Incidental Mutation 'R0276:Siglec1'
| ID |
35355 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Siglec1
|
| Ensembl Gene |
ENSMUSG00000027322 |
| Gene Name |
sialic acid binding Ig-like lectin 1, sialoadhesin |
| Synonyms |
Sn, CD169, Siglec-1 |
| MMRRC Submission |
038498-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.076)
|
| Stock # |
R0276 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
130911140-130928685 bp(-) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
G to A
at 130925861 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamine to Stop codon
at position 282
(Q282*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105856
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028794]
[ENSMUST00000110226]
[ENSMUST00000110227]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000028794
AA Change: Q282*
|
| SMART Domains |
Protein: ENSMUSP00000028794
Gene: ENSMUSG00000027322
AA Change: Q282*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IG
|
32 |
142 |
2.92e-5 |
SMART |
|
Pfam:C2-set_2
|
148 |
235 |
9.4e-18 |
PFAM |
|
IGc2
|
260 |
319 |
8.78e-9 |
SMART |
|
IGc2
|
344 |
404 |
4.07e-4 |
SMART |
|
IGc2
|
431 |
505 |
3.3e-4 |
SMART |
|
IGc2
|
529 |
589 |
5.75e-4 |
SMART |
|
IGc2
|
622 |
698 |
3.54e-4 |
SMART |
|
low complexity region
|
700 |
705 |
N/A |
INTRINSIC |
|
IG
|
716 |
795 |
3.35e-5 |
SMART |
|
IG
|
804 |
896 |
6.51e-3 |
SMART |
|
IGc2
|
909 |
969 |
4.13e-5 |
SMART |
|
IG_like
|
1001 |
1076 |
6.78e-2 |
SMART |
|
low complexity region
|
1077 |
1088 |
N/A |
INTRINSIC |
|
IG
|
1094 |
1171 |
4.32e-8 |
SMART |
|
IG_like
|
1185 |
1250 |
1.94e-2 |
SMART |
|
IG
|
1268 |
1345 |
1.36e-5 |
SMART |
|
IG_like
|
1354 |
1447 |
1.45e1 |
SMART |
|
IG_like
|
1365 |
1435 |
4.51e-2 |
SMART |
|
IG
|
1454 |
1534 |
4.56e-7 |
SMART |
|
IG_like
|
1549 |
1624 |
1.21e-1 |
SMART |
|
transmembrane domain
|
1647 |
1669 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000110226
AA Change: Q282*
|
| SMART Domains |
Protein: ENSMUSP00000105855
Gene: ENSMUSG00000027322
AA Change: Q282*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IG
|
32 |
142 |
2.92e-5 |
SMART |
|
Pfam:C2-set_2
|
148 |
235 |
7.7e-18 |
PFAM |
|
IGc2
|
260 |
319 |
8.78e-9 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000110227
AA Change: Q282*
|
| SMART Domains |
Protein: ENSMUSP00000105856
Gene: ENSMUSG00000027322
AA Change: Q282*
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IG
|
32 |
142 |
2.92e-5 |
SMART |
|
Pfam:C2-set_2
|
148 |
235 |
7e-17 |
PFAM |
|
IGc2
|
260 |
319 |
8.78e-9 |
SMART |
|
IGc2
|
344 |
404 |
4.07e-4 |
SMART |
|
IGc2
|
431 |
505 |
3.3e-4 |
SMART |
|
IGc2
|
529 |
589 |
5.75e-4 |
SMART |
|
IGc2
|
622 |
698 |
3.54e-4 |
SMART |
|
low complexity region
|
700 |
705 |
N/A |
INTRINSIC |
|
IG
|
716 |
795 |
3.35e-5 |
SMART |
|
IG
|
804 |
896 |
6.51e-3 |
SMART |
|
IGc2
|
909 |
969 |
4.13e-5 |
SMART |
|
IG_like
|
1001 |
1076 |
6.78e-2 |
SMART |
|
low complexity region
|
1077 |
1088 |
N/A |
INTRINSIC |
|
IG
|
1094 |
1171 |
4.32e-8 |
SMART |
|
IG_like
|
1185 |
1250 |
1.94e-2 |
SMART |
|
IG
|
1268 |
1345 |
1.36e-5 |
SMART |
|
IG_like
|
1354 |
1447 |
1.45e1 |
SMART |
|
IG_like
|
1365 |
1435 |
4.51e-2 |
SMART |
|
IG
|
1454 |
1534 |
4.56e-7 |
SMART |
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 98.7%
- 3x: 97.8%
- 10x: 96.2%
- 20x: 93.8%
|
| Validation Efficiency |
