Incidental Mutation 'R4715:Ptprd'
| ID |
353933 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ptprd
|
| Ensembl Gene |
ENSMUSG00000028399 |
| Gene Name |
protein tyrosine phosphatase, receptor type, D |
| Synonyms |
1110002J03Rik, 3000002J10Rik, B230219D21Rik |
| MMRRC Submission |
041982-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4715 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
4 |
| Chromosomal Location |
75941238-78211961 bp(-) (GRCm38) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 76107333 bp (GRCm38)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 543
(T543A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000102910
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000050757]
[ENSMUST00000098005]
[ENSMUST00000102834]
[ENSMUST00000107289]
[ENSMUST00000173376]
[ENSMUST00000174023]
[ENSMUST00000174180]
[ENSMUST00000174531]
[ENSMUST00000174831]
|
| AlphaFold |
Q64487 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000050757
AA Change: T533A
PolyPhen 2
Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000058466
Gene: ENSMUSG00000028399
AA Change: T533A
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
36 |
105 |
8.57e-12 |
SMART |
|
IGc2
|
138 |
208 |
1.38e-15 |
SMART |
|
IGc2
|
238 |
299 |
8.13e-4 |
SMART |
|
FN3
|
313 |
392 |
7.92e-14 |
SMART |
|
FN3
|
408 |
491 |
5.73e-11 |
SMART |
|
IG_like
|
499 |
593 |
8.34e1 |
SMART |
|
FN3
|
506 |
584 |
9.1e-14 |
SMART |
|
FN3
|
597 |
674 |
1.21e0 |
SMART |
|
transmembrane domain
|
847 |
869 |
N/A |
INTRINSIC |
|
low complexity region
|
870 |
882 |
N/A |
INTRINSIC |
|
PTPc
|
949 |
1207 |
6.38e-134 |
SMART |
|
PTPc
|
1236 |
1498 |
9.17e-135 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000098005
AA Change: T543A
PolyPhen 2
Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
|
| SMART Domains |
Protein: ENSMUSP00000095614
Gene: ENSMUSG00000028399
AA Change: T543A
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
36 |
105 |
8.57e-12 |
SMART |
|
IGc2
|
138 |
214 |
8.5e-16 |
SMART |
|
low complexity region
|
225 |
237 |
N/A |
INTRINSIC |
|
IGc2
|
248 |
309 |
8.13e-4 |
SMART |
|
FN3
|
323 |
402 |
7.92e-14 |
SMART |
|
FN3
|
418 |
501 |
5.73e-11 |
SMART |
|
IG_like
|
509 |
603 |
8.34e1 |
SMART |
|
FN3
|
516 |
594 |
9.1e-14 |
SMART |
|
FN3
|
607 |
684 |
1.21e0 |
SMART |
|
transmembrane domain
|
857 |
879 |
N/A |
INTRINSIC |
|
low complexity region
|
886 |
897 |
N/A |
INTRINSIC |
|
PTPc
|
950 |
1208 |
6.38e-134 |
SMART |
|
PTPc
|
1237 |
1499 |
9.17e-135 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000102834
AA Change: T296A
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000099898
Gene: ENSMUSG00000028399
AA Change: T296A
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
1 |
62 |
8.13e-4 |
SMART |
|
FN3
|
76 |
155 |
7.92e-14 |
SMART |
|
FN3
|
171 |
254 |
5.73e-11 |
SMART |
|
IG_like
|
262 |
356 |
8.34e1 |
SMART |
|
FN3
|
269 |
347 |
9.1e-14 |
SMART |
|
FN3
|
360 |
437 |
1.21e0 |
SMART |
|
transmembrane domain
|
610 |
632 |
N/A |
INTRINSIC |
|
low complexity region
|
633 |
645 |
N/A |
INTRINSIC |
|
PTPc
|
698 |
956 |
6.38e-134 |
SMART |
|
PTPc
|
985 |
1247 |
9.17e-135 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000107289
AA Change: T543A
PolyPhen 2
Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000102910
