Incidental Mutation 'R4687:Zfp735'
| ID |
353777 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp735
|
| Ensembl Gene |
ENSMUSG00000060630 |
| Gene Name |
zinc finger protein 735 |
| Synonyms |
1700012C15Rik |
| MMRRC Submission |
041938-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.069)
|
| Stock # |
R4687 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
11 |
| Chromosomal Location |
73579604-73604624 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 73602681 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Tyrosine
at position 542
(N542Y)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000079269
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000080407]
|
| AlphaFold |
B1ARH2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000080407
AA Change: N542Y
PolyPhen 2
Score 0.979 (Sensitivity: 0.75; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000079269
Gene: ENSMUSG00000060630
AA Change: N542Y
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
8 |
68 |
2.2e-34 |
SMART |
|
ZnF_C2H2
|
483 |
505 |
4.38e1 |
SMART |
|
ZnF_C2H2
|
511 |
533 |
2.67e-1 |
SMART |
|
ZnF_C2H2
|
539 |
561 |
1.81e1 |
SMART |
|
ZnF_C2H2
|
567 |
589 |
1.5e-4 |
SMART |
|
ZnF_C2H2
|
595 |
617 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
623 |
645 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
651 |
673 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
679 |
701 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
707 |
729 |
4.87e-4 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145996
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000149560
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.1%
- 20x: 94.8%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 81 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010I14Rik |
T |
A |
17: 9,210,985 (GRCm39) |
Y45N |
probably damaging |
Het |
| Agbl3 |
T |
C |
6: 34,775,261 (GRCm39) |
V189A |
probably damaging |
Het |
| Akip1 |
C |
A |
7: 109,304,193 (GRCm39) |
S90* |
probably null |
Het |
| Amn |
A |
T |
12: 111,242,502 (GRCm39) |
D439V |
probably benign |
Het |
| Arhgap17 |
T |
A |
7: 122,920,826 (GRCm39) |
D149V |
probably damaging |
Het |
| Atp6v0a4 |
A |
T |
6: 38,069,400 (GRCm39) |
I76N |
possibly damaging |
Het |
| Atp6v1h |
A |
T |
1: 5,203,308 (GRCm39) |
N291I |
probably damaging |
Het |
| Baiap2l2 |
G |
T |
15: 79,143,453 (GRCm39) |
P462T |
probably damaging |
Het |
| Bves |
C |
T |
10: 45,230,936 (GRCm39) |
|
probably null |
Het |
| Cabp7 |
T |
A |
11: 4,689,265 (GRCm39) |
K127* |
probably null |
Het |
| Cacna1h |
A |
G |
17: 25,612,884 (GRCm39) |
V313A |
possibly damaging |
Het |
| Camkk2 |
T |
C |
5: 122,891,787 (GRCm39) |
H245R |
probably damaging |
Het |
| Celsr1 |
T |
A |
15: 85,816,661 (GRCm39) |
S1761C |
possibly damaging |
Het |
| Cfap46 |
T |
C |
7: 139,207,372 (GRCm39) |
E1849G |
possibly damaging |
Het |
| Ciz1 |
T |
C |
2: 32,257,477 (GRCm39) |
L174P |
probably damaging |
Het |
| Crim1 |
G |
T |
17: 78,610,454 (GRCm39) |
C303F |
probably damaging |
Het |
| Cyp26c1 |
A |
G |
19: 37,681,385 (GRCm39) |
Q396R |
probably damaging |
Het |
| Dnajc7 |
G |
A |
11: 100,490,126 (GRCm39) |
P43L |
probably damaging |
Het |
| Dpf2 |
T |
C |
19: 5,957,040 (GRCm39) |
H16R |
probably damaging |
Het |
| Dsp |
A |
G |
13: 38,375,595 (GRCm39) |
T1127A |
probably damaging |
Het |
| Dst |
T |
C |
1: 34,240,204 (GRCm39) |
L1525P |
probably damaging |
Het |
| Ehf |
T |
A |
2: 103,097,471 (GRCm39) |
D192V |
probably damaging |
Het |
| Frem1 |
G |
T |
4: 82,938,868 (GRCm39) |
N71K |
probably damaging |
Het |
| Furin |
T |
A |
7: 80,043,195 (GRCm39) |
T339S |
probably benign |
Het |
| Gad1 |
T |
A |
2: 70,431,064 (GRCm39) |
I569N |
possibly damaging |
