Incidental Mutation 'R4688:Lrrc7'
| ID |
353830 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrrc7
|
| Ensembl Gene |
ENSMUSG00000028176 |
| Gene Name |
leucine rich repeat containing 7 |
| Synonyms |
densin |
| MMRRC Submission |
041939-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.798)
|
| Stock # |
R4688 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
3 |
| Chromosomal Location |
157788528-158267858 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 157854242 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Alanine
at position 1322
(V1322A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000142498
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000106044]
[ENSMUST00000199890]
[ENSMUST00000200137]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000106044
AA Change: V1369A
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000101659
Gene: ENSMUSG00000028176
AA Change: V1369A
| Domain | Start | End | E-Value | Type |
|---|
|
LRR
|
53 |
73 |
3.65e0 |
SMART |
|
LRR
|
96 |
118 |
2.2e1 |
SMART |
|
LRR
|
142 |
164 |
4.21e1 |
SMART |
|
LRR
|
165 |
187 |
7.36e0 |
SMART |
|
LRR
|
188 |
210 |
7.05e-1 |
SMART |
|
LRR
|
211 |
233 |
3.09e1 |
SMART |
|
LRR
|
234 |
257 |
4.21e1 |
SMART |
|
LRR
|
258 |
279 |
2.61e2 |
SMART |
|
LRR
|
280 |
303 |
3.52e-1 |
SMART |
|
LRR
|
326 |
349 |
1.99e0 |
SMART |
|
LRR
|
372 |
394 |
2.63e0 |
SMART |
|
low complexity region
|
466 |
476 |
N/A |
INTRINSIC |
|
low complexity region
|
692 |
705 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
708 |
736 |
1e-5 |
BLAST |
|
low complexity region
|
787 |
797 |
N/A |
INTRINSIC |
|
low complexity region
|
864 |
878 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
1349 |
1378 |
2e-11 |
BLAST |
|
PDZ
|
1460 |
1540 |
1.33e-19 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000199890
|
| SMART Domains |
Protein: ENSMUSP00000142440
Gene: ENSMUSG00000028176
| Domain | Start | End | E-Value | Type |
|---|
|
LRR
|
53 |
73 |
3.65e0 |
SMART |
|
LRR
|
96 |
118 |
2.2e1 |
SMART |
|
LRR
|
142 |
164 |
4.21e1 |
SMART |
|
LRR
|
165 |
187 |
7.36e0 |
SMART |
|
LRR
|
188 |
210 |
7.05e-1 |
SMART |
|
LRR
|
211 |
233 |
3.09e1 |
SMART |
|
LRR
|
234 |
257 |
4.21e1 |
SMART |
|
LRR
|
258 |
279 |
2.61e2 |
SMART |
|
LRR
|
280 |
303 |
3.52e-1 |
SMART |
|
LRR
|
326 |
349 |
1.99e0 |
SMART |
|
LRR
|
372 |
394 |
2.63e0 |
SMART |
|
low complexity region
|
466 |
476 |
N/A |
INTRINSIC |
|
low complexity region
|
692 |
705 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
708 |
736 |
9e-6 |
BLAST |
|
low complexity region
|
787 |
797 |
N/A |
INTRINSIC |
|
low complexity region
|
864 |
878 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
1328 |
1364 |
1e-15 |
BLAST |
|
low complexity region
|
1374 |
1387 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000200137
AA Change: V1322A
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000142498
Gene: ENSMUSG00000028176
AA Change: V1322A
| Domain | Start | End | E-Value | Type |
|---|
|
LRR
|
52 |
69 |
7.6e-1 |
SMART |
|
LRR
|
73 |
92 |
4.2e-1 |
SMART |
|
LRR
|
96 |
115 |
3.4e-1 |
SMART |
|
LRR
|
142 |
164 |
1.8e-1 |
SMART |
|
LRR
|
165 |
184 |
1.5e-1 |
SMART |
|
LRR
|
188 |
207 |
2e-2 |
SMART |
|
LRR
|
211 |
233 |
1.3e-1 |
SMART |
|
LRR
|
234 |
257 |
1.7e-1 |
SMART |
|
LRR
|
257 |
276 |
1e0 |
SMART |
|
LRR
|
280 |
299 |
3.1e-2 |
SMART |
|
LRR
|
303 |
322 |
6.6e-1 |
SMART |
|
LRR
|
326 |
345 |
2.1e-1 |
SMART |
|
LRR
|
372 |
391 |
1.2e-1 |
