Incidental Mutation 'R4684:Disp2'
ID 353490
Institutional Source Beutler Lab
Gene Symbol Disp2
Ensembl Gene ENSMUSG00000040035
Gene Name dispatched RND tramsporter family member 2
Synonyms B230210L08Rik, DispB
Accession Numbers
Essential gene? Probably essential (E-score: 0.875) question?
Stock # R4684 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 118779719-118811293 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) A to G at 118792756 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Asparagine to Serine at position 1323 (N1323S)
Ref Sequence ENSEMBL: ENSMUSP00000037136 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037547] [ENSMUST00000063975] [ENSMUST00000110843] [ENSMUST00000110846]
AlphaFold Q8CIP5
Predicted Effect probably damaging
Transcript: ENSMUST00000037547
AA Change: N1323S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000037136
Gene: ENSMUSG00000040035
AA Change: N1323S

DomainStartEndE-ValueType
transmembrane domain 123 145 N/A INTRINSIC
low complexity region 195 203 N/A INTRINSIC
Pfam:MMPL 435 635 9.7e-8 PFAM
Pfam:Sterol-sensing 458 611 9.1e-9 PFAM
transmembrane domain 657 679 N/A INTRINSIC
low complexity region 682 695 N/A INTRINSIC
low complexity region 748 761 N/A INTRINSIC
transmembrane domain 914 936 N/A INTRINSIC
transmembrane domain 943 965 N/A INTRINSIC
transmembrane domain 975 997 N/A INTRINSIC
transmembrane domain 1018 1040 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000063975
SMART Domains Protein: ENSMUSP00000070031
Gene: ENSMUSG00000040035

DomainStartEndE-ValueType
transmembrane domain 123 145 N/A INTRINSIC
low complexity region 195 203 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110843
SMART Domains Protein: ENSMUSP00000106467
Gene: ENSMUSG00000040035

DomainStartEndE-ValueType
transmembrane domain 123 145 N/A INTRINSIC
low complexity region 195 203 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000110846
SMART Domains Protein: ENSMUSP00000106470
Gene: ENSMUSG00000040035

DomainStartEndE-ValueType
transmembrane domain 123 145 N/A INTRINSIC
low complexity region 195 203 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142072
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. [provided by RefSeq, Sep 2015]
Allele List at MGI
Other mutations in this stock
Total: 89 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310039H08Rik T C 17: 46,772,946 (GRCm38) V45A probably benign Het
4921509C19Rik A G 2: 151,471,871 (GRCm38) I629T unknown Het
4933402N03Rik T C 7: 131,138,684 (GRCm38) R268G probably damaging Het
Abca13 A T 11: 9,434,193 (GRCm38) R3882* probably null Het
Adamts3 T G 5: 89,703,007 (GRCm38) T558P probably damaging Het
Ano2 A G 6: 125,790,341 (GRCm38) N214S probably benign Het
Arhgef4 A T 1: 34,811,785 (GRCm38) probably null Het
Boc C T 16: 44,500,380 (GRCm38) A306T probably benign Het
Capn10 T C 1: 92,943,781 (GRCm38) F367S probably damaging Het
Ccdc6 T C 10: 70,189,256 (GRCm38) probably benign Het
Cobll1 G T 2: 65,099,028 (GRCm38) S688R possibly damaging Het
Cpxm2 G T 7: 132,049,038 (GRCm38) P631Q possibly damaging Het
Cyp2c68 A G 19: 39,699,335 (GRCm38) V406A possibly damaging Het
Cyp4a30b T A 4: 115,455,003 (GRCm38) Y118N probably damaging Het
Dgki A T 6: 37,299,846 (GRCm38) probably benign Het
Dock1 T A 7: 134,724,409 (GRCm38) Y42* probably null Het
Eps8l1 C A 7: 4,473,945 (GRCm38) P471Q probably damaging Het
Fam20a A C 11: 109,721,687 (GRCm38) L10R unknown Het