Het |
| Gfi1 |
T |
C |
5: 107,871,676 (GRCm39) |
K10R |
probably damaging |
Het |
| Gm20775 |
T |
A |
Y: 10,641,258 (GRCm39) |
|
noncoding transcript |
Homo |
| Gpn3 |
A |
C |
5: 122,516,638 (GRCm39) |
D89A |
possibly damaging |
Het |
| Gpr18 |
T |
A |
14: 122,149,090 (GRCm39) |
R312* |
probably null |
Het |
| Gsap |
T |
C |
5: 21,451,969 (GRCm39) |
|
probably benign |
Het |
| H2-Ab1 |
C |
A |
17: 34,483,783 (GRCm39) |
T48K |
probably damaging |
Het |
| Hmcn2 |
A |
T |
2: 31,328,297 (GRCm39) |
N4326I |
probably benign |
Het |
| Igkv4-51 |
A |
C |
6: 69,658,714 (GRCm39) |
|
probably benign |
Het |
| Insr |
T |
C |
8: 3,211,709 (GRCm39) |
H1104R |
probably benign |
Het |
| Ipo13 |
A |
T |
4: 117,758,773 (GRCm39) |
N697K |
probably benign |
Het |
| Iqcm |
T |
G |
8: 76,489,617 (GRCm39) |
F362V |
probably damaging |
Het |
| Irak4 |
T |
C |
15: 94,464,704 (GRCm39) |
S425P |
probably damaging |
Het |
| Jakmip2 |
T |
C |
18: 43,710,477 (GRCm39) |
E242G |
possibly damaging |
Het |
| Kdm4a |
T |
C |
4: 118,001,280 (GRCm39) |
K829R |
probably damaging |
Het |
| Kdr |
T |
C |
5: 76,129,452 (GRCm39) |
N145S |
possibly damaging |
Het |
| Klra9 |
A |
T |
6: 130,162,480 (GRCm39) |
D185E |
probably benign |
Het |
| Lcn12 |
T |
C |
2: 25,383,333 (GRCm39) |
N15S |
probably benign |
Het |
| Mei4 |
T |
A |
9: 81,809,370 (GRCm39) |
M151K |
probably damaging |
Het |
| Mmp3 |
T |
A |
9: 7,451,223 (GRCm39) |
S320T |
probably benign |
Het |
| Mrps5 |
C |
G |
2: 127,432,690 (GRCm39) |
A37G |
probably benign |
Het |
| Mttp |
A |
G |
3: 137,798,496 (GRCm39) |
I800T |
possibly damaging |
Het |
| Nags |
A |
T |
11: 102,039,022 (GRCm39) |
Q451L |
probably damaging |
Het |
| Nbea |
T |
C |
3: 55,965,486 (GRCm39) |
T476A |
probably damaging |
Het |
| Ndufb10 |
T |
C |
17: 24,941,393 (GRCm39) |
E145G |
possibly damaging |
Het |
| Neb |
T |
G |
2: 52,194,047 (GRCm39) |
S660R |
possibly damaging |
Het |
| Nppb |
A |
G |
4: 148,070,753 (GRCm39) |
K43E |
probably benign |
Het |
| Nup188 |
A |
T |
2: 30,220,645 (GRCm39) |
Q906L |
probably benign |
Het |
| Or10k2 |
T |
A |
8: 84,268,489 (GRCm39) |
S239T |
probably damaging |
Het |
| Or4c12 |
T |
C |
2: 89,774,213 (GRCm39) |
D82G |
probably damaging |
Het |
| Or8c17 |
C |
A |
9: 38,180,710 (GRCm39) |
N292K |
probably damaging |
Het |
| Or9s23 |
T |
C |
1: 92,501,052 (GRCm39) |
I53T |
possibly damaging |
Het |
| Ovch2 |
T |
A |
7: 107,395,755 (GRCm39) |
I88F |
possibly damaging |
Het |
| Palm3 |
A |
G |
8: 84,756,564 (GRCm39) |
E692G |
probably benign |
Het |
| Pcsk6 |
T |
C |
7: 65,633,501 (GRCm39) |
F578L |
probably damaging |
Het |
| Piezo2 |
A |
C |
18: 63,203,034 (GRCm39) |
D1535E |
probably damaging |
Het |
| Ppp1r15b |
T |
C |
1: 133,059,873 (GRCm39) |
V130A |
probably benign |
Het |
| Proca1 |
T |
C |
11: 78,095,724 (GRCm39) |
Y32H |
probably damaging |
Het |
| Prtg |
T |
A |
9: 72,798,080 (GRCm39) |
V682E |
probably damaging |
Het |
| Pyroxd1 |
A |
T |
6: 142,307,594 (GRCm39) |
M455L |
probably benign |
Het |
| Rasa1 |
T |
C |
13: 85,374,754 (GRCm39) |
D739G |
possibly damaging |
Het |
| Scn3a |
T |
C |
2: 65,295,074 (GRCm39) |
I1550V |
possibly damaging |
Het |
| Sepsecs |
T |
C |
5: 52,801,213 (GRCm39) |
D483G |
probably benign |
Het |
| Setd7 |
T |
C |
3: 51,457,776 (GRCm39) |
D17G |
probably damaging |
Het |
| Sipa1l2 |
C |
T |
8: 126,217,984 (GRCm39) |
C451Y |
probably damaging |
Het |
| Slc31a1 |
A |
G |
4: 62,306,939 (GRCm39) |
Y165C |
probably damaging |
Het |
| Smg5 |
T |
C |
3: 88,249,776 (GRCm39) |
F68L |
possibly damaging |
Het |
| Sptbn5 |
A |
G |
2: 119,907,689 (GRCm39) |
|
probably benign |
Het |
| Stk3 |
A |
G |
15: 35,114,711 (GRCm39) |
I65T |
probably damaging |
Het |
| Tas2r115 |
C |
T |
