Incidental Mutation 'R4697:Dpp7'
ID 355746
Institutional Source Beutler Lab
Gene Symbol Dpp7
Ensembl Gene ENSMUSG00000026958
Gene Name dipeptidylpeptidase 7
Synonyms QPP
MMRRC Submission 041947-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R4697 (G1)
Quality Score 225
Status Validated
Chromosome 2
Chromosomal Location 25242302-25246365 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 25244931 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 209 (Y209H)
Ref Sequence ENSEMBL: ENSMUSP00000028332 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000028332] [ENSMUST00000042390] [ENSMUST00000102925]
AlphaFold Q9ET22
Predicted Effect probably benign
Transcript: ENSMUST00000028332
AA Change: Y209H

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000028332
Gene: ENSMUSG00000026958
AA Change: Y209H

DomainStartEndE-ValueType
signal peptide 1 33 N/A INTRINSIC
Pfam:Peptidase_S28 48 475 2.3e-90 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000042390
SMART Domains Protein: ENSMUSP00000036996
Gene: ENSMUSG00000036646

DomainStartEndE-ValueType
low complexity region 3 11 N/A INTRINSIC
low complexity region 29 42 N/A INTRINSIC
transmembrane domain 49 71 N/A INTRINSIC
Pfam:Glyco_hydro_47 215 654 9.5e-167 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000102925
SMART Domains Protein: ENSMUSP00000099989
Gene: ENSMUSG00000026956

DomainStartEndE-ValueType
low complexity region 24 48 N/A INTRINSIC
Pfam:UDPGP 68 453 2.1e-63 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000125248
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131665
Predicted Effect noncoding transcript
Transcript: ENSMUST00000133253
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135473
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139108
Predicted Effect noncoding transcript
Transcript: ENSMUST00000139971
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150305
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149953
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144218
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.5%
Validation Efficiency 96% (75/78)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a post-proline cleaving aminopeptidase expressed in quiescent lymphocytes. The resting lymphocytes are maintained through suppression of apoptosis, a state which is disrupted by inhibition of this novel serine protease. The enzyme has strong sequence homology with prolylcarboxypeptidase and is active at both acidic and neutral pH. [provided by RefSeq, Jul 2008]
Allele List at MGI

All alleles(4) : Targeted, knock-out(1) Targeted, other(2) Gene trapped(1)

Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T C 6: 121,615,243 (GRCm39) M1T probably null Het
Aatf T A 11: 84,339,964 (GRCm39) D449V probably damaging Het
Acbd3 T A 1: 180,549,509 (GRCm39) probably benign Het
Bicc1 T A 10: 70,789,314 (GRCm39) I366F possibly damaging Het
Ccdc74a T C 16: 17,467,613 (GRCm39) S184P possibly damaging Het
Cntn4 T C 6: 106,502,446 (GRCm39) V401A probably damaging Het
Cux2 T C 5: 122,011,816 (GRCm39) T540A probably damaging Het
Disp2 G T 2: 118,622,165 (GRCm39) E966* probably null Het
Dstyk T A 1: 132,377,225 (GRCm39) F277Y probably damaging Het
Dtx1 A T 5: 120,832,473 (GRCm39) probably null Het
Ear-ps2 G A 14: 44,284,517 (GRCm39) noncoding transcript Het
Ednra T C 8: 78,391,624 (GRCm39) H422R probably benign Het
Erlec1 T A 11: 30,902,640 (GRCm39) I67F probably benign Het
Fam161b G A 12: 84,395,332 (GRCm39) probably benign Het
Gata5 A T 2: 179,969,172 (GRCm39) C345* probably null Het
Glmp T C 3: 88,235,581 (GRCm39) V47A probably damaging Het
Gm9762 T A 3: 78,873,857 (GRCm39) noncoding transcript Het
Gnas A T 2: 174,139,873 (GRCm39) D14V probably damaging Het
Gnl3 T C 14: 30,739,286 (GRCm39) S53G probably damaging Het
Grhl3 C T 4: 135,275,777 (GRCm39) V527M probably damaging Het
Hoxd10 T A 2: 74,524,531 (GRCm39) L281* probably null Het
Kif16b T G 2: 142,532,614 (GRCm39) Y1175S probably benign Het
Kif2b A G 11: 91,467,672 (GRCm39) S204P probably benign Het
Klhl40 T A 9: 121,607,800 (GRCm39) I320N probably damaging Het
Ksr2 G A 5: 117,846,212 (GRCm39) R693Q probably damaging Het
Mis12 A G 11: 70,916,152 (GRCm39) K62E possibly damaging Het
Mlc1 A G 15: 88,858,980 (GRCm39) C102R probably damaging Het
Muc5b T C 7: 141,411,098 (GRCm39) I1348T unknown Het
Myh7b A G 2: 155,471,242 (GRCm39) E1130G probably damaging Het
Nat8f4 T C 6: 85,878,368 (GRCm39) T52A probably benign Het
Nxpe2 C A 9: 48,231,821 (GRCm39) V379L probably benign Het
Or10ad1c G A 15: 98,084,749 (GRCm39) R310W probably damaging Het
Or4c1 T A 2: 89,133,247 (GRCm39) S230C probably damaging Het
Or4c1 C A 2: 89,133,246 (GRCm39) S230I possibly damaging Het
Or5b111 A T 19: 13,291,081 (GRCm39) D189E probably benign Het
Or5b12 C T 19: 12,897,298 (GRCm39) C125Y probably damaging Het
Pcdhga7 A T 18: 37,850,261 (GRCm39) Y756F probably damaging Het
Pcsk6 T A 7: 65,608,989 (GRCm39) Y284N probably damaging Het
Pdcd11 T C 19: 47,114,786 (GRCm39) V1367A possibly damaging Het
Postn T A 3: 54,282,492 (GRCm39) N484K probably damaging Het
Prkd3 C T 17: 79,268,600 (GRCm39) V572I probably benign Het
Qser1 T C 2: 104,617,528 (GRCm39) S1005G probably benign Het
Radil G T 5: 142,472,556 (GRCm39) D951E probably benign Het
Ripk1 C T 13: 34,211,925 (GRCm39) R352* probably null Het
Sacs T C 14: 61,450,196 (GRCm39) F4081L probably benign Het
Sbf1 A G 15: 89,199,288 (GRCm39) V11A possibly damaging Het
Sgip1 T A 4: 102,791,784 (GRCm39) F536I probably damaging Het
Slc45a1 A G 4: 150,722,741 (GRCm39) L381P probably damaging Het
Smarcad1 C T 6: 65,029,625 (GRCm39) P71L probably benign Het
Spns1 T A 7: 125,976,209 (GRCm39) D14V probably damaging Het
Sv2c T A 13: 96,122,526 (GRCm39) I417F possibly damaging Het
Tas2r113 T A 6: 132,870,479 (GRCm39) M169K probably benign Het
Tgm1 A T 14: 55,943,138 (GRCm39) N567K probably benign Het
Thoc2l A G 5: 104,670,106 (GRCm39) K1543E probably benign Het
Tln2 C T 9: 67,302,743 (GRCm39) R76Q probably damaging Het
Trpm6 T C 19: 18,831,155 (GRCm39) V1340A probably benign Het
Tspan18 A T 2: 93,142,375 (GRCm39) probably null Het
Txndc11 C T 16: 10,902,178 (GRCm39) V679I probably damaging Het
Usf1 G T 1: 171,244,532 (GRCm39) G144V possibly damaging Het
Vmn1r59 T C 7: 5,457,451 (GRCm39) Y103C probably damaging Het
Vmn2r23 A T 6: 123,718,785 (GRCm39) I713F probably damaging Het
Vmn2r79 A T 7: 86,687,168 (GRCm39) I850F probably damaging Het
Vps35l T A 7: 118,390,671 (GRCm39) I455N probably damaging Het
Wdr90 C T 17: 26,074,337 (GRCm39) R676H probably benign Het
Zfp867 G A 11: 59,354,487 (GRCm39) R281W probably damaging Het
Zfp939 T C 7: 39,122,366 (GRCm39) noncoding transcript Het
Other mutations in Dpp7
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01637:Dpp7 APN 2 25,244,625 (GRCm39) missense probably benign 0.01
IGL02897:Dpp7 APN 2 25,243,684 (GRCm39) missense probably damaging 1.00
IGL02992:Dpp7 APN 2 25,244,589 (GRCm39) missense possibly damaging 0.65
IGL03069:Dpp7 APN 2 25,245,735 (GRCm39) critical splice acceptor site probably null
1mM(1):Dpp7 UTSW 2 25,246,152 (GRCm39) missense probably benign 0.05
PIT4519001:Dpp7 UTSW 2 25,242,460 (GRCm39) missense probably damaging 0.97
R0051:Dpp7 UTSW 2 25,246,107 (GRCm39) missense possibly damaging 0.80
R0051:Dpp7 UTSW 2 25,246,107 (GRCm39) missense possibly damaging 0.80
R0900:Dpp7 UTSW 2 25,246,311 (GRCm39) missense probably damaging 0.99
R1889:Dpp7 UTSW 2 25,243,691 (GRCm39) splice site probably null
R1895:Dpp7 UTSW 2 25,243,691 (GRCm39) splice site probably null
R2055:Dpp7 UTSW 2 25,244,490 (GRCm39) missense possibly damaging 0.84
R4832:Dpp7 UTSW 2 25,242,398 (GRCm39) unclassified probably benign
R4887:Dpp7 UTSW 2 25,242,770 (GRCm39) critical splice acceptor site probably null
R5114:Dpp7 UTSW 2 25,242,749 (GRCm39) missense possibly damaging 0.51
R6976:Dpp7 UTSW 2 25,244,836 (GRCm39) critical splice acceptor site probably null
R7577:Dpp7 UTSW 2 25,245,603 (GRCm39) missense probably benign
R8459:Dpp7 UTSW 2 25,242,550 (GRCm39) missense probably damaging 1.00
R8486:Dpp7 UTSW 2 25,242,561 (GRCm39) missense probably damaging 1.00
R8672:Dpp7 UTSW 2 25,246,133 (GRCm39) missense probably benign 0.00
R8690:Dpp7 UTSW 2 25,245,645 (GRCm39) missense probably damaging 1.00
X0058:Dpp7 UTSW 2 25,244,764 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- TCCCTGGAGGAACAAGTCTTTG -3'
(R):5'- CAGTGAAGGCTGTATCTGCC -3'

Sequencing Primer
(F):5'- GATTTGCTGAAAGGCATCCC -3'
(R):5'- ACCCTTGGGCGTTCTGAG -3'
Posted On 2015-10-21