SMART |
|
low complexity region
|
466 |
476 |
N/A |
INTRINSIC |
|
low complexity region
|
692 |
705 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
708 |
736 |
1e-5 |
BLAST |
|
low complexity region
|
787 |
797 |
N/A |
INTRINSIC |
|
low complexity region
|
864 |
878 |
N/A |
INTRINSIC |
|
Blast:PDZ
|
1302 |
1331 |
2e-11 |
BLAST |
|
PDZ
|
1413 |
1493 |
6.4e-22 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000200196
AA Change: V1357A
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit limb grasping, reduced long term depression, increased anxiety, increased aggression towards other mice, impaired spatial memory, decreased prepulse inhibition, decreased nesting building behavior, and abnormal dendritic spines. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(2) : Gene trapped(2) |
| Other mutations in this stock |
Total: 96 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700003E16Rik |
A |
G |
6: 83,139,680 (GRCm39) |
N535S |
probably damaging |
Het |
| Abcc12 |
T |
C |
8: 87,275,323 (GRCm39) |
S452G |
possibly damaging |
Het |
| Acacb |
C |
A |
5: 114,342,824 (GRCm39) |
Q897K |
probably benign |
Het |
| Acot3 |
C |
A |
12: 84,100,691 (GRCm39) |
R145S |
probably damaging |
Het |
| Ankrd54 |
A |
T |
15: 78,938,782 (GRCm39) |
Y247N |
probably damaging |
Het |
| Arl11 |
G |
A |
14: 61,548,546 (GRCm39) |
V119I |
probably benign |
Het |
| Atosb |
A |
G |
4: 43,034,663 (GRCm39) |
F352S |
probably damaging |
Het |
| Atxn7 |
T |
A |
14: 14,089,288 (GRCm38) |
M268K |
probably benign |
Het |
| Bms1 |
G |
A |
6: 118,369,667 (GRCm39) |
R934C |
probably damaging |
Het |
| Brd10 |
A |
G |
19: 29,694,501 (GRCm39) |
I1664T |
probably benign |
Het |
| Chrnb3 |
T |
C |
8: 27,884,147 (GRCm39) |
S295P |
probably damaging |
Het |
| Cic |
TCCCCC |
TCCCCCCC |
7: 24,991,095 (GRCm39) |
|
probably null |
Het |
| Cnr1 |
A |
T |
4: 33,944,571 (GRCm39) |
I320F |
probably benign |
Het |
| Cntn4 |
C |
T |
6: 106,414,910 (GRCm39) |
P147L |
probably damaging |
Het |
| Col24a1 |
G |
A |
3: 145,020,144 (GRCm39) |
V172I |
probably benign |
Het |
| Col9a3 |
A |
G |
2: 180,249,424 (GRCm39) |
D262G |
probably damaging |
Het |
| Csrnp2 |
A |
G |
15: 100,380,241 (GRCm39) |
V350A |
probably damaging |
Het |
| D630045J12Rik |
A |
G |
6: 38,173,592 (GRCm39) |
V192A |
possibly damaging |
Het |
| Deptor |
A |
G |
15: 55,072,177 (GRCm39) |
M219V |
probably benign |
Het |
| Dmrtb1 |
A |
T |
4: 107,541,247 (GRCm39) |
L38Q |
probably damaging |
Het |
| Dvl2 |
G |
A |
11: 69,898,344 (GRCm39) |
R367Q |
possibly damaging |
Het |
| Dync1h1 |
T |
G |
12: 110,621,962 (GRCm39) |
I3435S |
probably damaging |
Het |
| Ecpas |
A |
G |
4: 58,840,757 (GRCm39) |
V667A |
probably damaging |
Het |
| Eif2b3 |
A |
G |
4: 116,916,046 (GRCm39) |
N218D |
probably benign |
Het |
| Epha2 |
A |
G |
4: 141,046,292 (GRCm39) |
D497G |
probably benign |
Het |
| Epha7 |
G |
T |
4: 28,821,367 (GRCm39) |
L177F |
probably damaging |
Het |
| Fam98c |
C |
T |
7: 28,854,666 (GRCm39) |
E147K |
probably damaging |
Het |
| Fbxo17 |
A |
G |
7: 28,431,979 (GRCm39) |
T19A |
probably benign |
Het |
| Fbxo47 |
A |
G |
11: 97,747,049 (GRCm39) |
F339S |
probably damaging |
Het |
| Frmd4a |
G |
T |
2: 4,542,122 (GRCm39) |
V234L |
possibly damaging |
Het |
| Gal3st2 |
A |
G |
1: 93,800,245 (GRCm39) |
D32G |
probably damaging |
Het |
| Gpr135 |
T |
C |
12: 72,117,720 (GRCm39) |
T16A |
probably benign |
Het |
| Gpr160 |
A |
T |
3: 30,950,835 (GRCm39) |
