Incidental Mutation 'R4711:Tas2r121'
ID 353267
Institutional Source Beutler Lab
Gene Symbol Tas2r121
Ensembl Gene ENSMUSG00000071150
Gene Name taste receptor, type 2, member 121
Synonyms mGR21, T2R21, Tas2r21, mT2r48
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R4711 (G1)
Quality Score 225
Status Not validated
Chromosome 6
Chromosomal Location 132677053-132677970 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 132677853 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 40 (T40A)
Ref Sequence ENSEMBL: ENSMUSP00000093044 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000095395]
AlphaFold Q7M720
Predicted Effect probably benign
Transcript: ENSMUST00000095395
AA Change: T40A

PolyPhen 2 Score 0.283 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000093044
Gene: ENSMUSG00000071150
AA Change: T40A

DomainStartEndE-ValueType
Pfam:TAS2R 1 300 4.5e-108 PFAM
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Atg14 G A 14: 47,783,298 (GRCm39) R346C probably damaging Het
Bin3 A G 14: 70,366,288 (GRCm39) probably null Het
Ccser1 A G 6: 61,288,910 (GRCm39) N358D possibly damaging Het
Col20a1 G C 2: 180,634,284 (GRCm39) G83A probably damaging Het
Copa T G 1: 171,947,555 (GRCm39) F1124V probably damaging Het
Cyp2c66 G A 19: 39,151,843 (GRCm39) R186H possibly damaging Het
Dmxl2 G A 9: 54,358,208 (GRCm39) T323M probably benign Het
Dner T C 1: 84,361,618 (GRCm39) I664V possibly damaging Het
Erp29 A G 5: 121,583,293 (GRCm39) I211T possibly damaging Het
Exd1 A G 2: 119,369,232 (GRCm39) S128P possibly damaging Het
Grik4 T A 9: 42,540,389 (GRCm39) N264Y probably damaging Het
Gsdma2 T A 11: 98,540,439 (GRCm39) S119R probably damaging Het
H2ac1 C T 13: 24,118,796 (GRCm39) P118S possibly damaging Het
Ift140 T A 17: 25,313,691 (GRCm39) probably null Het
Ino80c T C 18: 24,247,222 (GRCm39) N59S probably benign Het
Maob T C X: 16,582,662 (GRCm39) T400A probably benign Het
Mast4 A G 13: 103,470,627 (GRCm39) V25A probably benign Het
Mr1 T C 1: 155,012,336 (GRCm39) T193A probably benign Het
Muc5b C A 7: 141,399,770 (GRCm39) F414L unknown Het
Nat10 A T 2: 103,578,612 (GRCm39) C197* probably null Het
Nt5c1b A G 12: 10,420,093 (GRCm39) K11E probably damaging Het
Or5k8 A T 16: 58,645,069 (GRCm39) M1K probably null Het
Or8i2 T C 2: 86,852,370 (GRCm39) I173V probably damaging Het
Pak5 A G 2: 135,929,437 (GRCm39) I582T probably damaging Het
Pcdha12 A G 18: 37,153,976 (GRCm39) I232V probably benign Het
Pde8b T A 13: 95,166,958 (GRCm39) T664S probably benign Het
Pdik1l G C 4: 134,006,301 (GRCm39) R214G probably benign Het
Prss37 C T 6: 40,492,381 (GRCm39) V157M probably benign Het
Psma5-ps A G 10: 85,149,667 (GRCm39) noncoding transcript Het
Ring1 T C 17: 34,241,333 (GRCm39) E261G possibly damaging Het
Sf3a3 C A 4: 124,621,974 (GRCm39) D371E probably benign Het
Spag9 T A 11: 94,005,177 (GRCm39) probably null Het
Spred1 T A 2: 117,005,866 (GRCm39) S209R probably benign Het
Tbc1d5 T C 17: 51,242,537 (GRCm39) T187A probably damaging Het
Tenm2 C T 11: 36,191,039 (GRCm39) V311I probably damaging Het
Thoc2l T C 5: 104,667,527 (GRCm39) V683A probably damaging Het
Tnrc6a A G 7: 122,770,301 (GRCm39) D697G probably damaging Het
Trappc14 T C 5: 138,261,167 (GRCm39) probably benign Het
Ttn G A 2: 76,660,404 (GRCm39) A7439V possibly damaging Het
Wdr64 T C 1: 175,626,795 (GRCm39) I838T probably damaging Het
Wdr7 A G 18: 63,861,536 (GRCm39) T183A probably benign Het
Other mutations in Tas2r121
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00559:Tas2r121 APN 6 132,677,484 (GRCm39) missense probably benign 0.28
IGL01868:Tas2r121 APN 6 132,677,235 (GRCm39) missense probably benign 0.00
IGL02182:Tas2r121 APN 6 132,677,133 (GRCm39) missense probably damaging 0.99
IGL02728:Tas2r121 APN 6 132,677,480 (GRCm39) missense probably damaging 1.00
R0833:Tas2r121 UTSW 6 132,677,325 (GRCm39) missense probably damaging 1.00
R0836:Tas2r121 UTSW 6 132,677,325 (GRCm39) missense probably damaging 1.00
R1181:Tas2r121 UTSW 6 132,677,132 (GRCm39) missense probably damaging 1.00
R1424:Tas2r121 UTSW 6 132,677,645 (GRCm39) missense probably damaging 1.00
R1583:Tas2r121 UTSW 6 132,677,193 (GRCm39) nonsense probably null
R2179:Tas2r121 UTSW 6 132,677,831 (GRCm39) missense probably damaging 1.00
R5274:Tas2r121 UTSW 6 132,677,811 (GRCm39) missense probably damaging 1.00
R5308:Tas2r121 UTSW 6 132,677,480 (GRCm39) missense possibly damaging 0.84
R5663:Tas2r121 UTSW 6 132,677,520 (GRCm39) missense probably benign 0.10
R5668:Tas2r121 UTSW 6 132,677,756 (GRCm39) missense possibly damaging 0.95
R5885:Tas2r121 UTSW 6 132,677,254 (GRCm39) missense probably damaging 1.00
R6395:Tas2r121 UTSW 6 132,677,495 (GRCm39) missense probably benign 0.23
R7552:Tas2r121 UTSW 6 132,677,505 (GRCm39) missense probably benign 0.17
R8094:Tas2r121 UTSW 6 132,677,772 (GRCm39) missense probably benign
R9192:Tas2r121 UTSW 6 132,677,492 (GRCm39) missense probably benign 0.00
R9718:Tas2r121 UTSW 6 132,677,765 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- TGGAGAAACTGGCTATTTTGAGC -3'
(R):5'- TACAGGGACATTTCACCTTGCC -3'

Sequencing Primer
(F):5'- TGCTGAGAATAGTGGCAAGCC -3'
(R):5'- GGGACATTTCACCTTGCCAAATGAG -3'
Posted On 2015-10-21