Gene: ENSMUSG00000028399
AA Change: T543A
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
36 |
105 |
8.57e-12 |
SMART |
|
IGc2
|
138 |
214 |
8.5e-16 |
SMART |
|
low complexity region
|
225 |
237 |
N/A |
INTRINSIC |
|
IGc2
|
248 |
309 |
8.13e-4 |
SMART |
|
FN3
|
323 |
402 |
7.92e-14 |
SMART |
|
FN3
|
418 |
501 |
5.73e-11 |
SMART |
|
IG_like
|
509 |
603 |
8.34e1 |
SMART |
|
FN3
|
516 |
594 |
9.1e-14 |
SMART |
|
FN3
|
609 |
696 |
2.72e-12 |
SMART |
|
FN3
|
712 |
809 |
2.87e-11 |
SMART |
|
FN3
|
824 |
904 |
4.96e-6 |
SMART |
|
FN3
|
919 |
1003 |
4.12e-12 |
SMART |
|
FN3
|
1018 |
1095 |
1.95e0 |
SMART |
|
transmembrane domain
|
1268 |
1290 |
N/A |
INTRINSIC |
|
low complexity region
|
1291 |
1303 |
N/A |
INTRINSIC |
|
PTPc
|
1356 |
1614 |
6.38e-134 |
SMART |
|
PTPc
|
1643 |
1905 |
9.17e-135 |
SMART |
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000172811
AA Change: T21A
|
| SMART Domains |
Protein: ENSMUSP00000134190
Gene: ENSMUSG00000028399
AA Change: T21A
| Domain | Start | End | E-Value | Type |
|---|
|
FN3
|
1 |
73 |
1.29e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000173376
AA Change: T550A
PolyPhen 2
Score 0.008 (Sensitivity: 0.96; Specificity: 0.76)
|
| SMART Domains |
Protein: ENSMUSP00000133468
Gene: ENSMUSG00000028399
AA Change: T550A
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
43 |
112 |
8.57e-12 |
SMART |
|
IGc2
|
145 |
221 |
8.5e-16 |
SMART |
|
low complexity region
|
232 |
244 |
N/A |
INTRINSIC |
|
IGc2
|
255 |
316 |
8.13e-4 |
SMART |
|
FN3
|
330 |
409 |
7.92e-14 |
SMART |
|
FN3
|
425 |
508 |
5.73e-11 |
SMART |
|
IG_like
|
516 |
610 |
8.34e1 |
SMART |
|
FN3
|
523 |
601 |
9.1e-14 |
SMART |
|
FN3
|
614 |
691 |
1.21e0 |
SMART |
|
transmembrane domain
|
864 |
886 |
N/A |
INTRINSIC |
|
low complexity region
|
887 |
899 |
N/A |
INTRINSIC |
|
PTPc
|
952 |
1210 |
6.38e-134 |
SMART |
|
PTPc
|
1239 |
1501 |
9.17e-135 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174023
AA Change: T540A
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000133562
Gene: ENSMUSG00000028399
AA Change: T540A
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
36 |
105 |
8.57e-12 |
SMART |
|
IGc2
|
138 |
211 |
4.88e-16 |
SMART |
|
low complexity region
|
222 |
234 |
N/A |
INTRINSIC |
|
IGc2
|
245 |
306 |
8.13e-4 |
SMART |
|
FN3
|
320 |
399 |
7.92e-14 |
SMART |
|
FN3
|
415 |
498 |
5.73e-11 |
SMART |
|
IG_like
|
506 |
600 |
8.34e1 |
SMART |
|
FN3
|
513 |
591 |
9.1e-14 |
SMART |
|
FN3
|
604 |
681 |
1.21e0 |
SMART |
|
transmembrane domain
|
853 |
875 |
N/A |
INTRINSIC |
|
low complexity region
|
882 |
893 |
N/A |
INTRINSIC |
|
PTPc
|
946 |
1204 |
6.38e-134 |
SMART |
|
PTPc
|
1233 |
1495 |
9.17e-135 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174180
AA Change: T530A
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| SMART Domains |
Protein: ENSMUSP00000133973
Gene: ENSMUSG00000028399
AA Change: T530A
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
36 |
105 |
8.57e-12 |
SMART |
|
IGc2
|
138 |
205 |
2.09e-15 |
SMART |
|
IGc2
|
235 |
296 |
8.13e-4 |
SMART |
|
FN3
|
310 |
389 |
7.92e-14 |
SMART |
|
FN3
|
405 |
488 |
5.73e-11 |
SMART |
|
IG_like
|
496 |
590 |
8.34e1 |
SMART |
|
FN3
|
503 |
581 |
9.1e-14 |
SMART |
|
FN3
|
596 |
683 |
2.72e-12 |
SMART |
|
FN3
|
699 |
787 |
6.15e-11 |
SMART |
|
FN3
|
802 |
882 |
