Mutagenetix > Incidental Mutation

Incidental Mutation 'R4720:Dnah8'

354414

Institutional Source

Beutler Lab

Gene Symbol

Dnah8

Ensembl Gene

ENSMUSG00000033826

Gene Name

dynein, axonemal, heavy chain 8

Synonyms

P1-Loop, Dnahc8, Hst6.7b

MMRRC Submission

041958-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.477) question?

Stock #

R4720 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

30845909-31094736 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 30902608 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Phenylalanine at position 889 (L889F)

Ref Sequence

ENSEMBL: ENSMUSP00000127878 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000170651]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000170651
AA Change: L889F

PolyPhen 2 Score 0.081 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000127878
Gene: ENSMUSG00000033826
AA Change: L889F

Domain	Start	End	E-Value	Type
low complexity region	2	54	N/A	INTRINSIC
Pfam:DHC_N1	379	936	8.4e-159	PFAM
low complexity region	1069	1080	N/A	INTRINSIC
low complexity region	1224	1237	N/A	INTRINSIC
Pfam:DHC_N2	1509	1917	1.6e-134	PFAM
AAA	2082	2226	1.38e-1	SMART
AAA	2363	2516	2.04e-1	SMART
AAA	2689	2837	8.15e-2	SMART
Pfam:AAA_8	3022	3294	4e-72	PFAM
Pfam:MT	3306	3656	3.6e-48	PFAM
Pfam:AAA_9	3676	3901	6.7e-85	PFAM
Pfam:Dynein_heavy	4039	4728	8.4e-250	PFAM

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.8%
20x: 94.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a heavy chain of an axonemal dynein involved in sperm and respiratory cilia motility. Axonemal dyneins generate force through hydrolysis of ATP and binding to microtubules. [provided by RefSeq, Jan 2012]

