	T	C	8: 3,924,215 (GRCm38)	E99G	probably damaging	Het
Cntn2	T	A	1: 132,528,225 (GRCm38)	H185L	possibly damaging	Het
Col4a2	C	A	8: 11,409,462 (GRCm38)	P299Q	probably benign	Het
Commd3	A	G	2: 18,674,282 (GRCm38)	N106S	probably benign	Het
Coro7	T	G	16: 4,634,933 (GRCm38)		probably benign	Het
Ctf1	C	A	7: 127,717,080 (GRCm38)	P66Q	probably damaging	Het
Dclre1c	T	C	2: 3,440,861 (GRCm38)		probably null	Het
Dnaaf3	A	T	7: 4,526,494 (GRCm38)	L317Q	probably damaging	Het
Dnah2	A	G	11: 69,478,077 (GRCm38)	L1667P	probably damaging	Het
Dpp4	A	G	2: 62,360,315 (GRCm38)	I399T	probably benign	Het
Dysf	C	A	6: 84,097,715 (GRCm38)	D499E	probably damaging	Het
Erg	T	C	16: 95,390,034 (GRCm38)	D90G	possibly damaging	Het
F11	T	C	8: 45,250,146 (GRCm38)	Y169C	probably damaging	Het
Fabp3	C	T	4: 130,312,387 (GRCm38)	T57I	probably benign	Het
Fcgbp	A	T	7: 28,094,961 (GRCm38)	M1197L	probably benign	Het
Gimd1	T	C	3: 132,634,848 (GRCm38)	S42P	possibly damaging	Het
Gm12666	T	C	4: 92,190,975 (GRCm38)	E203G	possibly damaging	Het
Gm5526	T	A	1: 45,857,419 (GRCm38)		noncoding transcript	Het
Gnl2	T	A	4: 125,053,459 (GRCm38)	S625T	probably benign	Het
H2-Q2	A	G	17: 35,343,302 (GRCm38)	E175G	probably damaging	Het
Hmgxb3	G	A	18: 61,137,475 (GRCm38)	P926S	probably damaging	Het
Ifi213	G	A	1: 173,567,172 (GRCm38)		probably benign	Het
Inhba	T	C	13: 16,026,483 (GRCm38)	V210A	probably benign	Het
Kansl1l	G	A	1: 66,801,496 (GRCm38)	A215V	possibly damaging	Het
Kcnk1	T	A	8: 126,029,528 (GRCm38)	V263D	probably damaging	Het
Kcnk9	A	G	15: 72,512,975 (GRCm38)	I118T	probably damaging	Het
Lamb1	A	G	12: 31,282,583 (GRCm38)	I283V	probably benign	Het
Lias	A	G	5: 65,397,727 (GRCm38)	D88G	probably benign	Het
Maea	C	T	5: 33,368,690 (GRCm38)	R237C	probably benign	Het
Mdfi	T	A	17: 47,824,586 (GRCm38)	N73I	probably damaging	Het
Mphosph6	T	A	8: 117,801,902 (GRCm38)	M1L	probably damaging	Het
Mta2	T	A	19: 8,949,153 (GRCm38)	I486N	probably damaging	Het
Nbr1	C	T	11: 101,575,275 (GRCm38)	P769L	probably damaging	Het
Ncam2	T	A	16: 81,465,706 (GRCm38)		probably null	Het
Ndel1	A	G	11: 68,845,337 (GRCm38)	Y26H	probably damaging	Het
Neb	T	C	2: 52,260,598 (GRCm38)	R2473G	probably benign	Het
Olfr1115	T	A	2: 87,252,040 (GRCm38)	D34E	possibly damaging	Het
Olfr140	T	C	2: 90,052,150 (GRCm38)	Y58C	probably damaging	Het
Olfr187	T	A	16: 59,036,275 (GRCm38)	H154L	possibly damaging	Het
Olfr213	T	C	6: 116,540,650 (GRCm38)	Y66H	possibly damaging	Het
Olfr325	A	T	11: 58,581,722 (GRCm38)	I293F	probably damaging	Het
Olfr459	G	T	6: 41,771,508 (GRCm38)	Q264K	probably benign	Het
Park2	A	C	17: 11,854,833 (GRCm38)	Q346P	possibly damaging	Het
Prrc2b	T	A	2: 32,193,857 (GRCm38)	S236R	possibly damaging	Het
Rae1	G	T	2: 173,015,392 (GRCm38)		probably benign	Het