Fpr-rs4 T A 17: 18,022,184 (GRCm38) I151K probably damaging Het
Gga1 C A 15: 78,885,309 (GRCm38) P161T probably damaging Het
Gm8909 A T 17: 36,165,858 (GRCm38) H241Q possibly damaging Het
Gm9923 T A 10: 72,309,476 (GRCm38) Y52* probably null Het
Gucy2g A G 19: 55,206,256 (GRCm38) F910L probably damaging Het
Helz T C 11: 107,649,145 (GRCm38) V315A probably damaging Het
Hk2 T C 6: 82,739,648 (GRCm38) Y301C probably damaging Het
Htt C T 5: 34,852,765 (GRCm38) P1521S probably damaging Het
Iah1 T C 12: 21,316,433 (GRCm38) M1T probably null Het
Ik T C 18: 36,752,414 (GRCm38) S287P probably damaging Het
Itga1 T A 13: 115,049,370 (GRCm38) D32V probably damaging Het
Itpr2 A G 6: 146,373,173 (GRCm38) F837S probably damaging Het
Klk14 A G 7: 43,691,968 (GRCm38) I15V probably benign Het
Kng2 T C 16: 22,987,641 (GRCm38) I603V possibly damaging Het
Lama1 T C 17: 67,773,778 (GRCm38) I1267T possibly damaging Het
Lrp1b A C 2: 40,922,304 (GRCm38) L2430V probably benign Het
Lrrn3 T G 12: 41,454,244 (GRCm38) K25Q possibly damaging Het
Lta4h T A 10: 93,468,816 (GRCm38) N233K probably benign Het
Mapk13 T C 17: 28,770,049 (GRCm38) I53T probably damaging Het
Mdn1 T C 4: 32,666,430 (GRCm38) F123L probably damaging Het
Mettl7b G T 10: 128,960,702 (GRCm38) C79* probably null Het
Myh4 G C 11: 67,245,811 (GRCm38) D472H probably damaging Het
Nipa2 A T 7: 55,935,826 (GRCm38) N121K probably benign Het
Nostrin C T 2: 69,183,924 (GRCm38) T408M probably benign Het
Olfr347 A G 2: 36,734,674 (GRCm38) M118V probably damaging Het
Olfr725 T C 14: 50,034,830 (GRCm38) D191G probably damaging Het
Oosp2 C T 19: 11,649,653 (GRCm38) R102H probably damaging Het
Osgin2 T A 4: 16,001,946 (GRCm38) I202L probably benign Het
Pbld2 C A 10: 63,057,697 (GRCm38) R271S probably damaging Het
Pex6 C T 17: 46,712,101 (GRCm38) T201I probably benign Het
Pilra T C 5: 137,835,515 (GRCm38) I96M probably damaging Het
Pllp T A 8: 94,677,278 (GRCm38) D47V possibly damaging Het
Plxna2 A G 1: 194,762,594 (GRCm38) S765G probably benign Het
Prkca A T 11: 107,961,608 (GRCm38) Y100N probably damaging Het
Prkg1 T A 19: 31,664,179 (GRCm38) K35* probably null Het
Psmc2 A G 5: 21,803,265 (GRCm38) D389G possibly damaging Het
Rnf213 A G 11: 119,441,125 (GRCm38) T2387A probably damaging Het
Ros1 T C 10: 52,129,096 (GRCm38) N914S probably damaging Het
Ruvbl1 C A 6: 88,491,599 (GRCm38) T367K probably benign Het
Scube2 C T 7: 109,810,713 (GRCm38) R525H probably damaging Het
Sec14l4 T C 11: 4,035,200 (GRCm38) probably null Het
Secisbp2l T C 2: 125,745,942 (GRCm38) D751G probably damaging Het
Setd3 T C 12: 108,108,690 (GRCm38) D402G probably benign Het
Slc15a2 T A 16: 36,757,849 (GRCm38) K359N probably damaging Het
Slc25a21 A G 12: 57,196,936 (GRCm38) S2P probably benign Het
Slfn8 A T 11: 83,017,506 (GRCm38) H70Q probably benign Het
Spef2 T C 15: 9,647,490 (GRCm38) I944V probably benign Het
Spg11 A G 2: 122,065,076 (GRCm38) F1887S probably damaging Het
Sptbn4 T C 7: 27,364,419 (GRCm38) E879G probably damaging Het
Sptbn4 A T 7: 27,366,735 (GRCm38) D649E possibly damaging Het
Stx5a C A 19: 8,743,361 (GRCm38) R121S probably damaging Het
Tbcd T C 11: 121,493,771 (GRCm38) L26P probably damaging Het
Tecpr1 T C 5: 144,207,437 (GRCm38) D649G probably benign Het
Tfam A G 10: 71,237,847 (GRCm38) S32P probably benign Het
Trmt44 C T 5: 35,558,043 (GRCm38) R642H probably benign Het
Trpm3 G A 19: 22,987,781 (GRCm38) A1547T probably benign Het
Ttll6 T C 11: 96,153,177 (GRCm38) V519A probably benign Het