4.96e-6 |
SMART |
|
FN3
|
897 |
981 |
4.12e-12 |
SMART |
|
FN3
|
996 |
1073 |
1.95e0 |
SMART |
|
transmembrane domain
|
1246 |
1268 |
N/A |
INTRINSIC |
|
low complexity region
|
1269 |
1281 |
N/A |
INTRINSIC |
|
PTPc
|
1334 |
1592 |
6.38e-134 |
SMART |
|
PTPc
|
1621 |
1883 |
9.17e-135 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174531
AA Change: T537A
PolyPhen 2
Score 0.015 (Sensitivity: 0.96; Specificity: 0.79)
|
| SMART Domains |
Protein: ENSMUSP00000134229
Gene: ENSMUSG00000028399
AA Change: T537A
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
36 |
105 |
8.57e-12 |
SMART |
|
IGc2
|
138 |
208 |
1.38e-15 |
SMART |
|
low complexity region
|
219 |
231 |
N/A |
INTRINSIC |
|
IGc2
|
242 |
303 |
8.13e-4 |
SMART |
|
FN3
|
317 |
396 |
7.92e-14 |
SMART |
|
FN3
|
412 |
495 |
5.73e-11 |
SMART |
|
IG_like
|
503 |
597 |
8.34e1 |
SMART |
|
FN3
|
510 |
588 |
9.1e-14 |
SMART |
|
FN3
|
601 |
678 |
1.21e0 |
SMART |
|
transmembrane domain
|
851 |
873 |
N/A |
INTRINSIC |
|
low complexity region
|
874 |
886 |
N/A |
INTRINSIC |
|
PTPc
|
939 |
1197 |
6.38e-134 |
SMART |
|
PTPc
|
1226 |
1488 |
9.17e-135 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000174831
AA Change: T543A
PolyPhen 2
Score 0.009 (Sensitivity: 0.96; Specificity: 0.77)
|
| SMART Domains |
Protein: ENSMUSP00000133328
Gene: ENSMUSG00000028399
AA Change: T543A
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
36 |
105 |
8.57e-12 |
SMART |
|
IGc2
|
138 |
214 |
8.5e-16 |
SMART |
|
low complexity region
|
225 |
237 |
N/A |
INTRINSIC |
|
IGc2
|
248 |
309 |
8.13e-4 |
SMART |
|
FN3
|
323 |
402 |
7.92e-14 |
SMART |
|
FN3
|
418 |
501 |
5.73e-11 |
SMART |
|
IG_like
|
509 |
603 |
8.34e1 |
SMART |
|
FN3
|
516 |
594 |
9.1e-14 |
SMART |
|
FN3
|
607 |
684 |
1.21e0 |
SMART |
|
transmembrane domain
|
856 |
878 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
896 |
N/A |
INTRINSIC |
|
PTPc
|
949 |
1207 |
6.38e-134 |
SMART |
|
PTPc
|
1236 |
1498 |
9.17e-135 |
SMART |
|
| Meta Mutation Damage Score |
0.0787 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.2%
- 20x: 95.0%
|
| Validation Efficiency |
92% (86/93) |
| MGI Phenotype |
Strain: 2158795
PHENOTYPE: Homozygotes for a targeted null mutation exhibit impaired learning of spatial tasks, enhanced long-term potentiation at hippocampal synapses, and high mortality associated with reduced food intake. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(9) : Targeted(4) Gene trapped(5)
|
| Other mutations in this stock |
Total: 80 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc2 |
A |
C |
19: 43,816,882 (GRCm38) |
E725A |
possibly damaging |
Het |
| Abcc5 |
G |
T |
16: 20,398,876 (GRCm38) |
L362I |
probably damaging |
Het |
| Ammecr1l |
C |
T |
18: 31,774,653 (GRCm38) |
R179* |
probably null |
Het |
| Arap2 |
G |
T |
5: 62,749,094 (GRCm38) |
T194K |
probably benign |
Het |
| Atf2 |
C |
A |
2: 73,823,300 (GRCm38) |
V282F |
probably damaging |
Het |
| Atp1a1 |
T |
C |
3: 101,591,806 (GRCm38) |
E159G |
possibly damaging |
Het |
| B4galt2 |
T |
C |
4: 117,877,179 (GRCm38) |
S258G |
possibly damaging |
Het |
| Bptf |
G |
T |
11: 107,047,181 (GRCm38) |
H2695N |
probably damaging |
Het |
| Casq2 |
T |
C |
3: 102,110,244 (GRCm38) |
V80A |
probably benign |
Het |
| Ccdc130 |
A |
G |
8: 84,263,874 (GRCm38) |
I43T |
probably damaging |