98% (101/103) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a disruption in this gene display subtle changes in B- and T-cell populations and decreased IgM levels. Mice homozygous for a knock-out or knock-in allele exhibit impaired phagocytosis of sialylated C. jejuni. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 100 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts13 |
A |
G |
2: 26,865,772 (GRCm39) |
N109S |
possibly damaging |
Het |
| Adcy10 |
T |
A |
1: 165,400,160 (GRCm39) |
M1523K |
possibly damaging |
Het |
| Agtpbp1 |
C |
T |
13: 59,609,845 (GRCm39) |
S1095N |
possibly damaging |
Het |
| Ang2 |
C |
T |
14: 51,432,975 (GRCm39) |
V136I |
probably damaging |
Het |
| Arhgap10 |
A |
T |
8: 78,140,210 (GRCm39) |
M250K |
probably benign |
Het |
| Arhgap33 |
A |
T |
7: 30,222,669 (GRCm39) |
W1088R |
probably benign |
Het |
| Arhgef15 |
T |
C |
11: 68,844,298 (GRCm39) |
|
probably benign |
Het |
| Aspm |
T |
C |
1: 139,406,209 (GRCm39) |
S1699P |
possibly damaging |
Het |
| Atp12a |
C |
A |
14: 56,625,151 (GRCm39) |
D1014E |
probably damaging |
Het |
| Atp1a4 |
T |
A |
1: 172,085,468 (GRCm39) |
K45M |
probably damaging |
Het |
| Atp8a1 |
A |
T |
5: 67,944,016 (GRCm39) |
|
probably benign |
Het |
| Baiap3 |
A |
C |
17: 25,462,661 (GRCm39) |
F1099C |
probably damaging |
Het |
| Bcas3 |
T |
A |
11: 85,361,663 (GRCm39) |
|
probably null |
Het |
| Bms1 |
G |
A |
6: 118,385,095 (GRCm39) |
T371M |
possibly damaging |
Het |
| Camta1 |
C |
A |
4: 151,159,597 (GRCm39) |
R1614L |
probably damaging |
Het |
| Capn3 |
T |
C |
2: 120,318,546 (GRCm39) |
|
probably benign |
Het |
| Ccdc180 |
A |
G |
4: 45,923,534 (GRCm39) |
D1105G |
probably damaging |
Het |
| Ccdc33 |
G |
T |
9: 57,965,675 (GRCm39) |
P364Q |
probably damaging |
Het |
| Clstn3 |
A |
G |
6: 124,408,699 (GRCm39) |
|
probably benign |
Het |
| Cntrl |
A |
T |
2: 35,041,744 (GRCm39) |
Y619F |
possibly damaging |
Het |
| Col12a1 |
A |
T |
9: 79,538,023 (GRCm39) |
Y2514* |
probably null |
Het |
| Cpt1b |
T |
C |
15: 89,304,162 (GRCm39) |
H503R |
probably benign |
Het |
| Crb1 |
T |
A |
1: 139,251,073 (GRCm39) |
T293S |
possibly damaging |
Het |
| D130043K22Rik |
C |
T |
13: 25,042,028 (GRCm39) |
T319I |
possibly damaging |
Het |
| Dnaaf10 |
T |
C |
11: 17,179,821 (GRCm39) |
I274T |
probably benign |
Het |
| Dzip1l |
G |
A |
9: 99,543,051 (GRCm39) |
R502Q |
probably benign |
Het |
| Efcab5 |
A |
G |
11: 77,020,702 (GRCm39) |
M673T |
probably damaging |
Het |
| Efcab5 |
G |
A |
11: 77,031,749 (GRCm39) |
R42W |
probably damaging |
Het |
| F2rl3 |
A |
G |
8: 73,489,426 (GRCm39) |
T218A |
probably benign |
Het |
| Fam135a |
C |
T |
1: 24,107,045 (GRCm39) |
R31H |
probably damaging |
Het |
| Fcer2a |
A |
T |
8: 3,739,811 (GRCm39) |
N53K |
possibly damaging |
Het |
| Golgb1 |
A |
C |
16: 36,734,238 (GRCm39) |
K1162Q |
probably damaging |
Het |
| Gpr137b |
A |
T |
13: 13,542,160 (GRCm39) |
|
probably benign |
Het |
| Haspin |
A |
T |
11: 73,027,313 (GRCm39) |
L592Q |
probably damaging |
Het |
| Helq |
A |
G |
5: 100,938,013 (GRCm39) |
F478L |
probably damaging |
Het |
| Iho1 |
A |
T |
9: 108,305,639 (GRCm39) |
M11K |
possibly damaging |
Het |
| Il17rb |
T |
A |
14: 29,726,337 (GRCm39) |
T84S |
probably damaging |
Het |
| Itga4 |
T |
C |
2: 79,151,837 (GRCm39) |
L880P |
probably damaging |
Het |
| Itih5 |
A |
G |