Allele List at MGI

Other mutations in this stock

Total: 91 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	A	G	11: 110,018,248 (GRCm39)	I1124T	probably damaging	Het
Acacb	A	G	5: 114,367,975 (GRCm39)	T1658A	possibly damaging	Het
Acvrl1	C	A	15: 101,033,654 (GRCm39)	P112Q	probably damaging	Het
Ankar	A	T	1: 72,738,170 (GRCm39)	I4K	possibly damaging	Het
Ankfn1	G	C	11: 89,332,252 (GRCm39)	D431E	possibly damaging	Het
Apobec4	T	C	1: 152,632,425 (GRCm39)	V151A	possibly damaging	Het
Atp10b	A	G	11: 43,093,949 (GRCm39)	S498G	probably benign	Het
Azin1	A	G	15: 38,493,744 (GRCm39)	V293A	probably benign	Het
Ccdc88b	T	C	19: 6,835,083 (GRCm39)	E46G	probably damaging	Het
Ccdc96	T	C	5: 36,642,219 (GRCm39)		probably benign	Het
Ccnyl1	A	G	1: 64,752,290 (GRCm39)	D169G	probably benign	Het
Cdca3	T	A	6: 124,809,127 (GRCm39)	V89E	probably damaging	Het
Cdh19	A	T	1: 110,823,111 (GRCm39)		probably null	Het
Chka	G	A	19: 3,936,375 (GRCm39)	V238I	probably damaging	Het
Cntn3	T	C	6: 102,218,983 (GRCm39)	K546E	possibly damaging	Het
Crybg3	A	G	16: 59,360,180 (GRCm39)	V787A	probably damaging	Het
Dlgap3	T	C	4: 127,089,508 (GRCm39)		probably null	Het
Dnah9	T	C	11: 65,967,184 (GRCm39)	E1658G	probably damaging	Het
Dnajc11	A	G	4: 152,052,996 (GRCm39)	D102G	probably damaging	Het
Dync1i2	T	G	2: 71,064,018 (GRCm39)	S121A	probably damaging	Het
Ece1	G	A	4: 137,684,486 (GRCm39)	E591K	probably damaging	Het
Enthd1	G	A	15: 80,444,510 (GRCm39)	S15L	probably damaging	Het
Epb41l2	T	A	10: 25,347,524 (GRCm39)	H372Q	probably damaging	Het
Errfi1	T	A	4: 150,951,204 (GRCm39)	Y211N	probably damaging	Het
Fam193b	G	A	13: 55,691,250 (GRCm39)	T208M	probably benign	Het
Flacc1	T	C	1: 58,717,507 (GRCm39)	I135V	possibly damaging	Het
Fmnl2	C	T	2: 52,997,552 (GRCm39)	T501M	possibly damaging	Het
Gkn3	C	T	6: 87,360,507 (GRCm39)	A163T	probably damaging	Het
Gm4841	G	T	18: 60,403,135 (GRCm39)	D319E	probably benign	Het
Gucd1	A	G	10: 75,345,494 (GRCm39)	F187S	probably damaging	Het
Hcar2	GCGGATGCGCAC	GC	5: 124,002,752 (GRCm39)		probably null	Het
Helz2	T	C	2: 180,880,210 (GRCm39)	D502G	probably damaging	Het
Hspa2	A	G	12: 76,451,639 (GRCm39)	E111G	possibly damaging	Het
Htr2a	T	A	14: 74,882,499 (GRCm39)	S162T	probably damaging	Het
Ift80	A	G	3: 68,869,623 (GRCm39)	Y223H	possibly damaging	Het
Il1rl1	A	G	1: 40,485,838 (GRCm39)	K330E	probably benign	Het
Il23r	A	T	6: 67,400,645 (GRCm39)	F562I	probably damaging	Het
Isx	T	C	8: 75,600,487 (GRCm39)		probably null	Het
Jcad	G	A	18: 4,674,055 (GRCm39)	V606I	probably benign	Het
Kcnn2	A	T	18: 45,816,187 (GRCm39)	T333S	possibly damaging	Het
Kcnq5	C	T	1: 21,473,274 (GRCm39)	A630T	probably damaging	Het
Kif2c	T	C	4: 117,028,946 (GRCm39)	M188V	probably benign	Het
Kntc1	T	C	5: 123,903,086 (GRCm39)	V321A	possibly damaging	Het
Krtap4-8	A	T	11: 99,671,271 (GRCm39)		probably benign	Het
Lcor	G	C	19: 41,574,334 (GRCm39)	A1030P	probably benign	Het
Lgals3bp	A	C	11: 118,289,295 (GRCm39)	L52R	probably damaging	Het
Lipk	C	A	19: 33,999,099 (GRCm39)	H126Q	probably damaging	Het
Lpgat1	T	C	1: 191,495,779 (GRCm39)	Y323H	probably damaging	Het
Lrp2	T	G	2: 69,311,517 (GRCm39)	N2654H	probably damaging	Het
Lsm14b	C	T	2: 179,669,774 (GRCm39)	Q6*	probably null	Het
Lysmd3	C	T	13: 81,817,584 (GRCm39)	A187V	possibly damaging	Het
Map2k5	A	G	9: 63,201,001 (GRCm39)	S211P	probably damaging	Het
Mlph	A	T	1: 90,869,419 (GRCm39)	I474F	probably damaging	Het
Mpped2	T	C	2: 106,614,091 (GRCm39)	S142P	probably damaging	Het
Nemf	A	C	12: 69,371,062 (GRCm39)	M678R	probably benign	Het
Nfe2l1	A	T	11: 96,718,515 (GRCm39)	Y7N	probably damaging	Het
Nfkbie	T	G	17: 45,867,232 (GRCm39)	D122E	probably benign	Het
Noc3l	C	A	19: 38,778,066 (GRCm39)	A783S	probably benign	Het
Nol8	T	C	13: 49,816,229 (GRCm39)	V761A	probably damaging	Het
Nvl	A	G	1: 180,929,152 (GRCm39)	L743P	probably damaging	Het
Or1j1	T	A	2: 36,702,484 (GRCm39)	I207F	probably benign	Het
Plcb1	A	G	2: 135,093,667 (GRCm39)	K160R	possibly damaging	Het
Plekhg3	G	T	12: 76,625,096 (GRCm39)	G1313C	possibly damaging	Het
Plekhh1	GTCAAA	G	12: 79,122,194 (GRCm39)		probably null	Het
Popdc3	G	A	10: 45,191,002 (GRCm39)	V38I	probably benign	Het
Prdx3	A	T	19: 60,858,551 (GRCm39)	V114D	possibly damaging	Het
Prkdc	T	A	16: 15,485,579 (GRCm39)	S469T	probably benign	Het
Rbm22	G	A	18: 60,697,463 (GRCm39)	R56H	probably damaging	Het
Reln	A	T	5: 22,491,894 (GRCm39)	F113I	possibly damaging	Het
Rims1	A	G	1: 22,497,731 (GRCm39)	Y808H	probably damaging	Het
Rsbn1	C	A	3: 103,836,336 (GRCm39)	T458N	possibly damaging	Het
Serpina3b	A	G	12: 104,096,889 (GRCm39)	S57G	possibly damaging	Het
Skor2	G	T	18: 76,948,878 (GRCm39)		probably null	Het
Slc22a4	A	T	11: 53,879,719 (GRCm39)	Y447N	probably damaging	Het
Slco1a7	C	A	6: 141,668,948 (GRCm39)	A495S	probably damaging	Het
Stx19	G	T	16: 62,642,682 (GRCm39)	R166L	probably damaging	Het
Svep1	T	C	4: 58,205,869 (GRCm39)	T170A	possibly damaging	Het
Sycp2	T	G	2: 178,016,225 (GRCm39)	S746R	probably benign	Het
Tchh	G	T	3: 93,355,189 (GRCm39)	R1543L	unknown	Het
Tjp2	T	C	19: 24,078,169 (GRCm39)	D908G	probably damaging	Het
Ttc8	C	A	12: 98,946,068 (GRCm39)	A452E	possibly damaging	Het
Unc5a	T	A	13: 55,151,696 (GRCm39)	W709R	probably null	Het
Unc80	T	A	1: 66,549,951 (GRCm39)	S736R	possibly damaging	Het
Vmn2r100	C	A	17: 19,742,788 (GRCm39)	H387Q	probably benign	Het
Vmn2r39	C	T	7: 9,026,469 (GRCm39)		probably null	Het
Vmn2r88	T	A	14: 51,650,702 (GRCm39)	D138E	probably benign	Het
Vwce	T	C	19: 10,625,831 (GRCm39)	F448L	possibly damaging	Het
Wdr75	C	T	1: 45,861,645 (GRCm39)	S695F	probably benign	Het
Zfand4	T	C	6: 116,265,122 (GRCm39)		probably null	Het
Zfp511	T	A	7: 139,617,424 (GRCm39)		probably null	Het
Zfyve9	T	C	4: 108,501,565 (GRCm39)	K584E	possibly damaging	Het

