Incidental Mutation 'R4689:Slc39a10'
ID 354749
Institutional Source Beutler Lab
Gene Symbol Slc39a10
Ensembl Gene ENSMUSG00000025986
Gene Name solute carrier family 39 (zinc transporter), member 10
Synonyms 2900042E17Rik, Zip10
MMRRC Submission 041940-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.622) question?
Stock # R4689 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 46846704-46932012 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 46875173 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Methionine to Arginine at position 43 (M43R)
Ref Sequence ENSEMBL: ENSMUSP00000140176 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027131] [ENSMUST00000185520] [ENSMUST00000186852]
AlphaFold Q6P5F6
Predicted Effect probably benign
Transcript: ENSMUST00000027131
AA Change: M43R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000027131
Gene: ENSMUSG00000025986
AA Change: M43R

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
low complexity region 122 134 N/A INTRINSIC
low complexity region 170 195 N/A INTRINSIC
low complexity region 224 244 N/A INTRINSIC
Pfam:Zip 406 607 9.9e-44 PFAM
Pfam:Zip 588 821 2.5e-69 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141226
Predicted Effect probably benign
Transcript: ENSMUST00000185520
AA Change: M53R

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000140570
Gene: ENSMUSG00000025986
AA Change: M53R

DomainStartEndE-ValueType
low complexity region 30 41 N/A INTRINSIC
low complexity region 132 144 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000186852
AA Change: M43R

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000140176
Gene: ENSMUSG00000025986
AA Change: M43R

