Incidental Mutation 'R4715:Siglec1'
| ID |
353924 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Siglec1
|
| Ensembl Gene |
ENSMUSG00000027322 |
| Gene Name |
sialic acid binding Ig-like lectin 1, sialoadhesin |
| Synonyms |
Sn, CD169, Siglec-1 |
| MMRRC Submission |
041982-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.076)
|
| Stock # |
R4715 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
130911140-130928685 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 130916356 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 1198
(D1198G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105856
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000028794]
[ENSMUST00000110227]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000028794
AA Change: D1198G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000028794
Gene: ENSMUSG00000027322
AA Change: D1198G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IG
|
32 |
142 |
2.92e-5 |
SMART |
|
Pfam:C2-set_2
|
148 |
235 |
9.4e-18 |
PFAM |
|
IGc2
|
260 |
319 |
8.78e-9 |
SMART |
|
IGc2
|
344 |
404 |
4.07e-4 |
SMART |
|
IGc2
|
431 |
505 |
3.3e-4 |
SMART |
|
IGc2
|
529 |
589 |
5.75e-4 |
SMART |
|
IGc2
|
622 |
698 |
3.54e-4 |
SMART |
|
low complexity region
|
700 |
705 |
N/A |
INTRINSIC |
|
IG
|
716 |
795 |
3.35e-5 |
SMART |
|
IG
|
804 |
896 |
6.51e-3 |
SMART |
|
IGc2
|
909 |
969 |
4.13e-5 |
SMART |
|
IG_like
|
1001 |
1076 |
6.78e-2 |
SMART |
|
low complexity region
|
1077 |
1088 |
N/A |
INTRINSIC |
|
IG
|
1094 |
1171 |
4.32e-8 |
SMART |
|
IG_like
|
1185 |
1250 |
1.94e-2 |
SMART |
|
IG
|
1268 |
1345 |
1.36e-5 |
SMART |
|
IG_like
|
1354 |
1447 |
1.45e1 |
SMART |
|
IG_like
|
1365 |
1435 |
4.51e-2 |
SMART |
|
IG
|
1454 |
1534 |
4.56e-7 |
SMART |
|
IG_like
|
1549 |
1624 |
1.21e-1 |
SMART |
|
transmembrane domain
|
1647 |
1669 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000110227
AA Change: D1198G
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000105856
Gene: ENSMUSG00000027322
AA Change: D1198G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
IG
|
32 |
142 |
2.92e-5 |
SMART |
|
Pfam:C2-set_2
|
148 |
235 |
7e-17 |
PFAM |
|
IGc2
|
260 |
319 |
8.78e-9 |
SMART |
|
IGc2
|
344 |
404 |
4.07e-4 |
SMART |
|
IGc2
|
431 |
505 |
3.3e-4 |
SMART |
|
IGc2
|
529 |
589 |
5.75e-4 |
SMART |
|
IGc2
|
622 |
698 |
3.54e-4 |
SMART |
|
low complexity region
|
700 |
705 |
N/A |
INTRINSIC |
|
IG
|
716 |
795 |
3.35e-5 |
SMART |
|
IG
|
804 |
896 |
6.51e-3 |
SMART |
|
IGc2
|
909 |
969 |
4.13e-5 |
SMART |
|
IG_like
|
1001 |
1076 |
6.78e-2 |
SMART |
|
low complexity region
|
1077 |
1088 |
N/A |
INTRINSIC |
|
IG
|
1094 |
1171 |
4.32e-8 |
SMART |
|
IG_like
|
1185 |
1250 |
1.94e-2 |
SMART |
|
IG
|
1268 |
1345 |
1.36e-5 |
SMART |
|
IG_like
|
1354 |
1447 |
1.45e1 |
SMART |
|
IG_like
|
1365 |
1435 |
4.51e-2 |
SMART |
|
IG
|
1454 |
1534 |
4.56e-7 |
SMART |
|
| Meta Mutation Damage Score |
0.5932 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.0%
|
| Validation Efficiency |
92% (86/93) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a lectin-like adhesion molecule that binds glycoconjugate ligands on cell surfaces in a sialic acid-dependent manner. It is a type I transmembrane protein expressed only by a subpopulation of macrophages and is involved in mediating cell-cell interactions. Alternative splicing produces a transcript variant encoding an isoform that is soluble rather than membrane-bound; however, the full-length nature of this variant has not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a disruption in this gene display subtle changes in B- and T-cell populations and decreased IgM levels. Mice homozygous for a knock-out or knock-in allele exhibit impaired phagocytosis of sialylated C. jejuni. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc2 |