Rnf112	T	C	11: 61,449,831 (GRCm38)	D491G	probably damaging	Het
Rnf220	C	T	4: 117,289,214 (GRCm38)		probably benign	Het
Ryr3	G	A	2: 112,766,301 (GRCm38)	L2483F	probably damaging	Het
Sema6a	T	C	18: 47,270,683 (GRCm38)	N624S	probably benign	Het
Sgms1	C	T	19: 32,160,137 (GRCm38)	V10M	probably damaging	Het
Slc23a2	T	C	2: 132,056,709 (GRCm38)	N636S	probably benign	Het
Slc25a48	C	T	13: 56,463,566 (GRCm38)	T162I	probably damaging	Het
Smtn	G	A	11: 3,524,663 (GRCm38)	S716F	probably damaging	Het
Snrnp200	T	C	2: 127,226,133 (GRCm38)	L850P	probably damaging	Het
Sost	G	A	11: 101,966,844 (GRCm38)	P44S	probably damaging	Het
Sox18	A	G	2: 181,670,895 (GRCm38)	Y148H	probably damaging	Het
Stk-ps1	A	G	17: 36,397,670 (GRCm38)		noncoding transcript	Het
Tas2r104	T	A	6: 131,685,444 (GRCm38)	T101S	probably damaging	Het
Traf3ip2	C	T	10: 39,639,260 (GRCm38)	P345S	possibly damaging	Het
Ttn	A	G	2: 76,752,084 (GRCm38)	Y22822H	probably damaging	Het
Vmn2r4	A	G	3: 64,409,780 (GRCm38)		probably null	Het
Vmn2r53	T	A	7: 12,601,202 (GRCm38)	H177L	probably benign	Het
Zbtb20	G	T	16: 43,610,676 (GRCm38)	A517S	probably damaging	Het
Zfat	A	T	15: 68,180,282 (GRCm38)	D554E	probably benign	Het
Zfp719	C	T	7: 43,590,232 (GRCm38)	H415Y	probably damaging	Het

Other mutations in Lrrk2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00159:Lrrk2	APN	15	91,747,799 (GRCm38)	missense	possibly damaging	0.90
IGL00542:Lrrk2	APN	15	91,699,943 (GRCm38)	missense	probably benign
IGL00770:Lrrk2	APN	15	91,801,833 (GRCm38)	splice site	probably benign
IGL00774:Lrrk2	APN	15	91,801,833 (GRCm38)	splice site	probably benign
IGL00791:Lrrk2	APN	15	91,779,841 (GRCm38)	missense	probably damaging	1.00
IGL00827:Lrrk2	APN	15	91,755,790 (GRCm38)	missense	probably damaging	1.00
IGL00843:Lrrk2	APN	15	91,757,058 (GRCm38)	missense	possibly damaging	0.58
IGL01109:Lrrk2	APN	15	91,738,832 (GRCm38)	missense	probably damaging	1.00
IGL01293:Lrrk2	APN	15	91,726,137 (GRCm38)	missense	probably benign	0.21
IGL01296:Lrrk2	APN	15	91,683,142 (GRCm38)	missense	probably benign
IGL01301:Lrrk2	APN	15	91,767,339 (GRCm38)	missense	probably damaging	1.00
IGL01360:Lrrk2	APN	15	91,700,569 (GRCm38)	splice site	probably null
IGL01465:Lrrk2	APN	15	91,728,925 (GRCm38)	missense	probably benign	0.21
IGL01529:Lrrk2	APN	15	91,812,313 (GRCm38)	missense	possibly damaging	0.92
IGL01557:Lrrk2	APN	15	91,699,989 (GRCm38)	missense	probably damaging	1.00
IGL01560:Lrrk2	APN	15	91,774,988 (GRCm38)	missense	probably benign	0.33
IGL01991:Lrrk2	APN	15	91,779,946 (GRCm38)	missense	probably damaging	0.99
IGL02003:Lrrk2	APN	15	91,731,491 (GRCm38)	missense	probably damaging	0.99
IGL02325:Lrrk2	APN	15	91,726,308 (GRCm38)	critical splice donor site	probably null
IGL02711:Lrrk2	APN	15	91,685,822 (GRCm38)	missense	possibly damaging	0.71
