Incidental Mutation 'R4706:Vmn2r98'
ID |
355263 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r98
|
Ensembl Gene |
ENSMUSG00000096717 |
Gene Name |
vomeronasal 2, receptor 98 |
Synonyms |
EG224552 |
MMRRC Submission |
041954-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.096)
|
Stock # |
R4706 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
17 |
Chromosomal Location |
19273755-19301573 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to G
at 19290007 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Arginine
at position 514
(S514R)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000131261
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170424]
|
AlphaFold |
E9PZ56 |
Predicted Effect |
probably damaging
Transcript: ENSMUST00000170424
AA Change: S514R
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
SMART Domains |
Protein: ENSMUSP00000131261 Gene: ENSMUSG00000096717 AA Change: S514R
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
19 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
82 |
460 |
2.6e-35 |
PFAM |
Pfam:NCD3G
|
509 |
562 |
7.4e-22 |
PFAM |
Pfam:7tm_3
|
594 |
830 |
1.4e-52 |
PFAM |
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 94.8%
|
Validation Efficiency |
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 78 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca16 |
T |
A |
7: 120,064,988 (GRCm39) |
N548K |
probably damaging |
Het |
Abcd2 |
T |
C |
15: 91,043,385 (GRCm39) |
D601G |
probably benign |
Het |
Afap1l2 |
A |
T |
19: 56,925,672 (GRCm39) |
I152N |
possibly damaging |
Het |
Ankrd52 |
T |
G |
10: 128,214,030 (GRCm39) |
M62R |
probably benign |
Het |
Aox4 |
A |
T |
1: 58,305,946 (GRCm39) |
T1317S |
probably damaging |
Het |
Apol7c |
T |
A |
15: 77,409,923 (GRCm39) |
Q341L |
probably benign |
Het |
Arhgef4 |
C |
T |
1: 34,771,298 (GRCm39) |
R1202W |
probably benign |
Het |
B4galnt2 |
C |
T |
11: 95,766,923 (GRCm39) |
|
probably null |
Het |
Cecr2 |
A |
T |
6: 120,732,539 (GRCm39) |
E477V |
possibly damaging |
Het |
Chmp7 |
A |
T |
14: 69,956,010 (GRCm39) |
D419E |
probably benign |
Het |
Cmip |
A |
C |
8: 118,103,893 (GRCm39) |
K127T |
probably damaging |
Het |
Csmd2 |
T |
C |
4: 128,438,544 (GRCm39) |
V3041A |
probably benign |
Het |
Cyp1b1 |
T |
A |
17: 80,020,771 (GRCm39) |
I324F |
possibly damaging |
Het |
Dapp1 |
T |
C |
3: 137,638,928 (GRCm39) |
D225G |
probably benign |
Het |
Ddx10 |
T |
C |
9: 53,145,231 (GRCm39) |
T249A |
probably damaging |
Het |
Dscaml1 |
T |
C |
9: 45,361,878 (GRCm39) |
Y213H |
probably damaging |
Het |
Eef1a2 |
T |
C |
2: 180,797,150 (GRCm39) |
D17G |
probably damaging |
Het |
Fbn1 |
T |
C |
2: 125,212,069 (GRCm39) |
I848V |
probably benign |
Het |
Fbxw18 |
A |
G |
9: 109,519,585 (GRCm39) |
I307T |
probably benign |
Het |
Fxr1 |
T |
A |
3: 34,118,278 (GRCm39) |