Het |
| Cdc42ep3 |
G |
A |
17: 79,335,458 (GRCm38) |
A11V |
probably benign |
Het |
| Cdh4 |
A |
T |
2: 179,780,467 (GRCm38) |
H128L |
probably benign |
Het |
| Cdk5rap1 |
C |
A |
2: 154,361,835 (GRCm38) |
*191L |
probably null |
Het |
| Cfdp1 |
G |
A |
8: 111,830,891 (GRCm38) |
T206I |
probably benign |
Het |
| Cgn |
C |
A |
3: 94,779,438 (GRCm38) |
G185W |
probably damaging |
Het |
| Clpx |
A |
C |
9: 65,312,114 (GRCm38) |
R231S |
possibly damaging |
Het |
| Copg1 |
T |
A |
6: 87,912,286 (GRCm38) |
L870* |
probably null |
Het |
| Cyp4a10 |
A |
T |
4: 115,525,338 (GRCm38) |
D275V |
probably benign |
Het |
| Dip2a |
T |
C |
10: 76,296,406 (GRCm38) |
T504A |
probably benign |
Het |
| Dmxl2 |
A |
C |
9: 54,446,405 (GRCm38) |
|
probably null |
Het |
| Dnaaf5 |
A |
T |
5: 139,178,000 (GRCm38) |
I671F |
probably damaging |
Het |
| Dnah14 |
A |
G |
1: 181,757,223 (GRCm38) |
D3173G |
probably damaging |
Het |
| Dock2 |
T |
C |
11: 34,294,118 (GRCm38) |
Y1074C |
probably damaging |
Het |
| Dthd1 |
A |
C |
5: 62,888,187 (GRCm38) |
M765L |
probably benign |
Het |
| E2f3 |
A |
C |
13: 29,911,275 (GRCm38) |
C220W |
probably damaging |
Het |
| Elf3 |
C |
T |
1: 135,257,752 (GRCm38) |
S8N |
probably damaging |
Het |
| F2rl1 |
A |
T |
13: 95,513,267 (GRCm38) |
V369E |
probably damaging |
Het |
| Fam214a |
T |
A |
9: 75,012,968 (GRCm38) |
W799R |
probably damaging |
Het |
| Fpr-rs7 |
C |
T |
17: 20,113,428 (GRCm38) |
G267R |
probably benign |
Het |
| Ggact |
A |
T |
14: 122,891,635 (GRCm38) |
L56Q |
possibly damaging |
Het |
| Gm10698 |
A |
T |
9: 33,728,488 (GRCm38) |
|
noncoding transcript |
Het |
| Gm5546 |
T |
C |
3: 104,366,508 (GRCm38) |
|
noncoding transcript |
Het |
| Gm8267 |
A |
G |
14: 44,717,835 (GRCm38) |
V243A |
probably benign |
Het |
| Gtf2h1 |
A |
G |
7: 46,815,412 (GRCm38) |
T424A |
possibly damaging |
Het |
| Gucy1b2 |
A |
G |
14: 62,423,017 (GRCm38) |
V140A |
possibly damaging |
Het |
| Htatip2 |
T |
C |
7: 49,770,844 (GRCm38) |
L146P |
probably damaging |
Het |
| Htr1b |
T |
C |
9: 81,631,510 (GRCm38) |
D348G |
possibly damaging |
Het |
| Ifi205 |
T |
C |
1: 174,028,321 (GRCm38) |
I48V |
possibly damaging |
Het |
| Igkv18-36 |
C |
T |
6: 69,992,591 (GRCm38) |
R72K |
probably damaging |
Het |
| Kcnk7 |
T |
C |
19: 5,706,253 (GRCm38) |
L169P |
probably damaging |
Het |
| Klf17 |
T |
C |
4: 117,760,536 (GRCm38) |
D208G |
probably benign |
Het |
| Ltn1 |
A |
G |
16: 87,418,494 (GRCm38) |
F418L |
probably damaging |
Het |
| Map4k4 |
G |
A |
1: 40,019,564 (GRCm38) |
V1040I |
probably damaging |
Het |
| Mark1 |
A |
G |
1: 184,912,132 (GRCm38) |
V445A |
probably benign |
Het |
| Med11 |
T |
C |
11: 70,453,196 (GRCm38) |
I114T |
probably benign |
Het |
| Moxd2 |
A |
G |
6: 40,887,247 (GRCm38) |
V83A |
probably damaging |
Het |
| Mrpl33 |
A |
G |
5: 31,616,358 (GRCm38) |
|
probably benign |
Het |
| Mrps27 |
A |
G |
13: 99,414,815 (GRCm38) |
|
probably null |
Het |
| Nop58 |
T |
C |
1: 59,696,026 (GRCm38) |
V75A |
probably benign |
Het |
| Olfr1290 |
A |
C |
2: 111,489,744 (GRCm38) |
M138R |
probably benign |
Het |
| Olfr1339 |
T |
C |
4: 118,734,655 (GRCm38) |
L42P |
probably damaging |
Het |
| Olfr136 |
A |
C |
17: 38,335,840 (GRCm38) |
I228L |
possibly damaging |
Het |
| Olfr325 |
A |
G |
11: 58,581,429 (GRCm38) |
D195G |
probably damaging |
