Mutagenetix > Incidental Mutation

Incidental Mutation 'R4707:Arhgef10l'

355303

Institutional Source

Beutler Lab

Gene Symbol

Arhgef10l

Ensembl Gene

ENSMUSG00000040964

Gene Name

Rho guanine nucleotide exchange factor 10-like

Synonyms

2810441C07Rik

MMRRC Submission

041955-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.101) question?

Stock #

R4707 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

140241796-140393318 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 140264194 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 671 (M671I)

Ref Sequence

ENSEMBL: ENSMUSP00000101423 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039204] [ENSMUST00000069623] [ENSMUST00000097820] [ENSMUST00000105797] [ENSMUST00000105798] [ENSMUST00000105799]

AlphaFold

A2AWP8

Predicted Effect

probably benign
Transcript: ENSMUST00000039204
AA Change: M958I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000040531
Gene: ENSMUSG00000040964
AA Change: M958I

Domain	Start	End	E-Value	Type
low complexity region	10	25	N/A	INTRINSIC
low complexity region	28	49	N/A	INTRINSIC
low complexity region	78	89	N/A	INTRINSIC
low complexity region	105	116	N/A	INTRINSIC
low complexity region	170	184	N/A	INTRINSIC
RhoGEF	318	500	1.95e-52	SMART
Blast:PH	535	748	3e-82	BLAST
low complexity region	821	833	N/A	INTRINSIC
low complexity region	864	876	N/A	INTRINSIC
Blast:WD40	1217	1270	8e-18	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000069623
AA Change: M924I

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)

SMART Domains

Protein: ENSMUSP00000066249
Gene: ENSMUSG00000040964
AA Change: M924I

Domain	Start	End	E-Value	Type
low complexity region	10	25	N/A	INTRINSIC
low complexity region	28	49	N/A	INTRINSIC
low complexity region	78	89	N/A	INTRINSIC
low complexity region	105	116	N/A	INTRINSIC
low complexity region	170	184	N/A	INTRINSIC
RhoGEF	279	461	1.95e-52	SMART
Blast:PH	496	714	5e-80	BLAST
low complexity region	787	799	N/A	INTRINSIC
low complexity region	830	842	N/A	INTRINSIC
Blast:WD40	1183	1236	7e-18	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000097820
AA Change: M919I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000095431
Gene: ENSMUSG00000040964
AA Change: M919I

Domain	Start	End	E-Value	Type
low complexity region	10	25	N/A	INTRINSIC
low complexity region	28	49	N/A	INTRINSIC
low complexity region	78	89	N/A	INTRINSIC
low complexity region	105	116	N/A	INTRINSIC
low complexity region	170	184	N/A	INTRINSIC
RhoGEF	279	461	1.95e-52	SMART
Blast:PH	496	709	3e-82	BLAST
low complexity region	782	794	N/A	INTRINSIC
low complexity region	825	837	N/A	INTRINSIC
Blast:WD40	1178	1231	6e-18	BLAST

Predicted Effect

possibly damaging
Transcript: ENSMUST00000105797
AA Change: M671I

PolyPhen 2 Score 0.627 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000101423
Gene: ENSMUSG00000040964
AA Change: M671I

Domain	Start	End	E-Value	Type
low complexity region	50	62	N/A	INTRINSIC
Pfam:RhoGEF	101	183	7.1e-15	PFAM
low complexity region	195	213	N/A	INTRINSIC
Blast:PH	248	461	7e-83	BLAST
low complexity region	534	546	N/A	INTRINSIC
low complexity region	577	589	N/A	INTRINSIC
Blast:WD40	618	656	6e-15	BLAST
Blast:WD40	930	983	1e-17	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000105798
AA Change: M723I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000101424
Gene: ENSMUSG00000040964
AA Change: M723I

Domain	Start	End	E-Value	Type
RhoGEF	78	260	1.95e-52	SMART
Blast:PH	295	513	8e-81	BLAST
low complexity region	586	598	N/A	INTRINSIC
low complexity region	629	641	N/A	INTRINSIC
Blast:WD40	982	1035	6e-18	BLAST

Predicted Effect

probably benign
Transcript: ENSMUST00000105799
AA Change: M963I

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000101425
Gene: ENSMUSG00000040964
AA Change: M963I