D500E |
probably damaging |
Het |
Gars1 |
G |
A |
6: 55,046,363 (GRCm39) |
G492D |
probably damaging |
Het |
Gria2 |
A |
T |
3: 80,648,297 (GRCm39) |
D146E |
probably benign |
Het |
Gstz1 |
A |
G |
12: 87,205,894 (GRCm39) |
N37S |
probably benign |
Het |
Hnrnph3 |
C |
A |
10: 62,853,059 (GRCm39) |
G194V |
probably damaging |
Het |
Il2rb |
T |
C |
15: 78,370,600 (GRCm39) |
R172G |
possibly damaging |
Het |
Itga11 |
T |
A |
9: 62,662,578 (GRCm39) |
V517D |
possibly damaging |
Het |
Kcnq4 |
A |
G |
4: 120,561,683 (GRCm39) |
I462T |
probably benign |
Het |
Klf6 |
T |
A |
13: 5,911,639 (GRCm39) |
M1K |
probably null |
Het |
Lrp8 |
G |
A |
4: 107,718,470 (GRCm39) |
A817T |
probably benign |
Het |
Map3k5 |
T |
A |
10: 19,934,684 (GRCm39) |
Y509N |
probably damaging |
Het |
Mdc1 |
C |
T |
17: 36,163,671 (GRCm39) |
S1073F |
probably damaging |
Het |
Mme |
A |
G |
3: 63,256,133 (GRCm39) |
D531G |
possibly damaging |
Het |
Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
Mroh7 |
A |
T |
4: 106,548,821 (GRCm39) |
V1014E |
possibly damaging |
Het |
Msantd5l |
A |
T |
11: 51,144,668 (GRCm39) |
F204L |
possibly damaging |
Het |
Myo1d |
C |
T |
11: 80,557,467 (GRCm39) |
C491Y |
probably damaging |
Het |
Ncoa3 |
C |
A |
2: 165,889,799 (GRCm39) |
D61E |
probably damaging |
Het |
Nmrk1 |
A |
G |
19: 18,622,491 (GRCm39) |
E190G |
probably benign |
Het |
Nr4a2 |
G |
T |
2: 57,002,225 (GRCm39) |
P13H |
probably damaging |
Het |
Nup205 |
T |
C |
6: 35,178,943 (GRCm39) |
L671P |
probably damaging |
Het |
Omt2a |
T |
C |
9: 78,220,352 (GRCm39) |
I16V |
probably benign |
Het |
Or4c116 |
A |
T |
2: 88,942,576 (GRCm39) |
F93L |
probably damaging |
Het |
Or51f2 |
T |
A |
7: 102,526,640 (GRCm39) |
H104Q |
probably damaging |
Het |
Or6n1 |
A |
G |
1: 173,917,268 (GRCm39) |
I221V |
probably damaging |
Het |
Or8k24 |
G |
A |
2: 86,216,732 (GRCm39) |
T10I |
probably benign |
Het |
Or8s5 |
G |
T |
15: 98,238,659 (GRCm39) |
H70Q |
possibly damaging |
Het |
Osbpl9 |
A |
T |
4: 109,013,884 (GRCm39) |
I70N |
probably damaging |
Het |
Pclo |
A |
T |
5: 14,764,221 (GRCm39) |
L4231F |
unknown |
Het |
Per1 |
C |
T |
11: 68,991,444 (GRCm39) |
|
probably benign |
Het |
Perm1 |
G |
T |
4: 156,301,531 (GRCm39) |
C25F |
probably damaging |
Het |
Phf3 |
A |
G |
1: 30,844,687 (GRCm39) |
V1424A |
probably damaging |
Het |
Plxnb1 |
T |
G |
9: 108,941,096 (GRCm39) |
L1625R |
probably damaging |
Het |
Ppid |
G |
A |
3: 79,506,359 (GRCm39) |
V216I |
probably benign |
Het |
Ppp4r3a |
C |
T |
12: 101,008,175 (GRCm39) |
G754D |
probably damaging |
Het |
Prex2 |
G |
T |
1: 11,270,212 (GRCm39) |
W1299L |
probably damaging |
Het |
Ptprn2 |
C |
A |
12: 116,835,714 (GRCm39) |
Q350K |
probably benign |
Het |
Ralyl |
G |
A |
3: 14,104,850 (GRCm39) |
|
probably null |
Het |
Rbm8a |
G |
A |
3: 96,537,368 (GRCm39) |
|
