Incidental Mutation 'R4721:3425401B19Rik'
ID 354489
Institutional Source Beutler Lab
Gene Symbol 3425401B19Rik
Ensembl Gene ENSMUSG00000071540
Gene Name RIKEN cDNA 3425401B19 gene
Synonyms
MMRRC Submission 041986-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # R4721 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 32381076-32407250 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 32385107 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 286 (D286G)
Ref Sequence ENSEMBL: ENSMUSP00000093741 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096038]
AlphaFold D3Z1D3
Predicted Effect probably benign
Transcript: ENSMUST00000096038
AA Change: D286G

PolyPhen 2 Score 0.014 (Sensitivity: 0.96; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000093741
Gene: ENSMUSG00000071540
AA Change: D286G

DomainStartEndE-ValueType
low complexity region 135 145 N/A INTRINSIC
low complexity region 162 175 N/A INTRINSIC
low complexity region 386 399 N/A INTRINSIC
low complexity region 587 602 N/A INTRINSIC
low complexity region 605 624 N/A INTRINSIC
low complexity region 728 744 N/A INTRINSIC
low complexity region 1002 1015 N/A INTRINSIC
low complexity region 1086 1097 N/A INTRINSIC
low complexity region 1147 1158 N/A INTRINSIC
low complexity region 1161 1176 N/A INTRINSIC
Pfam:DUF4585 1251 1322 6.5e-30 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226958
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.2%
Validation Efficiency 98% (90/92)
Allele List at MGI
Other mutations in this stock
Total: 77 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca15 G A 7: 119,949,998 (GRCm39) E491K probably benign Het
Acsl5 A G 19: 55,268,962 (GRCm39) T208A probably benign Het
Adamts10 T A 17: 33,764,511 (GRCm39) probably null Het
Ahcyl1 T C 3: 107,577,233 (GRCm39) Q313R possibly damaging Het
Ccdc71 C T 9: 108,340,622 (GRCm39) S145L possibly damaging Het
Cep250 A G 2: 155,812,119 (GRCm39) T472A probably damaging Het
Copa T C 1: 171,931,841 (GRCm39) probably benign Het
Crybg1 C A 10: 43,873,883 (GRCm39) R1075L probably damaging Het
Ddr2 T A 1: 169,832,809 (GRCm39) K84* probably null Het
Ddx59 C T 1: 136,344,844 (GRCm39) P172S probably benign Het
Dhx34 T A 7: 15,931,307 (GRCm39) Q1118L possibly damaging Het
Dkkl1 T A 7: 44,857,232 (GRCm39) I112F probably damaging Het
Dnah8 T A 17: 30,944,140 (GRCm39) C1786S probably damaging Het
Eml6 T A 11: 29,788,525 (GRCm39) D520V possibly damaging Het
Ergic1 T A 17: 26,857,750 (GRCm39) V192E probably damaging Het
Fat3 T C 9: 15,941,262 (GRCm39) E1343G probably damaging Het
Fxr1 T C 3: 34,118,381 (GRCm39) S535P possibly damaging Het
Gkn3 C T 6: 87,360,507 (GRCm39) A163T probably damaging Het
Gm15446 C T 5: 110,090,866 (GRCm39) H373Y probably damaging Het
Gpr157 A T 4: 150,183,420 (GRCm39) N197Y probably benign Het
Grid2 G A 6: 64,643,185 (GRCm39) M982I probably benign Het
Hey2 G T 10: 30,710,304 (GRCm39) R150S possibly damaging Het
Hmcn1 T C 1: 150,648,322 (GRCm39) probably null Het
Ighv3-3 G A 12: 114,160,156 (GRCm39) R85* probably null Het
Ighv5-4 A T 12: 113,561,060 (GRCm39) probably benign Het
Igsf21 A G 4: 139,834,621 (GRCm39) S84P probably benign Het
Kif20b A G 19: 34,915,773 (GRCm39) T517A probably benign Het
Krt87 T C 15: 101,385,863 (GRCm39) E244G probably damaging Het