Domain	Start	End	E-Value	Type
low complexity region	10	25	N/A	INTRINSIC
low complexity region	28	49	N/A	INTRINSIC
low complexity region	78	89	N/A	INTRINSIC
low complexity region	105	116	N/A	INTRINSIC
low complexity region	170	184	N/A	INTRINSIC
RhoGEF	318	500	1.95e-52	SMART
Blast:PH	535	753	5e-80	BLAST
low complexity region	826	838	N/A	INTRINSIC
low complexity region	869	881	N/A	INTRINSIC
Blast:WD40	1222	1275	8e-18	BLAST

Predicted Effect

unknown
Transcript: ENSMUST00000138493
AA Change: M503I

SMART Domains

Protein: ENSMUSP00000119471
Gene: ENSMUSG00000040964
AA Change: M503I

Domain	Start	End	E-Value	Type
Pfam:RhoGEF	1	46	3.1e-11	PFAM
Blast:PH	81	294	3e-86	BLAST
low complexity region	367	379	N/A	INTRINSIC
Blast:WD40	387	446	8e-6	BLAST
Blast:WD40	451	489	3e-15	BLAST

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 97.0%
20x: 94.7%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]

Allele List at MGI

Other mutations in this stock

Total: 115 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700010I14Rik	A	G	17: 9,224,544 (GRCm39)	K450R	probably damaging	Het
Abcd2	T	C	15: 91,043,385 (GRCm39)	D601G	probably benign	Het
Abcf3	A	G	16: 20,367,808 (GRCm39)	K56E	possibly damaging	Het
Acaca	T	C	11: 84,203,680 (GRCm39)	V1477A	probably damaging	Het
Adamts20	G	A	15: 94,231,528 (GRCm39)	P887L	possibly damaging	Het
Ahnak	T	G	19: 8,994,099 (GRCm39)	S5128A	probably benign	Het
Ahsa2	C	A	11: 23,443,162 (GRCm39)	V197F	probably benign	Het
Ak9	C	A	10: 41,221,456 (GRCm39)	H402N	probably benign	Het
Alpk1	G	T	3: 127,481,241 (GRCm39)	N175K	possibly damaging	Het
Als2	A	G	1: 59,254,472 (GRCm39)	V295A	probably benign	Het
Ankrd16	A	G	2: 11,783,608 (GRCm39)	D70G	probably damaging	Het
Apob	A	T	12: 8,056,205 (GRCm39)	K1562N	probably damaging	Het
Arfgap2	C	A	2: 91,100,316 (GRCm39)	S250R	probably damaging	Het
Atrnl1	A	G	19: 57,617,590 (GRCm39)	I122V	probably damaging	Het
B4galnt2	C	T	11: 95,766,923 (GRCm39)		probably null	Het
C8a	A	G	4: 104,713,618 (GRCm39)	Y171H	probably damaging	Het
Cacnb4	A	G	2: 52,364,927 (GRCm39)	V112A	probably benign	Het
Capn9	G	T	8: 125,340,195 (GRCm39)	C566F	possibly damaging	Het
Ccdc88a	T	A	11: 29,397,956 (GRCm39)	S230T	probably benign	Het
Cd300c2	A	T	11: 114,887,811 (GRCm39)	F197Y	probably benign	Het
Chd5	A	G	4: 152,445,039 (GRCm39)	Y340C	probably damaging	Het
Chrd	A	T	16: 20,557,558 (GRCm39)	I726F	possibly damaging	Het
Chrna10	G	A	7: 101,762,426 (GRCm39)	P255S	possibly damaging	Het
Clasp1	T	A	1: 118,470,927 (GRCm39)	Y197*	probably null	Het
Cyp2c69	C	G	19: 39,837,852 (GRCm39)	G410A	probably benign	Het
Cyp2e1	G	A	7: 140,343,821 (GRCm39)	V20I	possibly damaging	Het
Dapp1	T	C	3: 137,638,928 (GRCm39)	D225G	probably benign	Het
