Incidental Mutation 'R4684:Secisbp2l'
ID 353492
Institutional Source Beutler Lab
Gene Symbol Secisbp2l
Ensembl Gene ENSMUSG00000035093
Gene Name SECIS binding protein 2-like
Synonyms 3110001I20Rik
Accession Numbers
Essential gene? Probably essential (E-score: 0.751) question?
Stock # R4684 (G1)
Quality Score 225
Status Not validated
Chromosome 2
Chromosomal Location 125736986-125782870 bp(-) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) T to C at 125745942 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 751 (D751G)
Ref Sequence ENSEMBL: ENSMUSP00000055772 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053699]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000053699
AA Change: D751G

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000055772
Gene: ENSMUSG00000035093
AA Change: D751G

DomainStartEndE-ValueType
low complexity region 441 459 N/A INTRINSIC
low complexity region 555 568 N/A INTRINSIC
Pfam:Ribosomal_L7Ae 700 802 7.6e-24 PFAM
low complexity region 821 831 N/A INTRINSIC
low complexity region 970 978 N/A INTRINSIC
low complexity region 985 996 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136450
Predicted Effect unknown
Transcript: ENSMUST00000139944
AA Change: D376G
SMART Domains Protein: ENSMUSP00000121529
Gene: ENSMUSG00000035093
AA Change: D376G

DomainStartEndE-ValueType
low complexity region 67 85 N/A INTRINSIC
low complexity region 181 194 N/A INTRINSIC
Pfam:Ribosomal_L7Ae 326 427 3.5e-24 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 89 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310039H08Rik T C 17: 46,772,946 (GRCm38) V45A probably benign Het
4921509C19Rik A G 2: 151,471,871 (GRCm38) I629T unknown Het
4933402N03Rik T C 7: 131,138,684 (GRCm38) R268G probably damaging Het
Abca13 A T 11: 9,434,193 (GRCm38) R3882* probably null Het
Adamts3 T G 5: 89,703,007 (GRCm38) T558P probably damaging Het
Ano2 A G 6: 125,790,341 (GRCm38) N214S probably benign Het
Arhgef4 A T 1: 34,811,785 (GRCm38) probably null Het
Boc C T 16: 44,500,380 (GRCm38) A306T probably benign Het
Capn10 T C 1: 92,943,781 (GRCm38) F367S probably damaging Het
Ccdc6 T C 10: 70,189,256 (GRCm38) probably benign Het
Cobll1 G T 2: 65,099,028 (GRCm38) S688R possibly damaging Het
Cpxm2 G T 7: 132,049,038 (GRCm38) P631Q possibly damaging Het
Cyp2c68 A G 19: 39,699,335 (GRCm38) V406A possibly damaging Het
Cyp4a30b T A 4: 115,455,003 (GRCm38) Y118N probably damaging Het
Dgki A T 6: 37,299,846 (GRCm38) probably benign Het
Disp2 A G 2: 118,792,756 (GRCm38) N1323S probably damaging Het
Dock1 T A 7: 134,724,409 (GRCm38) Y42* probably null Het
Eps8l1 C A 7: 4,473,945 (GRCm38) P471Q probably damaging Het
Fam20a A C 11: 109,721,687 (GRCm38) L10R unknown Het
Fpr-rs4 T A 17: 18,022,184 (GRCm38) I151K probably damaging Het
Gga1 C A 15: 78,885,309 (GRCm38) P161T probably damaging Het
Gm8909 A T 17: 36,165,858 (GRCm38) H241Q possibly damaging Het
Gm9923 T A 10: 72,309,476 (GRCm38) Y52* probably null Het
Gucy2g A G 19: 55,206,256 (GRCm38) F910L probably damaging Het
Helz T C 11: 107,649,145 (GRCm38) V315A probably damaging Het
Hk2 T C 6: 82,739,648 (GRCm38) Y301C probably damaging Het
Htt C T 5: 34,852,765 (GRCm38) P1521S probably damaging Het
Iah1 T C 12: 21,316,433 (GRCm38) M1T probably null Het
