Incidental Mutation 'R4712:Or9k7'
ID 353315
Institutional Source Beutler Lab
Gene Symbol Or9k7
Ensembl Gene ENSMUSG00000045559
Gene Name olfactory receptor family 9 subfamily K member 7
Synonyms MOR210-5, Olfr827, GA_x6K02T2PULF-11878777-11877809
MMRRC Submission 041981-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # R4712 (G1)
Quality Score 225
Status Validated
Chromosome 10
Chromosomal Location 130046029-130046997 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 130046291 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 236 (T236I)
Ref Sequence ENSEMBL: ENSMUSP00000149200 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000058123] [ENSMUST00000213568]
AlphaFold Q8VEV5
Predicted Effect possibly damaging
Transcript: ENSMUST00000058123
AA Change: T236I

PolyPhen 2 Score 0.777 (Sensitivity: 0.85; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000089609
Gene: ENSMUSG00000045559
AA Change: T236I

DomainStartEndE-ValueType
Pfam:7tm_4 43 318 6e-53 PFAM
Pfam:7tm_1 53 300 2.5e-25 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000213568
AA Change: T236I

PolyPhen 2 Score 0.777 (Sensitivity: 0.85; Specificity: 0.92)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000216253
Meta Mutation Damage Score 0.1795 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.3%
Validation Efficiency 98% (54/55)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A4galt G T 15: 83,111,810 (GRCm39) N324K probably damaging Het
Ahcyl1 A G 3: 107,574,547 (GRCm39) probably benign Het
Atrnl1 T A 19: 57,641,382 (GRCm39) N343K probably benign Het
Batf2 C A 19: 6,221,357 (GRCm39) Q56K probably benign Het
Cfh A T 1: 140,036,274 (GRCm39) V691D probably damaging Het
Chst10 T C 1: 38,904,922 (GRCm39) Y257C probably damaging Het
Dlg5 A T 14: 24,228,051 (GRCm39) L290Q possibly damaging Het
Dnah2 T A 11: 69,407,416 (GRCm39) T456S possibly damaging Het
Dnah6 T C 6: 73,001,995 (GRCm39) probably null Het
Efhb T C 17: 53,758,697 (GRCm39) K313R probably damaging Het
Eprs1 T A 1: 185,160,305 (GRCm39) N1500K probably benign Het
Fbn1 T C 2: 125,183,236 (GRCm39) T1748A probably benign Het
Gfra2 T A 14: 71,163,377 (GRCm39) L87H probably damaging Het
Gfral T A 9: 76,100,727 (GRCm39) Y237F possibly damaging Het
Gpr137b T C 13: 13,533,974 (GRCm39) N361D probably benign Het
Gsdmc G T 15: 63,651,386 (GRCm39) T272N probably benign Het
Hspe1 T A 1: 55,128,269 (GRCm39) S21R probably benign Het
Kctd16 G T 18: 40,390,233 (GRCm39) probably benign Het
Kif21a A T 15: 90,868,958 (GRCm39) I483N probably damaging Het
Kif4-ps T C 12: 101,112,534 (GRCm39) noncoding transcript Het
Lpp T C 16: 24,580,407 (GRCm39) V166A possibly damaging Het
Lrp2 A C 2: 69,336,895 (GRCm39) D1292E probably damaging Het
Manba T C 3: 135,250,575 (GRCm39) Y401H probably damaging Het
Msh2 T G 17: 87,985,813 (GRCm39) probably benign Het
Myef2 A T 2: 124,930,757 (GRCm39) probably benign Het
Ncor1 T A 11: 62,235,660 (GRCm39) Q598L probably damaging Het