probably benign |
Het |
Relch |
T |
A |
1: 105,620,004 (GRCm39) |
M353K |
probably benign |
Het |
Ros1 |
A |
G |
10: 51,977,990 (GRCm39) |
S1419P |
possibly damaging |
Het |
Rps6ka5 |
C |
T |
12: 100,564,144 (GRCm39) |
|
probably null |
Het |
Rps6ka5 |
T |
A |
12: 100,547,578 (GRCm39) |
I311F |
probably damaging |
Het |
Rtel1 |
T |
C |
2: 180,965,539 (GRCm39) |
|
probably null |
Het |
Sacs |
A |
G |
14: 61,441,722 (GRCm39) |
E1256G |
probably damaging |
Het |
Sec23a |
A |
G |
12: 59,029,372 (GRCm39) |
V467A |
probably damaging |
Het |
Sec24d |
T |
A |
3: 123,149,427 (GRCm39) |
N811K |
possibly damaging |
Het |
Sf3b1 |
G |
A |
1: 55,029,666 (GRCm39) |
T1112M |
probably damaging |
Het |
Shisa5 |
T |
A |
9: 108,885,128 (GRCm39) |
C133S |
probably null |
Het |
Slc16a6 |
A |
G |
11: 109,354,193 (GRCm39) |
S59P |
probably benign |
Het |
Slc25a31 |
G |
A |
3: 40,670,975 (GRCm39) |
A89T |
probably damaging |
Het |
Slc6a1 |
G |
T |
6: 114,284,713 (GRCm39) |
R257L |
possibly damaging |
Het |
Sntb1 |
C |
T |
15: 55,612,670 (GRCm39) |
V303M |
probably benign |
Het |
Snx20 |
A |
G |
8: 89,354,439 (GRCm39) |
V97A |
probably damaging |
Het |
Vmn1r29 |
T |
A |
6: 58,285,136 (GRCm39) |
N285K |
probably benign |
Het |
Zfp28 |
A |
T |
7: 6,392,793 (GRCm39) |
E156D |
probably damaging |
Het |
Zfp39 |
A |
G |
11: 58,793,633 (GRCm39) |
V35A |
probably benign |
Het |
Zfp536 |
A |
C |
7: 37,268,891 (GRCm39) |
I175S |
probably damaging |
Het |
Zic5 |
A |
T |
14: 122,696,969 (GRCm39) |
S549T |
unknown |
Het |
|
Other mutations in Vmn2r98 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00897:Vmn2r98
|
APN |
17 |
19,286,007 (GRCm39) |
splice site |
probably benign |
|
IGL01296:Vmn2r98
|
APN |
17 |
19,285,447 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01363:Vmn2r98
|
APN |
17 |
19,286,020 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01618:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
possibly damaging |
0.93 |
IGL01746:Vmn2r98
|
APN |
17 |
19,286,713 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01747:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01770:Vmn2r98
|
APN |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01868:Vmn2r98
|
APN |
17 |
19,286,548 (GRCm39) |
missense |
probably benign |
|
IGL02123:Vmn2r98
|
APN |
17 |
19,300,941 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02323:Vmn2r98
|
APN |
17 |
19,286,113 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL02543:Vmn2r98
|
APN |
17 |
19,286,083 (GRCm39) |
missense |
probably benign |
|
IGL02650:Vmn2r98
|
APN |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02676:Vmn2r98
|
APN |
17 |
19,285,521 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02803:Vmn2r98
|
APN |
17 |
19,286,275 (GRCm39) |
missense |
probably benign |
|
IGL02807:Vmn2r98
|
APN |
17 |
