Incidental Mutation 'R4686:Arhgap21'
| ID |
353650 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgap21
|
| Ensembl Gene |
ENSMUSG00000036591 |
| Gene Name |
Rho GTPase activating protein 21 |
| Synonyms |
ARHGAP10, 5530401C11Rik |
| MMRRC Submission |
041937-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.570)
|
| Stock # |
R4686 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
20852730-20973692 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 20868033 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 830
(D830G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000133347
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000114594]
[ENSMUST00000141298]
[ENSMUST00000154230]
[ENSMUST00000173194]
[ENSMUST00000173784]
[ENSMUST00000174584]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000114594
AA Change: D995G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000110241
Gene: ENSMUSG00000036591
AA Change: D995G
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
58 |
159 |
1.03e-16 |
SMART |
|
low complexity region
|
351 |
362 |
N/A |
INTRINSIC |
|
low complexity region
|
445 |
459 |
N/A |
INTRINSIC |
|
low complexity region
|
625 |
635 |
N/A |
INTRINSIC |
|
low complexity region
|
911 |
925 |
N/A |
INTRINSIC |
|
PH
|
930 |
1040 |
2.09e-16 |
SMART |
|
RhoGAP
|
1157 |
1334 |
3.26e-62 |
SMART |
|
low complexity region
|
1381 |
1399 |
N/A |
INTRINSIC |
|
low complexity region
|
1448 |
1466 |
N/A |
INTRINSIC |
|
low complexity region
|
1533 |
1565 |
N/A |
INTRINSIC |
|
low complexity region
|
1573 |
1593 |
N/A |
INTRINSIC |
|
low complexity region
|
1891 |
1900 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127512
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000141298
AA Change: D1001G
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000120357
Gene: ENSMUSG00000036591
AA Change: D1001G
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
357 |
368 |
N/A |
INTRINSIC |
|
low complexity region
|
451 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
931 |
N/A |
INTRINSIC |
|
PH
|
936 |
1046 |
2.09e-16 |
SMART |
|
RhoGAP
|
1163 |
1340 |
3.26e-62 |
SMART |
|
low complexity region
|
1387 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1472 |
N/A |
INTRINSIC |
|
low complexity region
|
1539 |
1571 |
N/A |
INTRINSIC |
|
low complexity region
|
1579 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1897 |
1906 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000154230
AA Change: D1001G
PolyPhen 2
Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000122497
Gene: ENSMUSG00000036591
AA Change: D1001G
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
357 |
368 |
N/A |
INTRINSIC |
|
low complexity region
|
451 |
465 |
N/A |
INTRINSIC |
|
low complexity region
|
631 |
641 |
N/A |
INTRINSIC |
|
low complexity region
|
917 |
931 |
N/A |
INTRINSIC |
|
PH
|
936 |
1046 |
2.09e-16 |
SMART |
|
RhoGAP
|
1163 |
1340 |
3.26e-62 |
SMART |
|
low complexity region
|
1387 |
1405 |
N/A |
INTRINSIC |
|
low complexity region
|
1454 |
1472 |
N/A |
INTRINSIC |
|
low complexity region
|
1539 |
1571 |
N/A |
INTRINSIC |
|
low complexity region
|
1579 |
1599 |
N/A |
INTRINSIC |
|
low complexity region
|
1897 |
1906 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000154657
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000173194
AA Change: D991G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000133851
Gene: ENSMUSG00000036591
AA Change: D991G
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
64 |
165 |
1.03e-16 |
SMART |
|
low complexity region
|
347 |
358 |
N/A |
INTRINSIC |
|
low complexity region
|
441 |
455 |
N/A |
INTRINSIC |
|
low complexity region
|
621 |
631 |
N/A |
INTRINSIC |
|
low complexity region
|
907 |
921 |
N/A |
INTRINSIC |
|
PH
|
926 |
1036 |
2.09e-16 |
SMART |
|
RhoGAP
|
1153 |
1330 |
3.26e-62 |
SMART |
|
low complexity region
|
1377 |
1395 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1462 |