Obox3 A G 7: 15,360,764 (GRCm39) V125A probably benign Het
Or1n1 A T 2: 36,750,381 (GRCm39) probably null Het
Or2b4 T A 17: 38,116,591 (GRCm39) L185* probably null Het
Pcdh9 C A 14: 94,126,067 (GRCm39) L34F probably damaging Het
Pcdha3 A T 18: 37,079,560 (GRCm39) I101F probably damaging Het
Pced1b A G 15: 97,282,675 (GRCm39) E238G probably benign Het
Pla2r1 A T 2: 60,258,994 (GRCm39) N1131K probably damaging Het
Prmt1 A T 7: 44,631,060 (GRCm39) S99R probably damaging Het
Qng1 G A 13: 58,529,617 (GRCm39) R332C probably benign Het
Rbp3 T C 14: 33,682,615 (GRCm39) S1116P probably damaging Het
Rhobtb2 T C 14: 70,037,160 (GRCm39) D88G probably damaging Het
Rngtt A G 4: 33,379,394 (GRCm39) E432G probably benign Het
Sh3rf1 A G 8: 61,814,793 (GRCm39) T451A probably benign Het
Shroom3 G T 5: 93,090,945 (GRCm39) V1151F probably damaging Het
Siva1 T A 12: 112,613,336 (GRCm39) D61E probably benign Het
Skor1 A C 9: 63,046,855 (GRCm39) probably null Het
Slc20a1 A G 2: 129,041,611 (GRCm39) probably benign Het
Slc2a7 A G 4: 150,252,926 (GRCm39) E522G probably benign Het
Tmprss7 A T 16: 45,511,123 (GRCm39) I85N probably damaging Het
Tpx2 T A 2: 152,726,958 (GRCm39) D408E probably damaging Het
Ulk4 A T 9: 121,073,436 (GRCm39) I551N probably benign Het
Zfat A T 15: 67,982,324 (GRCm39) probably null Het
Zfp101 C A 17: 33,613,457 (GRCm39) probably null Het
Other mutations in Or9k7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02351:Or9k7 APN 10 130,046,603 (GRCm39) missense probably damaging 1.00
IGL02358:Or9k7 APN 10 130,046,603 (GRCm39) missense probably damaging 1.00
R0179:Or9k7 UTSW 10 130,046,207 (GRCm39) missense probably damaging 1.00
R0401:Or9k7 UTSW 10 130,046,489 (GRCm39) missense probably damaging 1.00
R0607:Or9k7 UTSW 10 130,046,939 (GRCm39) missense probably benign 0.33
R1139:Or9k7 UTSW 10 130,046,948 (GRCm39) missense possibly damaging 0.53
R1462:Or9k7 UTSW 10 130,046,592 (GRCm39) missense probably benign 0.30
R1462:Or9k7 UTSW 10 130,046,592 (GRCm39) missense probably benign 0.30
R1645:Or9k7 UTSW 10 130,046,081 (GRCm39) missense probably damaging 0.99
R4966:Or9k7 UTSW 10 130,046,306 (GRCm39) missense probably benign 0.31
R5219:Or9k7 UTSW 10 130,046,793 (GRCm39) missense possibly damaging 0.84
R6363:Or9k7 UTSW 10 130,046,906 (GRCm39) missense possibly damaging 0.93
R6734:Or9k7 UTSW 10 130,046,126 (GRCm39) missense probably benign 0.31
R6909:Or9k7 UTSW 10 130,046,622 (GRCm39) missense probably benign
R7180:Or9k7 UTSW 10 130,046,811 (GRCm39) missense probably benign 0.05
R7549:Or9k7 UTSW 10 130,046,853 (GRCm39) missense probably benign 0.01
R7665:Or9k7 UTSW 10 130,047,130 (GRCm39) splice site probably null
R8001:Or9k7 UTSW 10 130,046,729 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TAGGGGATTCAACATAGGTGTG -3'
(R):5'- GGTCAGTTCCATCCTCCAAATC -3'

Sequencing Primer
(F):5'- TTTGGAGGTGTGAGATACA -3'
(R):5'- GTTCCATCCTCCAAATCAGTGTAAC -3'
Posted On 2015-10-21