Other mutations in Dnah8

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00498:Dnah8	APN	17	30,896,150 (GRCm39)	missense	probably benign	0.06
IGL00508:Dnah8	APN	17	31,074,904 (GRCm39)	missense	probably damaging	1.00
IGL00547:Dnah8	APN	17	31,034,677 (GRCm39)	nonsense	probably null
IGL00551:Dnah8	APN	17	30,882,452 (GRCm39)	nonsense	probably null
IGL00732:Dnah8	APN	17	30,875,615 (GRCm39)	missense	probably damaging	1.00
IGL00775:Dnah8	APN	17	30,986,880 (GRCm39)	nonsense	probably null
IGL00840:Dnah8	APN	17	31,009,915 (GRCm39)	missense	probably damaging	1.00
IGL00845:Dnah8	APN	17	31,038,250 (GRCm39)	critical splice donor site	probably null
IGL00953:Dnah8	APN	17	30,925,431 (GRCm39)	nonsense	probably null
IGL00976:Dnah8	APN	17	31,070,684 (GRCm39)	missense	probably damaging	0.98
IGL01395:Dnah8	APN	17	30,854,979 (GRCm39)	missense	probably benign	0.06
IGL01467:Dnah8	APN	17	30,998,890 (GRCm39)	missense	probably damaging	1.00
IGL01469:Dnah8	APN	17	30,902,688 (GRCm39)	splice site	probably benign
IGL01515:Dnah8	APN	17	30,867,459 (GRCm39)	missense	probably benign
IGL01723:Dnah8	APN	17	30,927,445 (GRCm39)	missense	probably damaging	1.00
IGL01837:Dnah8	APN	17	30,970,565 (GRCm39)	critical splice donor site	probably null
IGL01921:Dnah8	APN	17	30,955,115 (GRCm39)	missense	probably benign
IGL01958:Dnah8	APN	17	31,074,869 (GRCm39)	splice site	probably benign
IGL01968:Dnah8	APN	17	30,875,572 (GRCm39)	nonsense	probably null
IGL02093:Dnah8	APN	17	30,936,854 (GRCm39)	missense	probably damaging	0.99
IGL02151:Dnah8	APN	17	30,867,391 (GRCm39)	missense	possibly damaging	0.50
IGL02182:Dnah8	APN	17	31,013,737 (GRCm39)	missense	possibly damaging	0.45
IGL02233:Dnah8	APN	17	30,925,487 (GRCm39)	critical splice donor site	probably null
IGL02236:Dnah8	APN	17	30,868,747 (GRCm39)	nonsense	probably null
IGL02259:Dnah8	APN	17	30,978,588 (GRCm39)	missense	probably benign
IGL02263:Dnah8	APN	17	30,948,139 (GRCm39)	missense	probably benign	0.00
IGL02303:Dnah8	APN	17	30,932,021 (GRCm39)	missense	probably benign	0.03
IGL02341:Dnah8	APN	17	30,966,231 (GRCm39)	missense	probably damaging	1.00
IGL02351:Dnah8	APN	17	30,986,785 (GRCm39)	missense	probably damaging	1.00
IGL02358:Dnah8	APN	17	30,986,785 (GRCm39)	missense	probably damaging	1.00
IGL02377:Dnah8	APN	17	31,013,770 (GRCm39)	missense	probably damaging	0.98
IGL02390:Dnah8	APN	17	31,049,819 (GRCm39)	missense	probably benign	0.01
IGL02392:Dnah8	APN	17	31,037,025 (GRCm39)	splice site	probably benign
IGL02414:Dnah8	APN	17	30,919,387 (GRCm39)	missense	probably benign
IGL02455:Dnah8	APN	17	30,891,308 (GRCm39)	missense	probably damaging	0.99
IGL02817:Dnah8	APN	17	30,887,269 (GRCm39)	missense	probably benign
IGL02831:Dnah8	APN	17	30,931,250 (GRCm39)	missense	probably benign	0.23
IGL02863:Dnah8	APN	17	30,988,671 (GRCm39)	missense	probably damaging	1.00
IGL02894:Dnah8	APN	17	30,940,084 (GRCm39)	nonsense	probably null
IGL02954:Dnah8	APN	17	30,923,809 (GRCm39)	missense	probably benign	0.30
IGL02964:Dnah8	APN	17	30,965,735 (GRCm39)	missense	probably damaging	1.00
IGL03080:Dnah8	APN	17	30,937,980 (GRCm39)	missense	probably benign	0.01
IGL03081:Dnah8	APN	17	30,905,347 (GRCm39)	splice site	probably benign
IGL03086:Dnah8	APN	17	30,961,754 (GRCm39)	missense	probably damaging	1.00
IGL03087:Dnah8	APN	17	31,003,118 (GRCm39)	missense	probably benign
IGL03176:Dnah8	APN	17	30,913,011 (GRCm39)	missense	probably benign
IGL03191:Dnah8	APN	17	30,945,804 (GRCm39)	missense	probably damaging	0.99
IGL03210:Dnah8	APN	17	31,034,639 (GRCm39)	missense	probably damaging	0.96
IGL03252:Dnah8	APN	17	30,892,894 (GRCm39)	splice site	probably null
IGL03255:Dnah8	APN	17	30,960,355 (GRCm39)	missense	probably damaging	1.00
IGL03288:Dnah8	APN	17	30,891,323 (GRCm39)	missense	probably benign
IGL03348:Dnah8	APN	17	30,965,960 (GRCm39)	missense	probably damaging	0.99
Alternator	UTSW	17	30,984,609 (GRCm39)	missense	probably benign
armature	UTSW	17	30,927,364 (GRCm39)	missense	probably benign	0.02
Brush	UTSW	17	30,965,964 (GRCm39)	missense	probably damaging	1.00