A |
C |
19: 43,805,321 (GRCm39) |
E725A |
possibly damaging |
Het |
| Abcc5 |
G |
T |
16: 20,217,626 (GRCm39) |
L362I |
probably damaging |
Het |
| Ammecr1l |
C |
T |
18: 31,907,706 (GRCm39) |
R179* |
probably null |
Het |
| Arap2 |
G |
T |
5: 62,906,437 (GRCm39) |
T194K |
probably benign |
Het |
| Atf2 |
C |
A |
2: 73,653,644 (GRCm39) |
V282F |
probably damaging |
Het |
| Atosa |
T |
A |
9: 74,920,250 (GRCm39) |
W799R |
probably damaging |
Het |
| Atp1a1 |
T |
C |
3: 101,499,122 (GRCm39) |
E159G |
possibly damaging |
Het |
| B4galt2 |
T |
C |
4: 117,734,376 (GRCm39) |
S258G |
possibly damaging |
Het |
| Bptf |
G |
T |
11: 106,938,007 (GRCm39) |
H2695N |
probably damaging |
Het |
| Casq2 |
T |
C |
3: 102,017,560 (GRCm39) |
V80A |
probably benign |
Het |
| Cdc42ep3 |
G |
A |
17: 79,642,887 (GRCm39) |
A11V |
probably benign |
Het |
| Cdh4 |
A |
T |
2: 179,422,260 (GRCm39) |
H128L |
probably benign |
Het |
| Cdk5rap1 |
C |
A |
2: 154,203,755 (GRCm39) |
*191L |
probably null |
Het |
| Cfdp1 |
G |
A |
8: 112,557,523 (GRCm39) |
T206I |
probably benign |
Het |
| Cgn |
C |
A |
3: 94,686,748 (GRCm39) |
G185W |
probably damaging |
Het |
| Clpx |
A |
C |
9: 65,219,396 (GRCm39) |
R231S |
possibly damaging |
Het |
| Copg1 |
T |
A |
6: 87,889,268 (GRCm39) |
L870* |
probably null |
Het |
| Cyp4a10 |
A |
T |
4: 115,382,535 (GRCm39) |
D275V |
probably benign |
Het |
| Dip2a |
T |
C |
10: 76,132,240 (GRCm39) |
T504A |
probably benign |
Het |
| Dmxl2 |
A |
C |
9: 54,353,689 (GRCm39) |
|
probably null |
Het |
| Dnaaf5 |
A |
T |
5: 139,163,755 (GRCm39) |
I671F |
probably damaging |
Het |
| Dnah14 |
A |
G |
1: 181,584,788 (GRCm39) |
D3173G |
probably damaging |
Het |
| Dock2 |
T |
C |
11: 34,244,118 (GRCm39) |
Y1074C |
probably damaging |
Het |
| Dthd1 |
A |
C |
5: 63,045,530 (GRCm39) |
M765L |
probably benign |
Het |
| E2f3 |
A |
C |
13: 30,095,258 (GRCm39) |
C220W |
probably damaging |
Het |
| Elf3 |
C |
T |
1: 135,185,490 (GRCm39) |
S8N |
probably damaging |
Het |
| F2rl1 |
A |
T |
13: 95,649,775 (GRCm39) |
V369E |
probably damaging |
Het |
| Fpr-rs7 |
C |
T |
17: 20,333,690 (GRCm39) |
G267R |
probably benign |
Het |
| Ggact |
A |
T |
14: 123,129,047 (GRCm39) |
L56Q |
possibly damaging |
Het |
| Gm5546 |
T |
C |
3: 104,273,824 (GRCm39) |
|
noncoding transcript |
Het |
| Gm8267 |
A |
G |
14: 44,955,292 (GRCm39) |
V243A |
probably benign |
Het |
| Gtf2h1 |
A |
G |
7: 46,464,836 (GRCm39) |
T424A |
possibly damaging |
Het |
| Gucy1b2 |
A |
G |
14: 62,660,466 (GRCm39) |
V140A |
possibly damaging |
Het |
| Htatip2 |
T |
C |
7: 49,420,592 (GRCm39) |
L146P |
probably damaging |
Het |
| Htr1b |
T |
C |
9: 81,513,563 (GRCm39) |
D348G |
possibly damaging |
Het |
| Ifi205 |
T |
C |
1: 173,855,887 (GRCm39) |
I48V |
possibly damaging |
Het |
| Igkv18-36 |
C |
T |
6: 69,969,575 (GRCm39) |
R72K |
probably damaging |
Het |
| Kcnk7 |
T |
C |
19: 5,756,281 (GRCm39) |
L169P |
probably damaging |
Het |
| Klf17 |
T |
C |
4: 117,617,733 (GRCm39) |
D208G |
probably benign |
Het |
| Ltn1 |
A |
G |
16: 87,215,382 (GRCm39) |
F418L |
probably damaging |
Het |
| Map4k4 |
G |
A |
1: 40,058,724 (GRCm39) |
V1040I |
probably damaging |
Het |
| Mark1 |
A |
G |
1: 184,644,329 (GRCm39) |
V445A |
probably benign |
Het |
| Med11 |
T |
C |
11: 70,344,022 (GRCm39) |
I114T |
probably benign |
Het |
| Moxd2 |
A |
G |
6: 40,864,181 (GRCm39) |
V83A |
probably damaging |
Het |
| Mrpl33 |
A |
G |
5: 31,773,702 (GRCm39) |
|
probably benign |
Het |
| Mrps27 |
A |
G |
13: 99,551,323 (GRCm39) |
|
probably null |
Het |
| Nop58 |
T |
C |
1: 59,735,185 (GRCm39) |
V75A |
probably benign |
Het |
| Or13p5 |
T |
C |
4: 118,591,852 (GRCm39) |
L42P |
probably damaging |
Het |
| Or2n1d |
A |
C |
17: 38,646,731 (GRCm39) |