IGL02869:Lrrk2	APN	15	91,750,277 (GRCm38)	missense	probably damaging	1.00
IGL03104:Lrrk2	APN	15	91,747,755 (GRCm38)	missense	possibly damaging	0.68
IGL03179:Lrrk2	APN	15	91,700,578 (GRCm38)	missense	probably damaging	1.00
IGL03395:Lrrk2	APN	15	91,797,414 (GRCm38)	splice site	probably null
horned	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R1312_Lrrk2_980	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R4710_lrrk2_232	UTSW	15	91,699,927 (GRCm38)	missense	possibly damaging	0.88
R5245_Lrrk2_127	UTSW	15	91,796,089 (GRCm38)	missense	probably damaging	1.00
spree	UTSW	15	91,702,247 (GRCm38)	missense	probably benign	0.00
Spur	UTSW	15	91,774,995 (GRCm38)	nonsense	probably null
3-1:Lrrk2	UTSW	15	91,801,934 (GRCm38)	missense	probably benign	0.01
ANU18:Lrrk2	UTSW	15	91,767,339 (GRCm38)	missense	probably damaging	1.00
H8562:Lrrk2	UTSW	15	91,673,358 (GRCm38)	missense	probably benign
H8786:Lrrk2	UTSW	15	91,673,358 (GRCm38)	missense	probably benign
IGL02835:Lrrk2	UTSW	15	91,814,660 (GRCm38)	critical splice acceptor site	probably null
R0014:Lrrk2	UTSW	15	91,802,045 (GRCm38)	splice site	probably benign
R0014:Lrrk2	UTSW	15	91,802,045 (GRCm38)	splice site	probably benign
R0078:Lrrk2	UTSW	15	91,734,009 (GRCm38)	missense	probably benign	0.01
R0100:Lrrk2	UTSW	15	91,745,796 (GRCm38)	missense	probably damaging	1.00
R0282:Lrrk2	UTSW	15	91,778,414 (GRCm38)	splice site	probably benign
R0448:Lrrk2	UTSW	15	91,709,305 (GRCm38)	missense	probably damaging	0.99
R0449:Lrrk2	UTSW	15	91,750,275 (GRCm38)	missense	probably damaging	1.00
R0610:Lrrk2	UTSW	15	91,815,416 (GRCm38)	missense	probably benign
R0617:Lrrk2	UTSW	15	91,752,278 (GRCm38)	missense	probably benign	0.00
R0632:Lrrk2	UTSW	15	91,796,028 (GRCm38)	missense	probably damaging	0.98
R0639:Lrrk2	UTSW	15	91,772,996 (GRCm38)	missense	probably benign	0.03
R0661:Lrrk2	UTSW	15	91,787,016 (GRCm38)	missense	probably damaging	1.00
R0666:Lrrk2	UTSW	15	91,757,070 (GRCm38)	critical splice donor site	probably null
R0764:Lrrk2	UTSW	15	91,775,046 (GRCm38)	splice site	probably null
R0766:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R0845:Lrrk2	UTSW	15	91,755,962 (GRCm38)	missense	probably benign	0.22
R0940:Lrrk2	UTSW	15	91,729,081 (GRCm38)	missense	possibly damaging	0.83
R0970:Lrrk2	UTSW	15	91,729,169 (GRCm38)	missense	probably benign	0.22
R1080:Lrrk2	UTSW	15	91,673,689 (GRCm38)	missense	probably benign	0.01
R1114:Lrrk2	UTSW	15	91,700,468 (GRCm38)	nonsense	probably null
R1223:Lrrk2	UTSW	15	91,673,635 (GRCm38)	missense	probably benign	0.00
R1289:Lrrk2	UTSW	15	91,812,360 (GRCm38)	missense	probably benign	0.00
R1296:Lrrk2	UTSW	15	91,728,920 (GRCm38)	missense	probably damaging	1.00