Dynos	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
joule	UTSW	17	30,932,072 (GRCm39)	critical splice donor site	probably null
solenoid	UTSW	17	30,960,152 (GRCm39)	missense	probably damaging	1.00
FR4340:Dnah8	UTSW	17	30,854,437 (GRCm39)	small deletion	probably benign
FR4737:Dnah8	UTSW	17	30,854,451 (GRCm39)	small deletion	probably benign
FR4737:Dnah8	UTSW	17	30,854,439 (GRCm39)	small deletion	probably benign
I2288:Dnah8	UTSW	17	30,882,428 (GRCm39)	missense	probably benign
P0029:Dnah8	UTSW	17	30,984,694 (GRCm39)	missense	probably damaging	1.00
PIT4812001:Dnah8	UTSW	17	30,927,419 (GRCm39)	missense	probably benign	0.04
R0016:Dnah8	UTSW	17	30,882,290 (GRCm39)	missense	probably benign
R0035:Dnah8	UTSW	17	30,902,595 (GRCm39)	splice site	probably benign
R0035:Dnah8	UTSW	17	30,902,595 (GRCm39)	splice site	probably benign
R0062:Dnah8	UTSW	17	30,984,685 (GRCm39)	missense	probably damaging	1.00
R0062:Dnah8	UTSW	17	30,984,685 (GRCm39)	missense	probably damaging	1.00
R0087:Dnah8	UTSW	17	30,974,093 (GRCm39)	missense	probably damaging	1.00
R0090:Dnah8	UTSW	17	31,003,064 (GRCm39)	missense	probably benign	0.20
R0119:Dnah8	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
R0164:Dnah8	UTSW	17	30,967,639 (GRCm39)	missense	probably benign
R0164:Dnah8	UTSW	17	30,967,639 (GRCm39)	missense	probably benign
R0184:Dnah8	UTSW	17	30,902,657 (GRCm39)	missense	probably benign	0.04
R0240:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0240:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0241:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0241:Dnah8	UTSW	17	30,984,653 (GRCm39)	missense	probably damaging	0.98
R0265:Dnah8	UTSW	17	30,909,245 (GRCm39)	missense	probably benign
R0268:Dnah8	UTSW	17	30,988,681 (GRCm39)	missense	probably damaging	1.00
R0282:Dnah8	UTSW	17	30,955,130 (GRCm39)	missense	probably damaging	1.00
R0299:Dnah8	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
R0334:Dnah8	UTSW	17	31,090,325 (GRCm39)	missense	probably damaging	0.99
R0393:Dnah8	UTSW	17	30,927,364 (GRCm39)	missense	probably benign	0.02
R0423:Dnah8	UTSW	17	30,920,955 (GRCm39)	missense	probably benign
R0470:Dnah8	UTSW	17	30,927,514 (GRCm39)	splice site	probably benign
R0477:Dnah8	UTSW	17	30,974,054 (GRCm39)	missense	probably damaging	1.00
R0490:Dnah8	UTSW	17	30,919,393 (GRCm39)	missense	probably benign
R0499:Dnah8	UTSW	17	30,934,483 (GRCm39)	missense	possibly damaging	0.84
R0582:Dnah8	UTSW	17	30,937,935 (GRCm39)	missense	probably benign	0.01
R0601:Dnah8	UTSW	17	30,927,332 (GRCm39)	missense	probably benign	0.06
R0646:Dnah8	UTSW	17	30,903,147 (GRCm39)	missense	probably damaging	0.97
R0665:Dnah8	UTSW	17	30,955,129 (GRCm39)	missense	probably damaging	0.99
R0800:Dnah8	UTSW	17	30,923,636 (GRCm39)	missense	probably benign
R0843:Dnah8	UTSW	17	31,032,069 (GRCm39)	missense	probably damaging	1.00
R0940:Dnah8	UTSW	17	31,022,217 (GRCm39)	missense	probably damaging	1.00
R0964:Dnah8	UTSW	17	30,892,894 (GRCm39)	splice site	probably null
R1102:Dnah8	UTSW	17	31,073,738 (GRCm39)	splice site	probably null
R1137:Dnah8	UTSW	17	31,074,910 (GRCm39)	missense	probably damaging	1.00
R1342:Dnah8	UTSW	17	30,939,974 (GRCm39)	missense	probably damaging	0.99
R1375:Dnah8	UTSW	17	30,956,269 (GRCm39)	missense	probably damaging	1.00
R1377:Dnah8	UTSW	17	31,059,596 (GRCm39)	nonsense	probably null
R1464:Dnah8	UTSW	17	30,914,147 (GRCm39)	missense	possibly damaging	0.81
R1464:Dnah8	UTSW	17	30,914,147 (GRCm39)	missense	possibly damaging	0.81
R1470:Dnah8	UTSW	17	30,966,251 (GRCm39)	nonsense	probably null
R1470:Dnah8	UTSW	17	30,966,251 (GRCm39)	nonsense	probably null
R1497:Dnah8	UTSW	17	30,971,049 (GRCm39)	missense	probably damaging	1.00
R1513:Dnah8	UTSW	17	30,892,862 (GRCm39)	missense	probably benign
R1541:Dnah8	UTSW	17	30,966,221 (GRCm39)	missense	probably damaging	1.00
R1563:Dnah8	UTSW	17	30,854,638 (GRCm39)	missense	probably benign	0.07
R1634:Dnah8	UTSW	17	30,932,072 (GRCm39)	critical splice donor site	probably null
R1670:Dnah8	UTSW	17	30,944,098 (GRCm39)	missense	probably damaging	1.00