DomainStartEndE-ValueType
signal peptide 1 25 N/A INTRINSIC
low complexity region 122 134 N/A INTRINSIC
Meta Mutation Damage Score 0.0589 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency 97% (72/74)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A10 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
PHENOTYPE: Mice with conditional loss of function display defects in cellular proliferation and differentiation. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc10 C A 17: 46,634,996 (GRCm39) V336L probably benign Het
Acbd4 T C 11: 102,996,194 (GRCm39) L165P possibly damaging Het
Adam10 T C 9: 70,673,236 (GRCm39) S456P possibly damaging Het
Adgre4 T C 17: 56,109,096 (GRCm39) F368L probably damaging Het
Ahcyl1 G T 3: 107,572,834 (GRCm39) Y528* probably null Het
Aldh3b3 G A 19: 4,014,516 (GRCm39) V84M probably damaging Het
Cdca8 C T 4: 124,824,896 (GRCm39) G78E probably damaging Het
Cry2 T C 2: 92,254,899 (GRCm39) D152G probably benign Het
Cyp2c67 T C 19: 39,627,032 (GRCm39) Y266C probably benign Het
Dkk4 T C 8: 23,115,336 (GRCm39) F62S probably benign Het
Dnah12 G A 14: 26,427,994 (GRCm39) V207I probably benign Het
Dthd1 T C 5: 63,000,255 (GRCm39) C526R probably damaging Het
Dubr A T 16: 50,552,866 (GRCm39) noncoding transcript Het
F5 T C 1: 163,979,542 (GRCm39) probably benign Het
Flcn A C 11: 59,691,870 (GRCm39) W260G possibly damaging Het
Fmnl1 G A 11: 103,084,562 (GRCm39) probably null Het
Frem2 A T 3: 53,455,056 (GRCm39) D2173E probably benign Het
Fstl4 C T 11: 52,959,477 (GRCm39) Q173* probably null Het
Gfra3 G A 18: 34,823,640 (GRCm39) P381S unknown Het
Gm28308 C A 6: 52,190,291 (GRCm39) probably benign Het
Gm8730 T A 8: 103,592,379 (GRCm39) noncoding transcript Het
Gzmd T C 14: 56,368,683 (GRCm39) probably null Het
Hexb A G 13: 97,317,600 (GRCm39) Y366H probably damaging Het
Hydin A T 8: 111,322,046 (GRCm39) H4566L probably benign Het
Ifi213 G A 1: 173,417,986 (GRCm39) T142I possibly damaging Het
Kif13b T A 14: 65,010,513 (GRCm39) C1271S probably damaging Het
Krtap9-5 G T 11: 99,840,286 (GRCm39) C329F unknown Het
Larp1 G T 11: 57,932,439 (GRCm39) G207W probably damaging Het
Lfng A G 5: 140,600,194 (GRCm39) D368G probably damaging Het
Mbd5 G A 2: 49,148,291 (GRCm39) V834I possibly damaging Het
Mterf1b T A 5: 4,247,263 (GRCm39) Y301* probably null Het
Myh7b T C 2: 155,472,434 (GRCm39) I1305T possibly damaging Het
Myo16 T C 8: 10,488,890 (GRCm39) V687A probably damaging Het
Naip2 A T 13: 100,285,320 (GRCm39) I1292N probably damaging Het
Nmral1 A G 16: 4,532,422 (GRCm39) F130L probably damaging Het
Nos1 A G 5: 118,017,450 (GRCm39) N271S probably benign Het
Nrap A G 19: 56,374,458 (GRCm39) S23P probably damaging Het
Or12d16-ps1 A T 17: 37,705,662 (GRCm39) N77I probably damaging Het
Or2aj4 A T 16: 19,385,263 (GRCm39) Y123* probably null Het
Or4e2 T C 14: 52,688,671 (GRCm39) I267T probably benign Het
Or6c210 T C 10: 129,496,185 (GRCm39) V170A probably benign Het
Pkdcc C G 17: 83,523,290 (GRCm39) C132W probably damaging Het
Plekhg6 G A 6: 125,350,144 (GRCm39) L265F probably benign Het
Prkaa1 A G 15: 5,208,177 (GRCm39) T473A probably benign Het
Prpf3 G A 3: 95,743,801 (GRCm39) Q451* probably null Het
Psma5-ps T A 10: 85,150,065 (GRCm39) noncoding transcript Het
Ptprh T A 7: 4,600,996 (GRCm39) D127V possibly damaging Het
Rab36 T C 10: 74,877,765 (GRCm39) probably null Het
Rasa1 A T 13: 85,386,282 (GRCm39) Y427* probably null Het
Rgs11 T C 17: 26,423,521 (GRCm39) probably null Het
Serpinb13 C T 1: 106,910,574 (GRCm39) S66L probably damaging Het
Shank2 G A 7: 143,974,342 (GRCm39) V1087I probably benign Het
Slc40a1 T A 1: 45,951,473 (GRCm39) Q228L probably benign Het
Slc45a1 A T 4: 150,722,996 (GRCm39) L296Q probably benign Het
Stambpl1 A G 19: 34,213,691 (GRCm39) T307A probably benign Het
Stt3a T C 9: 36,644,225 (GRCm39) T705A possibly damaging Het