Ik T C 18: 36,752,414 (GRCm38) S287P probably damaging Het
Itga1 T A 13: 115,049,370 (GRCm38) D32V probably damaging Het
Itpr2 A G 6: 146,373,173 (GRCm38) F837S probably damaging Het
Klk14 A G 7: 43,691,968 (GRCm38) I15V probably benign Het
Kng2 T C 16: 22,987,641 (GRCm38) I603V possibly damaging Het
Lama1 T C 17: 67,773,778 (GRCm38) I1267T possibly damaging Het
Lrp1b A C 2: 40,922,304 (GRCm38) L2430V probably benign Het
Lrrn3 T G 12: 41,454,244 (GRCm38) K25Q possibly damaging Het
Lta4h T A 10: 93,468,816 (GRCm38) N233K probably benign Het
Mapk13 T C 17: 28,770,049 (GRCm38) I53T probably damaging Het
Mdn1 T C 4: 32,666,430 (GRCm38) F123L probably damaging Het
Myh4 G C 11: 67,245,811 (GRCm38) D472H probably damaging Het
Nipa2 A T 7: 55,935,826 (GRCm38) N121K probably benign Het
Nostrin C T 2: 69,183,924 (GRCm38) T408M probably benign Het
Oosp2 C T 19: 11,649,653 (GRCm38) R102H probably damaging Het
Or1j18 A G 2: 36,734,674 (GRCm38) M118V probably damaging Het
Or4k15b T C 14: 50,034,830 (GRCm38) D191G probably damaging Het
Osgin2 T A 4: 16,001,946 (GRCm38) I202L probably benign Het
Pbld2 C A 10: 63,057,697 (GRCm38) R271S probably damaging Het
Pex6 C T 17: 46,712,101 (GRCm38) T201I probably benign Het
Pilra T C 5: 137,835,515 (GRCm38) I96M probably damaging Het
Pllp T A 8: 94,677,278 (GRCm38) D47V possibly damaging Het
Plxna2 A G 1: 194,762,594 (GRCm38) S765G probably benign Het
Prkca A T 11: 107,961,608 (GRCm38) Y100N probably damaging Het
Prkg1 T A 19: 31,664,179 (GRCm38) K35* probably null Het
Psmc2 A G 5: 21,803,265 (GRCm38) D389G possibly damaging Het
Rnf213 A G 11: 119,441,125 (GRCm38) T2387A probably damaging Het
Ros1 T C 10: 52,129,096 (GRCm38) N914S probably damaging Het
Ruvbl1 C A 6: 88,491,599 (GRCm38) T367K probably benign Het
Scube2 C T 7: 109,810,713 (GRCm38) R525H probably damaging Het
Sec14l4 T C 11: 4,035,200 (GRCm38) probably null Het
Setd3 T C 12: 108,108,690 (GRCm38) D402G probably benign Het
Slc15a2 T A 16: 36,757,849 (GRCm38) K359N probably damaging Het
Slc25a21 A G 12: 57,196,936 (GRCm38) S2P probably benign Het
Slfn8 A T 11: 83,017,506 (GRCm38) H70Q probably benign Het
Spef2 T C 15: 9,647,490 (GRCm38) I944V probably benign Het
Spg11 A G 2: 122,065,076 (GRCm38) F1887S probably damaging Het
Sptbn4 T C 7: 27,364,419 (GRCm38) E879G probably damaging Het
Sptbn4 A T 7: 27,366,735 (GRCm38) D649E possibly damaging Het
Stx5a C A 19: 8,743,361 (GRCm38) R121S probably damaging Het
Tbcd T C 11: 121,493,771 (GRCm38) L26P probably damaging Het
Tecpr1 T C 5: 144,207,437 (GRCm38) D649G probably benign Het
Tfam A G 10: 71,237,847 (GRCm38) S32P probably benign Het
Tmt1b G T 10: 128,960,702 (GRCm38) C79* probably null Het
Trmt44 C T 5: 35,558,043 (GRCm38) R642H probably benign Het
Trpm3 G A 19: 22,987,781 (GRCm38) A1547T probably benign Het
Ttll6 T C 11: 96,153,177 (GRCm38) V519A probably benign Het
Umodl1 T C 17: 30,998,114 (GRCm38) F1107L probably benign Het
Usp5 A T 6: 124,817,956 (GRCm38) V677E probably damaging Het
Utp20 A T 10: 88,807,445 (GRCm38) L605* probably null Het
Utrn T C 10: 12,745,240 (GRCm38) D229G probably damaging Het
Uty A T Y: 1,176,502 (GRCm38) L178* probably null Het
Vmn2r88 A T 14: 51,413,334 (GRCm38) D168V possibly damaging Het
Vps13b T C 15: 35,646,178 (GRCm38) V1476A probably damaging Het
Vps13b C T 15: 35,841,341 (GRCm38) H2506Y probably benign Het