Het |
| Olfr832 |
A |
G |
9: 18,945,446 (GRCm38) |
H266R |
probably benign |
Het |
| Olfr844 |
C |
A |
9: 19,319,147 (GRCm38) |
F210L |
probably benign |
Het |
| Pdzd2 |
G |
T |
15: 12,419,516 (GRCm38) |
N263K |
possibly damaging |
Het |
| Podnl1 |
C |
A |
8: 84,126,061 (GRCm38) |
|
probably benign |
Het |
| Prkd3 |
G |
T |
17: 78,951,937 (GRCm38) |
H864N |
possibly damaging |
Het |
| Pum2 |
T |
A |
12: 8,747,272 (GRCm38) |
I788N |
probably damaging |
Het |
| Ralgapa1 |
T |
A |
12: 55,693,458 (GRCm38) |
N1328I |
probably damaging |
Het |
| Rhoc |
T |
C |
3: 104,794,039 (GRCm38) |
L193P |
probably damaging |
Het |
| Rif1 |
T |
C |
2: 52,073,139 (GRCm38) |
|
probably benign |
Het |
| Rspo2 |
A |
T |
15: 43,075,904 (GRCm38) |
C163* |
probably null |
Het |
| Sco1 |
A |
G |
11: 67,056,599 (GRCm38) |
Y204C |
probably damaging |
Het |
| Shc2 |
T |
C |
10: 79,622,379 (GRCm38) |
K490R |
probably benign |
Het |
| Siglec1 |
T |
C |
2: 131,074,436 (GRCm38) |
D1198G |
probably damaging |
Het |
| Slc25a18 |
T |
C |
6: 120,786,090 (GRCm38) |
V31A |
probably damaging |
Het |
| Smpd5 |
A |
T |
15: 76,295,693 (GRCm38) |
I112L |
probably benign |
Het |
| Synpr |
CT |
C |
14: 13,285,198 (GRCm38) |
|
probably null |
Het |
| Tdrd9 |
T |
G |
12: 112,041,689 (GRCm38) |
S988A |
probably benign |
Het |
| Tiam2 |
T |
A |
17: 3,454,168 (GRCm38) |
F982I |
probably damaging |
Het |
| Tmc3 |
G |
A |
7: 83,622,396 (GRCm38) |
V919I |
probably benign |
Het |
| Tmem200c |
A |
T |
17: 68,840,470 (GRCm38) |
D16V |
probably damaging |
Het |
| Tmem37 |
A |
T |
1: 120,068,205 (GRCm38) |
D47E |
probably damaging |
Het |
| Top3a |
T |
A |
11: 60,742,997 (GRCm38) |
R733* |
probably null |
Het |
| Treh |
T |
C |
9: 44,683,318 (GRCm38) |
V8A |
probably benign |
Het |
| Trim17 |
A |
C |
11: 58,968,450 (GRCm38) |
|
probably benign |
Het |
| Ubash3b |
T |
C |
9: 41,016,600 (GRCm38) |
K471E |
probably damaging |
Het |
| Usp8 |
T |
A |
2: 126,729,222 (GRCm38) |
L144Q |
possibly damaging |
Het |
| Wnk2 |
T |
A |
13: 49,147,232 (GRCm38) |
M1L |
unknown |
Het |
|
| Other mutations in Ptprd |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00964:Ptprd
|
APN |
4 |
75,998,556 (GRCm38) |
nonsense |
probably null |
|
|
IGL01067:Ptprd
|
APN |
4 |
76,059,685 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01121:Ptprd
|
APN |
4 |
75,954,201 (GRCm38) |
splice site |
probably benign |
|
|
IGL01531:Ptprd
|
APN |
4 |
76,085,520 (GRCm38) |
missense |
probably damaging |
0.98 |
|
IGL01661:Ptprd
|
APN |
4 |
75,954,083 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01723:Ptprd
|
APN |
4 |
76,243,673 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01735:Ptprd
|
APN |
4 |
76,136,820 (GRCm38) |
splice site |
probably null |
|
|
IGL01810:Ptprd
|
APN |
4 |
76,140,507 (GRCm38) |
splice site |
probably benign |
|
|
IGL01834:Ptprd
|
APN |
4 |
76,128,595 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL01835:Ptprd
|
APN |
4 |
76,246,821 (GRCm38) |
missense |
probably benign |
0.02 |
|
IGL01867:Ptprd
|
APN |
4 |
76,243,647 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02582:Ptprd
|
APN |
4 |
75,947,124 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02591:Ptprd
|
APN |
4 |
75,982,050 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02741:Ptprd
|
APN |
4 |