6: 132,714,247 (GRCm39) |
A235T |
possibly damaging |
Het |
| Tenm2 |
C |
T |
11: 35,939,924 (GRCm39) |
A1400T |
probably benign |
Het |
| Tet1 |
T |
A |
10: 62,674,570 (GRCm39) |
N1169Y |
probably benign |
Het |
| Treml2 |
T |
A |
17: 48,616,425 (GRCm39) |
|
probably null |
Het |
| Tspan11 |
A |
G |
6: 127,915,198 (GRCm39) |
E104G |
probably damaging |
Het |
| Wdtc1 |
G |
A |
4: 133,023,742 (GRCm39) |
A543V |
probably damaging |
Het |
| Zfp148 |
T |
A |
16: 33,317,189 (GRCm39) |
D578E |
probably damaging |
Het |
| Zfp869 |
T |
A |
8: 70,160,793 (GRCm39) |
E65D |
probably benign |
Het |
|
| Other mutations in Zfp735 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00492:Zfp735
|
APN |
11 |
73,602,192 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL00798:Zfp735
|
APN |
11 |
73,602,386 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL01642:Zfp735
|
APN |
11 |
73,601,305 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL01684:Zfp735
|
APN |
11 |
73,581,191 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02096:Zfp735
|
APN |
11 |
73,602,254 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02238:Zfp735
|
APN |
11 |
73,601,319 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02505:Zfp735
|
APN |
11 |
73,580,626 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02740:Zfp735
|
APN |
11 |
73,601,412 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02957:Zfp735
|
APN |
11 |
73,601,755 (GRCm39) |
missense |
probably benign |
0.00 |
|
bananaquit
|
UTSW |
11 |
73,601,412 (GRCm39) |
nonsense |
probably null |
|
|
bescher
|
UTSW |
11 |
73,602,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
Galvanic
|
UTSW |
11 |
73,602,504 (GRCm39) |
nonsense |
probably null |
|
|
grassquit
|
UTSW |
11 |
73,603,029 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R0114:Zfp735
|
UTSW |
11 |
73,601,488 (GRCm39) |
missense |
probably benign |
0.33 |
|
R0217:Zfp735
|
UTSW |
11 |
73,602,112 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0943:Zfp735
|
UTSW |
11 |
73,602,909 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1421:Zfp735
|
UTSW |
11 |
73,601,523 (GRCm39) |
missense |
probably benign |
|
|
R1460:Zfp735
|
UTSW |
11 |
73,603,159 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1493:Zfp735
|
UTSW |
11 |
73,601,305 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1517:Zfp735
|
UTSW |
11 |
73,601,470 (GRCm39) |
missense |
probably benign |
|
|
R1676:Zfp735
|
UTSW |
11 |
73,602,301 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1709:Zfp735
|
UTSW |
11 |
73,602,589 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1871:Zfp735
|
UTSW |
11 |
73,601,412 (GRCm39) |
nonsense |
probably null |
|
|
R1931:Zfp735
|
UTSW |
11 |
73,602,677 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R2219:Zfp735
|
UTSW |
11 |
73,601,851 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R2227:Zfp735
|
UTSW |
11 |
73,602,223 (GRCm39) |
nonsense |
probably null |
|
|
R2227:Zfp735
|
UTSW |
11 |
73,602,222 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R3552:Zfp735
|
UTSW |
11 |
73,602,067 (GRCm39) |
nonsense |
probably null |
|
|
R3856:Zfp735
|
UTSW |
11 |
73,602,282 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3925:Zfp735
|
UTSW |
11 |
73,601,950 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4572:Zfp735
|
UTSW |
11 |
73,580,611 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4585:Zfp735
|
UTSW |
11 |
73,580,550 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4586:Zfp735
|
UTSW |
11 |
73,580,550 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4619:Zfp735
|
UTSW |
11 |
73,602,031 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4687:Zfp735
|
UTSW |
11 |