Dnah5	A	T	15: 28,372,521 (GRCm39)	D2924V	probably damaging	Het
Efcab12	A	T	6: 115,791,510 (GRCm39)	L554Q	possibly damaging	Het
Emsy	T	C	7: 98,246,311 (GRCm39)	T228A	possibly damaging	Het
Evc2	G	A	5: 37,579,204 (GRCm39)	V1106I	probably benign	Het
Exoc8	G	T	8: 125,624,209 (GRCm39)	Q53K	possibly damaging	Het
Fbn2	A	T	18: 58,189,344 (GRCm39)	V1594D	probably damaging	Het
Fer1l4	T	C	2: 155,887,543 (GRCm39)	Y551C	possibly damaging	Het
Fhip1a	G	T	3: 85,595,877 (GRCm39)	T115K	probably damaging	Het
Fmnl3	A	G	15: 99,221,362 (GRCm39)	M481T	probably benign	Het
Fras1	A	G	5: 96,883,097 (GRCm39)	N2543S	probably damaging	Het
Fsd2	T	C	7: 81,209,428 (GRCm39)	D138G	probably damaging	Het
Gda	C	T	19: 21,405,992 (GRCm39)	V5I	probably benign	Het
Glt8d2	A	T	10: 82,496,583 (GRCm39)	D158E	probably damaging	Het
Gpx6	C	T	13: 21,496,434 (GRCm39)	Q3*	probably null	Het
Greb1l	A	G	18: 10,532,922 (GRCm39)	M830V	probably benign	Het
Hnrnpul1	A	C	7: 25,426,258 (GRCm39)	V531G	probably damaging	Het
Ifi206	A	T	1: 173,308,432 (GRCm39)	H521Q	probably benign	Het
Igsf3	G	C	3: 101,365,410 (GRCm39)	R1127P	probably benign	Het
Il1rl1	A	G	1: 40,489,348 (GRCm39)	R367G	probably damaging	Het
Islr	T	C	9: 58,064,970 (GRCm39)	D179G	possibly damaging	Het
Jcad	G	T	18: 4,649,338 (GRCm39)	E70*	probably null	Het
Kcnd2	T	C	6: 21,723,211 (GRCm39)	I467T	probably benign	Het
Lrrc27	A	G	7: 138,822,614 (GRCm39)	T502A	probably benign	Het
Lrrtm3	T	A	10: 63,923,781 (GRCm39)	H462L	probably benign	Het
Mbd5	T	C	2: 49,140,168 (GRCm39)	L44S	probably damaging	Het
Mccc1	C	A	3: 36,030,022 (GRCm39)	M429I	probably damaging	Het
Mgam	A	T	6: 40,691,566 (GRCm39)		probably null	Het
Mipep	T	A	14: 61,109,552 (GRCm39)	I643N	probably damaging	Het
Mmrn1	A	T	6: 60,965,457 (GRCm39)	I1162L	probably benign	Het
Mrc2	G	A	11: 105,239,257 (GRCm39)		probably null	Het
Mug1	G	A	6: 121,861,600 (GRCm39)	C1354Y	probably damaging	Het
Nbeal2	A	T	9: 110,461,123 (GRCm39)	S1647T	probably benign	Het
Ndufaf2	C	G	13: 108,189,314 (GRCm39)	A145P	probably damaging	Het
Nedd9	A	T	13: 41,492,051 (GRCm39)		probably null	Het
Nr4a2	T	A	2: 57,002,105 (GRCm39)	H116L	probably benign	Het
Nwd2	A	G	5: 63,951,665 (GRCm39)	Y232C	probably damaging	Het
Odf4	A	G	11: 68,817,514 (GRCm39)	L58P	probably damaging	Het
Or2a20	T	A	6: 43,193,883 (GRCm39)	V12D	probably benign	Het
Or4a27	T	A	2: 88,559,056 (GRCm39)	M296L	possibly damaging	Het
Or4c116	A	T	2: 88,942,576 (GRCm39)	F93L	probably damaging	Het
Or4g17	T	A	2: 111,209,990 (GRCm39)	L215H	probably damaging	Het
Or7e165	C	T	9: 19,694,596 (GRCm39)	H18Y	probably damaging	Het
Or8g24	A	G	9: 38,989,558 (GRCm39)	V161A	probably benign	Het
Or8s5	G	T	15: 98,238,659 (GRCm39)	H70Q	possibly damaging	Het