76,133,284 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02866:Ptprd
|
APN |
4 |
76,050,437 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL02960:Ptprd
|
APN |
4 |
76,128,868 (GRCm38) |
missense |
probably damaging |
1.00 |
|
IGL03155:Ptprd
|
APN |
4 |
76,066,219 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
IGL03230:Ptprd
|
APN |
4 |
76,050,417 (GRCm38) |
nonsense |
probably null |
|
|
IGL03343:Ptprd
|
APN |
4 |
76,059,729 (GRCm38) |
missense |
probably damaging |
1.00 |
|
unhurried
|
UTSW |
4 |
76,100,633 (GRCm38) |
nonsense |
probably null |
|
|
ANU22:Ptprd
|
UTSW |
4 |
76,100,456 (GRCm38) |
missense |
probably damaging |
0.99 |
|
F5493:Ptprd
|
UTSW |
4 |
76,084,408 (GRCm38) |
missense |
probably damaging |
1.00 |
|
P0033:Ptprd
|
UTSW |
4 |
76,128,854 (GRCm38) |
nonsense |
probably null |
|
|
R0044:Ptprd
|
UTSW |
4 |
76,086,329 (GRCm38) |
missense |
probably benign |
0.08 |
|
R0044:Ptprd
|
UTSW |
4 |
76,086,329 (GRCm38) |
missense |
probably benign |
0.08 |
|
R0076:Ptprd
|
UTSW |
4 |
75,947,039 (GRCm38) |
splice site |
probably benign |
|
|
R0137:Ptprd
|
UTSW |
4 |
76,136,903 (GRCm38) |
missense |
probably benign |
0.24 |
|
R0358:Ptprd
|
UTSW |
4 |
75,944,989 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0365:Ptprd
|
UTSW |
4 |
76,136,846 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0385:Ptprd
|
UTSW |
4 |
76,128,665 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0601:Ptprd
|
UTSW |
4 |
76,100,474 (GRCm38) |
missense |
probably benign |
|
|
R0646:Ptprd
|
UTSW |
4 |
76,084,403 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R0667:Ptprd
|
UTSW |
4 |
75,957,346 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0707:Ptprd
|
UTSW |
4 |
75,957,239 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0734:Ptprd
|
UTSW |
4 |
76,140,597 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R0827:Ptprd
|
UTSW |
4 |
76,128,915 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R0932:Ptprd
|
UTSW |
4 |
76,136,885 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1069:Ptprd
|
UTSW |
4 |
76,100,633 (GRCm38) |
nonsense |
probably null |
|
|
R1069:Ptprd
|
UTSW |
4 |
75,998,487 (GRCm38) |
splice site |
probably benign |
|
|
R1086:Ptprd
|
UTSW |
4 |
76,133,258 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1439:Ptprd
|
UTSW |
4 |
76,066,200 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1440:Ptprd
|
UTSW |
4 |
76,084,552 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R1688:Ptprd
|
UTSW |
4 |
75,982,684 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R1858:Ptprd
|
UTSW |
4 |
75,947,147 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2001:Ptprd
|
UTSW |
4 |
75,954,122 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2020:Ptprd
|
UTSW |
4 |
76,133,161 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2023:Ptprd
|
UTSW |
4 |
75,957,104 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2413:Ptprd
|
UTSW |
4 |
76,133,200 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2510:Ptprd
|
UTSW |
4 |
76,086,011 (GRCm38) |
critical splice donor site |
probably null |
|
|
R2914:Ptprd
|
UTSW |
4 |
75,947,101 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R2971:Ptprd
|
UTSW |
4 |
76,107,324 (GRCm38) |
missense |
probably benign |
0.10 |
|
R3051:Ptprd
|
UTSW |
4 |