Umodl1 T C 17: 30,998,114 (GRCm38) F1107L probably benign Het
Usp5 A T 6: 124,817,956 (GRCm38) V677E probably damaging Het
Utp20 A T 10: 88,807,445 (GRCm38) L605* probably null Het
Utrn T C 10: 12,745,240 (GRCm38) D229G probably damaging Het
Uty A T Y: 1,176,502 (GRCm38) L178* probably null Het
Vmn2r88 A T 14: 51,413,334 (GRCm38) D168V possibly damaging Het
Vps13b T C 15: 35,646,178 (GRCm38) V1476A probably damaging Het
Vps13b C T 15: 35,841,341 (GRCm38) H2506Y probably benign Het
Vps13b C A 15: 35,879,821 (GRCm38) T3014K probably benign Het
Vps37c T C 19: 10,712,768 (GRCm38) V198A probably benign Het
Zfc3h1 T C 10: 115,423,385 (GRCm38) Y1621H probably benign Het
Zfp251 T C 15: 76,854,407 (GRCm38) D162G possibly damaging Het
Zfp292 T C 4: 34,807,078 (GRCm38) T1994A probably benign Het
Zfp791 A G 8: 85,110,930 (GRCm38) Y102H probably benign Het
Other mutations in Disp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00790:Disp2 APN 2 118,786,278 (GRCm38) missense probably damaging 1.00
IGL00970:Disp2 APN 2 118,791,793 (GRCm38) missense probably damaging 1.00
IGL01790:Disp2 APN 2 118,790,880 (GRCm38) missense probably damaging 1.00
IGL01809:Disp2 APN 2 118,787,264 (GRCm38) splice site probably benign
IGL02069:Disp2 APN 2 118,790,680 (GRCm38) missense possibly damaging 0.93
IGL02140:Disp2 APN 2 118,790,869 (GRCm38) missense probably benign
IGL02143:Disp2 APN 2 118,789,969 (GRCm38) missense probably damaging 1.00
IGL02155:Disp2 APN 2 118,791,804 (GRCm38) missense probably damaging 1.00
IGL02884:Disp2 APN 2 118,787,551 (GRCm38) splice site probably benign
IGL03113:Disp2 APN 2 118,790,778 (GRCm38) splice site probably null
IGL03194:Disp2 APN 2 118,787,629 (GRCm38) missense probably damaging 1.00
PIT4453001:Disp2 UTSW 2 118,787,644 (GRCm38) missense probably benign 0.01
R0109:Disp2 UTSW 2 118,791,816 (GRCm38) missense probably damaging 1.00
R0126:Disp2 UTSW 2 118,790,338 (GRCm38) missense probably damaging 1.00
R0603:Disp2 UTSW 2 118,792,006 (GRCm38) missense probably damaging 1.00
R0610:Disp2 UTSW 2 118,792,236 (GRCm38) missense probably benign 0.02
R0639:Disp2 UTSW 2 118,790,844 (GRCm38) missense possibly damaging 0.74
R0673:Disp2 UTSW 2 118,790,844 (GRCm38) missense possibly damaging 0.74
R0755:Disp2 UTSW 2 118,789,762 (GRCm38) missense probably benign 0.00
R0781:Disp2 UTSW 2 118,790,439 (GRCm38) missense probably damaging 1.00
R1110:Disp2 UTSW 2 118,790,439 (GRCm38) missense probably damaging 1.00
R1148:Disp2 UTSW 2 118,806,418 (GRCm38) critical splice donor site probably null
R1148:Disp2 UTSW 2 118,806,418 (GRCm38) critical splice donor site probably null
R1243:Disp2 UTSW 2 118,791,822 (GRCm38) missense probably damaging 1.00
R1587:Disp2 UTSW 2 118,791,583 (GRCm38) missense probably damaging 1.00
R1739:Disp2 UTSW 2 118,791,550 (GRCm38) missense probably damaging 1.00
R1771:Disp2 UTSW 2 118,791,297 (GRCm38) nonsense probably null
R1781:Disp2 UTSW 2 118,792,561 (GRCm38) missense probably damaging 0.96
R1918:Disp2 UTSW 2 118,791,927 (GRCm38) missense probably benign
R1956:Disp2 UTSW 2 118,792,223 (GRCm38) missense probably benign 0.02
R2167:Disp2 UTSW 2 118,791,685 (GRCm38) missense probably damaging 1.00
R2206:Disp2 UTSW 2 118,792,244 (GRCm38) missense probably benign 0.02
R4031:Disp2 UTSW 2 118,791,880 (GRCm38) missense probably benign 0.27
R4617:Disp2 UTSW 2 118,790,162 (GRCm38) missense probably benign
R4656:Disp2 UTSW 2 118,790,563 (GRCm38) missense probably damaging 1.00