N/A |
INTRINSIC |
|
low complexity region
|
1529 |
1561 |
N/A |
INTRINSIC |
|
low complexity region
|
1569 |
1589 |
N/A |
INTRINSIC |
|
low complexity region
|
1887 |
1896 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000173784
AA Change: D105G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000133539
Gene: ENSMUSG00000036591
AA Change: D105G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
21 |
35 |
N/A |
INTRINSIC |
|
PH
|
40 |
150 |
2.09e-16 |
SMART |
|
RhoGAP
|
268 |
395 |
1.55e-22 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000174584
AA Change: D830G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000133347
Gene: ENSMUSG00000036591
AA Change: D830G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
186 |
197 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
294 |
N/A |
INTRINSIC |
|
low complexity region
|
460 |
470 |
N/A |
INTRINSIC |
|
low complexity region
|
746 |
760 |
N/A |
INTRINSIC |
|
PH
|
765 |
875 |
2.09e-16 |
SMART |
|
RhoGAP
|
992 |
1169 |
3.26e-62 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000174825
|
| Meta Mutation Damage Score |
0.5031 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 95.0%
|
| Validation Efficiency |
97% (68/70) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] ARHGAP21 functions preferentially as a GTPase-activating protein (GAP) for CDC42 (MIM 116952) and regulates the ARP2/3 complex (MIM 604221) and F-actin dynamics at the Golgi through control of CDC42 activity (Dubois et al., 2005 [PubMed 15793564]).[supplied by OMIM, Mar 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 64 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamtsl2 |
A |
G |
2: 26,983,837 (GRCm39) |
N411S |
probably damaging |
Het |
| Adnp |
A |
C |
2: 168,024,309 (GRCm39) |
C995W |
possibly damaging |
Het |
| Akap6 |
CA |
C |
12: 52,934,406 (GRCm39) |
|
probably null |
Het |
| Ano2 |
T |
G |
6: 125,767,254 (GRCm39) |
I228M |
probably benign |
Het |
| Atp13a2 |
G |
A |
4: 140,730,587 (GRCm39) |
|
probably null |
Het |
| Ccdc175 |
C |
T |
12: 72,159,052 (GRCm39) |
S629N |
probably damaging |
Het |
| Cdhr4 |
T |
C |
9: 107,872,883 (GRCm39) |
W311R |
probably benign |
Het |
| Chaf1b |
A |
G |
16: 93,681,472 (GRCm39) |
H30R |
probably benign |
Het |
| Clnk |
G |
A |
5: 38,899,180 (GRCm39) |
|
probably benign |
Het |
| Copb1 |
A |
G |
7: 113,820,971 (GRCm39) |
S773P |
possibly damaging |
Het |
| Cse1l |
A |
G |
2: 166,774,080 (GRCm39) |
D198G |
probably damaging |
Het |
| Ears2 |
A |
G |
7: 121,647,427 (GRCm39) |
S286P |
probably damaging |
Het |
| Efcab7 |
A |
G |
4: 99,735,318 (GRCm39) |
E114G |
probably benign |
Het |
| Fanca |
G |
C |
8: 123,995,673 (GRCm39) |
|
probably benign |
Het |
| Flt3 |
A |
G |
5: 147,313,858 (GRCm39) |
L64P |
probably damaging |
Het |
| Gabrb1 |
A |
G |
5: 71,857,365 (GRCm39) |
T3A |
possibly damaging |
Het |
| Gm10384 |
T |
C |
15: 36,871,897 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5117 |
G |
A |
8: 32,229,284 (GRCm39) |
|
noncoding transcript |
Het |
| Gpr141 |
T |
A |
13: 19,935,951 (GRCm39) |
I275F |
probably benign |
Het |
| Greb1l |
A |
T |
18: 10,522,112 (GRCm39) |
E736V |
probably damaging |
Het |
| Hc |
T |
C |
2: 34,929,260 (GRCm39) |
E279G |
possibly damaging |
Het |
| Hivep1 |
C |
T |
13: 42,309,326 (GRCm39) |
T522M |
probably benign |
Het |
| Hspa12a |
T |
A |
19: 58,788,181 (GRCm39) |
E547V |
possibly damaging |
Het |
| Il10ra |
A |
G |
9: 45,180,357 (GRCm39) |
L5S |
probably damaging |
Het |
| Iqcf6 |
G |
T |
9: 106,504,543 (GRCm39) |
W69L |
probably damaging |
Het |
| Iqgap2 |
T |
C |
13: 95,858,117 (GRCm39) |
N379S |
probably damaging |
Het |
| Itpr2 |
A |
G |
6: 146,131,273 (GRCm39) |
I1977T |
probably damaging |
Het |
| Kcnq1 |
A |
T |
7: 142,661,466 (GRCm39) |
Y124F |
probably benign |
Het |
| Lamp5 |
C |
T |
2: 135,900,923 (GRCm39) |
T41M |
probably damaging |
Het |
| Lgr5 |
A |
G |
10: 115,294,648 (GRCm39) |