I228L |
possibly damaging |
Het |
| Or2t46 |
A |
G |
11: 58,472,255 (GRCm39) |
D195G |
probably damaging |
Het |
| Or4k42 |
A |
C |
2: 111,320,089 (GRCm39) |
M138R |
probably benign |
Het |
| Or7g19 |
A |
G |
9: 18,856,742 (GRCm39) |
H266R |
probably benign |
Het |
| Or7g26 |
C |
A |
9: 19,230,443 (GRCm39) |
F210L |
probably benign |
Het |
| Pdzd2 |
G |
T |
15: 12,419,602 (GRCm39) |
N263K |
possibly damaging |
Het |
| Podnl1 |
C |
A |
8: 84,852,690 (GRCm39) |
|
probably benign |
Het |
| Prkd3 |
G |
T |
17: 79,259,366 (GRCm39) |
H864N |
possibly damaging |
Het |
| Ptprd |
T |
C |
4: 76,025,570 (GRCm39) |
T543A |
probably benign |
Het |
| Pum2 |
T |
A |
12: 8,797,272 (GRCm39) |
I788N |
probably damaging |
Het |
| Ralgapa1 |
T |
A |
12: 55,740,243 (GRCm39) |
N1328I |
probably damaging |
Het |
| Rhoc |
T |
C |
3: 104,701,355 (GRCm39) |
L193P |
probably damaging |
Het |
| Rif1 |
T |
C |
2: 51,963,151 (GRCm39) |
|
probably benign |
Het |
| Rspo2 |
A |
T |
15: 42,939,300 (GRCm39) |
C163* |
probably null |
Het |
| Sco1 |
A |
G |
11: 66,947,425 (GRCm39) |
Y204C |
probably damaging |
Het |
| Shc2 |
T |
C |
10: 79,458,213 (GRCm39) |
K490R |
probably benign |
Het |
| Slc25a18 |
T |
C |
6: 120,763,051 (GRCm39) |
V31A |
probably damaging |
Het |
| Smpd5 |
A |
T |
15: 76,179,893 (GRCm39) |
I112L |
probably benign |
Het |
| Synpr |
CT |
C |
14: 13,285,198 (GRCm38) |
|
probably null |
Het |
| Tdrd9 |
T |
G |
12: 112,008,123 (GRCm39) |
S988A |
probably benign |
Het |
| Tiam2 |
T |
A |
17: 3,504,443 (GRCm39) |
F982I |
probably damaging |
Het |
| Tmc3 |
G |
A |
7: 83,271,604 (GRCm39) |
V919I |
probably benign |
Het |
| Tmed2b |
A |
T |
9: 33,639,784 (GRCm39) |
|
noncoding transcript |
Het |
| Tmem200c |
A |
T |
17: 69,147,465 (GRCm39) |
D16V |
probably damaging |
Het |
| Tmem37 |
A |
T |
1: 119,995,935 (GRCm39) |
D47E |
probably damaging |
Het |
| Top3a |
T |
A |
11: 60,633,823 (GRCm39) |
R733* |
probably null |
Het |
| Treh |
T |
C |
9: 44,594,615 (GRCm39) |
V8A |
probably benign |
Het |
| Trim17 |
A |
C |
11: 58,859,276 (GRCm39) |
|
probably benign |
Het |
| Ubash3b |
T |
C |
9: 40,927,896 (GRCm39) |
K471E |
probably damaging |
Het |
| Usp8 |
T |
A |
2: 126,571,142 (GRCm39) |
L144Q |
possibly damaging |
Het |
| Wnk2 |
T |
A |
13: 49,300,708 (GRCm39) |
M1L |
unknown |
Het |
| Yju2b |
A |
G |
8: 84,990,503 (GRCm39) |
I43T |
probably damaging |
Het |
|
| Other mutations in Siglec1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00482:Siglec1
|
APN |
2 |
130,921,245 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01092:Siglec1
|
APN |
2 |
130,921,137 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01115:Siglec1
|
APN |
2 |
130,916,422 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01324:Siglec1
|
APN |
2 |
130,927,461 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01330:Siglec1
|
APN |
2 |
130,916,925 (GRCm39) |
nonsense |
probably null |
|
|
IGL01330:Siglec1
|
APN |
2 |
130,925,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01558:Siglec1
|
APN |
2 |
130,920,419 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01632:Siglec1
|
APN |
2 |
130,925,740 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL01768:Siglec1
|
APN |
2 |
130,916,314 (GRCm39) |
missense |
probably benign |
|
|
IGL02399:Siglec1
|
APN |
2 |
130,913,098 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL02558:Siglec1
|
APN |
2 |
130,916,915 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02794:Siglec1
|
APN |
2 |
130,917,889 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02839:Siglec1
|
APN |
2 |
130,926,852 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
aggressor
|
UTSW |
2 |
130,925,861 (GRCm39) |
nonsense |
probably null |
|
|
boris
|
UTSW |
2 |
130,921,297 (GRCm39) |