R4696:Disp2 UTSW 2 118,791,684 (GRCm38) nonsense probably null
R4697:Disp2 UTSW 2 118,791,684 (GRCm38) nonsense probably null
R4738:Disp2 UTSW 2 118,790,326 (GRCm38) missense probably damaging 0.97
R4834:Disp2 UTSW 2 118,792,504 (GRCm38) missense probably benign 0.09
R4914:Disp2 UTSW 2 118,790,454 (GRCm38) missense probably damaging 0.99
R4915:Disp2 UTSW 2 118,790,454 (GRCm38) missense probably damaging 0.99
R4918:Disp2 UTSW 2 118,790,454 (GRCm38) missense probably damaging 0.99
R5045:Disp2 UTSW 2 118,792,062 (GRCm38) missense probably benign 0.03
R5208:Disp2 UTSW 2 118,791,805 (GRCm38) missense probably damaging 1.00
R5303:Disp2 UTSW 2 118,810,848 (GRCm38) unclassified probably benign
R5350:Disp2 UTSW 2 118,787,575 (GRCm38) missense probably benign 0.23
R5355:Disp2 UTSW 2 118,786,911 (GRCm38) missense probably benign 0.00
R6011:Disp2 UTSW 2 118,790,820 (GRCm38) missense possibly damaging 0.65
R6031:Disp2 UTSW 2 118,789,794 (GRCm38) missense probably benign 0.01
R6031:Disp2 UTSW 2 118,789,794 (GRCm38) missense probably benign 0.01
R6139:Disp2 UTSW 2 118,790,662 (GRCm38) missense probably damaging 0.97
R6169:Disp2 UTSW 2 118,791,550 (GRCm38) missense probably damaging 1.00
R6187:Disp2 UTSW 2 118,792,143 (GRCm38) missense probably damaging 1.00
R6209:Disp2 UTSW 2 118,786,921 (GRCm38) missense probably damaging 1.00
R6250:Disp2 UTSW 2 118,790,766 (GRCm38) missense probably damaging 1.00
R6392:Disp2 UTSW 2 118,790,749 (GRCm38) missense probably damaging 1.00
R7138:Disp2 UTSW 2 118,786,880 (GRCm38) missense probably benign
R7156:Disp2 UTSW 2 118,791,811 (GRCm38) missense probably damaging 1.00
R7230:Disp2 UTSW 2 118,791,805 (GRCm38) missense probably damaging 1.00
R7400:Disp2 UTSW 2 118,791,886 (GRCm38) missense probably damaging 1.00
R7460:Disp2 UTSW 2 118,789,780 (GRCm38) missense probably damaging 1.00
R7505:Disp2 UTSW 2 118,791,088 (GRCm38) missense probably damaging 1.00
R7542:Disp2 UTSW 2 118,791,118 (GRCm38) missense probably damaging 0.97
R7728:Disp2 UTSW 2 118,791,480 (GRCm38) missense probably benign 0.31
R7757:Disp2 UTSW 2 118,790,910 (GRCm38) missense probably damaging 1.00
R7798:Disp2 UTSW 2 118,791,879 (GRCm38) missense probably benign
R7945:Disp2 UTSW 2 118,792,789 (GRCm38) missense probably damaging 1.00
R8013:Disp2 UTSW 2 118,789,682 (GRCm38) nonsense probably null
R8085:Disp2 UTSW 2 118,786,971 (GRCm38) missense possibly damaging 0.94
R8179:Disp2 UTSW 2 118,792,549 (GRCm38) missense probably damaging 0.99
R8288:Disp2 UTSW 2 118,790,281 (GRCm38) missense probably damaging 1.00
R8345:Disp2 UTSW 2 118,810,803 (GRCm38) missense unknown
R8385:Disp2 UTSW 2 118,790,410 (GRCm38) missense probably damaging 1.00
R8700:Disp2 UTSW 2 118,789,859 (GRCm38) nonsense probably null
R8808:Disp2 UTSW 2 118,790,008 (GRCm38) missense probably damaging 1.00
R8880:Disp2 UTSW 2 118,790,758 (GRCm38) missense probably damaging 1.00
R8997:Disp2 UTSW 2 118,786,986 (GRCm38) missense probably damaging 1.00
R9022:Disp2 UTSW 2 118,790,698 (GRCm38) missense probably benign 0.22
R9181:Disp2 UTSW 2 118,786,912 (GRCm38) missense probably benign 0.08
R9660:Disp2 UTSW 2 118,790,146 (GRCm38) missense probably benign
Z1177:Disp2 UTSW 2 118,790,827 (GRCm38) missense probably damaging 1.00
Z1177:Disp2 UTSW 2 118,789,702 (GRCm38) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCATGAATGGCACTGGACAC -3'
(R):5'- GAACATCTGGCAGGGTTTAGAATC -3'

Sequencing Primer
(F):5'- TGGACACCCCATACTTGAGCG -3'
(R):5'- CTGGCAGGGTTTAGAATCCATAC -3'
Posted On 2015-10-21