Lrp1 T C 10: 127,390,928 (GRCm39) T2990A possibly damaging Het
Lrp1b T A 2: 40,605,381 (GRCm39) probably null Het
Lrrc42 A T 4: 107,091,050 (GRCm39) S382T probably benign Het
Magi2 C T 5: 20,739,467 (GRCm39) R737W probably damaging Het
Mcc A G 18: 44,652,623 (GRCm39) L267P probably damaging Het
Mzf1 T A 7: 12,777,223 (GRCm39) Q727L possibly damaging Het
Mzf1 C T 7: 12,777,448 (GRCm39) R652Q possibly damaging Het
Nkain3 C T 4: 20,485,015 (GRCm39) A21T probably damaging Het
Nlrp4e T A 7: 23,020,521 (GRCm39) V336E possibly damaging Het
Nptn C T 9: 58,548,059 (GRCm39) R155C probably damaging Het
Nr2c2 T C 6: 92,116,828 (GRCm39) I10T possibly damaging Het
Or12e13 T A 2: 87,663,515 (GRCm39) I44N probably damaging Het
Or1e26 C T 11: 73,480,273 (GRCm39) C97Y probably damaging Het
Or1j13 T C 2: 36,369,836 (GRCm39) Y102C probably benign Het
Pdzk1 G T 3: 96,776,518 (GRCm39) E493* probably null Het
Plekhh1 GTCAAA G 12: 79,122,194 (GRCm39) probably null Het
Polr3b T C 10: 84,491,867 (GRCm39) V342A possibly damaging Het
Prg3 T C 2: 84,821,750 (GRCm39) V125A possibly damaging Het
Raph1 G A 1: 60,542,160 (GRCm39) probably benign Het
Rassf2 A G 2: 131,846,358 (GRCm39) V133A probably benign Het
Rbm22 G A 18: 60,697,463 (GRCm39) R56H probably damaging Het
Rbpjl A C 2: 164,246,447 (GRCm39) S31R probably benign Het
Reln A G 5: 22,124,220 (GRCm39) V2762A probably damaging Het
Rxrg T A 1: 167,452,621 (GRCm39) I141N probably damaging Het
Scn7a C A 2: 66,514,529 (GRCm39) G1082C probably damaging Het
Selenon C A 4: 134,270,387 (GRCm39) E322* probably null Het
Sipa1 C T 19: 5,710,413 (GRCm39) R199Q probably damaging Het
Slc26a7 A T 4: 14,510,261 (GRCm39) probably null Het
Slc37a4 T C 9: 44,312,787 (GRCm39) S314P possibly damaging Het
Smarce1 T C 11: 99,111,543 (GRCm39) I59V probably benign Het
Stk19 T C 17: 35,042,120 (GRCm39) probably null Het
Susd2 C T 10: 75,473,964 (GRCm39) D544N probably benign Het
Tcf7l2 G T 19: 55,919,886 (GRCm39) R465L possibly damaging Het
Tfap2d T A 1: 19,174,984 (GRCm39) S146T possibly damaging Het
Tmem156 A G 5: 65,248,870 (GRCm39) F10S probably benign Het
Tmem63c G T 12: 87,103,954 (GRCm39) A68S possibly damaging Het
Tnfrsf21 T C 17: 43,396,395 (GRCm39) C560R probably damaging Het
Trav10n C T 14: 53,359,590 (GRCm39) T7I probably benign Het
Ttc38 C T 15: 85,722,947 (GRCm39) R132W probably benign Het
Tvp23a T C 16: 10,245,275 (GRCm39) K108R probably benign Het
Vmn1r233 T C 17: 21,214,879 (GRCm39) M24V probably benign Het
Vmn1r88 T A 7: 12,912,451 (GRCm39) L269* probably null Het
Vmn2r101 T A 17: 19,832,287 (GRCm39) M761K probably damaging Het
Vps13b C T 15: 35,910,864 (GRCm39) Q3543* probably null Het
Wdr37 T C 13: 8,904,065 (GRCm39) E101G possibly damaging Het
Zc3hc1 A G 6: 30,374,899 (GRCm39) V214A probably benign Het
Zcchc9 A T 13: 91,948,728 (GRCm39) probably null Het
Zdbf2 A T 1: 63,347,951 (GRCm39) Q2110L possibly damaging Het
Zfp516 T G 18: 82,975,236 (GRCm39) L478R possibly damaging Het
Other mutations in 3425401B19Rik
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00839:3425401B19Rik APN 14 32,382,873 (GRCm39) missense probably benign 0.18
IGL00844:3425401B19Rik APN 14 32,384,956 (GRCm39) nonsense probably null
IGL01292:3425401B19Rik APN 14 32,382,831 (GRCm39) missense probably benign 0.18