R1312:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R1637:Lrrk2	UTSW	15	91,734,058 (GRCm38)	missense	probably benign
R1773:Lrrk2	UTSW	15	91,779,981 (GRCm38)	missense	possibly damaging	0.96
R1809:Lrrk2	UTSW	15	91,699,892 (GRCm38)	missense	possibly damaging	0.86
R1839:Lrrk2	UTSW	15	91,683,134 (GRCm38)	missense	probably benign	0.00
R1946:Lrrk2	UTSW	15	91,736,661 (GRCm38)	splice site	probably null
R2160:Lrrk2	UTSW	15	91,796,060 (GRCm38)	missense	probably damaging	1.00
R2232:Lrrk2	UTSW	15	91,764,716 (GRCm38)	missense	probably benign	0.05
R2419:Lrrk2	UTSW	15	91,797,526 (GRCm38)	splice site	probably benign
R2516:Lrrk2	UTSW	15	91,755,927 (GRCm38)	missense	probably benign
R3110:Lrrk2	UTSW	15	91,814,695 (GRCm38)	missense	probably benign	0.02
R3112:Lrrk2	UTSW	15	91,814,695 (GRCm38)	missense	probably benign	0.02
R3801:Lrrk2	UTSW	15	91,737,111 (GRCm38)	missense	probably benign
R3842:Lrrk2	UTSW	15	91,755,916 (GRCm38)	missense	probably benign	0.01
R3903:Lrrk2	UTSW	15	91,747,701 (GRCm38)	missense	probably damaging	1.00
R3903:Lrrk2	UTSW	15	91,747,700 (GRCm38)	missense	probably damaging	1.00
R3930:Lrrk2	UTSW	15	91,767,461 (GRCm38)	critical splice donor site	probably null
R3937:Lrrk2	UTSW	15	91,778,504 (GRCm38)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,778,504 (GRCm38)	missense	probably damaging	0.98
R3938:Lrrk2	UTSW	15	91,712,780 (GRCm38)	missense	possibly damaging	0.69
R3982:Lrrk2	UTSW	15	91,709,284 (GRCm38)	missense	probably benign	0.22
R4125:Lrrk2	UTSW	15	91,815,483 (GRCm38)	missense	probably benign	0.01
R4130:Lrrk2	UTSW	15	91,755,794 (GRCm38)	missense	probably benign	0.19
R4296:Lrrk2	UTSW	15	91,699,895 (GRCm38)	missense	probably damaging	1.00
R4465:Lrrk2	UTSW	15	91,747,820 (GRCm38)	missense	probably damaging	0.96
R4478:Lrrk2	UTSW	15	91,723,188 (GRCm38)	missense	probably damaging	1.00
R4517:Lrrk2	UTSW	15	91,705,120 (GRCm38)	missense	probably benign
R4539:Lrrk2	UTSW	15	91,729,142 (GRCm38)	missense	possibly damaging	0.86
R4654:Lrrk2	UTSW	15	91,765,681 (GRCm38)	missense	probably damaging	0.96
R4722:Lrrk2	UTSW	15	91,688,901 (GRCm38)	missense	probably damaging	1.00
R4723:Lrrk2	UTSW	15	91,764,759 (GRCm38)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,765,747 (GRCm38)	missense	probably damaging	1.00
R4732:Lrrk2	UTSW	15	91,688,849 (GRCm38)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,765,747 (GRCm38)	missense	probably damaging	1.00
R4733:Lrrk2	UTSW	15	91,688,849 (GRCm38)	missense	probably damaging	1.00
R4787:Lrrk2	UTSW	15	91,712,828 (GRCm38)	missense	probably benign
R4945:Lrrk2	UTSW	15	91,804,920 (GRCm38)	missense	probably benign	0.02
R4948:Lrrk2	UTSW	15	91,803,389 (GRCm38)	missense	probably benign	0.20
R5000:Lrrk2	UTSW	15	91,749,878 (GRCm38)	missense	probably damaging	1.00
