Mutagenetix > Incidental Mutations

Incidental Mutation 'R4724:Olfr1434'

354744

Institutional Source

Beutler Lab

Gene Symbol

Olfr1434

Ensembl Gene

ENSMUSG00000095640

Gene Name

olfactory receptor 1434

Synonyms

MOR214-4, Olfr1433, MOR214-4, GA_x6K02T2RE5P-2618516-2619454, GA_x6K02T2RE5P-2610001-2610414

MMRRC Submission

041988-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.111) question?

Stock #

R4724 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

12279854-12285626 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 12283096 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Leucine to Proline at position 16 (L16P)

Ref Sequence

ENSEMBL: ENSMUSP00000146411 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000207186] [ENSMUST00000207915] [ENSMUST00000208197]

AlphaFold

Q7TQR9

Predicted Effect

probably damaging
Transcript: ENSMUST00000087814
AA Change: L16P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000085115
Gene: ENSMUSG00000095640
AA Change: L16P

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	308	9.2e-55	PFAM
Pfam:7tm_1	42	307	2.5e-18	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000207186
AA Change: L16P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000207915
AA Change: L16P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

probably damaging
Transcript: ENSMUST00000208197
AA Change: L16P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.4%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 105 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4933434E20Rik	C	G	3: 90,053,541	Q34E	probably damaging	Het
4933434E20Rik	A	T	3: 90,053,542	Q34L	probably damaging	Het
4933434E20Rik	G	T	3: 90,053,583	V48F	probably damaging	Het
8430408G22Rik	T	A	6: 116,652,135	C146*	probably null	Het
Abra	T	C	15: 41,865,906	D366G	probably damaging	Het
Acvr2a	T	C	2: 48,870,435	S68P	probably damaging	Het
Adam28	T	A	14: 68,626,877	R492S	probably damaging	Het
Adamts1	T	A	16: 85,802,505	E69V	probably benign	Het
Adgra1	A	T	7: 139,875,589	M378L	probably benign	Het
Adgra2	T	A	8: 27,098,822	N101K	possibly damaging	Het
Adhfe1	T	A	1: 9,576,250	F449L	probably damaging	Het
Akap6	T	A	12: 52,795,885	S5R	possibly damaging	Het
Akap9	G	A	5: 4,055,339	R2883Q	probably benign	Het
Ank3	T	A	10: 69,706,858	I16N	probably benign	Het
Api5	A	T	2: 94,423,471	F296I	possibly damaging	Het
Ceacam14	G	T	7: 17,814,050		probably null	Het
Cep295	C	T	9: 15,330,832	G1768S	probably damaging	Het
Cldn12	A	G	5: 5,508,385	F14S	probably damaging	Het
Cp	C	A	3: 19,972,647	T413K	probably benign	Het
Ctdsp2	T	G	10: 126,993,069	V104G	probably damaging	Het
Ctrc	T	A	4: 141,846,296		probably null	Het
Dbt	T	C	3: 116,533,296	I98T	probably damaging	Het
Dcaf10	G	A	4: 45,372,769	R394Q	possibly damaging	Het
Dctn1	T	A	6: 83,189,938	M257K	possibly damaging	Het
Dlgap5	C	T	14: 47,401,520		probably null	Het
Drd3	G	T	16: 43,822,801	E467*	probably null	Het
Exoc8	A	G	8: 124,897,250	V126A	probably benign	Het
Fam185a	T	A	5: 21,455,787	S267T	probably damaging	Het
Fhod1	T	C	8: 105,337,861		probably benign	Het
Fn1	T	C	1: 71,648,148		probably null	Het
Gadl1	A	T	9: 115,954,617	T214S	possibly damaging	Het
Gem	G	T	4: 11,706,074	R54L	probably damaging	Het
Ghr	A	G	15: 3,325,940	V287A	probably benign	Het
Gm3642	G	A	14: 6,833,344	T215I	probably benign	Het
Grip1	T	A	10: 120,038,683	I732K	probably benign	Het
Gtpbp2	A	T	17: 46,167,221		probably null	Het
Heatr6	C	T	11: 83,779,548	R976*	probably null	Het
Hipk2	T	A	6: 38,698,392	T1084S	probably benign	Het
Hmcn1	T	C	1: 150,694,833		probably null	Het
Hspg2	T	A	4: 137,522,127	M1328K	probably damaging	Het
Ifna4	C	A	4: 88,842,282	T141K	probably benign	Het
Ighv1-64	A	G	12: 115,507,846	V17A	probably benign	Het
Iqgap2	G	T	13: 95,635,497	N1391K	possibly damaging	Het
Irf7	A	T	7: 141,264,735	L148Q	possibly damaging	Het
Kat6b	G	A	14: 21,660,962	R768K	probably benign	Het
Lepr	G	A	4: 101,765,365	W447*	probably null	Het
Letmd1	A	G	15: 100,469,738	Y59C	probably damaging	Het
Lingo4	A	T	3: 94,402,876	K374*	probably null	Het
Loxl4	G	T	19: 42,608,346	D62E	probably benign	Het
Lrfn2	A	G	17: 49,070,434	D181G	probably damaging	Het
Lrrc71	A	T	3: 87,739,174	F526L	probably damaging	Het
Ltbp1	A	T	17: 75,313,008	M711L	probably damaging	Het
Mcm7	A	T	5: 138,169,125	D78E	probably damaging	Het
Mdh1	T	C	11: 21,562,957	N136D	probably damaging	Het
Meltf	T	A	16: 31,892,505	N515K	probably benign	Het
Mis18bp1	T	A	12: 65,158,739	T220S	probably benign	Het
Mtss1	C	T	15: 59,081,518	V4M	probably damaging	Het
Nacc2	A	T	2: 26,090,173	F84I	probably damaging	Het
Nedd9	A	G	13: 41,316,597	V360A	possibly damaging	Het
Nek11	T	A	9: 105,392,970	I18F	possibly damaging	Het
Nkd2	C	T	13: 73,847,005	V13M	probably damaging	Het
Nkx6-3	A	G	8: 23,156,269	I152V	probably damaging	Het
Npdc1	G	A	2: 25,408,945	D284N	probably damaging	Het
Olfr1	A	T	11: 73,395,155	I289N	probably damaging	Het
Olfr1352	A	G	10: 78,984,522	H244R	probably damaging	Het
Olfr215	T	C	6: 116,582,937	N3S	probably damaging	Het
Olfr494	T	A	7: 108,367,998	F169L	probably benign	Het
Olfr66	A	G	7: 103,881,649	V198A	probably benign	Het
Oprm1	A	T	10: 6,758,656	R16*	probably null	Het
Ostf1	G	A	19: 18,593,867	P62L	probably damaging	Het
Pcdha2	A	T	18: 36,940,515	T400S	possibly damaging	Het
Pcdha5	A	T	18: 36,961,496	T353S	possibly damaging	Het
Pelo	A	G	13: 115,088,735	F318S	probably damaging	Het
Polr2f	T	C	15: 79,146,069	V36A	probably benign	Het
Ppan	G	A	9: 20,888,510	R41H	probably benign	Het
Ppp1r21	C	T	17: 88,555,591	R253*	probably null	Het
Prf1	T	A	10: 61,303,708	W482R	probably damaging	Het
Ralgapa2	T	C	2: 146,345,533	T1397A	possibly damaging	Het
Rev3l	T	A	10: 39,846,806	Y2598*	probably null	Het
Scaf11	G	T	15: 96,414,848	D1437E	probably benign	Het
Sec23a	C	T	12: 58,978,506	G510R	probably damaging	Het
Sel1l2	A	G	2: 140,240,927	M597T	probably damaging	Het
Slc11a2	A	T	15: 100,406,338	S160T	possibly damaging	Het
Slc18a1	A	T	8: 69,073,649	L129*	probably null	Het
Smg8	A	C	11: 87,086,221	L178R	probably benign	Het
Sp4	T	C	12: 118,261,809	T607A	probably benign	Het
Ssbp2	A	G	13: 91,688,814	D266G	possibly damaging	Het
Sstr3	A	T	15: 78,539,697	Y283*	probably null	Het
Stk32b	C	T	5: 37,454,934		probably null	Het
Svep1	T	C	4: 58,070,752	T2345A	possibly damaging	Het
Synpo2	A	G	3: 123,114,291	S459P	probably damaging	Het
Sytl2	A	G	7: 90,348,792	M1V	probably null	Het
Tas2r102	T	A	6: 132,762,557	W143R	probably damaging	Het
Thy1	T	C	9: 44,047,348	V129A	probably damaging	Het
Tlr2	A	T	3: 83,838,185	I197N	probably damaging	Het
Tmem101	A	G	11: 102,153,443	I206T	probably benign	Het
Tmem108	A	G	9: 103,499,489	S254P	possibly damaging	Het
Tmem198b	T	C	10: 128,801,481	Q263R	probably damaging	Het
Vangl1	T	C	3: 102,184,554	D72G	probably damaging	Het
Vmn1r4	T	A	6: 56,957,364	D284E	probably benign	Het
Vmn2r31	G	A	7: 7,384,758	L605F	possibly damaging	Het
Zfand4	T	C	6: 116,273,819	V70A	probably damaging	Het
Zfp54	A	G	17: 21,433,403	E53G	probably damaging	Het
Zfp541	A	T	7: 16,081,687	I805F	probably damaging	Het
Zfp976	T	C	7: 42,613,033	H460R	possibly damaging	Het