IGL01295:3425401B19Rik APN 14 32,383,893 (GRCm39) missense possibly damaging 0.53
IGL01457:3425401B19Rik APN 14 32,382,908 (GRCm39) missense probably benign
IGL01470:3425401B19Rik APN 14 32,382,414 (GRCm39) missense possibly damaging 0.53
IGL01612:3425401B19Rik APN 14 32,381,988 (GRCm39) missense possibly damaging 0.53
IGL01974:3425401B19Rik APN 14 32,381,762 (GRCm39) missense possibly damaging 0.85
IGL02095:3425401B19Rik APN 14 32,383,583 (GRCm39) missense probably benign 0.33
IGL02138:3425401B19Rik APN 14 32,384,672 (GRCm39) missense possibly damaging 0.83
IGL02178:3425401B19Rik APN 14 32,384,418 (GRCm39) missense possibly damaging 0.83
IGL02245:3425401B19Rik APN 14 32,381,772 (GRCm39) missense probably benign 0.03
IGL02529:3425401B19Rik APN 14 32,383,190 (GRCm39) missense probably benign
IGL03401:3425401B19Rik APN 14 32,384,223 (GRCm39) nonsense probably null
PIT4515001:3425401B19Rik UTSW 14 32,383,068 (GRCm39) nonsense probably null
R0233:3425401B19Rik UTSW 14 32,385,330 (GRCm39) missense probably benign
R0233:3425401B19Rik UTSW 14 32,385,330 (GRCm39) missense probably benign
R0320:3425401B19Rik UTSW 14 32,384,571 (GRCm39) missense probably benign 0.19
R0519:3425401B19Rik UTSW 14 32,384,919 (GRCm39) missense possibly damaging 0.92
R0551:3425401B19Rik UTSW 14 32,384,598 (GRCm39) missense probably benign 0.03
R0759:3425401B19Rik UTSW 14 32,384,454 (GRCm39) missense possibly damaging 0.93
R0831:3425401B19Rik UTSW 14 32,384,228 (GRCm39) missense probably benign 0.01
R1124:3425401B19Rik UTSW 14 32,384,039 (GRCm39) missense possibly damaging 0.53
R1346:3425401B19Rik UTSW 14 32,382,771 (GRCm39) missense probably benign 0.07
R1997:3425401B19Rik UTSW 14 32,382,005 (GRCm39) missense possibly damaging 0.71
R2055:3425401B19Rik UTSW 14 32,384,508 (GRCm39) missense probably benign
R2212:3425401B19Rik UTSW 14 32,383,559 (GRCm39) missense probably benign 0.33
R2416:3425401B19Rik UTSW 14 32,385,791 (GRCm39) missense probably benign 0.04
R2441:3425401B19Rik UTSW 14 32,385,449 (GRCm39) missense possibly damaging 0.53
R2513:3425401B19Rik UTSW 14 32,383,809 (GRCm39) missense possibly damaging 0.53
R3414:3425401B19Rik UTSW 14 32,383,559 (GRCm39) missense probably benign 0.33
R3800:3425401B19Rik UTSW 14 32,385,025 (GRCm39) missense possibly damaging 0.83
R3809:3425401B19Rik UTSW 14 32,385,650 (GRCm39) missense possibly damaging 0.96
R4166:3425401B19Rik UTSW 14 32,382,912 (GRCm39) missense possibly damaging 0.53
R4581:3425401B19Rik UTSW 14 32,383,828 (GRCm39) missense possibly damaging 0.73
R4769:3425401B19Rik UTSW 14 32,382,174 (GRCm39) missense probably benign 0.32
R4809:3425401B19Rik UTSW 14 32,384,588 (GRCm39) missense probably benign 0.19
R4919:3425401B19Rik UTSW 14 32,385,245 (GRCm39) missense possibly damaging 0.85
R4925:3425401B19Rik UTSW 14 32,385,137 (GRCm39) missense possibly damaging 0.86
R4972:3425401B19Rik UTSW 14 32,383,361 (GRCm39) missense possibly damaging 0.73
R5068:3425401B19Rik UTSW 14 32,383,749 (GRCm39) missense possibly damaging 0.73
R5069:3425401B19Rik UTSW 14 32,383,749 (GRCm39) missense possibly damaging 0.73
R5070:3425401B19Rik UTSW 14 32,383,749 (GRCm39) missense possibly damaging 0.73
R5258:3425401B19Rik UTSW 14 32,385,266 (GRCm39) missense probably damaging 0.98