2: 10,190,375 (GRCm39) |
I61V |
possibly damaging |
Het |
| Ivl |
G |
A |
3: 92,478,821 (GRCm39) |
L415F |
unknown |
Het |
| Kif2a |
A |
G |
13: 107,113,158 (GRCm39) |
|
probably benign |
Het |
| Kmt2d |
T |
C |
15: 98,748,192 (GRCm39) |
|
probably benign |
Het |
| Lars2 |
A |
G |
9: 123,267,186 (GRCm39) |
|
probably benign |
Het |
| Lilrb4a |
T |
C |
10: 51,367,677 (GRCm39) |
V73A |
probably benign |
Het |
| Lratd2 |
G |
T |
15: 60,695,523 (GRCm39) |
Y74* |
probably null |
Het |
| Lrrc8a |
A |
G |
2: 30,146,800 (GRCm39) |
D538G |
possibly damaging |
Het |
| Lrrk1 |
G |
A |
7: 65,946,011 (GRCm39) |
|
probably benign |
Het |
| Mc2r |
A |
T |
18: 68,541,203 (GRCm39) |
I30K |
possibly damaging |
Het |
| Mybbp1a |
C |
A |
11: 72,340,933 (GRCm39) |
|
probably null |
Het |
| Napg |
C |
T |
18: 63,120,034 (GRCm39) |
R149C |
probably damaging |
Het |
| Ncam2 |
A |
G |
16: 81,314,517 (GRCm39) |
|
probably benign |
Het |
| Nlk |
T |
C |
11: 78,462,301 (GRCm39) |
I509V |
probably benign |
Het |
| Nlrp2 |
A |
T |
7: 5,331,108 (GRCm39) |
N429K |
probably benign |
Het |
| Nlrp9b |
A |
G |
7: 19,762,423 (GRCm39) |
T247A |
probably benign |
Het |
| Noxo1 |
A |
T |
17: 24,919,136 (GRCm39) |
|
probably null |
Het |
| Or1n1b |
A |
T |
2: 36,780,035 (GRCm39) |
M275K |
probably benign |
Het |
| Or2ag2b |
A |
T |
7: 106,417,904 (GRCm39) |
I205L |
probably benign |
Het |
| Or3a10 |
A |
G |
11: 73,935,944 (GRCm39) |
I52T |
probably damaging |
Het |
| Or4c107 |
T |
A |
2: 88,789,099 (GRCm39) |
C96* |
probably null |
Het |
| Or4m1 |
C |
A |
14: 50,557,636 (GRCm39) |
A219S |
probably benign |
Het |
| Oxr1 |
T |
C |
15: 41,683,458 (GRCm39) |
S294P |
probably damaging |
Het |
| Pfpl |
A |
G |
19: 12,406,601 (GRCm39) |
Y284C |
probably damaging |
Het |
| Pi16 |
A |
T |
17: 29,545,917 (GRCm39) |
T232S |
probably benign |
Het |
| Plcxd2 |
A |
T |
16: 45,830,070 (GRCm39) |
N50K |
probably benign |
Het |
| Plekhn1 |
T |
A |
4: 156,312,703 (GRCm39) |
N52Y |
probably damaging |
Het |
| Prl2c5 |
T |
C |
13: 13,357,634 (GRCm39) |
|
probably benign |
Het |
| Prrc2b |
G |
A |
2: 32,109,666 (GRCm39) |
V1080I |
probably damaging |
Het |
| Psg28 |
A |
T |
7: 18,164,321 (GRCm39) |
N130K |
probably benign |
Het |
| Psme4 |
C |
A |
11: 30,761,980 (GRCm39) |
T440K |
probably damaging |
Het |
| Ptcd2 |
T |
C |
13: 99,458,104 (GRCm39) |
K296E |
probably benign |
Het |
| Ptprq |
T |
C |
10: 107,378,596 (GRCm39) |
|
probably null |
Het |
| Rab5b |
A |
C |
10: 128,522,615 (GRCm39) |
|
probably null |
Het |
| Rft1 |
T |
A |
14: 30,412,540 (GRCm39) |
S534T |
probably benign |
Het |
| Rif1 |
GCCACCA |
GCCA |
2: 52,000,336 (GRCm39) |
|
probably benign |
Het |
| Rsu1 |
A |
T |
2: 13,174,946 (GRCm39) |
|
probably benign |
Het |
| Senp6 |
A |
G |
9: 80,044,029 (GRCm39) |
M887V |
probably benign |
Het |
| Sgcz |
T |
A |
8: 38,420,073 (GRCm39) |
M60L |
probably benign |
Het |
| Sipa1l2 |
T |
C |
8: 126,148,679 (GRCm39) |
T1655A |
probably damaging |
Het |
| Slc28a2b |
T |
A |
2: 122,352,409 (GRCm39) |
S389T |
probably damaging |
Het |
| Slc43a3 |
G |
A |
2: 84,768,007 (GRCm39) |
|
probably benign |
Het |
| Snx29 |
T |
C |
16: 11,556,237 (GRCm39) |
V756A |
probably benign |
Het |
| Spta1 |
T |
A |
1: 174,045,460 (GRCm39) |
H1539Q |
probably damaging |
Het |
| Stk3 |
A |
C |
15: 35,099,615 (GRCm39) |
S104A |
probably damaging |
Het |
| Stk38 |