Vps13b C A 15: 35,879,821 (GRCm38) T3014K probably benign Het
Vps37c T C 19: 10,712,768 (GRCm38) V198A probably benign Het
Zfc3h1 T C 10: 115,423,385 (GRCm38) Y1621H probably benign Het
Zfp251 T C 15: 76,854,407 (GRCm38) D162G possibly damaging Het
Zfp292 T C 4: 34,807,078 (GRCm38) T1994A probably benign Het
Zfp791 A G 8: 85,110,930 (GRCm38) Y102H probably benign Het
Other mutations in Secisbp2l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00421:Secisbp2l APN 2 125,743,856 (GRCm38) missense probably damaging 0.99
IGL00644:Secisbp2l APN 2 125,743,844 (GRCm38) missense probably damaging 1.00
IGL01093:Secisbp2l APN 2 125,740,325 (GRCm38) missense probably benign
IGL01621:Secisbp2l APN 2 125,773,211 (GRCm38) missense probably benign
IGL01955:Secisbp2l APN 2 125,743,812 (GRCm38) critical splice donor site probably null
IGL02036:Secisbp2l APN 2 125,758,207 (GRCm38) missense probably benign
IGL02045:Secisbp2l APN 2 125,775,578 (GRCm38) missense possibly damaging 0.82
IGL02182:Secisbp2l APN 2 125,747,577 (GRCm38) missense probably damaging 1.00
IGL02408:Secisbp2l APN 2 125,740,869 (GRCm38) nonsense probably null
IGL02455:Secisbp2l APN 2 125,773,478 (GRCm38) missense possibly damaging 0.89
IGL02953:Secisbp2l APN 2 125,760,274 (GRCm38) missense probably benign 0.36
Rift UTSW 2 125,768,193 (GRCm38) missense probably damaging 1.00
Seismic UTSW 2 125,745,909 (GRCm38) missense probably damaging 1.00
R0097:Secisbp2l UTSW 2 125,771,456 (GRCm38) missense probably damaging 0.96
R0097:Secisbp2l UTSW 2 125,771,456 (GRCm38) missense probably damaging 0.96
R1415:Secisbp2l UTSW 2 125,740,365 (GRCm38) missense probably benign 0.00
R1626:Secisbp2l UTSW 2 125,775,686 (GRCm38) missense probably damaging 0.99
R1926:Secisbp2l UTSW 2 125,740,677 (GRCm38) missense probably damaging 0.99
R1940:Secisbp2l UTSW 2 125,740,339 (GRCm38) missense probably damaging 1.00
R1970:Secisbp2l UTSW 2 125,747,510 (GRCm38) missense probably damaging 1.00
R2100:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R2240:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R2252:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R2253:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R2472:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R2474:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R2475:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R2990:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R2993:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R3113:Secisbp2l UTSW 2 125,750,286 (GRCm38) missense probably damaging 1.00
R3696:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R3749:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R3750:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R3800:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R3810:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R3812:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R3815:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R3816:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R3817:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R3880:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R4077:Secisbp2l UTSW 2 125,751,865 (GRCm38) splice site probably benign