R302S |
probably benign |
Het |
| Hrh2 |
C |
A |
13: 54,368,820 (GRCm39) |
N265K |
probably benign |
Het |
| Htatip2 |
C |
A |
7: 49,423,171 (GRCm39) |
A242E |
probably damaging |
Het |
| Igfbp7 |
T |
C |
5: 77,555,482 (GRCm39) |
Y127C |
probably damaging |
Het |
| Igkv16-104 |
A |
G |
6: 68,402,878 (GRCm39) |
Q57R |
possibly damaging |
Het |
| Ino80c |
A |
G |
18: 24,241,903 (GRCm39) |
S161P |
probably damaging |
Het |
| Itprid1 |
G |
A |
6: 55,944,132 (GRCm39) |
|
probably null |
Het |
| Kcnc1 |
A |
G |
7: 46,047,259 (GRCm39) |
D53G |
probably benign |
Het |
| Khdc4 |
T |
A |
3: 88,593,824 (GRCm39) |
M71K |
probably damaging |
Het |
| Lce1h |
G |
T |
3: 92,670,874 (GRCm39) |
R93S |
unknown |
Het |
| Lce1k |
T |
C |
3: 92,713,951 (GRCm39) |
S78G |
unknown |
Het |
| Lhcgr |
T |
A |
17: 89,072,580 (GRCm39) |
I156F |
probably damaging |
Het |
| Lpl |
T |
C |
8: 69,352,077 (GRCm39) |
Y343H |
probably damaging |
Het |
| Lrp6 |
G |
T |
6: 134,456,706 (GRCm39) |
R853S |
probably damaging |
Het |
| Lrrc74a |
C |
T |
12: 86,784,472 (GRCm39) |
Q67* |
probably null |
Het |
| Megf6 |
A |
T |
4: 154,338,271 (GRCm39) |
D447V |
probably damaging |
Het |
| Mep1a |
T |
C |
17: 43,793,139 (GRCm39) |
D355G |
possibly damaging |
Het |
| Ncoa1 |
T |
C |
12: 4,365,781 (GRCm39) |
D95G |
probably benign |
Het |
| Npepl1 |
A |
T |
2: 173,956,235 (GRCm39) |
I139F |
possibly damaging |
Het |
| Nrcam |
T |
C |
12: 44,594,020 (GRCm39) |
S262P |
probably benign |
Het |
| Nrp1 |
A |
G |
8: 129,229,047 (GRCm39) |
N842D |
probably benign |
Het |
| Olfml3 |
A |
G |
3: 103,639,497 (GRCm39) |
|
probably benign |
Het |
| Or1x6 |
A |
G |
11: 50,939,815 (GRCm39) |
R294G |
probably damaging |
Het |
| Or4b1d |
T |
A |
2: 89,969,343 (GRCm39) |
N47Y |
possibly damaging |
Het |
| Or6b6 |
T |
A |
7: 106,571,068 (GRCm39) |
Y161F |
probably benign |
Het |
| Or6c204 |
G |
A |
10: 129,022,514 (GRCm39) |
P259S |
probably damaging |
Het |
| Or6k8-ps1 |
T |
C |
1: 173,979,162 (GRCm39) |
Y27H |
possibly damaging |
Het |
| Or8b3b |
A |
G |
9: 38,584,659 (GRCm39) |
L27P |
probably damaging |
Het |
| Or9i1b |
A |
T |
19: 13,896,605 (GRCm39) |
T74S |
probably benign |
Het |
| Pde2a |
A |
G |
7: 101,152,041 (GRCm39) |
N316S |
probably benign |
Het |
| Pde4dip |
T |
A |
3: 97,750,993 (GRCm39) |
R74* |
probably null |
Het |
| Pex13 |
A |
T |
11: 23,605,472 (GRCm39) |
W253R |
possibly damaging |
Het |
| Piezo1 |
A |
T |
8: 123,215,278 (GRCm39) |
W1444R |
probably damaging |
Het |
| Pla2g4e |
T |
C |
2: 119,998,414 (GRCm39) |
K843R |
possibly damaging |
Het |
| Plxna2 |
C |
T |
1: 194,326,753 (GRCm39) |
P229L |
probably damaging |
Het |
| Prelid3b |
G |
T |
2: 174,308,592 (GRCm39) |
T131K |
probably benign |
Het |
| Pros1 |
T |
C |
16: 62,709,370 (GRCm39) |
|
probably null |
Het |
| Prrc2c |
G |
T |
1: 162,525,256 (GRCm39) |
P450Q |
unknown |
Het |
| Ptbp1 |
G |
T |
10: 79,692,342 (GRCm39) |
V5F |
possibly damaging |
Het |
| Ptk2 |
T |
A |
15: 73,078,074 (GRCm39) |
L997F |
probably damaging |
Het |
| Rims1 |
G |
T |
1: 22,518,528 (GRCm39) |
S525* |
probably null |
Het |
| Sanbr |
A |
G |
11: 23,543,449 (GRCm39) |
S530P |
probably benign |
Het |
| Sh2b3 |
T |
A |
5: 121,956,697 (GRCm39) |
D318V |
probably benign |
Het |
| Slc16a13 |
A |
T |
11: 70,111,101 (GRCm39) |
I88N |
probably damaging |
Het |
| Slit2 |
T |
A |
5: 48,414,345 (GRCm39) |
|
probably null |
Het |
| Snx10 |
A |
G |
6: 51,556,918 (GRCm39) |
N67S |
probably damaging |