C |
A |
17: 29,211,390 (GRCm39) |
|
probably null |
Het |
| Stx6 |
T |
C |
1: 155,049,909 (GRCm39) |
|
probably benign |
Het |
| Thbs4 |
G |
A |
13: 92,912,040 (GRCm39) |
T230I |
probably benign |
Het |
| Thrsp |
A |
G |
7: 97,066,709 (GRCm39) |
M1T |
probably null |
Het |
| Tmem63b |
A |
T |
17: 45,986,299 (GRCm39) |
|
probably benign |
Het |
| Top2a |
A |
G |
11: 98,900,733 (GRCm39) |
|
probably benign |
Het |
| Tpd52l2 |
T |
C |
2: 181,143,852 (GRCm39) |
|
probably null |
Het |
| Trak1 |
A |
G |
9: 121,283,404 (GRCm39) |
E390G |
probably damaging |
Het |
| Trappc3 |
T |
A |
4: 126,167,745 (GRCm39) |
D101E |
possibly damaging |
Het |
| Trhr |
A |
G |
15: 44,060,482 (GRCm39) |
M1V |
probably null |
Het |
| Triobp |
T |
A |
15: 78,857,876 (GRCm39) |
I1159K |
probably benign |
Het |
| Unc45a |
A |
G |
7: 79,976,045 (GRCm39) |
|
probably benign |
Het |
| Usb1 |
A |
G |
8: 96,060,085 (GRCm39) |
D12G |
probably damaging |
Het |
| Ushbp1 |
C |
T |
8: 71,847,293 (GRCm39) |
C113Y |
possibly damaging |
Het |
| Vim |
A |
G |
2: 13,579,670 (GRCm39) |
K143R |
probably benign |
Het |
| Vmn2r75 |
T |
C |
7: 85,797,515 (GRCm39) |
K766R |
probably benign |
Het |
| Xpo5 |
T |
G |
17: 46,552,433 (GRCm39) |
C1089G |
probably damaging |
Het |
|
| Other mutations in Siglec1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00482:Siglec1
|
APN |
2 |
130,921,245 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01092:Siglec1
|
APN |
2 |
130,921,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01115:Siglec1
|
APN |
2 |
130,916,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01324:Siglec1
|
APN |
2 |
130,927,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01330:Siglec1
|
APN |
2 |
130,916,925 (GRCm39) |
nonsense |
probably null |
|
|
IGL01330:Siglec1
|
APN |
2 |
130,925,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01558:Siglec1
|
APN |
2 |
130,920,419 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01632:Siglec1
|
APN |
2 |
130,925,740 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01768:Siglec1
|
APN |
2 |
130,916,314 (GRCm39) |
missense |
probably benign |
|
|
IGL02399:Siglec1
|
APN |
2 |
130,913,098 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02558:Siglec1
|
APN |
2 |
130,916,915 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02794:Siglec1
|
APN |
2 |
130,917,889 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02839:Siglec1
|
APN |
2 |
130,926,852 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
aggressor
|
UTSW |
2 |
130,925,861 (GRCm39) |
nonsense |
probably null |
|
|
boris
|
UTSW |
2 |
130,921,297 (GRCm39) |
nonsense |
probably null |
|
|
espia
|
UTSW |
2 |
130,914,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
hoodlum
|
UTSW |
2 |
130,914,667 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
microfische
|
UTSW |
2 |
130,928,015 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
K3955:Siglec1
|
UTSW |
2 |
130,923,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
P0038:Siglec1
|
UTSW |
2 |
130,923,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4576001:Siglec1
|
UTSW |
2 |
130,920,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4677001:Siglec1
|
UTSW |
2 |
130,914,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0003:Siglec1
|
UTSW |
2 |
130,916,980 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0048:Siglec1
