Incidental Mutation 'R4688:Arl11'
ID 353896
Institutional Source Beutler Lab
Gene Symbol Arl11
Ensembl Gene ENSMUSG00000043157
Gene Name ADP-ribosylation factor-like 11
Synonyms ARLTS1, C730007L20Rik
MMRRC Submission 041939-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.064) question?
Stock # R4688 (G1)
Quality Score 225
Status Not validated
Chromosome 14
Chromosomal Location 61309753-61311936 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) G to A at 61311097 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 119 (V119I)
Ref Sequence ENSEMBL: ENSMUSP00000153531 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055159] [ENSMUST00000224727]
AlphaFold Q6P3A9
Predicted Effect probably benign
Transcript: ENSMUST00000055159
AA Change: V119I

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000055447
Gene: ENSMUSG00000043157
AA Change: V119I

ARF 1 176 4.96e-42 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000188538
Predicted Effect probably benign
Transcript: ENSMUST00000224727
AA Change: V119I

PolyPhen 2 Score 0.163 (Sensitivity: 0.92; Specificity: 0.87)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]
Allele List at MGI
Other mutations in this stock
Total: 96 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610010F05Rik A G 11: 23,593,449 (GRCm38) S530P probably benign Het
1700003E16Rik A G 6: 83,162,698 (GRCm38) N535S probably damaging Het
2810403A07Rik T A 3: 88,686,517 (GRCm38) M71K probably damaging Het
9930021J03Rik A G 19: 29,717,101 (GRCm38) I1664T probably benign Het
Abcc12 T C 8: 86,548,694 (GRCm38) S452G possibly damaging Het
Acacb C A 5: 114,204,763 (GRCm38) Q897K probably benign Het
Acot3 C A 12: 84,053,917 (GRCm38) R145S probably damaging Het
AI314180 A G 4: 58,840,757 (GRCm38) V667A probably damaging Het
Ankrd54 A T 15: 79,054,582 (GRCm38) Y247N probably damaging Het
Atxn7 T A 14: 14,089,288 (GRCm38) M268K probably benign Het
Bms1 G A 6: 118,392,706 (GRCm38) R934C probably damaging Het
Ccdc129 G A 6: 55,967,147 (GRCm38) probably null Het
Chrnb3 T C 8: 27,394,119 (GRCm38) S295P probably damaging Het
Cic TCCCCC TCCCCCCC 7: 25,291,670 (GRCm38) probably null Het
Cnr1 A T 4: 33,944,571 (GRCm38) I320F probably benign Het
Cntn4 C T 6: 106,437,949 (GRCm38) P147L probably damaging Het
Col24a1 G A 3: 145,314,383 (GRCm38) V172I probably benign Het
Col9a3 A G 2: 180,607,631 (GRCm38) D262G probably damaging Het
Csrnp2 A G 15: 100,482,360 (GRCm38) V350A probably damaging Het
D630045J12Rik A G 6: 38,196,657 (GRCm38) V192A possibly damaging Het
Deptor A G 15: 55,208,781 (GRCm38) M219V probably benign Het
Dmrtb1 A T 4: 107,684,050 (GRCm38) L38Q probably damaging Het
Dvl2 G A 11: 70,007,518 (GRCm38) R367Q possibly damaging Het
Dync1h1 T G 12: 110,655,528 (GRCm38) I3435S probably damaging Het
Eif2b3 A G 4: 117,058,849 (GRCm38) N218D probably benign Het
Epha2 A G 4: 141,318,981 (GRCm38) D497G probably benign Het
Epha7 G T 4: 28,821,367 (GRCm38) L177F probably damaging Het
Fam214b A G 4: 43,034,663 (GRCm38) F352S probably damaging Het
Fam98c C T 7: 29,155,241 (GRCm38) E147K probably damaging Het
Fbxo17 A G 7: 28,732,554 (GRCm38) T19A probably benign Het
Fbxo47 A G 11: 97,856,223 (GRCm38) F339S probably damaging Het
Frmd4a G T 2: 4,537,311 (GRCm38) V234L possibly damaging Het
Gal3st2 A G 1: 93,872,523 (GRCm38) D32G probably damaging Het
Gpr135 T C 12: 72,070,946 (GRCm38) T16A probably benign Het
Gpr160 A T 3: 30,896,686 (GRCm38) R302S probably benign Het
Hrh2 C A 13: 54,214,801 (GRCm38) N265K probably benign Het
Htatip2 C A 7: 49,773,423 (GRCm38) A242E probably damaging Het
Igfbp7 T C 5: 77,407,635 (GRCm38) Y127C probably damaging Het
Igkv16-104 A G 6: 68,425,894 (GRCm38) Q57R possibly damaging Het
Ino80c A G 18: 24,108,846 (GRCm38) S161P probably damaging Het
Kcnc1 A G 7: 46,397,835 (GRCm38) D53G probably benign Het
Lce1h G T 3: 92,763,567 (GRCm38) R93S unknown Het
Lce1k T C 3: 92,806,644 (GRCm38) S78G unknown Het
Lhcgr T A 17: 88,765,152 (GRCm38) I156F probably damaging Het