Het |
| Stil |
A |
G |
4: 114,898,505 (GRCm39) |
Y1045C |
probably damaging |
Het |
| Stra6 |
A |
G |
9: 58,042,359 (GRCm39) |
|
probably null |
Het |
| Sympk |
A |
G |
7: 18,788,335 (GRCm39) |
S1254G |
probably benign |
Het |
| Syt15 |
G |
T |
14: 33,950,011 (GRCm39) |
G377V |
probably damaging |
Het |
| Taar4 |
A |
T |
10: 23,836,731 (GRCm39) |
I114F |
probably damaging |
Het |
| Tcaf3 |
G |
A |
6: 42,570,300 (GRCm39) |
|
probably null |
Het |
| Tgm7 |
A |
T |
2: 120,924,502 (GRCm39) |
N558K |
probably benign |
Het |
| Tln2 |
T |
G |
9: 67,304,935 (GRCm39) |
M1L |
probably benign |
Het |
| Trim50 |
C |
T |
5: 135,395,994 (GRCm39) |
T314I |
probably damaging |
Het |
| Trp53rka |
A |
T |
2: 165,333,312 (GRCm39) |
Y192* |
probably null |
Het |
| Ube3b |
T |
C |
5: 114,531,139 (GRCm39) |
V211A |
probably benign |
Het |
| Ush2a |
A |
G |
1: 188,132,138 (GRCm39) |
S787G |
probably benign |
Het |
| Vmn1r189 |
T |
C |
13: 22,286,289 (GRCm39) |
M183V |
probably damaging |
Het |
| Vps13d |
G |
T |
4: 144,904,782 (GRCm39) |
Q115K |
probably benign |
Het |
| Zfp358 |
A |
G |
8: 3,545,493 (GRCm39) |
D25G |
probably damaging |
Het |
| Zfp521 |
T |
G |
18: 13,977,647 (GRCm39) |
K922T |
probably damaging |
Het |
| Zfp521 |
T |
A |
18: 13,977,648 (GRCm39) |
K922* |
probably null |
Het |
| Zfp68 |
T |
A |
5: 138,614,743 (GRCm39) |
K4* |
probably null |
Het |
|
| Other mutations in Lrrc7 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00594:Lrrc7
|
APN |
3 |
157,892,647 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL00644:Lrrc7
|
APN |
3 |
157,908,005 (GRCm39) |
nonsense |
probably null |
|
|
IGL00822:Lrrc7
|
APN |
3 |
157,891,111 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00927:Lrrc7
|
APN |
3 |
157,866,727 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL00946:Lrrc7
|
APN |
3 |
157,866,993 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL00948:Lrrc7
|
APN |
3 |
157,867,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01838:Lrrc7
|
APN |
3 |
157,891,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01874:Lrrc7
|
APN |
3 |
157,946,080 (GRCm39) |
splice site |
probably benign |
|
|
IGL02514:Lrrc7
|
APN |
3 |
157,865,929 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02545:Lrrc7
|
APN |
3 |
157,891,011 (GRCm39) |
splice site |
probably benign |
|
|
IGL02665:Lrrc7
|
APN |
3 |
157,866,742 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03129:Lrrc7
|
APN |
3 |
157,866,696 (GRCm39) |
missense |
probably benign |
0.02 |
|
N/A:Lrrc7
|
UTSW |
3 |
157,865,977 (GRCm39) |
missense |
probably benign |
|
|
R0021:Lrrc7
|
UTSW |
3 |
157,866,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0041:Lrrc7
|
UTSW |
3 |
157,869,897 (GRCm39) |
splice site |
probably benign |
|
|
R0255:Lrrc7
|
UTSW |
3 |
157,866,475 (GRCm39) |
nonsense |
probably null |
|
|
R0278:Lrrc7
|
UTSW |
3 |
157,885,432 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R0409:Lrrc7
|
UTSW |
3 |
157,867,063 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R0612:Lrrc7
|
UTSW |
3 |
157,869,990 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0866:Lrrc7
|
UTSW |
3 |
157,869,903 (GRCm39) |
splice site |
probably benign |
|
|
R1077:Lrrc7
|
UTSW |
3 |
157,866,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1103:Lrrc7
|
UTSW |
3 |
157,854,343 (GRCm39) |
splice site |
probably benign |
|
|
R1157:Lrrc7
|
UTSW |
3 |
157,865,892 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1187:Lrrc7