Orc6	T	A	8: 86,029,579 (GRCm39)	I41K	probably damaging	Het
Pikfyve	A	G	1: 65,307,005 (GRCm39)	T1798A	probably benign	Het
Prdx6b	T	C	2: 80,123,404 (GRCm39)	L71P	probably damaging	Het
Prmt2	A	G	10: 76,062,055 (GRCm39)	I50T	probably damaging	Het
Ptdss1	T	C	13: 67,143,482 (GRCm39)		probably null	Het
Pygl	T	C	12: 70,254,532 (GRCm39)	T138A	possibly damaging	Het
Rab3c	T	C	13: 110,198,434 (GRCm39)	E198G	probably benign	Het
Rbl2	A	G	8: 91,812,196 (GRCm39)	Y255C	probably damaging	Het
Rev3l	T	A	10: 39,699,393 (GRCm39)	S1297T	probably damaging	Het
Rgma	C	A	7: 73,067,564 (GRCm39)	T367K	probably damaging	Het
Rps6ka5	C	T	12: 100,564,144 (GRCm39)		probably null	Het
Rslcan18	A	T	13: 67,246,590 (GRCm39)	C217S	probably damaging	Het
Rtp3	A	G	9: 110,815,279 (GRCm39)		probably benign	Het
Ryr1	A	T	7: 28,745,087 (GRCm39)	N3848K	probably damaging	Het
Sema6a	T	A	18: 47,381,779 (GRCm39)	T923S	probably benign	Het
Serpinb6d	A	T	13: 33,855,336 (GRCm39)	T337S	possibly damaging	Het
Sf3b1	G	A	1: 55,029,666 (GRCm39)	T1112M	probably damaging	Het
Shroom3	G	T	5: 93,090,945 (GRCm39)	V1151F	probably damaging	Het
Sidt1	A	T	16: 44,090,221 (GRCm39)	Y369*	probably null	Het
Slc16a6	A	G	11: 109,354,193 (GRCm39)	S59P	probably benign	Het
Slc25a17	A	C	15: 81,211,527 (GRCm39)	L163W	probably damaging	Het
Slc44a3	T	C	3: 121,320,723 (GRCm39)	T93A	possibly damaging	Het
Sptbn1	T	C	11: 30,087,197 (GRCm39)	T1081A	possibly damaging	Het
Sptbn4	T	C	7: 27,116,431 (GRCm39)	D456G	probably benign	Het
Sycp1	C	A	3: 102,760,805 (GRCm39)	A703S	possibly damaging	Het
Tas2r118	T	A	6: 23,969,225 (GRCm39)	M279L	probably benign	Het
Tc2n	T	G	12: 101,660,832 (GRCm39)	Q133H	probably benign	Het
Tctn1	A	G	5: 122,399,468 (GRCm39)		probably null	Het
Tenm4	A	C	7: 96,423,253 (GRCm39)	K683Q	probably damaging	Het
Tex10	A	T	4: 48,468,984 (GRCm39)	S64T	probably benign	Het
Tex15	A	G	8: 34,072,525 (GRCm39)	T2691A	probably benign	Het
Tmem175	A	T	5: 108,790,016 (GRCm39)	T123S	probably damaging	Het
Tsc1	C	A	2: 28,562,419 (GRCm39)	S348R	probably damaging	Het
Ttll4	A	T	1: 74,718,166 (GRCm39)	T6S	possibly damaging	Het
Ttll8	A	T	15: 88,801,293 (GRCm39)	I465N	probably damaging	Het
Ubr3	A	G	2: 69,768,714 (GRCm39)		probably benign	Het
Ugdh	A	T	5: 65,580,695 (GRCm39)		probably null	Het
Usp34	T	C	11: 23,437,215 (GRCm39)	L3326S	probably damaging	Het
Vmn2r125	A	T	4: 156,702,276 (GRCm39)	I21F	probably damaging	Het
Vps9d1	G	A	8: 123,975,351 (GRCm39)		probably benign	Het
Xab2	G	A	8: 3,668,117 (GRCm39)	R154C	possibly damaging	Het
Zbtb12	T	C	17: 35,114,475 (GRCm39)	S87P	probably damaging	Het
Zc3h12a	A	G	4: 125,014,686 (GRCm39)	M266T	probably damaging	Het
Zfp108	G	A	7: 23,959,837 (GRCm39)	A143T	probably benign	Het