76,100,630 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R3433:Ptprd
|
UTSW |
4 |
76,086,011 (GRCm38) |
critical splice donor site |
probably null |
|
|
R3964:Ptprd
|
UTSW |
4 |
76,059,836 (GRCm38) |
splice site |
probably benign |
|
|
R4009:Ptprd
|
UTSW |
4 |
75,956,397 (GRCm38) |
missense |
possibly damaging |
0.94 |
|
R4394:Ptprd
|
UTSW |
4 |
76,128,685 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4420:Ptprd
|
UTSW |
4 |
76,039,377 (GRCm38) |
missense |
possibly damaging |
0.92 |
|
R4424:Ptprd
|
UTSW |
4 |
76,102,963 (GRCm38) |
missense |
probably benign |
0.22 |
|
R4575:Ptprd
|
UTSW |
4 |
76,243,786 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R4578:Ptprd
|
UTSW |
4 |
76,243,786 (GRCm38) |
missense |
possibly damaging |
0.55 |
|
R4782:Ptprd
|
UTSW |
4 |
76,091,532 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4785:Ptprd
|
UTSW |
4 |
76,140,553 (GRCm38) |
missense |
probably benign |
0.05 |
|
R4799:Ptprd
|
UTSW |
4 |
76,091,532 (GRCm38) |
missense |
probably benign |
0.01 |
|
R4944:Ptprd
|
UTSW |
4 |
76,128,899 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R4950:Ptprd
|
UTSW |
4 |
76,140,515 (GRCm38) |
splice site |
probably null |
|
|
R4969:Ptprd
|
UTSW |
4 |
76,133,305 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5153:Ptprd
|
UTSW |
4 |
76,012,102 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5164:Ptprd
|
UTSW |
4 |
76,100,758 (GRCm38) |
splice site |
probably null |
|
|
R5287:Ptprd
|
UTSW |
4 |
75,954,168 (GRCm38) |
nonsense |
probably null |
|
|
R5305:Ptprd
|
UTSW |
4 |
75,982,626 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5362:Ptprd
|
UTSW |
4 |
76,128,813 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5403:Ptprd
|
UTSW |
4 |
75,954,168 (GRCm38) |
nonsense |
probably null |
|
|
R5531:Ptprd
|
UTSW |
4 |
76,059,667 (GRCm38) |
critical splice donor site |
probably null |
|
|
R5543:Ptprd
|
UTSW |
4 |
76,059,753 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R5634:Ptprd
|
UTSW |
4 |
76,072,018 (GRCm38) |
missense |
probably benign |
0.01 |
|
R5719:Ptprd
|
UTSW |
4 |
76,054,602 (GRCm38) |
critical splice acceptor site |
probably null |
|
|
R5884:Ptprd
|
UTSW |
4 |
75,982,690 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6247:Ptprd
|
UTSW |
4 |
76,066,291 (GRCm38) |
missense |
probably benign |
0.06 |
|
R6250:Ptprd
|
UTSW |
4 |
76,128,995 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6335:Ptprd
|
UTSW |
4 |
75,954,183 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6352:Ptprd
|
UTSW |
4 |
76,091,552 (GRCm38) |
splice site |
probably null |
|
|
R6533:Ptprd
|
UTSW |
4 |
76,128,528 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6756:Ptprd
|
UTSW |
4 |
75,955,299 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R6782:Ptprd
|
UTSW |
4 |
76,325,140 (GRCm38) |
splice site |
probably null |
|
|
R7131:Ptprd
|
UTSW |
4 |
76,066,340 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7170:Ptprd
|
UTSW |
4 |
76,071,962 (GRCm38) |
missense |
probably benign |
0.06 |
|
R7233:Ptprd
|
UTSW |
4 |
76,059,783 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7246:Ptprd
|
UTSW |
4 |
76,128,676 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7413:Ptprd
|
UTSW |
4 |
76,246,839 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7428:Ptprd
|
UTSW |
4 |