|
UTSW |
3 |
157,866,039 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1301:Lrrc7
|
UTSW |
3 |
157,840,968 (GRCm39) |
missense |
probably benign |
0.20 |
|
R1433:Lrrc7
|
UTSW |
3 |
157,882,943 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1450:Lrrc7
|
UTSW |
3 |
157,892,681 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1595:Lrrc7
|
UTSW |
3 |
157,882,914 (GRCm39) |
nonsense |
probably null |
|
|
R1659:Lrrc7
|
UTSW |
3 |
157,867,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1693:Lrrc7
|
UTSW |
3 |
157,790,170 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1774:Lrrc7
|
UTSW |
3 |
157,865,929 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2273:Lrrc7
|
UTSW |
3 |
157,892,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2276:Lrrc7
|
UTSW |
3 |
157,885,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2302:Lrrc7
|
UTSW |
3 |
157,840,881 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2326:Lrrc7
|
UTSW |
3 |
157,876,298 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2371:Lrrc7
|
UTSW |
3 |
157,866,697 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2383:Lrrc7
|
UTSW |
3 |
157,869,593 (GRCm39) |
missense |
probably benign |
|
|
R2679:Lrrc7
|
UTSW |
3 |
157,880,745 (GRCm39) |
nonsense |
probably null |
|
|
R2698:Lrrc7
|
UTSW |
3 |
157,841,028 (GRCm39) |
missense |
probably benign |
0.22 |
|
R2858:Lrrc7
|
UTSW |
3 |
157,867,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3758:Lrrc7
|
UTSW |
3 |
157,869,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3791:Lrrc7
|
UTSW |
3 |
157,869,593 (GRCm39) |
missense |
probably benign |
|
|
R3805:Lrrc7
|
UTSW |
3 |
157,891,130 (GRCm39) |
missense |
probably benign |
0.10 |
|
R3806:Lrrc7
|
UTSW |
3 |
157,891,130 (GRCm39) |
missense |
probably benign |
0.10 |
|
R3807:Lrrc7
|
UTSW |
3 |
157,891,130 (GRCm39) |
missense |
probably benign |
0.10 |
|
R3892:Lrrc7
|
UTSW |
3 |
157,866,333 (GRCm39) |
missense |
probably benign |
0.08 |
|
R3912:Lrrc7
|
UTSW |
3 |
157,997,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3913:Lrrc7
|
UTSW |
3 |
157,997,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3963:Lrrc7
|
UTSW |
3 |
157,866,042 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4665:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4666:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4671:Lrrc7
|
UTSW |
3 |
157,908,132 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4725:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4726:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4728:Lrrc7
|
UTSW |
3 |
158,024,045 (GRCm39) |
critical splice donor site |
probably benign |
|
|
R4783:Lrrc7
|
UTSW |
3 |
157,832,850 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4867:Lrrc7
|
UTSW |
3 |
157,866,642 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4907:Lrrc7
|
UTSW |
3 |
157,866,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5032:Lrrc7
|
UTSW |
3 |
157,887,217 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R5107:Lrrc7
|
UTSW |
3 |
157,867,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5295:Lrrc7
|
UTSW |
3 |
157,876,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5348:Lrrc7
|
UTSW |
3 |
157,880,963 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5468:Lrrc7
|
UTSW |
3 |
158,024,073 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5778:Lrrc7
|
UTSW |
3 |
157,876,380 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5897:Lrrc7