Tec G A 5: 72,980,980 (GRCm39) probably benign Het
Trp63 A T 16: 25,684,012 (GRCm39) T300S possibly damaging Het
Vmn1r235 A G 17: 21,482,623 (GRCm39) H316R probably benign Het
Vmn2r1 A G 3: 64,012,074 (GRCm39) H645R possibly damaging Het
Wdfy4 A G 14: 32,831,505 (GRCm39) I907T possibly damaging Het
Zcchc10 A G 11: 53,218,151 (GRCm39) T33A probably benign Het
Zfp318 T A 17: 46,710,560 (GRCm39) V761D probably damaging Het
Zfp358 T C 8: 3,546,146 (GRCm39) probably null Het
Zfp661 G A 2: 127,419,468 (GRCm39) P224L probably damaging Het
Zfp937 T C 2: 150,078,706 (GRCm39) M33T probably damaging Het
Zfp955a T C 17: 33,461,040 (GRCm39) H364R probably damaging Het
Other mutations in Slc39a10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00543:Slc39a10 APN 1 46,858,217 (GRCm39) splice site probably benign
IGL01628:Slc39a10 APN 1 46,874,683 (GRCm39) missense probably benign 0.23
IGL01939:Slc39a10 APN 1 46,871,895 (GRCm39) missense probably benign 0.07
IGL02068:Slc39a10 APN 1 46,858,599 (GRCm39) splice site probably benign
IGL02093:Slc39a10 APN 1 46,874,369 (GRCm39) missense probably damaging 1.00
IGL02101:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02122:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02125:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02171:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02175:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02186:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02699:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
IGL02700:Slc39a10 APN 1 46,857,288 (GRCm39) missense probably damaging 1.00
R0217:Slc39a10 UTSW 1 46,874,700 (GRCm39) missense probably benign
R0704:Slc39a10 UTSW 1 46,875,021 (GRCm39) missense possibly damaging 0.76
R0782:Slc39a10 UTSW 1 46,875,156 (GRCm39) missense probably damaging 0.97
R1527:Slc39a10 UTSW 1 46,858,422 (GRCm39) missense probably benign
R1566:Slc39a10 UTSW 1 46,875,245 (GRCm39) missense possibly damaging 0.90
R1568:Slc39a10 UTSW 1 46,865,375 (GRCm39) missense probably benign 0.00
R1664:Slc39a10 UTSW 1 46,865,269 (GRCm39) missense probably damaging 1.00
R1830:Slc39a10 UTSW 1 46,875,230 (GRCm39) missense probably damaging 1.00
R1954:Slc39a10 UTSW 1 46,874,334 (GRCm39) missense possibly damaging 0.50
R2327:Slc39a10 UTSW 1 46,875,156 (GRCm39) missense probably damaging 0.97
R3434:Slc39a10 UTSW 1 46,874,877 (GRCm39) missense probably benign
R3761:Slc39a10 UTSW 1 46,851,285 (GRCm39) missense possibly damaging 0.88
R4035:Slc39a10 UTSW 1 46,851,234 (GRCm39) missense probably damaging 1.00
R4419:Slc39a10 UTSW 1 46,849,226 (GRCm39) missense probably benign 0.42
R4675:Slc39a10 UTSW 1 46,857,144 (GRCm39) intron probably benign
R5310:Slc39a10 UTSW 1 46,875,285 (GRCm39) missense probably damaging 1.00
R6073:Slc39a10 UTSW 1 46,871,772 (GRCm39) missense possibly damaging 0.68
R6161:Slc39a10 UTSW 1 46,866,567 (GRCm39) missense probably damaging 1.00
R6199:Slc39a10 UTSW 1 46,874,993 (GRCm39) missense probably damaging 1.00
R6562:Slc39a10 UTSW 1 46,874,724 (GRCm39) missense probably benign 0.02
R7087:Slc39a10 UTSW 1 46,874,880 (GRCm39) missense probably damaging 1.00
R7222:Slc39a10 UTSW 1 46,858,452 (GRCm39) missense possibly damaging 0.82
R7286:Slc39a10 UTSW 1 46,849,230 (GRCm39) missense probably damaging 0.97
R7568:Slc39a10 UTSW 1 46,874,290 (GRCm39) missense probably benign 0.14
R7891:Slc39a10 UTSW 1 46,851,328 (GRCm39) missense probably damaging 1.00
R7918:Slc39a10 UTSW 1 46,874,912 (GRCm39) missense possibly damaging 0.88
R9725:Slc39a10 UTSW 1 46,849,223 (GRCm39) missense probably damaging 1.00
RF020:Slc39a10 UTSW 1 46,849,175 (GRCm39) missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CACTGCCAGAATGTCTAAGTGAG -3'
(R):5'- TGTTGGCATACACTAATCAGCTG -3'

Sequencing Primer
(F):5'- ATGGCCAAGGTCCTCGTGATTAATC -3'
(R):5'- AGCTGTCTTTTTCAATCCCTGTAGG -3'
Posted On 2015-10-21