76,086,468 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7442:Ptprd
|
UTSW |
4 |
76,059,821 (GRCm38) |
nonsense |
probably null |
|
|
R7491:Ptprd
|
UTSW |
4 |
76,133,155 (GRCm38) |
missense |
probably benign |
0.23 |
|
R7526:Ptprd
|
UTSW |
4 |
76,066,327 (GRCm38) |
missense |
probably benign |
0.00 |
|
R7609:Ptprd
|
UTSW |
4 |
76,072,003 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7612:Ptprd
|
UTSW |
4 |
76,086,459 (GRCm38) |
missense |
probably benign |
0.45 |
|
R7659:Ptprd
|
UTSW |
4 |
76,128,916 (GRCm38) |
missense |
probably benign |
0.03 |
|
R7743:Ptprd
|
UTSW |
4 |
76,086,089 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7748:Ptprd
|
UTSW |
4 |
76,099,504 (GRCm38) |
missense |
probably null |
0.39 |
|
R7788:Ptprd
|
UTSW |
4 |
75,998,604 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R7836:Ptprd
|
UTSW |
4 |
75,982,644 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R7937:Ptprd
|
UTSW |
4 |
76,095,535 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8000:Ptprd
|
UTSW |
4 |
76,066,242 (GRCm38) |
missense |
possibly damaging |
0.95 |
|
R8018:Ptprd
|
UTSW |
4 |
76,085,520 (GRCm38) |
missense |
probably damaging |
0.98 |
|
R8072:Ptprd
|
UTSW |
4 |
76,086,036 (GRCm38) |
missense |
probably benign |
0.01 |
|
R8119:Ptprd
|
UTSW |
4 |
76,129,026 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8350:Ptprd
|
UTSW |
4 |
75,950,661 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8387:Ptprd
|
UTSW |
4 |
75,955,289 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8458:Ptprd
|
UTSW |
4 |
76,066,259 (GRCm38) |
missense |
probably benign |
0.00 |
|
R8529:Ptprd
|
UTSW |
4 |
76,129,025 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R8699:Ptprd
|
UTSW |
4 |
76,041,392 (GRCm38) |
missense |
probably benign |
|
|
R8924:Ptprd
|
UTSW |
4 |
75,998,499 (GRCm38) |
critical splice donor site |
probably null |
|
|
R8984:Ptprd
|
UTSW |
4 |
75,945,014 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9024:Ptprd
|
UTSW |
4 |
75,956,330 (GRCm38) |
missense |
probably damaging |
1.00 |
|
R9204:Ptprd
|
UTSW |
4 |
75,954,078 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R9206:Ptprd
|
UTSW |
4 |
75,954,078 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R9259:Ptprd
|
UTSW |
4 |
76,071,963 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9311:Ptprd
|
UTSW |
4 |
76,133,083 (GRCm38) |
missense |
probably benign |
0.25 |
|
R9417:Ptprd
|
UTSW |
4 |
75,947,098 (GRCm38) |
missense |
probably damaging |
0.99 |
|
R9427:Ptprd
|
UTSW |
4 |
76,133,203 (GRCm38) |
missense |
probably benign |
0.01 |
|
R9579:Ptprd
|
UTSW |
4 |
75,954,078 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R9580:Ptprd
|
UTSW |
4 |
75,954,078 (GRCm38) |
missense |
possibly damaging |
0.46 |
|
R9701:Ptprd
|
UTSW |
4 |
75,998,659 (GRCm38) |
missense |
probably damaging |
1.00 |
|
RF016:Ptprd
|
UTSW |
4 |
76,128,655 (GRCm38) |
missense |
probably benign |
0.01 |
|
RF023:Ptprd
|
UTSW |
4 |
76,128,565 (GRCm38) |
missense |
probably damaging |
0.98 |
|
Z1176:Ptprd
|
UTSW |
4 |
76,133,214 (GRCm38) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- GCTGTGACCTGATGATTGAATAG -3'
(R):5'- GAGGCCCTTACATCTCAGATG -3'
Sequencing Primer
(F):5'- GACCTGATGATTGAATAGTATCTAGC -3'
(R):5'- CTCAGATGATGTAAGAGCCTTGTTC -3'
|
| Posted On |
2015-10-21 |
Incidental Mutation