R4096:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R4097:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R4164:Secisbp2l UTSW 2 125,751,883 (GRCm38) intron probably benign
R4332:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R4418:Secisbp2l UTSW 2 125,752,915 (GRCm38) missense probably benign 0.00
R4598:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R4600:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R4602:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R4603:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R4678:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R4679:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R4741:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R4749:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R4934:Secisbp2l UTSW 2 125,740,489 (GRCm38) missense probably damaging 0.99
R5245:Secisbp2l UTSW 2 125,747,591 (GRCm38) missense probably damaging 1.00
R5521:Secisbp2l UTSW 2 125,752,977 (GRCm38) missense possibly damaging 0.94
R5547:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R5630:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R5631:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R5632:Secisbp2l UTSW 2 125,740,737 (GRCm38) missense possibly damaging 0.66
R6039:Secisbp2l UTSW 2 125,773,216 (GRCm38) missense probably benign 0.28
R6039:Secisbp2l UTSW 2 125,773,216 (GRCm38) missense probably benign 0.28
R6378:Secisbp2l UTSW 2 125,768,325 (GRCm38) missense possibly damaging 0.78
R6616:Secisbp2l UTSW 2 125,768,226 (GRCm38) missense probably damaging 0.96
R6938:Secisbp2l UTSW 2 125,750,352 (GRCm38) missense probably damaging 1.00
R7287:Secisbp2l UTSW 2 125,740,369 (GRCm38) missense probably benign
R7373:Secisbp2l UTSW 2 125,757,271 (GRCm38) missense probably damaging 0.99
R7403:Secisbp2l UTSW 2 125,760,279 (GRCm38) missense possibly damaging 0.73
R7484:Secisbp2l UTSW 2 125,771,532 (GRCm38) nonsense probably null
R7504:Secisbp2l UTSW 2 125,758,171 (GRCm38) missense probably benign 0.30
R7762:Secisbp2l UTSW 2 125,768,193 (GRCm38) missense probably damaging 1.00
R7769:Secisbp2l UTSW 2 125,771,545 (GRCm38) critical splice acceptor site probably benign
R8018:Secisbp2l UTSW 2 125,745,909 (GRCm38) missense probably damaging 1.00
R8487:Secisbp2l UTSW 2 125,775,582 (GRCm38) nonsense probably null
R8784:Secisbp2l UTSW 2 125,760,343 (GRCm38) nonsense probably null
R8810:Secisbp2l UTSW 2 125,775,676 (GRCm38) missense possibly damaging 0.82
R8872:Secisbp2l UTSW 2 125,752,972 (GRCm38) missense probably benign
R9111:Secisbp2l UTSW 2 125,760,286 (GRCm38) missense probably benign
R9154:Secisbp2l UTSW 2 125,775,703 (GRCm38) missense probably damaging 1.00
R9155:Secisbp2l UTSW 2 125,775,703 (GRCm38) missense probably damaging 1.00
R9589:Secisbp2l UTSW 2 125,747,510 (GRCm38) missense probably damaging 1.00
R9589:Secisbp2l UTSW 2 125,747,505 (GRCm38) missense probably benign 0.03
R9592:Secisbp2l UTSW 2 125,740,641 (GRCm38) missense probably damaging 1.00
R9602:Secisbp2l UTSW 2 125,767,436 (GRCm38) missense probably benign 0.19
R9620:Secisbp2l UTSW 2 125,747,474 (GRCm38) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- TCACTAACTCACTCCTGGCATG -3'
(R):5'- TGCTTAGCCCTACAGAGAAAC -3'

Sequencing Primer
(F):5'- ACAGCTGTACATAACCTTGCTTGG -3'
(R):5'- CCCTACAGAGAAACTAAAGTACTGGG -3'
Posted On 2015-10-21