nonsense |
probably null |
|
|
espia
|
UTSW |
2 |
130,914,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
hoodlum
|
UTSW |
2 |
130,914,667 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
microfische
|
UTSW |
2 |
130,928,015 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
K3955:Siglec1
|
UTSW |
2 |
130,923,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
P0038:Siglec1
|
UTSW |
2 |
130,923,359 (GRCm39) |
missense |
probably benign |
0.00 |
|
PIT4576001:Siglec1
|
UTSW |
2 |
130,920,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4677001:Siglec1
|
UTSW |
2 |
130,914,677 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0003:Siglec1
|
UTSW |
2 |
130,916,980 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0048:Siglec1
|
UTSW |
2 |
130,915,317 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0048:Siglec1
|
UTSW |
2 |
130,915,317 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0243:Siglec1
|
UTSW |
2 |
130,927,396 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0276:Siglec1
|
UTSW |
2 |
130,925,861 (GRCm39) |
nonsense |
probably null |
|
|
R0379:Siglec1
|
UTSW |
2 |
130,916,445 (GRCm39) |
splice site |
probably benign |
|
|
R0464:Siglec1
|
UTSW |
2 |
130,921,279 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0507:Siglec1
|
UTSW |
2 |
130,916,445 (GRCm39) |
splice site |
probably benign |
|
|
R0560:Siglec1
|
UTSW |
2 |
130,912,266 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0620:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0621:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R0853:Siglec1
|
UTSW |
2 |
130,926,942 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1079:Siglec1
|
UTSW |
2 |
130,921,297 (GRCm39) |
nonsense |
probably null |
|
|
R1169:Siglec1
|
UTSW |
2 |
130,916,747 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1205:Siglec1
|
UTSW |
2 |
130,922,384 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1293:Siglec1
|
UTSW |
2 |
130,915,451 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1470:Siglec1
|
UTSW |
2 |
130,912,307 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1470:Siglec1
|
UTSW |
2 |
130,912,307 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1533:Siglec1
|
UTSW |
2 |
130,918,078 (GRCm39) |
missense |
probably benign |
|
|
R1717:Siglec1
|
UTSW |
2 |
130,925,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1717:Siglec1
|
UTSW |
2 |
130,915,876 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1744:Siglec1
|
UTSW |
2 |
130,923,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1852:Siglec1
|
UTSW |
2 |
130,923,420 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1941:Siglec1
|
UTSW |
2 |
130,920,051 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2011:Siglec1
|
UTSW |
2 |
130,925,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Siglec1
|
UTSW |
2 |
130,925,277 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2128:Siglec1
|
UTSW |
2 |
130,922,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2278:Siglec1
|
UTSW |
2 |
130,913,257 (GRCm39) |
missense |
probably benign |
0.28 |
|
R2403:Siglec1
|
UTSW |
2 |
130,916,395 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2449:Siglec1
|
UTSW |
2 |
130,920,645 (GRCm39) |
missense |
probably benign |
0.44 |
|
R2885:Siglec1
|
UTSW |
2 |
130,914,667 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4213:Siglec1
|
UTSW |
2 |
130,916,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4274:Siglec1
|
UTSW |
2 |
130,927,734 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4679:Siglec1
|
UTSW |
2 |
130,915,331 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R4782:Siglec1
|
UTSW |
2 |
130,917,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4896:Siglec1
|
UTSW |
2 |
130,911,789 (GRCm39) |