Other mutations in Arhgef10l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01420:Arhgef10l	APN	4	140,297,649 (GRCm39)	missense	probably damaging	0.98
IGL01732:Arhgef10l	APN	4	140,307,726 (GRCm39)	missense	probably damaging	0.99
IGL01988:Arhgef10l	APN	4	140,305,672 (GRCm39)	splice site	probably benign
IGL02031:Arhgef10l	APN	4	140,302,656 (GRCm39)	missense	probably damaging	1.00
IGL02253:Arhgef10l	APN	4	140,271,595 (GRCm39)	nonsense	probably null
IGL02445:Arhgef10l	APN	4	140,274,318 (GRCm39)	missense	probably benign	0.19
IGL02619:Arhgef10l	APN	4	140,321,504 (GRCm39)	missense	probably benign	0.07
IGL02798:Arhgef10l	APN	4	140,292,441 (GRCm39)	critical splice donor site	probably null
IGL03064:Arhgef10l	APN	4	140,306,590 (GRCm39)	missense	probably damaging	1.00
IGL03178:Arhgef10l	APN	4	140,271,739 (GRCm39)	missense	possibly damaging	0.92
IGL03236:Arhgef10l	APN	4	140,338,671 (GRCm39)	missense	probably damaging	1.00
IGL03352:Arhgef10l	APN	4	140,311,242 (GRCm39)	start codon destroyed	probably null	0.99
PIT4494001:Arhgef10l	UTSW	4	140,292,522 (GRCm39)	missense	probably damaging	0.98
R0057:Arhgef10l	UTSW	4	140,338,529 (GRCm39)	splice site	probably benign
R0062:Arhgef10l	UTSW	4	140,279,843 (GRCm39)	missense	probably damaging	1.00
R0109:Arhgef10l	UTSW	4	140,305,605 (GRCm39)	missense	probably benign	0.02
R0109:Arhgef10l	UTSW	4	140,305,605 (GRCm39)	missense	probably benign	0.02
R0114:Arhgef10l	UTSW	4	140,311,194 (GRCm39)	missense	probably benign	0.17
R0334:Arhgef10l	UTSW	4	140,311,237 (GRCm39)	nonsense	probably null
R0742:Arhgef10l	UTSW	4	140,264,156 (GRCm39)	missense	probably damaging	1.00
R1017:Arhgef10l	UTSW	4	140,242,617 (GRCm39)	missense	probably damaging	0.99
R1166:Arhgef10l	UTSW	4	140,302,581 (GRCm39)	unclassified	probably benign
R1397:Arhgef10l	UTSW	4	140,271,754 (GRCm39)	missense	probably damaging	0.98
R1521:Arhgef10l	UTSW	4	140,242,749 (GRCm39)	missense	possibly damaging	0.95
R1707:Arhgef10l	UTSW	4	140,291,600 (GRCm39)	missense	probably damaging	1.00
R1793:Arhgef10l	UTSW	4	140,242,684 (GRCm39)	missense	probably damaging	0.97
R2018:Arhgef10l	UTSW	4	140,271,695 (GRCm39)	missense	probably damaging	1.00
R2093:Arhgef10l	UTSW	4	140,297,601 (GRCm39)	missense	possibly damaging	0.57
R2098:Arhgef10l	UTSW	4	140,306,743 (GRCm39)	missense	probably damaging	1.00
R2310:Arhgef10l	UTSW	4	140,320,429 (GRCm39)	missense	probably damaging	1.00
R2879:Arhgef10l	UTSW	4	140,242,598 (GRCm39)	missense	probably benign	0.09
R2883:Arhgef10l	UTSW	4	140,244,113 (GRCm39)	missense	probably benign	0.02
R3732:Arhgef10l	UTSW	4	140,308,930 (GRCm39)	small deletion	probably benign
R3732:Arhgef10l	UTSW	4	140,308,930 (GRCm39)	small deletion	probably benign
R3861:Arhgef10l	UTSW	4	140,242,798 (GRCm39)	missense	possibly damaging	0.94
R4049:Arhgef10l	UTSW	4	140,242,762 (GRCm39)	missense	probably benign	0.05