R5031:Lrrk2	UTSW	15	91,700,619 (GRCm38)	missense	possibly damaging	0.50
R5067:Lrrk2	UTSW	15	91,765,790 (GRCm38)	missense	probably benign	0.01
R5245:Lrrk2	UTSW	15	91,796,089 (GRCm38)	missense	probably damaging	1.00
R5341:Lrrk2	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R5460:Lrrk2	UTSW	15	91,814,644 (GRCm38)	splice site	probably null
R5551:Lrrk2	UTSW	15	91,812,350 (GRCm38)	missense	probably benign
R5574:Lrrk2	UTSW	15	91,787,016 (GRCm38)	missense	probably damaging	1.00
R5577:Lrrk2	UTSW	15	91,765,745 (GRCm38)	missense	probably damaging	1.00
R5685:Lrrk2	UTSW	15	91,803,301 (GRCm38)	nonsense	probably null
R5712:Lrrk2	UTSW	15	91,702,222 (GRCm38)	nonsense	probably null
R5728:Lrrk2	UTSW	15	91,774,974 (GRCm38)	missense	probably benign	0.36
R5782:Lrrk2	UTSW	15	91,702,183 (GRCm38)	missense	probably damaging	1.00
R5788:Lrrk2	UTSW	15	91,764,648 (GRCm38)	missense	possibly damaging	0.55
R5821:Lrrk2	UTSW	15	91,709,390 (GRCm38)	critical splice donor site	probably null
R5852:Lrrk2	UTSW	15	91,755,949 (GRCm38)	missense	probably damaging	1.00
R5934:Lrrk2	UTSW	15	91,734,046 (GRCm38)	missense	probably benign	0.00
R5935:Lrrk2	UTSW	15	91,745,831 (GRCm38)	missense	probably benign	0.14
R5979:Lrrk2	UTSW	15	91,772,945 (GRCm38)	missense	possibly damaging	0.47
R6101:Lrrk2	UTSW	15	91,723,135 (GRCm38)	missense	probably benign	0.10
R6114:Lrrk2	UTSW	15	91,747,826 (GRCm38)	missense	probably benign	0.33
R6259:Lrrk2	UTSW	15	91,702,247 (GRCm38)	missense	probably benign	0.00
R6376:Lrrk2	UTSW	15	91,742,266 (GRCm38)	missense	possibly damaging	0.89
R6417:Lrrk2	UTSW	15	91,812,346 (GRCm38)	missense	probably benign	0.03
R6420:Lrrk2	UTSW	15	91,812,346 (GRCm38)	missense	probably benign	0.03
R6737:Lrrk2	UTSW	15	91,723,218 (GRCm38)	missense	possibly damaging	0.50
R7056:Lrrk2	UTSW	15	91,774,995 (GRCm38)	nonsense	probably null
R7072:Lrrk2	UTSW	15	91,801,920 (GRCm38)	missense	probably benign	0.03
R7109:Lrrk2	UTSW	15	91,764,782 (GRCm38)	missense	probably damaging	1.00
R7128:Lrrk2	UTSW	15	91,801,885 (GRCm38)	missense	probably benign
R7144:Lrrk2	UTSW	15	91,734,055 (GRCm38)	missense	possibly damaging	0.54
R7187:Lrrk2	UTSW	15	91,757,001 (GRCm38)	missense	possibly damaging	0.92
R7270:Lrrk2	UTSW	15	91,700,441 (GRCm38)	missense	probably benign	0.01
R7356:Lrrk2	UTSW	15	91,738,744 (GRCm38)	missense	probably benign	0.07
R7360:Lrrk2	UTSW	15	91,731,655 (GRCm38)	critical splice donor site	probably null
R7373:Lrrk2	UTSW	15	91,700,004 (GRCm38)	critical splice donor site	probably null
R7465:Lrrk2	UTSW	15	91,767,340 (GRCm38)	missense	probably damaging	1.00
R7477:Lrrk2	UTSW	15	91,812,325 (GRCm38)	missense	probably damaging	0.98
R7614:Lrrk2	UTSW	15	91,772,858 (GRCm38)	missense	probably damaging	1.00
R7622:Lrrk2	UTSW	15	91,812,323 (GRCm38)	missense	probably damaging	1.00