Other mutations in Olfr1434

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01933:Olfr1434	APN	19	12283705	missense	probably damaging	1.00
IGL02415:Olfr1434	APN	19	12283498	missense	probably benign	0.44
IGL02731:Olfr1434	APN	19	12283842	missense	probably damaging	0.99
IGL02803:Olfr1434	APN	19	12283983	missense	possibly damaging	0.94
IGL03050:Olfr1434	UTSW	19	12283512	missense	probably benign
R0432:Olfr1434	UTSW	19	12283903	missense	probably damaging	1.00
R2209:Olfr1434	UTSW	19	12283860	missense	probably benign	0.41
R3710:Olfr1434	UTSW	19	12283086	missense	probably damaging	1.00
R5133:Olfr1434	UTSW	19	12283306	missense	possibly damaging	0.96
R5974:Olfr1434	UTSW	19	12283836	missense	probably damaging	1.00
R6544:Olfr1434	UTSW	19	12283155	missense	probably damaging	1.00
R7225:Olfr1434	UTSW	19	12283467	missense	probably benign	0.00
R7320:Olfr1434	UTSW	19	12283816	missense	possibly damaging	0.72
R7467:Olfr1434	UTSW	19	12283475	nonsense	probably null
R7900:Olfr1434	UTSW	19	12283341	missense	probably damaging	1.00
R8719:Olfr1434	UTSW	19	12283428	missense	probably benign	0.13
R9135:Olfr1434	UTSW	19	12283444	missense	probably damaging	1.00
R9324:Olfr1434	UTSW	19	12283575	missense	probably benign	0.30

Predicted Primers

PCR Primer
(F):5'- CTGCTACAAAACACTGTGTCAG -3'
(R):5'- GGAAAGCATCTTTGGGACTGTAG -3'

Sequencing Primer
(F):5'- GCTACAAAACACTGTGTCAGAATTAC -3'
(R):5'- GCATCTTTGGGACTGTAGAAGAG -3'

Posted On

2015-10-21