|
UTSW |
3 |
157,869,990 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6179:Lrrc7
|
UTSW |
3 |
158,059,069 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6312:Lrrc7
|
UTSW |
3 |
157,866,246 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6313:Lrrc7
|
UTSW |
3 |
157,866,373 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6366:Lrrc7
|
UTSW |
3 |
157,841,012 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6389:Lrrc7
|
UTSW |
3 |
157,891,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6638:Lrrc7
|
UTSW |
3 |
157,840,940 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6956:Lrrc7
|
UTSW |
3 |
157,994,668 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6969:Lrrc7
|
UTSW |
3 |
157,862,550 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7073:Lrrc7
|
UTSW |
3 |
157,832,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7313:Lrrc7
|
UTSW |
3 |
157,866,111 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7365:Lrrc7
|
UTSW |
3 |
157,903,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7398:Lrrc7
|
UTSW |
3 |
157,997,595 (GRCm39) |
nonsense |
probably null |
|
|
R7403:Lrrc7
|
UTSW |
3 |
157,854,311 (GRCm39) |
nonsense |
probably null |
|
|
R7407:Lrrc7
|
UTSW |
3 |
157,840,878 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7427:Lrrc7
|
UTSW |
3 |
157,903,778 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7453:Lrrc7
|
UTSW |
3 |
157,891,046 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7461:Lrrc7
|
UTSW |
3 |
157,892,657 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7807:Lrrc7
|
UTSW |
3 |
157,866,124 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7872:Lrrc7
|
UTSW |
3 |
158,059,099 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8215:Lrrc7
|
UTSW |
3 |
157,915,387 (GRCm39) |
missense |
probably benign |
|
|
R8367:Lrrc7
|
UTSW |
3 |
157,908,007 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R8867:Lrrc7
|
UTSW |
3 |
157,867,521 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8880:Lrrc7
|
UTSW |
3 |
157,867,381 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8941:Lrrc7
|
UTSW |
3 |
157,869,593 (GRCm39) |
missense |
probably benign |
|
|
R8958:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9068:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9069:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9180:Lrrc7
|
UTSW |
3 |
157,867,011 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9193:Lrrc7
|
UTSW |
3 |
158,059,011 (GRCm39) |
nonsense |
probably null |
|
|
R9309:Lrrc7
|
UTSW |
3 |
157,915,361 (GRCm39) |
nonsense |
probably null |
|
|
R9418:Lrrc7
|
UTSW |
3 |
157,908,023 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9474:Lrrc7
|
UTSW |
3 |
157,841,028 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9515:Lrrc7
|
UTSW |
3 |
157,867,105 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9635:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9639:Lrrc7
|
UTSW |
3 |
157,946,138 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9682:Lrrc7
|
UTSW |
3 |
157,882,954 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9731:Lrrc7
|
UTSW |
3 |
157,880,888 (GRCm39) |
missense |
probably benign |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATGCACTGACAGTTGACCAGAAG -3'
(R):5'- CAGTAAATAACTCTGAGACGGTTAC -3'
Sequencing Primer
(F):5'- GTTGACCAGAAGCCCTTGAATGTC -3'
(R):5'- CTCATTGCTTCCAAAATAGTTGTCAG -3'
|
| Posted On |
2015-10-21 |
Incidental Mutation