R1710:Dnah8	UTSW	17	31,073,914 (GRCm39)	missense	probably damaging	1.00
R1743:Dnah8	UTSW	17	30,988,625 (GRCm39)	missense	probably benign	0.28
R1761:Dnah8	UTSW	17	30,998,890 (GRCm39)	missense	probably damaging	1.00
R1785:Dnah8	UTSW	17	30,941,911 (GRCm39)	missense	probably damaging	0.98
R1804:Dnah8	UTSW	17	30,927,381 (GRCm39)	missense	probably benign	0.00
R1808:Dnah8	UTSW	17	30,903,160 (GRCm39)	missense	probably damaging	1.00
R1824:Dnah8	UTSW	17	30,950,154 (GRCm39)	missense	possibly damaging	0.67
R1836:Dnah8	UTSW	17	31,093,901 (GRCm39)	missense	possibly damaging	0.94
R1935:Dnah8	UTSW	17	30,854,479 (GRCm39)	missense	unknown
R1935:Dnah8	UTSW	17	30,945,870 (GRCm39)	splice site	probably benign
R1940:Dnah8	UTSW	17	30,950,181 (GRCm39)	missense	probably damaging	1.00
R1946:Dnah8	UTSW	17	30,931,359 (GRCm39)	missense	probably benign	0.00
R2025:Dnah8	UTSW	17	30,950,133 (GRCm39)	missense	probably damaging	0.99
R2038:Dnah8	UTSW	17	30,977,255 (GRCm39)	missense	probably damaging	1.00
R2042:Dnah8	UTSW	17	30,854,632 (GRCm39)	missense	probably benign	0.01
R2148:Dnah8	UTSW	17	30,956,232 (GRCm39)	missense	probably damaging	1.00
R2177:Dnah8	UTSW	17	30,872,367 (GRCm39)	missense	probably benign
R2180:Dnah8	UTSW	17	31,059,621 (GRCm39)	missense	probably benign	0.00
R2262:Dnah8	UTSW	17	30,892,809 (GRCm39)	missense	probably damaging	1.00
R2263:Dnah8	UTSW	17	30,892,809 (GRCm39)	missense	probably damaging	1.00
R2328:Dnah8	UTSW	17	31,013,718 (GRCm39)	missense	probably damaging	1.00
R2357:Dnah8	UTSW	17	30,990,846 (GRCm39)	missense	probably benign
R2357:Dnah8	UTSW	17	31,093,909 (GRCm39)	missense	probably benign	0.00
R2360:Dnah8	UTSW	17	30,896,178 (GRCm39)	missense	probably benign	0.22
R2496:Dnah8	UTSW	17	31,070,705 (GRCm39)	missense	probably damaging	1.00
R2497:Dnah8	UTSW	17	30,960,339 (GRCm39)	nonsense	probably null
R2509:Dnah8	UTSW	17	30,994,019 (GRCm39)	missense	probably benign	0.02
R3114:Dnah8	UTSW	17	31,052,542 (GRCm39)	missense	probably benign	0.04
R3708:Dnah8	UTSW	17	30,958,631 (GRCm39)	missense	probably damaging	0.98
R3720:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3722:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3727:Dnah8	UTSW	17	30,958,622 (GRCm39)	nonsense	probably null
R3747:Dnah8	UTSW	17	31,003,148 (GRCm39)	nonsense	probably null
R3748:Dnah8	UTSW	17	31,003,148 (GRCm39)	nonsense	probably null
R3749:Dnah8	UTSW	17	31,003,148 (GRCm39)	nonsense	probably null
R3787:Dnah8	UTSW	17	30,974,015 (GRCm39)	missense	probably damaging	1.00
R3790:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3804:Dnah8	UTSW	17	30,889,621 (GRCm39)	missense	probably benign	0.00
R3857:Dnah8	UTSW	17	30,882,396 (GRCm39)	missense	probably damaging	0.96
R3898:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3899:Dnah8	UTSW	17	31,073,872 (GRCm39)	missense	probably damaging	1.00
R3938:Dnah8	UTSW	17	31,073,911 (GRCm39)	missense	probably damaging	1.00
R3943:Dnah8	UTSW	17	30,913,039 (GRCm39)	splice site	probably benign
R4091:Dnah8	UTSW	17	30,988,813 (GRCm39)	missense	probably damaging	1.00
R4291:Dnah8	UTSW	17	30,967,533 (GRCm39)	missense	probably benign
R4326:Dnah8	UTSW	17	30,971,066 (GRCm39)	missense	probably benign	0.04
R4346:Dnah8	UTSW	17	30,944,072 (GRCm39)	missense	possibly damaging	0.92
R4429:Dnah8	UTSW	17	30,971,120 (GRCm39)	missense	probably damaging	1.00
R4457:Dnah8	UTSW	17	31,032,125 (GRCm39)	missense	probably benign
R4475:Dnah8	UTSW	17	30,875,959 (GRCm39)	missense	probably benign	0.12
R4565:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4566:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4568:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4573:Dnah8	UTSW	17	30,919,380 (GRCm39)	missense	probably benign	0.00
R4580:Dnah8	UTSW	17	30,881,026 (GRCm39)	missense	probably benign	0.00
R4585:Dnah8	UTSW	17	30,970,541 (GRCm39)	missense	probably benign	0.01
R4611:Dnah8	UTSW	17	30,903,211 (GRCm39)	missense	probably damaging	1.00
R4721:Dnah8	UTSW	17	30,944,140 (GRCm39)	missense	probably damaging	1.00
R4727:Dnah8	UTSW	17	31,070,721 (GRCm39)	missense	probably damaging	1.00