missense |
probably benign |
0.21 |
|
R4993:Siglec1
|
UTSW |
2 |
130,915,281 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5004:Siglec1
|
UTSW |
2 |
130,915,331 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5004:Siglec1
|
UTSW |
2 |
130,911,789 (GRCm39) |
missense |
probably benign |
0.21 |
|
R5105:Siglec1
|
UTSW |
2 |
130,922,320 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5137:Siglec1
|
UTSW |
2 |
130,923,264 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5153:Siglec1
|
UTSW |
2 |
130,927,497 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5311:Siglec1
|
UTSW |
2 |
130,921,236 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5600:Siglec1
|
UTSW |
2 |
130,927,503 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5682:Siglec1
|
UTSW |
2 |
130,925,930 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5732:Siglec1
|
UTSW |
2 |
130,916,188 (GRCm39) |
missense |
probably benign |
0.30 |
|
R5870:Siglec1
|
UTSW |
2 |
130,914,767 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5898:Siglec1
|
UTSW |
2 |
130,915,553 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5909:Siglec1
|
UTSW |
2 |
130,919,884 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6488:Siglec1
|
UTSW |
2 |
130,923,227 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6920:Siglec1
|
UTSW |
2 |
130,919,997 (GRCm39) |
nonsense |
probably null |
|
|
R7064:Siglec1
|
UTSW |
2 |
130,925,834 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7270:Siglec1
|
UTSW |
2 |
130,923,471 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7355:Siglec1
|
UTSW |
2 |
130,922,371 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7400:Siglec1
|
UTSW |
2 |
130,928,015 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7470:Siglec1
|
UTSW |
2 |
130,917,744 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7568:Siglec1
|
UTSW |
2 |
130,914,602 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7781:Siglec1
|
UTSW |
2 |
130,923,258 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7853:Siglec1
|
UTSW |
2 |
130,923,212 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7999:Siglec1
|
UTSW |
2 |
130,913,083 (GRCm39) |
missense |
probably benign |
0.28 |
|
R8191:Siglec1
|
UTSW |
2 |
130,927,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8274:Siglec1
|
UTSW |
2 |
130,925,830 (GRCm39) |
missense |
probably benign |
|
|
R8345:Siglec1
|
UTSW |
2 |
130,920,498 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8670:Siglec1
|
UTSW |
2 |
130,923,387 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8814:Siglec1
|
UTSW |
2 |
130,914,664 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9102:Siglec1
|
UTSW |
2 |
130,915,389 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9311:Siglec1
|
UTSW |
2 |
130,916,013 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9416:Siglec1
|
UTSW |
2 |
130,925,390 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9462:Siglec1
|
UTSW |
2 |
130,916,404 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9521:Siglec1
|
UTSW |
2 |
130,915,246 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9683:Siglec1
|
UTSW |
2 |
130,921,236 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9799:Siglec1
|
UTSW |
2 |
130,915,941 (GRCm39) |
missense |
probably damaging |
0.99 |
|
X0024:Siglec1
|
UTSW |
2 |
130,922,411 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Siglec1
|
UTSW |
2 |
130,922,444 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Z1176:Siglec1
|
UTSW |
2 |
130,920,665 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGACAGGCAGTTCCTTCCC -3'
(R):5'- GAAGGATGAGTCACCCATGG -3'
Sequencing Primer
(F):5'- TTCCAGCAGAAGTTCCAGGGAC -3'
(R):5'- GTCACCCATGGGCTAGACATTAG -3'
|
| Posted On |
2015-10-21 |
Incidental Mutation