Lpl T C 8: 68,899,425 (GRCm38) Y343H probably damaging Het
Lrp6 G T 6: 134,479,743 (GRCm38) R853S probably damaging Het
Lrrc7 A G 3: 158,148,605 (GRCm38) V1322A probably damaging Het
Lrrc74a C T 12: 86,737,698 (GRCm38) Q67* probably null Het
Megf6 A T 4: 154,253,814 (GRCm38) D447V probably damaging Het
Mep1a T C 17: 43,482,248 (GRCm38) D355G possibly damaging Het
Ncoa1 T C 12: 4,315,781 (GRCm38) D95G probably benign Het
Npepl1 A T 2: 174,114,442 (GRCm38) I139F possibly damaging Het
Nrcam T C 12: 44,547,237 (GRCm38) S262P probably benign Het
Nrp1 A G 8: 128,502,566 (GRCm38) N842D probably benign Het
Olfml3 A G 3: 103,732,181 (GRCm38) probably benign Het
Olfr1375 A G 11: 51,048,988 (GRCm38) R294G probably damaging Het
Olfr1505 A T 19: 13,919,241 (GRCm38) T74S probably benign Het
Olfr32 T A 2: 90,138,999 (GRCm38) N47Y possibly damaging Het
Olfr421-ps1 T C 1: 174,151,596 (GRCm38) Y27H possibly damaging Het
Olfr711 T A 7: 106,971,861 (GRCm38) Y161F probably benign Het
Olfr773 G A 10: 129,186,645 (GRCm38) P259S probably damaging Het
Olfr918 A G 9: 38,673,363 (GRCm38) L27P probably damaging Het
Pde2a A G 7: 101,502,834 (GRCm38) N316S probably benign Het
Pde4dip T A 3: 97,843,677 (GRCm38) R74* probably null Het
Pex13 A T 11: 23,655,472 (GRCm38) W253R possibly damaging Het
Piezo1 A T 8: 122,488,539 (GRCm38) W1444R probably damaging Het
Pla2g4e T C 2: 120,167,933 (GRCm38) K843R possibly damaging Het
Plxna2 C T 1: 194,644,445 (GRCm38) P229L probably damaging Het
Prelid3b G T 2: 174,466,799 (GRCm38) T131K probably benign Het
Pros1 T C 16: 62,889,007 (GRCm38) probably null Het
Prrc2c G T 1: 162,697,687 (GRCm38) P450Q unknown Het
Ptbp1 G T 10: 79,856,508 (GRCm38) V5F possibly damaging Het
Ptk2 T A 15: 73,206,225 (GRCm38) L997F probably damaging Het
Rims1 G T 1: 22,479,447 (GRCm38) S525* probably null Het
Sh2b3 T A 5: 121,818,634 (GRCm38) D318V probably benign Het
Slc16a13 A T 11: 70,220,275 (GRCm38) I88N probably damaging Het
Slit2 T A 5: 48,257,003 (GRCm38) probably null Het
Snx10 A G 6: 51,579,938 (GRCm38) N67S probably damaging Het
Stil A G 4: 115,041,308 (GRCm38) Y1045C probably damaging Het
Stra6 A G 9: 58,135,076 (GRCm38) probably null Het
Sympk A G 7: 19,054,410 (GRCm38) S1254G probably benign Het
Syt15 G T 14: 34,228,054 (GRCm38) G377V probably damaging Het
Taar4 A T 10: 23,960,833 (GRCm38) I114F probably damaging Het
Tcaf3 G A 6: 42,593,366 (GRCm38) probably null Het
Tgm7 A T 2: 121,094,021 (GRCm38) N558K probably benign Het
Tln2 T G 9: 67,397,653 (GRCm38) M1L probably benign Het
Trim50 C T 5: 135,367,140 (GRCm38) T314I probably damaging Het
Trp53rka A T 2: 165,491,392 (GRCm38) Y192* probably null Het
Ube3b T C 5: 114,393,078 (GRCm38) V211A probably benign Het
Ush2a A G 1: 188,399,941 (GRCm38) S787G probably benign Het
Vmn1r189 T C 13: 22,102,119 (GRCm38) M183V probably damaging Het
Vps13d G T 4: 145,178,212 (GRCm38) Q115K probably benign Het
Zfp358 A G 8: 3,495,493 (GRCm38) D25G probably damaging Het
Zfp521 T G 18: 13,844,590 (GRCm38) K922T probably damaging Het
Zfp521 T A 18: 13,844,591 (GRCm38) K922* probably null Het
Zfp68 T A 5: 138,616,481 (GRCm38) K4* probably null Het
Other mutations in Arl11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00955:Arl11 APN 14 61,311,242 (GRCm38) missense probably benign 0.22
IGL02158:Arl11 APN 14 61,311,038 (GRCm38) missense probably damaging 0.99
IGL02756:Arl11 APN 14 61,311,086 (GRCm38) missense probably damaging 1.00
R1755:Arl11 UTSW 14 61,310,944 (GRCm38) missense probably benign
R5833:Arl11 UTSW 14 61,311,062 (GRCm38) missense probably damaging 1.00
R6438:Arl11 UTSW 14 61,310,944 (GRCm38) missense probably benign
R7129:Arl11 UTSW 14 61,310,897 (GRCm38) missense possibly damaging 0.67
R8213:Arl11 UTSW 14 61,311,265 (GRCm38) missense probably benign 0.00
R8812:Arl11 UTSW 14 61,310,973 (GRCm38) nonsense probably null
RF004:Arl11 UTSW 14 61,310,855 (GRCm38) missense probably damaging 1.00
Z1177:Arl11 UTSW 14 61,310,868 (GRCm38) frame shift probably null
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-10-21