R4731:Dnah8	UTSW	17	30,994,035 (GRCm39)	missense	probably null	0.02
R4732:Dnah8	UTSW	17	30,994,035 (GRCm39)	missense	probably null	0.02
R4733:Dnah8	UTSW	17	30,994,035 (GRCm39)	missense	probably null	0.02
R4798:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4814:Dnah8	UTSW	17	30,986,898 (GRCm39)	missense	probably damaging	1.00
R4892:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4894:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4900:Dnah8	UTSW	17	30,965,949 (GRCm39)	missense	probably damaging	1.00
R4901:Dnah8	UTSW	17	31,059,688 (GRCm39)	critical splice donor site	probably null
R4913:Dnah8	UTSW	17	31,038,113 (GRCm39)	missense	probably damaging	0.99
R4931:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4932:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4933:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R4942:Dnah8	UTSW	17	30,948,116 (GRCm39)	missense	probably benign
R4969:Dnah8	UTSW	17	30,941,988 (GRCm39)	missense	probably damaging	1.00
R4975:Dnah8	UTSW	17	30,875,959 (GRCm39)	missense	probably benign	0.12
R4977:Dnah8	UTSW	17	30,882,275 (GRCm39)	missense	probably benign	0.00
R5001:Dnah8	UTSW	17	31,006,159 (GRCm39)	missense	probably damaging	1.00
R5011:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5013:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5014:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5024:Dnah8	UTSW	17	30,955,070 (GRCm39)	missense	probably damaging	1.00
R5075:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5075:Dnah8	UTSW	17	31,019,505 (GRCm39)	missense	probably damaging	1.00
R5075:Dnah8	UTSW	17	30,958,731 (GRCm39)	critical splice donor site	probably null
R5112:Dnah8	UTSW	17	30,950,012 (GRCm39)	missense	probably benign	0.02
R5121:Dnah8	UTSW	17	31,029,327 (GRCm39)	missense	probably benign	0.14
R5138:Dnah8	UTSW	17	30,984,571 (GRCm39)	missense	probably damaging	0.99
R5151:Dnah8	UTSW	17	30,931,269 (GRCm39)	missense	probably benign	0.06
R5191:Dnah8	UTSW	17	30,965,739 (GRCm39)	missense	probably damaging	1.00
R5238:Dnah8	UTSW	17	31,009,891 (GRCm39)	missense	probably damaging	1.00
R5260:Dnah8	UTSW	17	30,919,393 (GRCm39)	missense	probably benign
R5358:Dnah8	UTSW	17	30,965,928 (GRCm39)	missense	probably damaging	1.00
R5403:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5404:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5482:Dnah8	UTSW	17	31,019,521 (GRCm39)	missense	probably damaging	0.96
R5489:Dnah8	UTSW	17	31,009,930 (GRCm39)	missense	probably damaging	1.00
R5513:Dnah8	UTSW	17	30,971,890 (GRCm39)	missense	probably damaging	0.99
R5635:Dnah8	UTSW	17	30,925,360 (GRCm39)	missense	probably benign	0.00
R5640:Dnah8	UTSW	17	31,022,082 (GRCm39)	missense	probably damaging	1.00
R5649:Dnah8	UTSW	17	31,019,561 (GRCm39)	missense	probably benign	0.13
R5662:Dnah8	UTSW	17	30,956,307 (GRCm39)	missense	probably damaging	1.00
R5673:Dnah8	UTSW	17	31,022,235 (GRCm39)	missense	probably damaging	1.00
R5677:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5699:Dnah8	UTSW	17	31,029,298 (GRCm39)	missense	probably benign	0.22
R5737:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5738:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R5739:Dnah8	UTSW	17	30,937,981 (GRCm39)	missense	probably benign	0.00
R5766:Dnah8	UTSW	17	30,909,235 (GRCm39)	missense	probably benign	0.01
R5790:Dnah8	UTSW	17	31,093,978 (GRCm39)	missense	probably damaging	0.98
R5848:Dnah8	UTSW	17	30,947,165 (GRCm39)	missense	possibly damaging	0.69
R5854:Dnah8	UTSW	17	31,013,737 (GRCm39)	missense	possibly damaging	0.45
R5885:Dnah8	UTSW	17	31,013,691 (GRCm39)	missense	probably damaging	1.00
R5886:Dnah8	UTSW	17	31,013,691 (GRCm39)	missense	probably damaging	1.00
R5887:Dnah8	UTSW	17	31,013,691 (GRCm39)	missense	probably damaging	1.00
R5899:Dnah8	UTSW	17	30,875,659 (GRCm39)	missense	probably benign	0.32
R5979:Dnah8	UTSW	17	31,034,638 (GRCm39)	nonsense	probably null
R5986:Dnah8	UTSW	17	31,070,604 (GRCm39)	missense	possibly damaging	0.83
R5999:Dnah8	UTSW	17	30,882,279 (GRCm39)	missense	probably benign	0.32