R4322:Arhgef10l	UTSW	4	140,270,037 (GRCm39)	missense	probably benign	0.07
R5395:Arhgef10l	UTSW	4	140,297,601 (GRCm39)	missense	probably benign	0.16
R5720:Arhgef10l	UTSW	4	140,308,930 (GRCm39)	small deletion	probably benign
R6066:Arhgef10l	UTSW	4	140,304,391 (GRCm39)	missense	probably damaging	1.00
R6190:Arhgef10l	UTSW	4	140,270,073 (GRCm39)	missense	possibly damaging	0.90
R6464:Arhgef10l	UTSW	4	140,314,126 (GRCm39)	missense	probably benign	0.05
R6476:Arhgef10l	UTSW	4	140,338,693 (GRCm39)	missense	probably damaging	1.00
R6478:Arhgef10l	UTSW	4	140,270,068 (GRCm39)	missense	possibly damaging	0.91
R6483:Arhgef10l	UTSW	4	140,344,226 (GRCm39)	missense	probably damaging	0.99
R6631:Arhgef10l	UTSW	4	140,245,058 (GRCm39)	intron	probably benign
R6721:Arhgef10l	UTSW	4	140,297,655 (GRCm39)	missense	probably damaging	1.00
R6890:Arhgef10l	UTSW	4	140,271,730 (GRCm39)	missense	probably damaging	1.00
R7098:Arhgef10l	UTSW	4	140,308,222 (GRCm39)	missense	probably benign	0.01
R7100:Arhgef10l	UTSW	4	140,244,126 (GRCm39)	missense	possibly damaging	0.60
R7117:Arhgef10l	UTSW	4	140,291,497 (GRCm39)	critical splice donor site	probably null
R7195:Arhgef10l	UTSW	4	140,338,721 (GRCm39)	missense	probably benign
R7222:Arhgef10l	UTSW	4	140,248,580 (GRCm39)	missense	probably damaging	1.00
R7397:Arhgef10l	UTSW	4	140,290,115 (GRCm39)	missense	probably damaging	1.00
R7776:Arhgef10l	UTSW	4	140,302,642 (GRCm39)	missense	probably damaging	1.00
R7801:Arhgef10l	UTSW	4	140,271,578 (GRCm39)	missense	probably benign	0.00
R7811:Arhgef10l	UTSW	4	140,242,335 (GRCm39)	missense	possibly damaging	0.63
R7832:Arhgef10l	UTSW	4	140,305,616 (GRCm39)	missense	possibly damaging	0.90
R7849:Arhgef10l	UTSW	4	140,311,245 (GRCm39)	critical splice acceptor site	probably null
R7963:Arhgef10l	UTSW	4	140,306,736 (GRCm39)	missense	probably damaging	1.00
R8434:Arhgef10l	UTSW	4	140,291,582 (GRCm39)	missense	possibly damaging	0.89
R8943:Arhgef10l	UTSW	4	140,292,550 (GRCm39)	missense	probably damaging	0.99
R9004:Arhgef10l	UTSW	4	140,279,921 (GRCm39)	missense	probably damaging	0.98
R9006:Arhgef10l	UTSW	4	140,271,659 (GRCm39)	missense	probably benign	0.04
R9033:Arhgef10l	UTSW	4	140,321,463 (GRCm39)	missense	probably damaging	0.99
R9302:Arhgef10l	UTSW	4	140,242,548 (GRCm39)	missense	probably benign	0.04
R9337:Arhgef10l	UTSW	4	140,338,624 (GRCm39)	missense	probably damaging	1.00
R9375:Arhgef10l	UTSW	4	140,319,265 (GRCm39)	missense	probably benign
R9454:Arhgef10l	UTSW	4	140,308,236 (GRCm39)	nonsense	probably null
Z1088:Arhgef10l	UTSW	4	140,309,046 (GRCm39)	missense	possibly damaging	0.53
Z1177:Arhgef10l	UTSW	4	140,244,083 (GRCm39)	missense	probably benign	0.28

Predicted Primers

PCR Primer
(F):5'- CTCAACACCTCTGTTTAAAGGGC -3'
(R):5'- CCTGTTCTCAGCACCAAGTG -3'

Sequencing Primer
(F):5'- TCTGTTTAAAGGGCAGAGGTCAC -3'
(R):5'- TGTTCTCAGCACCAAGTGGGAAG -3'

Posted On

2015-10-21