19,301,283 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03307:Vmn2r98
|
APN |
17 |
19,286,242 (GRCm39) |
missense |
possibly damaging |
0.62 |
IGL03396:Vmn2r98
|
APN |
17 |
19,290,107 (GRCm39) |
missense |
possibly damaging |
0.92 |
PIT4131001:Vmn2r98
|
UTSW |
17 |
19,301,223 (GRCm39) |
missense |
probably benign |
0.00 |
R0122:Vmn2r98
|
UTSW |
17 |
19,286,662 (GRCm39) |
missense |
probably benign |
0.06 |
R0329:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
R0330:Vmn2r98
|
UTSW |
17 |
19,286,609 (GRCm39) |
missense |
probably benign |
0.21 |
R0368:Vmn2r98
|
UTSW |
17 |
19,286,089 (GRCm39) |
nonsense |
probably null |
|
R0545:Vmn2r98
|
UTSW |
17 |
19,273,875 (GRCm39) |
missense |
probably benign |
0.15 |
R0635:Vmn2r98
|
UTSW |
17 |
19,300,759 (GRCm39) |
missense |
probably benign |
0.00 |
R0689:Vmn2r98
|
UTSW |
17 |
19,300,782 (GRCm39) |
missense |
possibly damaging |
0.83 |
R1035:Vmn2r98
|
UTSW |
17 |
19,301,011 (GRCm39) |
missense |
possibly damaging |
0.90 |
R1243:Vmn2r98
|
UTSW |
17 |
19,286,210 (GRCm39) |
missense |
possibly damaging |
0.52 |
R1421:Vmn2r98
|
UTSW |
17 |
19,285,440 (GRCm39) |
missense |
probably damaging |
1.00 |
R1629:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
R1643:Vmn2r98
|
UTSW |
17 |
19,301,170 (GRCm39) |
missense |
probably damaging |
1.00 |
R1795:Vmn2r98
|
UTSW |
17 |
19,286,702 (GRCm39) |
missense |
probably damaging |
1.00 |
R1958:Vmn2r98
|
UTSW |
17 |
19,286,680 (GRCm39) |
missense |
possibly damaging |
0.70 |
R1962:Vmn2r98
|
UTSW |
17 |
19,285,595 (GRCm39) |
nonsense |
probably null |
|
R2165:Vmn2r98
|
UTSW |
17 |
19,301,553 (GRCm39) |
missense |
unknown |
|
R2238:Vmn2r98
|
UTSW |
17 |
19,286,213 (GRCm39) |
missense |
probably damaging |
1.00 |
R2252:Vmn2r98
|
UTSW |
17 |
19,300,698 (GRCm39) |
missense |
probably benign |
0.00 |
R2323:Vmn2r98
|
UTSW |
17 |
19,286,081 (GRCm39) |
missense |
probably benign |
0.18 |
R2887:Vmn2r98
|
UTSW |
17 |
19,301,439 (GRCm39) |
missense |
possibly damaging |
0.83 |
R2909:Vmn2r98
|
UTSW |
17 |
19,287,664 (GRCm39) |
missense |
probably damaging |
1.00 |
R3001:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3002:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3003:Vmn2r98
|
UTSW |
17 |
19,286,125 (GRCm39) |
missense |
probably benign |
0.01 |
R3788:Vmn2r98
|
UTSW |
17 |
19,300,887 (GRCm39) |
missense |
probably benign |
0.31 |
R4570:Vmn2r98
|
UTSW |
17 |
19,286,354 (GRCm39) |
missense |
probably benign |
0.11 |
R4723:Vmn2r98
|
UTSW |
17 |
19,286,602 (GRCm39) |
missense |
probably benign |
0.01 |
R5036:Vmn2r98
|
UTSW |
17 |
19,286,419 (GRCm39) |
missense |
probably benign |
0.00 |
R5072:Vmn2r98
|
UTSW |
17 |
19,286,306 (GRCm39) |
missense |
probably benign |
0.07 |
R5121:Vmn2r98
|
UTSW |
17 |
19,273,815 (GRCm39) |
missense |
probably benign |
0.13 |
R5283:Vmn2r98
|
UTSW |
17 |
19,300,981 (GRCm39) |