73,602,682 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5435:Zfp735
|
UTSW |
11 |
73,602,939 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R5489:Zfp735
|
UTSW |
11 |
73,601,419 (GRCm39) |
nonsense |
probably null |
|
|
R5516:Zfp735
|
UTSW |
11 |
73,601,640 (GRCm39) |
missense |
probably benign |
|
|
R5654:Zfp735
|
UTSW |
11 |
73,602,964 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R5990:Zfp735
|
UTSW |
11 |
73,581,174 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R6332:Zfp735
|
UTSW |
11 |
73,602,504 (GRCm39) |
nonsense |
probably null |
|
|
R6427:Zfp735
|
UTSW |
11 |
73,581,140 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R6460:Zfp735
|
UTSW |
11 |
73,602,478 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6820:Zfp735
|
UTSW |
11 |
73,579,783 (GRCm39) |
start codon destroyed |
probably null |
0.01 |
|
R6831:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6833:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6834:Zfp735
|
UTSW |
11 |
73,601,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6897:Zfp735
|
UTSW |
11 |
73,601,880 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6941:Zfp735
|
UTSW |
11 |
73,581,159 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7335:Zfp735
|
UTSW |
11 |
73,602,379 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R7366:Zfp735
|
UTSW |
11 |
73,602,979 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7474:Zfp735
|
UTSW |
11 |
73,602,002 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R7487:Zfp735
|
UTSW |
11 |
73,581,154 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7583:Zfp735
|
UTSW |
11 |
73,601,933 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7866:Zfp735
|
UTSW |
11 |
73,601,629 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8005:Zfp735
|
UTSW |
11 |
73,603,140 (GRCm39) |
nonsense |
probably null |
|
|
R8500:Zfp735
|
UTSW |
11 |
73,601,811 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8551:Zfp735
|
UTSW |
11 |
73,603,122 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8754:Zfp735
|
UTSW |
11 |
73,603,000 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8769:Zfp735
|
UTSW |
11 |
73,581,127 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8794:Zfp735
|
UTSW |
11 |
73,603,029 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R8835:Zfp735
|
UTSW |
11 |
73,601,692 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8869:Zfp735
|
UTSW |
11 |
73,602,510 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8969:Zfp735
|
UTSW |
11 |
73,602,699 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9072:Zfp735
|
UTSW |
11 |
73,603,060 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9073:Zfp735
|
UTSW |
11 |
73,603,060 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9193:Zfp735
|
UTSW |
11 |
73,580,600 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9355:Zfp735
|
UTSW |
11 |
73,602,362 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9414:Zfp735
|
UTSW |
11 |
73,602,023 (GRCm39) |
nonsense |
probably null |
|
|
R9456:Zfp735
|
UTSW |
11 |
73,602,403 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9573:Zfp735
|
UTSW |
11 |
73,602,936 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9647:Zfp735
|
UTSW |
11 |
73,580,600 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9710:Zfp735
|
UTSW |
11 |
73,601,806 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
Z1176:Zfp735
|
UTSW |
11 |
73,601,641 (GRCm39) |
missense |
probably benign |
0.02 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGAAATCATGTATGCAATGTGGC -3'
(R):5'- AATCATGTAAATGATTCCCCATGC -3'
Sequencing Primer
(F):5'- CAAGTGCTTTGCTCAGTACTCAG -3'
(R):5'- AGGACTGTGTGAATGATTTCCCAC -3'
|
| Posted On |
2015-10-21 |
Incidental Mutation