|
probably benign |
Het |
| Mlec |
A |
G |
5: 115,288,355 (GRCm39) |
I167T |
possibly damaging |
Het |
| Myf6 |
A |
G |
10: 107,329,689 (GRCm39) |
V198A |
probably benign |
Het |
| Nceh1 |
C |
T |
3: 27,295,818 (GRCm39) |
R360C |
probably damaging |
Het |
| Nos2 |
C |
A |
11: 78,819,456 (GRCm39) |
T56N |
possibly damaging |
Het |
| Npw |
T |
G |
17: 24,876,386 (GRCm39) |
H175P |
probably benign |
Het |
| Nrxn3 |
A |
T |
12: 89,477,421 (GRCm39) |
I899F |
probably damaging |
Het |
| Ociad1 |
A |
G |
5: 73,464,078 (GRCm39) |
T179A |
possibly damaging |
Het |
| Or1e19 |
A |
G |
11: 73,316,264 (GRCm39) |
S182P |
probably benign |
Het |
| Or52b4 |
A |
G |
7: 102,184,356 (GRCm39) |
Y134C |
probably damaging |
Het |
| Or8b48 |
T |
A |
9: 38,493,327 (GRCm39) |
F251L |
probably damaging |
Het |
| Pacsin2 |
T |
C |
15: 83,265,976 (GRCm39) |
N74D |
probably benign |
Het |
| Pcdh7 |
A |
G |
5: 58,286,511 (GRCm39) |
I1196V |
probably benign |
Het |
| Pdxk |
A |
T |
10: 78,282,837 (GRCm39) |
|
probably null |
Het |
| Phb2 |
G |
A |
6: 124,690,105 (GRCm39) |
|
probably null |
Het |
| Pus7l |
T |
A |
15: 94,438,092 (GRCm39) |
N251I |
probably damaging |
Het |
| Rgs7bp |
T |
A |
13: 105,100,597 (GRCm39) |
N226I |
probably damaging |
Het |
| Runx2 |
T |
A |
17: 44,950,572 (GRCm39) |
D327V |
probably damaging |
Het |
| Srp68 |
A |
T |
11: 116,156,227 (GRCm39) |
C172S |
probably damaging |
Het |
| Stk25 |
A |
G |
1: 93,551,142 (GRCm39) |
|
probably null |
Het |
| Tbrg4 |
C |
T |
11: 6,568,468 (GRCm39) |
R437Q |
probably benign |
Het |
| Tedc2 |
C |
T |
17: 24,436,862 (GRCm39) |
|
probably null |
Het |
| Teddm1a |
T |
A |
1: 153,768,196 (GRCm39) |
I220N |
probably damaging |
Het |
| Thoc1 |
G |
T |
18: 9,970,312 (GRCm39) |
E221* |
probably null |
Het |
| Tmem132d |
G |
T |
5: 127,869,674 (GRCm39) |
D553E |
possibly damaging |
Het |
| Topors |
A |
T |
4: 40,261,694 (GRCm39) |
V530D |
probably benign |
Het |
| Tpx2 |
T |
C |
2: 152,731,103 (GRCm39) |
V515A |
possibly damaging |
Het |
| Trim24 |
A |
G |
6: 37,885,240 (GRCm39) |
H191R |
probably damaging |
Het |
| Ttn |
G |
A |
2: 76,567,914 (GRCm39) |
R27660W |
probably damaging |
Het |
| Vmn1r203 |
T |
C |
13: 22,708,528 (GRCm39) |
L103P |
probably damaging |
Het |
| Vmn1r233 |
C |
T |
17: 21,214,368 (GRCm39) |
S194N |
probably benign |
Het |
| Vmn2r108 |
T |
C |
17: 20,691,636 (GRCm39) |
K296E |
probably damaging |
Het |
| Vmn2r88 |
G |
A |
14: 51,650,796 (GRCm39) |
E170K |
probably benign |
Het |
| Zfp740 |
C |
T |
15: 102,117,184 (GRCm39) |
|
probably benign |
Het |
| Zmym5 |
A |
G |
14: 57,049,618 (GRCm39) |
|
probably benign |
Het |
|
| Other mutations in Arhgap21 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01382:Arhgap21
|
APN |
2 |
20,860,511 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01472:Arhgap21
|
APN |
2 |
20,854,392 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01634:Arhgap21
|
APN |
2 |
20,919,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01766:Arhgap21
|
APN |
2 |
20,854,448 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02097:Arhgap21
|
APN |
2 |
20,884,813 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL02197:Arhgap21
|
APN |
2 |
20,885,117 (GRCm39) |
missense |
probably benign |
|
|
IGL02264:Arhgap21
|
APN |
2 |
20,864,850 (GRCm39) |
splice site |
probably null |
|
|
IGL02346:Arhgap21
|
APN |
2 |
20,884,762 (GRCm39) |
splice site |
probably benign |
|
|
IGL02418:Arhgap21
|
APN |
2 |
20,885,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02605:Arhgap21
|
APN |
2 |
20,860,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02701:Arhgap21
|
APN |
2 |
20,896,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03019:Arhgap21
|
APN |
2 |
20,865,874 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03085:Arhgap21
|
APN |
2 |
20,919,532 (GRCm39) |
missense |
probably benign |
|
|
IGL03265:Arhgap21
|
APN |
2 |