R7658:Lrrk2	UTSW	15	91,700,358 (GRCm38)	missense	possibly damaging	0.91
R7679:Lrrk2	UTSW	15	91,726,186 (GRCm38)	missense	possibly damaging	0.58
R7737:Lrrk2	UTSW	15	91,815,446 (GRCm38)	missense	probably damaging	0.98
R7739:Lrrk2	UTSW	15	91,700,613 (GRCm38)	missense	probably damaging	1.00
R7740:Lrrk2	UTSW	15	91,767,324 (GRCm38)	missense	probably damaging	1.00
R7908:Lrrk2	UTSW	15	91,726,152 (GRCm38)	missense	probably damaging	1.00
R8299:Lrrk2	UTSW	15	91,673,240 (GRCm38)	start gained	probably benign
R8389:Lrrk2	UTSW	15	91,699,991 (GRCm38)	missense	probably damaging	1.00
R8462:Lrrk2	UTSW	15	91,731,477 (GRCm38)	missense	probably benign
R8698:Lrrk2	UTSW	15	91,752,197 (GRCm38)	missense	probably benign	0.38
R8947:Lrrk2	UTSW	15	91,702,270 (GRCm38)	nonsense	probably null
R9084:Lrrk2	UTSW	15	91,750,266 (GRCm38)	missense
R9086:Lrrk2	UTSW	15	91,755,848 (GRCm38)	missense	probably benign	0.01
R9096:Lrrk2	UTSW	15	91,673,256 (GRCm38)	start gained	probably benign
R9097:Lrrk2	UTSW	15	91,673,256 (GRCm38)	start gained	probably benign
R9267:Lrrk2	UTSW	15	91,700,426 (GRCm38)	missense	probably damaging	0.99
R9285:Lrrk2	UTSW	15	91,778,483 (GRCm38)	missense	probably damaging	1.00
R9341:Lrrk2	UTSW	15	91,700,415 (GRCm38)	missense	probably benign	0.18
R9343:Lrrk2	UTSW	15	91,700,415 (GRCm38)	missense	probably benign	0.18
R9371:Lrrk2	UTSW	15	91,723,204 (GRCm38)	missense	probably damaging	1.00
R9424:Lrrk2	UTSW	15	91,752,185 (GRCm38)	nonsense	probably null
R9489:Lrrk2	UTSW	15	91,737,217 (GRCm38)	missense	probably benign	0.37
R9502:Lrrk2	UTSW	15	91,723,162 (GRCm38)	missense	probably damaging	0.98
R9563:Lrrk2	UTSW	15	91,749,840 (GRCm38)	missense	possibly damaging	0.90
R9576:Lrrk2	UTSW	15	91,752,185 (GRCm38)	nonsense	probably null
R9605:Lrrk2	UTSW	15	91,737,217 (GRCm38)	missense	probably benign	0.37
R9635:Lrrk2	UTSW	15	91,812,324 (GRCm38)	missense	probably benign	0.21
R9641:Lrrk2	UTSW	15	91,787,048 (GRCm38)	missense	possibly damaging	0.94
R9660:Lrrk2	UTSW	15	91,734,025 (GRCm38)	missense	probably benign	0.00
R9673:Lrrk2	UTSW	15	91,765,681 (GRCm38)	missense	probably damaging	1.00
R9708:Lrrk2	UTSW	15	91,750,279 (GRCm38)	nonsense	probably null
R9728:Lrrk2	UTSW	15	91,734,025 (GRCm38)	missense	probably benign	0.00
R9757:Lrrk2	UTSW	15	91,811,026 (GRCm38)	missense	probably benign	0.03
RF001:Lrrk2	UTSW	15	91,736,633 (GRCm38)	missense	probably benign	0.11
X0028:Lrrk2	UTSW	15	91,738,851 (GRCm38)	missense	probably benign	0.00
Z1088:Lrrk2	UTSW	15	91,726,240 (GRCm38)	missense	probably benign	0.12

Predicted Primers

PCR Primer
(F):5'- GTCTCTTGCATTTAATGTACACCAC -3'
(R):5'- CAGGGAGATGCCAACACTTG -3'

Sequencing Primer
(F):5'- CACCACTATGTTGTAAAGAGCG -3'
(R):5'- GACTGGAAGAAGGTCCTT -3'

Posted On

2015-10-21