R5435:3425401B19Rik UTSW 14 32,383,413 (GRCm39) missense probably benign 0.18
R5549:3425401B19Rik UTSW 14 32,384,993 (GRCm39) missense possibly damaging 0.68
R5678:3425401B19Rik UTSW 14 32,384,010 (GRCm39) missense probably damaging 0.97
R5680:3425401B19Rik UTSW 14 32,384,010 (GRCm39) missense probably damaging 0.97
R5872:3425401B19Rik UTSW 14 32,382,309 (GRCm39) missense possibly damaging 0.73
R5896:3425401B19Rik UTSW 14 32,383,632 (GRCm39) nonsense probably null
R5940:3425401B19Rik UTSW 14 32,384,645 (GRCm39) missense possibly damaging 0.91
R6044:3425401B19Rik UTSW 14 32,382,614 (GRCm39) missense possibly damaging 0.53
R6136:3425401B19Rik UTSW 14 32,384,239 (GRCm39) missense possibly damaging 0.70
R6277:3425401B19Rik UTSW 14 32,385,651 (GRCm39) missense possibly damaging 0.86
R6385:3425401B19Rik UTSW 14 32,383,236 (GRCm39) missense probably benign 0.01
R6728:3425401B19Rik UTSW 14 32,384,645 (GRCm39) missense possibly damaging 0.91
R6984:3425401B19Rik UTSW 14 32,383,937 (GRCm39) missense probably benign 0.00
R7047:3425401B19Rik UTSW 14 32,382,131 (GRCm39) missense possibly damaging 0.89
R7249:3425401B19Rik UTSW 14 32,385,271 (GRCm39) missense possibly damaging 0.73
R7493:3425401B19Rik UTSW 14 32,385,257 (GRCm39) missense possibly damaging 0.96
R7575:3425401B19Rik UTSW 14 32,384,589 (GRCm39) missense probably benign 0.03
R7742:3425401B19Rik UTSW 14 32,384,714 (GRCm39) missense possibly damaging 0.68
R7747:3425401B19Rik UTSW 14 32,385,026 (GRCm39) missense possibly damaging 0.83
R7784:3425401B19Rik UTSW 14 32,381,797 (GRCm39) missense probably benign 0.00
R8098:3425401B19Rik UTSW 14 32,384,618 (GRCm39) missense probably damaging 0.99
R8111:3425401B19Rik UTSW 14 32,382,266 (GRCm39) nonsense probably null
R8171:3425401B19Rik UTSW 14 32,383,982 (GRCm39) missense probably benign
R8276:3425401B19Rik UTSW 14 32,385,885 (GRCm39) missense probably damaging 0.97
R8330:3425401B19Rik UTSW 14 32,381,750 (GRCm39) missense probably damaging 0.98
R8422:3425401B19Rik UTSW 14 32,384,254 (GRCm39) missense possibly damaging 0.84
R8464:3425401B19Rik UTSW 14 32,381,934 (GRCm39) missense possibly damaging 0.53
R8880:3425401B19Rik UTSW 14 32,382,837 (GRCm39) missense probably benign 0.33
R8898:3425401B19Rik UTSW 14 32,383,001 (GRCm39) nonsense probably null
R8911:3425401B19Rik UTSW 14 32,383,626 (GRCm39) missense possibly damaging 0.53
R8934:3425401B19Rik UTSW 14 32,382,614 (GRCm39) missense possibly damaging 0.53
R9094:3425401B19Rik UTSW 14 32,382,614 (GRCm39) missense possibly damaging 0.53
R9399:3425401B19Rik UTSW 14 32,384,615 (GRCm39) missense probably damaging 0.98
R9435:3425401B19Rik UTSW 14 32,382,562 (GRCm39) missense probably benign 0.08
R9485:3425401B19Rik UTSW 14 32,383,400 (GRCm39) missense possibly damaging 0.85
R9766:3425401B19Rik UTSW 14 32,385,788 (GRCm39) missense probably benign 0.00
X0025:3425401B19Rik UTSW 14 32,384,426 (GRCm39) missense probably damaging 0.98
Z1177:3425401B19Rik UTSW 14 32,383,355 (GRCm39) missense probably damaging 0.99
Z1177:3425401B19Rik UTSW 14 32,381,765 (GRCm39) missense possibly damaging 0.86
Predicted Primers PCR Primer
(F):5'- AGATGTGGATTGGCTCCCTG -3'
(R):5'- CTGGAGAACAAGAGTCTCCCAAG -3'

Sequencing Primer
(F):5'- ATTGGCTCCCTGACGGTGAC -3'
(R):5'- GAAATAGCCTCTCACAGCTCAG -3'
Posted On 2015-10-21