20,854,439 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL03379:Arhgap21
|
APN |
2 |
20,885,500 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0304:Arhgap21
|
UTSW |
2 |
20,864,612 (GRCm39) |
splice site |
probably benign |
|
|
R0363:Arhgap21
|
UTSW |
2 |
20,885,944 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0498:Arhgap21
|
UTSW |
2 |
20,867,928 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0539:Arhgap21
|
UTSW |
2 |
20,919,610 (GRCm39) |
nonsense |
probably null |
|
|
R0633:Arhgap21
|
UTSW |
2 |
20,860,198 (GRCm39) |
nonsense |
probably null |
|
|
R0905:Arhgap21
|
UTSW |
2 |
20,854,745 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1550:Arhgap21
|
UTSW |
2 |
20,886,576 (GRCm39) |
nonsense |
probably null |
|
|
R1570:Arhgap21
|
UTSW |
2 |
20,885,651 (GRCm39) |
missense |
probably benign |
|
|
R1686:Arhgap21
|
UTSW |
2 |
20,886,659 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1746:Arhgap21
|
UTSW |
2 |
20,865,910 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1864:Arhgap21
|
UTSW |
2 |
20,866,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1865:Arhgap21
|
UTSW |
2 |
20,866,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2209:Arhgap21
|
UTSW |
2 |
20,854,331 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2211:Arhgap21
|
UTSW |
2 |
20,886,451 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2276:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2277:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2279:Arhgap21
|
UTSW |
2 |
20,868,037 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2336:Arhgap21
|
UTSW |
2 |
20,884,862 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2516:Arhgap21
|
UTSW |
2 |
20,859,809 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3722:Arhgap21
|
UTSW |
2 |
20,855,102 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3877:Arhgap21
|
UTSW |
2 |
20,864,717 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4017:Arhgap21
|
UTSW |
2 |
20,896,915 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4232:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4233:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4234:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4235:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4236:Arhgap21
|
UTSW |
2 |
20,891,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4434:Arhgap21
|
UTSW |
2 |
20,972,146 (GRCm39) |
missense |
probably benign |
|
|
R4817:Arhgap21
|
UTSW |
2 |
20,854,967 (GRCm39) |
missense |
probably benign |
|
|
R4834:Arhgap21
|
UTSW |
2 |
20,870,130 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4845:Arhgap21
|
UTSW |
2 |
20,885,998 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4889:Arhgap21
|
UTSW |
2 |
20,885,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R4904:Arhgap21
|
UTSW |
2 |
20,854,872 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4911:Arhgap21
|
UTSW |
2 |
20,863,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4994:Arhgap21
|
UTSW |
2 |
20,854,701 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5067:Arhgap21
|
UTSW |
2 |
20,884,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5086:Arhgap21
|
UTSW |
2 |
20,853,645 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5281:Arhgap21
|
UTSW |
2 |
20,854,127 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5364:Arhgap21
|
UTSW |
2 |
20,854,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5420:Arhgap21
|
UTSW |
2 |
20,885,897 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5476:Arhgap21
|
UTSW |
2 |
20,885,497 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5831:Arhgap21
|
UTSW |
2 |
20,868,024 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5949:Arhgap21
|
UTSW |
2 |
20,853,852 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5994:Arhgap21
|
UTSW |
2 |
20,886,187 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R6014:Arhgap21
|
UTSW |
2 |
20,886,616 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6739:Arhgap21