R6042:Dnah8	UTSW	17	30,966,239 (GRCm39)	missense	probably damaging	1.00
R6175:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6181:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6237:Dnah8	UTSW	17	30,966,828 (GRCm39)	nonsense	probably null
R6239:Dnah8	UTSW	17	31,029,333 (GRCm39)	missense	probably damaging	0.99
R6337:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6365:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6416:Dnah8	UTSW	17	30,984,609 (GRCm39)	missense	probably benign
R6443:Dnah8	UTSW	17	30,990,859 (GRCm39)	missense	probably benign	0.10
R6478:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6479:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6480:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6481:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6533:Dnah8	UTSW	17	30,965,964 (GRCm39)	missense	probably damaging	1.00
R6606:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6608:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6610:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6675:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6723:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6724:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6754:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6755:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6759:Dnah8	UTSW	17	30,882,266 (GRCm39)	splice site	probably null
R6765:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6766:Dnah8	UTSW	17	30,967,542 (GRCm39)	missense	probably benign	0.00
R6778:Dnah8	UTSW	17	30,854,640 (GRCm39)	missense	probably benign	0.00
R6781:Dnah8	UTSW	17	30,984,698 (GRCm39)	frame shift	probably null
R6788:Dnah8	UTSW	17	30,867,439 (GRCm39)	missense	probably benign	0.14
R6814:Dnah8	UTSW	17	30,981,653 (GRCm39)	missense	probably damaging	1.00
R6825:Dnah8	UTSW	17	30,960,147 (GRCm39)	missense	probably damaging	1.00
R6838:Dnah8	UTSW	17	30,929,525 (GRCm39)	missense	probably damaging	1.00
R6872:Dnah8	UTSW	17	30,981,653 (GRCm39)	missense	probably damaging	1.00
R6877:Dnah8	UTSW	17	30,965,933 (GRCm39)	missense	probably damaging	1.00
R6944:Dnah8	UTSW	17	31,013,633 (GRCm39)	missense	probably benign	0.09
R6982:Dnah8	UTSW	17	30,986,899 (GRCm39)	missense	probably benign	0.03
R6984:Dnah8	UTSW	17	30,958,712 (GRCm39)	missense	probably damaging	1.00
R6987:Dnah8	UTSW	17	30,881,065 (GRCm39)	missense	possibly damaging	0.95
R6988:Dnah8	UTSW	17	30,862,249 (GRCm39)	missense	probably damaging	1.00
R7099:Dnah8	UTSW	17	30,923,698 (GRCm39)	missense	possibly damaging	0.93
R7106:Dnah8	UTSW	17	30,960,152 (GRCm39)	missense	probably damaging	1.00
R7112:Dnah8	UTSW	17	31,090,366 (GRCm39)	missense	possibly damaging	0.79
R7146:Dnah8	UTSW	17	30,988,618 (GRCm39)	missense	possibly damaging	0.90
R7146:Dnah8	UTSW	17	30,863,591 (GRCm39)	missense	probably benign	0.01
R7309:Dnah8	UTSW	17	31,093,988 (GRCm39)	missense	probably damaging	1.00
R7324:Dnah8	UTSW	17	31,003,099 (GRCm39)	missense	probably benign	0.01
R7373:Dnah8	UTSW	17	30,986,939 (GRCm39)	critical splice donor site	probably null
R7423:Dnah8	UTSW	17	30,923,743 (GRCm39)	missense	possibly damaging	0.86
R7430:Dnah8	UTSW	17	30,925,363 (GRCm39)	missense	probably damaging	0.98
R7450:Dnah8	UTSW	17	31,006,165 (GRCm39)	missense	probably damaging	0.99
R7580:Dnah8	UTSW	17	30,994,077 (GRCm39)	missense	probably damaging	0.98
R7604:Dnah8	UTSW	17	31,032,069 (GRCm39)	missense	probably damaging	1.00
R7635:Dnah8	UTSW	17	31,004,081 (GRCm39)	missense	probably damaging	1.00
R7646:Dnah8	UTSW	17	30,868,651 (GRCm39)	missense	probably benign	0.00
R7685:Dnah8	UTSW	17	30,876,947 (GRCm39)	missense	probably damaging	1.00
R7793:Dnah8	UTSW	17	31,074,918 (GRCm39)	missense	probably benign	0.20
R7827:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R7866:Dnah8	UTSW	17	31,093,901 (GRCm39)	missense	possibly damaging	0.94
R7877:Dnah8	UTSW	17	30,882,348 (GRCm39)	missense	probably benign
R7891:Dnah8	UTSW	17	30,931,263 (GRCm39)	missense	probably benign	0.09
R7977:Dnah8	UTSW	17	30,963,498 (GRCm39)	missense	probably damaging	1.00