|
UTSW |
2 |
130,915,317 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0048:Siglec1
|
UTSW |
2 |
130,915,317 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0243:Siglec1
|
UTSW |
2 |
130,927,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0379:Siglec1
|
UTSW |
2 |
130,916,445 (GRCm39) |
splice site |
probably benign |
|
|
R0464:Siglec1
|
UTSW |
2 |
130,921,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0507:Siglec1
|
UTSW |
2 |
130,916,445 (GRCm39) |
splice site |
probably benign |
|
|
R0560:Siglec1
|
UTSW |
2 |
130,912,266 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0620:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0621:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0853:Siglec1
|
UTSW |
2 |
130,926,942 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1079:Siglec1
|
UTSW |
2 |
130,921,297 (GRCm39) |
nonsense |
probably null |
|
|
R1169:Siglec1
|
UTSW |
2 |
130,916,747 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1205:Siglec1
|
UTSW |
2 |
130,922,384 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1293:Siglec1
|
UTSW |
2 |
130,915,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1470:Siglec1
|
UTSW |
2 |
130,912,307 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1470:Siglec1
|
UTSW |
2 |
130,912,307 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1533:Siglec1
|
UTSW |
2 |
130,918,078 (GRCm39) |
missense |
probably benign |
|
|
R1717:Siglec1
|
UTSW |
2 |
130,925,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1717:Siglec1
|
UTSW |
2 |
130,915,876 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1744:Siglec1
|
UTSW |
2 |
130,923,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1852:Siglec1
|
UTSW |
2 |
130,923,420 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1941:Siglec1
|
UTSW |
2 |
130,920,051 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2011:Siglec1
|
UTSW |
2 |
130,925,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Siglec1
|
UTSW |
2 |
130,925,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2128:Siglec1
|
UTSW |
2 |
130,922,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2278:Siglec1
|
UTSW |
2 |
130,913,257 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2403:Siglec1
|
UTSW |
2 |
130,916,395 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2449:Siglec1
|
UTSW |
2 |
130,920,645 (GRCm39) |
missense |
probably benign |
0.44 |
|
R2885:Siglec1
|
UTSW |
2 |
130,914,667 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4213:Siglec1
|
UTSW |
2 |
130,916,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4274:Siglec1
|
UTSW |
2 |
130,927,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4679:Siglec1
|
UTSW |
2 |
130,915,331 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4715:Siglec1
|
UTSW |
2 |
130,916,356 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4782:Siglec1
|
UTSW |
2 |
130,917,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4896:Siglec1
|
UTSW |
2 |
130,911,789 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4993:Siglec1
|
UTSW |
2 |
130,915,281 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5004:Siglec1
|
UTSW |
2 |
130,915,331 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5004:Siglec1
|
UTSW |
2 |
130,911,789 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5105:Siglec1
|
UTSW |