|
UTSW |
2 |
20,885,543 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R6817:Arhgap21
|
UTSW |
2 |
20,885,107 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6821:Arhgap21
|
UTSW |
2 |
20,853,659 (GRCm39) |
missense |
probably benign |
|
|
R6844:Arhgap21
|
UTSW |
2 |
20,886,116 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6870:Arhgap21
|
UTSW |
2 |
20,885,321 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6891:Arhgap21
|
UTSW |
2 |
20,855,142 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7011:Arhgap21
|
UTSW |
2 |
20,853,689 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7144:Arhgap21
|
UTSW |
2 |
20,870,198 (GRCm39) |
missense |
probably benign |
|
|
R7237:Arhgap21
|
UTSW |
2 |
20,854,783 (GRCm39) |
nonsense |
probably null |
|
|
R7261:Arhgap21
|
UTSW |
2 |
20,885,177 (GRCm39) |
missense |
probably benign |
|
|
R7558:Arhgap21
|
UTSW |
2 |
20,860,421 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7566:Arhgap21
|
UTSW |
2 |
20,917,102 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7738:Arhgap21
|
UTSW |
2 |
20,855,169 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7738:Arhgap21
|
UTSW |
2 |
20,854,290 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7820:Arhgap21
|
UTSW |
2 |
20,867,983 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7822:Arhgap21
|
UTSW |
2 |
20,885,524 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R7965:Arhgap21
|
UTSW |
2 |
20,854,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7986:Arhgap21
|
UTSW |
2 |
20,867,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8028:Arhgap21
|
UTSW |
2 |
20,885,216 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8209:Arhgap21
|
UTSW |
2 |
20,876,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8226:Arhgap21
|
UTSW |
2 |
20,876,556 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8251:Arhgap21
|
UTSW |
2 |
20,854,221 (GRCm39) |
missense |
probably benign |
|
|
R8486:Arhgap21
|
UTSW |
2 |
20,865,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8487:Arhgap21
|
UTSW |
2 |
20,886,116 (GRCm39) |
missense |
probably benign |
0.08 |
|
R8508:Arhgap21
|
UTSW |
2 |
20,858,991 (GRCm39) |
missense |
probably benign |
0.17 |
|
R8835:Arhgap21
|
UTSW |
2 |
20,972,144 (GRCm39) |
nonsense |
probably null |
|
|
R9140:Arhgap21
|
UTSW |
2 |
20,886,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9190:Arhgap21
|
UTSW |
2 |
20,858,983 (GRCm39) |
missense |
probably null |
0.04 |
|
R9204:Arhgap21
|
UTSW |
2 |
20,885,816 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9227:Arhgap21
|
UTSW |
2 |
20,860,469 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9230:Arhgap21
|
UTSW |
2 |
20,860,469 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9308:Arhgap21
|
UTSW |
2 |
20,854,061 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9374:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9449:Arhgap21
|
UTSW |
2 |
20,885,464 (GRCm39) |
missense |
probably benign |
|
|
R9454:Arhgap21
|
UTSW |
2 |
20,870,153 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9499:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9544:Arhgap21
|
UTSW |
2 |
20,858,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9552:Arhgap21
|
UTSW |
2 |
20,886,397 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9567:Arhgap21
|
UTSW |
2 |
20,896,953 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9588:Arhgap21
|
UTSW |
2 |
20,858,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9749:Arhgap21
|
UTSW |
2 |
20,854,026 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1191:Arhgap21
|
UTSW |
2 |
20,886,283 (GRCm39) |
missense |
probably benign |
0.30 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCAATGCTTTTAGTCAGCCTAG -3'
(R):5'- TATTGCATATTGACGAACATGGACC -3'
Sequencing Primer
(F):5'- CTGTGAGAATACCAAGTTTCGCC -3'
(R):5'- TTGACGAACATGGACCAATTATG -3'
|
| Posted On |
2015-10-21 |
Incidental Mutation