Incidental Mutation 'R4692:Zfp932'
| ID |
354967 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp932
|
| Ensembl Gene |
ENSMUSG00000066613 |
| Gene Name |
zinc finger protein 932 |
| Synonyms |
2310001H12Rik |
| MMRRC Submission |
041943-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.078)
|
| Stock # |
R4692 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
110144387-110158277 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
G to A
at 110157052 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glycine to Aspartic acid
at position 250
(G250D)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000108159
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000099484]
[ENSMUST00000112536]
[ENSMUST00000112540]
[ENSMUST00000125213]
[ENSMUST00000143639]
[ENSMUST00000187241]
|
| AlphaFold |
E9QAG8 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000099484
|
| SMART Domains |
Protein: ENSMUSP00000097083
Gene: ENSMUSG00000066613
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
61 |
1.74e-14 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112536
AA Change: G217D
PolyPhen 2
Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000108155
Gene: ENSMUSG00000066613
AA Change: G217D
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:KRAB
|
1 |
31 |
5e-12 |
BLAST |
|
ZnF_C2H2
|
71 |
93 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
99 |
121 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
127 |
149 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
155 |
177 |
1.76e-1 |
SMART |
|
ZnF_C2H2
|
183 |
205 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
211 |
233 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
239 |
261 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
267 |
289 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
295 |
317 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
323 |
345 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
351 |
373 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
379 |
401 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
407 |
429 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
435 |
457 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
463 |
485 |
2.43e-4 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000112540
AA Change: G250D
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000108159
Gene: ENSMUSG00000066613
AA Change: G250D
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
61 |
1.74e-14 |
SMART |
|
ZnF_C2H2
|
104 |
126 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
132 |
154 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
160 |
182 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
188 |
210 |
1.76e-1 |
SMART |
|
ZnF_C2H2
|
216 |
238 |
1.3e-4 |
SMART |
|
ZnF_C2H2
|
244 |
266 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
272 |
294 |
2.27e-4 |
SMART |
|
ZnF_C2H2
|
300 |
322 |
1.84e-4 |
SMART |
|
ZnF_C2H2
|
328 |
350 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
9.73e-4 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
412 |
434 |
1.58e-3 |
SMART |
|
ZnF_C2H2
|
440 |
462 |
5.14e-3 |
SMART |
|
ZnF_C2H2
|
468 |
490 |
2.61e-4 |
SMART |
|
ZnF_C2H2
|
496 |
518 |
2.43e-4 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000125213
|
| SMART Domains |
Protein: ENSMUSP00000119843
Gene: ENSMUSG00000066613
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:KRAB
|
1 |
34 |
2e-14 |
BLAST |
|
ZnF_C2H2
|
71 |
93 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
99 |
121 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
127 |
149 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
155 |
177 |
1.76e-1 |
SMART |
|
Pfam:zf-C2H2_6
|
182 |
191 |
7.3e-1 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143639
|
| SMART Domains |
Protein: ENSMUSP00000121749
Gene: ENSMUSG00000066613
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
60 |
1.74e-14 |
SMART |
|
ZnF_C2H2
|
103 |
125 |
1.1e-2 |
SMART |
|
ZnF_C2H2
|
131 |
153 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
3.39e-3 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
1.76e-1 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000187241
AA Change: G250D
PolyPhen 2
Score 0.956 (Sensitivity: 0.79; Specificity: 0.95)
|
| SMART Domains |
Protein: ENSMUSP00000140446
Gene: ENSMUSG00000066613
AA Change: G250D
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
5 |
61 |
7.1e-17 |
SMART |
|
ZnF_C2H2
|
104 |
126 |
4.8e-5 |
SMART |
|
ZnF_C2H2
|
132 |
154 |
2.2e-6 |
SMART |
|
ZnF_C2H2
|
160 |
182 |
1.5e-5 |
SMART |
|
ZnF_C2H2
|
188 |
210 |
7.2e-4 |
SMART |
|
ZnF_C2H2
|
216 |
238 |
5.4e-7 |
SMART |
|
ZnF_C2H2
|
244 |
266 |
4.5e-5 |
SMART |
|
ZnF_C2H2
|
272 |
294 |
9.2e-7 |
SMART |
|
ZnF_C2H2
|
300 |
322 |
7.5e-7 |
SMART |
|
ZnF_C2H2
|
328 |
350 |
2.1e-6 |
SMART |
|
ZnF_C2H2
|
356 |
378 |
4e-6 |
SMART |
|
ZnF_C2H2
|
384 |
406 |
6.5e-6 |
SMART |
|
ZnF_C2H2
|
412 |
434 |
6.9e-6 |
SMART |
|
ZnF_C2H2
|
440 |
462 |
2.1e-5 |
SMART |
|
ZnF_C2H2
|
468 |
490 |
1.1e-6 |
SMART |
|
ZnF_C2H2
|
496 |
518 |
1.1e-6 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 43 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2310057J18Rik |
A |
T |
10: 28,849,882 (GRCm39) |
Y230* |
probably null |
Het |
| 9230104M06Rik |
A |
T |
12: 112,963,692 (GRCm39) |
|
probably benign |
Het |
| Arhgap20 |
A |
G |
9: 51,697,088 (GRCm39) |
D53G |
probably damaging |
Het |
| Arl2 |
T |
C |
19: 6,187,776 (GRCm39) |
T54A |
probably damaging |
Het |
| Baz2a |
G |
A |
10: 127,960,762 (GRCm39) |
G1521S |
probably damaging |
Het |
| Begain |
A |
G |
12: 108,999,818 (GRCm39) |
S523P |
probably damaging |
Het |
| Car10 |
T |
C |
11: 93,075,984 (GRCm39) |
|
probably null |
Het |
| Cenpe |
A |
G |
3: 134,922,140 (GRCm39) |
I66V |
probably benign |
Het |
| Col14a1 |
T |
A |
15: 55,286,864 (GRCm39) |
V895E |
unknown |
Het |
| Coro1b |
T |
C |
19: 4,199,418 (GRCm39) |
Y26H |
probably damaging |
Het |
| Crebbp |
T |
C |
16: 3,932,727 (GRCm39) |
E1017G |
possibly damaging |
Het |
| Cwf19l2 |
T |
C |
9: 3,428,709 (GRCm39) |
S232P |
probably damaging |
Het |
| Cyp7b1 |
T |
A |
3: 18,126,728 (GRCm39) |
I473F |
probably damaging |
Het |
| Efcab5 |
A |
T |
11: 77,004,507 (GRCm39) |
I937N |
probably damaging |
Het |
| Fam53c |
A |
C |
18: 34,901,743 (GRCm39) |
E220A |
probably damaging |
Het |
| Gsn |
A |
G |
2: 35,188,883 (GRCm39) |
Y434C |
probably damaging |
Het |
| Igkv2-137 |
T |
C |
6: 67,532,971 (GRCm39) |
S45P |
possibly damaging |
Het |
| Katnip |
T |
C |
7: 125,466,841 (GRCm39) |
|
probably null |
Het |
| Kif13b |
C |
A |
14: 65,041,024 (GRCm39) |
T1704K |
probably benign |
Het |
| Mapk7 |
A |
G |
11: 61,380,068 (GRCm39) |
S697P |
possibly damaging |
Het |
| Mrgpra1 |
T |
A |
7: 46,985,446 (GRCm39) |
I78F |
probably damaging |
Het |
| N6amt1 |
T |
C |
16: 87,153,854 (GRCm39) |
V97A |
possibly damaging |
Het |
| Oas3 |
T |
C |
5: 120,907,420 (GRCm39) |
T406A |
probably benign |
Het |
| Or4f61 |
A |
G |
2: 111,923,026 (GRCm39) |
S7P |
probably damaging |
Het |
| Or8c17 |
C |
T |
9: 38,179,826 (GRCm39) |
Q6* |
probably null |
Het |
| Paxip1 |
T |
C |
5: 27,977,095 (GRCm39) |
|
probably benign |
Het |
| Pfn4 |
A |
T |
12: 4,824,486 (GRCm39) |
Y71F |
probably damaging |
Het |
| Plin4 |
C |
A |
17: 56,410,762 (GRCm39) |
G1090C |
probably damaging |
Het |
| Ptk2b |
C |
T |
14: 66,394,518 (GRCm39) |
G859S |
probably benign |
Het |
| Rbl2 |
T |
A |
8: 91,849,047 (GRCm39) |
D1084E |
probably damaging |
Het |
| Robo1 |
T |
G |
16: 72,757,090 (GRCm39) |
S350R |
probably damaging |
Het |
| Sbno2 |
A |
G |
10: 79,922,161 (GRCm39) |
V4A |
possibly damaging |
Het |
| Sh3rf1 |
T |
C |
8: 61,806,888 (GRCm39) |
|
probably null |
Het |
| Smgc |
T |
C |
15: 91,738,764 (GRCm39) |
V474A |
possibly damaging |
Het |
| Snx13 |
A |
G |
12: 35,136,917 (GRCm39) |
D126G |
possibly damaging |
Het |
| Sox9 |
C |
A |
11: 112,673,803 (GRCm39) |
H131Q |
probably benign |
Het |
| Spag6 |
T |
C |
2: 18,704,054 (GRCm39) |
I34T |
probably benign |
Het |
| Speer2 |
T |
A |
16: 69,654,860 (GRCm39) |
T202S |
possibly damaging |
Het |
| Sspo |
T |
A |
6: 48,459,621 (GRCm39) |
C3327S |
probably damaging |
Het |
| Vcpip1 |
G |
T |
1: 9,818,299 (GRCm39) |
A28E |
unknown |
Het |
| Vstm5 |
A |
T |
9: 15,168,718 (GRCm39) |
D94V |
probably damaging |
Het |
| Zfp329 |
T |
C |
7: 12,544,559 (GRCm39) |
K322E |
probably damaging |
Het |
| Zscan26 |
A |
G |
13: 21,629,427 (GRCm39) |
C359R |
probably damaging |
Het |
|
| Other mutations in Zfp932 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
R0153:Zfp932
|
UTSW |
5 |
110,154,834 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0268:Zfp932
|
UTSW |
5 |
110,156,929 (GRCm39) |
missense |
probably benign |
0.24 |
|
R1673:Zfp932
|
UTSW |
5 |
110,156,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1797:Zfp932
|
UTSW |
5 |
110,144,489 (GRCm39) |
start gained |
probably benign |
|
|
R1893:Zfp932
|
UTSW |
5 |
110,157,069 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1942:Zfp932
|
UTSW |
5 |
110,154,853 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2073:Zfp932
|
UTSW |
5 |
110,157,684 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R2076:Zfp932
|
UTSW |
5 |
110,157,334 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2329:Zfp932
|
UTSW |
5 |
110,157,406 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3944:Zfp932
|
UTSW |
5 |
110,157,820 (GRCm39) |
missense |
probably benign |
0.37 |
|
R4551:Zfp932
|
UTSW |
5 |
110,157,505 (GRCm39) |
missense |
probably benign |
0.03 |
|
R4679:Zfp932
|
UTSW |
5 |
110,157,760 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5116:Zfp932
|
UTSW |
5 |
110,157,242 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5260:Zfp932
|
UTSW |
5 |
110,157,501 (GRCm39) |
nonsense |
probably null |
|
|
R5536:Zfp932
|
UTSW |
5 |
110,157,713 (GRCm39) |
nonsense |
probably null |
|
|
R6351:Zfp932
|
UTSW |
5 |
110,157,209 (GRCm39) |
nonsense |
probably null |
|
|
R6786:Zfp932
|
UTSW |
5 |
110,157,606 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6843:Zfp932
|
UTSW |
5 |
110,156,581 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7437:Zfp932
|
UTSW |
5 |
110,157,880 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7496:Zfp932
|
UTSW |
5 |
110,156,694 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7704:Zfp932
|
UTSW |
5 |
110,157,630 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8224:Zfp932
|
UTSW |
5 |
110,144,480 (GRCm39) |
start gained |
probably benign |
|
|
R8317:Zfp932
|
UTSW |
5 |
110,156,922 (GRCm39) |
nonsense |
probably null |
|
|
R8765:Zfp932
|
UTSW |
5 |
110,154,827 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8967:Zfp932
|
UTSW |
5 |
110,156,883 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9083:Zfp932
|
UTSW |
5 |
110,157,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9142:Zfp932
|
UTSW |
5 |
110,157,520 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9511:Zfp932
|
UTSW |
5 |
110,155,177 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R9533:Zfp932
|
UTSW |
5 |
110,157,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9640:Zfp932
|
UTSW |
5 |
110,157,064 (GRCm39) |
missense |
probably benign |
0.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATTCACGACACAGCATTCTACAA -3'
(R):5'- CATGAGAGGCAAAGGCTTTACCA -3'
Sequencing Primer
(F):5'- GTGGTAAAGCCTTTGCATTCCATAG -3'
(R):5'- GAGGCAAAGGCTTTACCACACTG -3'
|
| Posted On |
2015-10-21 |
Incidental Mutation