R7987:Dnah8	UTSW	17	30,963,498 (GRCm39)	missense	probably damaging	1.00
R8025:Dnah8	UTSW	17	30,960,311 (GRCm39)	nonsense	probably null
R8076:Dnah8	UTSW	17	31,003,127 (GRCm39)	missense	possibly damaging	0.94
R8170:Dnah8	UTSW	17	30,892,797 (GRCm39)	missense	probably damaging	1.00
R8199:Dnah8	UTSW	17	31,090,393 (GRCm39)	missense	probably benign	0.06
R8253:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R8270:Dnah8	UTSW	17	31,059,687 (GRCm39)	missense	probably damaging	1.00
R8291:Dnah8	UTSW	17	30,984,701 (GRCm39)	missense	probably damaging	1.00
R8334:Dnah8	UTSW	17	30,988,805 (GRCm39)	missense	probably benign	0.12
R8348:Dnah8	UTSW	17	30,892,814 (GRCm39)	missense	probably benign
R8348:Dnah8	UTSW	17	30,955,121 (GRCm39)	missense	probably damaging	0.96
R8354:Dnah8	UTSW	17	30,862,234 (GRCm39)	missense	probably benign	0.17
R8355:Dnah8	UTSW	17	30,914,152 (GRCm39)	missense	possibly damaging	0.89
R8439:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R8448:Dnah8	UTSW	17	30,892,814 (GRCm39)	missense	probably benign
R8459:Dnah8	UTSW	17	30,944,221 (GRCm39)	critical splice donor site	probably null
R8462:Dnah8	UTSW	17	30,875,603 (GRCm39)	missense	probably damaging	1.00
R8506:Dnah8	UTSW	17	30,940,108 (GRCm39)	missense	probably benign
R8524:Dnah8	UTSW	17	30,934,472 (GRCm39)	missense	possibly damaging	0.95
R8555:Dnah8	UTSW	17	30,940,084 (GRCm39)	nonsense	probably null
R8698:Dnah8	UTSW	17	31,094,009 (GRCm39)	missense	probably damaging	1.00
R8719:Dnah8	UTSW	17	30,960,289 (GRCm39)	missense	probably damaging	0.97
R8778:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R8781:Dnah8	UTSW	17	30,944,078 (GRCm39)	missense	probably damaging	1.00
R8821:Dnah8	UTSW	17	31,013,712 (GRCm39)	missense	probably damaging	1.00
R8864:Dnah8	UTSW	17	30,981,616 (GRCm39)	missense	possibly damaging	0.95
R8885:Dnah8	UTSW	17	30,927,286 (GRCm39)	missense	possibly damaging	0.83
R8983:Dnah8	UTSW	17	31,070,628 (GRCm39)	missense	probably damaging	0.98
R8994:Dnah8	UTSW	17	31,009,807 (GRCm39)	missense	probably benign	0.05
R9031:Dnah8	UTSW	17	30,956,401 (GRCm39)	missense	probably damaging	1.00
R9068:Dnah8	UTSW	17	30,975,729 (GRCm39)	missense	possibly damaging	0.63
R9225:Dnah8	UTSW	17	30,854,647 (GRCm39)	missense	probably benign	0.01
R9280:Dnah8	UTSW	17	31,004,071 (GRCm39)	missense	possibly damaging	0.52
R9291:Dnah8	UTSW	17	30,944,099 (GRCm39)	missense	probably damaging	1.00
R9314:Dnah8	UTSW	17	30,990,857 (GRCm39)	missense	probably benign
R9347:Dnah8	UTSW	17	30,927,333 (GRCm39)	missense	probably benign	0.00
R9393:Dnah8	UTSW	17	30,872,361 (GRCm39)	missense	possibly damaging	0.53
R9415:Dnah8	UTSW	17	31,029,297 (GRCm39)	missense	probably benign	0.02
R9458:Dnah8	UTSW	17	31,049,777 (GRCm39)	missense	probably damaging	1.00
R9465:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9518:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9524:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9564:Dnah8	UTSW	17	30,932,021 (GRCm39)	missense	probably benign	0.07
R9587:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9599:Dnah8	UTSW	17	30,979,841 (GRCm39)	frame shift	probably null
R9641:Dnah8	UTSW	17	30,932,029 (GRCm39)	missense	probably benign	0.13
R9674:Dnah8	UTSW	17	30,998,112 (GRCm39)	missense	possibly damaging	0.84
R9679:Dnah8	UTSW	17	31,037,115 (GRCm39)	missense	probably benign
R9789:Dnah8	UTSW	17	30,980,104 (GRCm39)	critical splice donor site	probably null
RF027:Dnah8	UTSW	17	30,854,450 (GRCm39)	frame shift	probably null
X0001:Dnah8	UTSW	17	30,967,654 (GRCm39)	missense	probably damaging	1.00
X0013:Dnah8	UTSW	17	31,038,160 (GRCm39)	missense	possibly damaging	0.71
Z1176:Dnah8	UTSW	17	30,867,514 (GRCm39)	missense	probably benign
Z1177:Dnah8	UTSW	17	30,932,069 (GRCm39)	missense	probably null	1.00
Z1177:Dnah8	UTSW	17	30,913,007 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- TCCGAGCAGTTTCTCCAAAC -3'
(R):5'- TCAAGGCAAGGAGATGTATTCTG -3'

Sequencing Primer
(F):5'- GGGATACACCTGTGATTGACAGC -3'
(R):5'- CAAGGAGATGTATTCTGAGATCCATC -3'

Posted On

2015-10-21