missense |
probably benign |
0.05 |
R5294:Vmn2r98
|
UTSW |
17 |
19,290,016 (GRCm39) |
nonsense |
probably null |
|
R5371:Vmn2r98
|
UTSW |
17 |
19,290,015 (GRCm39) |
missense |
probably damaging |
1.00 |
R5532:Vmn2r98
|
UTSW |
17 |
19,287,645 (GRCm39) |
missense |
possibly damaging |
0.94 |
R5598:Vmn2r98
|
UTSW |
17 |
19,301,161 (GRCm39) |
missense |
probably benign |
0.37 |
R5800:Vmn2r98
|
UTSW |
17 |
19,286,260 (GRCm39) |
missense |
probably benign |
0.17 |
R6089:Vmn2r98
|
UTSW |
17 |
19,286,336 (GRCm39) |
missense |
probably benign |
0.29 |
R6155:Vmn2r98
|
UTSW |
17 |
19,286,143 (GRCm39) |
missense |
possibly damaging |
0.87 |
R6853:Vmn2r98
|
UTSW |
17 |
19,286,063 (GRCm39) |
missense |
probably benign |
0.00 |
R6920:Vmn2r98
|
UTSW |
17 |
19,285,510 (GRCm39) |
missense |
probably damaging |
0.98 |
R7012:Vmn2r98
|
UTSW |
17 |
19,286,530 (GRCm39) |
missense |
probably benign |
0.06 |
R7042:Vmn2r98
|
UTSW |
17 |
19,301,184 (GRCm39) |
missense |
probably benign |
|
R7068:Vmn2r98
|
UTSW |
17 |
19,285,575 (GRCm39) |
missense |
probably benign |
|
R7607:Vmn2r98
|
UTSW |
17 |
19,287,570 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7763:Vmn2r98
|
UTSW |
17 |
19,300,797 (GRCm39) |
missense |
probably benign |
0.00 |
R7771:Vmn2r98
|
UTSW |
17 |
19,287,460 (GRCm39) |
splice site |
probably null |
|
R7915:Vmn2r98
|
UTSW |
17 |
19,287,493 (GRCm39) |
missense |
probably benign |
0.10 |
R8028:Vmn2r98
|
UTSW |
17 |
19,273,912 (GRCm39) |
missense |
probably benign |
0.00 |
R8205:Vmn2r98
|
UTSW |
17 |
19,301,425 (GRCm39) |
missense |
probably damaging |
0.99 |
R8241:Vmn2r98
|
UTSW |
17 |
19,301,031 (GRCm39) |
missense |
probably damaging |
0.99 |
R8906:Vmn2r98
|
UTSW |
17 |
19,286,532 (GRCm39) |
missense |
probably benign |
|
R8952:Vmn2r98
|
UTSW |
17 |
19,285,531 (GRCm39) |
missense |
possibly damaging |
0.76 |
R9147:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
R9148:Vmn2r98
|
UTSW |
17 |
19,286,383 (GRCm39) |
missense |
probably benign |
0.04 |
R9187:Vmn2r98
|
UTSW |
17 |
19,301,481 (GRCm39) |
missense |
probably damaging |
1.00 |
R9344:Vmn2r98
|
UTSW |
17 |
19,286,777 (GRCm39) |
missense |
probably benign |
0.14 |
R9467:Vmn2r98
|
UTSW |
17 |
19,287,517 (GRCm39) |
missense |
probably benign |
0.01 |
R9487:Vmn2r98
|
UTSW |
17 |
19,301,496 (GRCm39) |
missense |
possibly damaging |
0.78 |
R9753:Vmn2r98
|
UTSW |
17 |
19,285,665 (GRCm39) |
missense |
probably benign |
0.27 |
Z1177:Vmn2r98
|
UTSW |
17 |
19,287,685 (GRCm39) |
nonsense |
probably null |
|
Z1177:Vmn2r98
|
UTSW |
17 |
19,285,398 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
Predicted Primers |
PCR Primer
(F):5'- CCAGGCATCTTTGAATTTCTGTTAGC -3'
(R):5'- GGCTGTTTTGAACTAATTAAAGGGG -3'
Sequencing Primer
(F):5'- GAATTTCTGTTAGCTACCCCAGTAC -3'
(R):5'- TTTGAACTAATTAAAGGGGATGGTG -3'
|
Posted On |
2015-10-21 |