2 |
130,922,320 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5137:Siglec1
|
UTSW |
2 |
130,923,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5153:Siglec1
|
UTSW |
2 |
130,927,497 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5311:Siglec1
|
UTSW |
2 |
130,921,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5600:Siglec1
|
UTSW |
2 |
130,927,503 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5682:Siglec1
|
UTSW |
2 |
130,925,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5732:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5870:Siglec1
|
UTSW |
2 |
130,914,767 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5898:Siglec1
|
UTSW |
2 |
130,915,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5909:Siglec1
|
UTSW |
2 |
130,919,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6488:Siglec1
|
UTSW |
2 |
130,923,227 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6920:Siglec1
|
UTSW |
2 |
130,919,997 (GRCm39) |
nonsense |
probably null |
|
|
R7064:Siglec1
|
UTSW |
2 |
130,925,834 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7270:Siglec1
|
UTSW |
2 |
130,923,471 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7355:Siglec1
|
UTSW |
2 |
130,922,371 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7400:Siglec1
|
UTSW |
2 |
130,928,015 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7470:Siglec1
|
UTSW |
2 |
130,917,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7568:Siglec1
|
UTSW |
2 |
130,914,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7781:Siglec1
|
UTSW |
2 |
130,923,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7853:Siglec1
|
UTSW |
2 |
130,923,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Siglec1
|
UTSW |
2 |
130,913,083 (GRCm39) |
missense |
probably benign |
0.28 |
|
R8191:Siglec1
|
UTSW |
2 |
130,927,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8274:Siglec1
|
UTSW |
2 |
130,925,830 (GRCm39) |
missense |
probably benign |
|
|
R8345:Siglec1
|
UTSW |
2 |
130,920,498 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8670:Siglec1
|
UTSW |
2 |
130,923,387 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8814:Siglec1
|
UTSW |
2 |
130,914,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9102:Siglec1
|
UTSW |
2 |
130,915,389 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9311:Siglec1
|
UTSW |
2 |
130,916,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9416:Siglec1
|
UTSW |
2 |
130,925,390 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9462:Siglec1
|
UTSW |
2 |
130,916,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9521:Siglec1
|
UTSW |
2 |
130,915,246 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9683:Siglec1
|
UTSW |
2 |
130,921,236 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9799:Siglec1
|
UTSW |
2 |
130,915,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0024:Siglec1
|
UTSW |
2 |
130,922,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Siglec1
|
UTSW |
2 |
130,922,444 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Z1176:Siglec1
|
UTSW |
2 |
130,920,665 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCTAGACAACCGCCATCGTCAATC -3'
(R):5'- AAGAAGTATGCCCAACGCCCTG -3'
Sequencing Primer
(F):5'- ATACCACCTGTGAGTGGATACTG -3'
(R):5'- GCCATCCACATGCACCTTC -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation