Incidental Mutation 'R4697:Wdr90'
ID 355802
Institutional Source Beutler Lab
Gene Symbol Wdr90
Ensembl Gene ENSMUSG00000073434
Gene Name WD repeat domain 90
Synonyms 3230401M21Rik
MMRRC Submission 041947-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.107) question?
Stock # R4697 (G1)
Quality Score 195
Status Validated
Chromosome 17
Chromosomal Location 26063745-26080475 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 26074337 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Histidine at position 676 (R676H)
Ref Sequence ENSEMBL: ENSMUSP00000078426 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079461] [ENSMUST00000176923]
AlphaFold Q6ZPG2
Predicted Effect probably benign
Transcript: ENSMUST00000079461
AA Change: R676H

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000078426
Gene: ENSMUSG00000073434
AA Change: R676H

DomainStartEndE-ValueType
low complexity region 32 53 N/A INTRINSIC
Pfam:DUF667 60 183 5e-26 PFAM
Pfam:DUF667 210 271 3.7e-9 PFAM
low complexity region 381 396 N/A INTRINSIC
WD40 478 519 5.94e0 SMART
WD40 522 565 3.2e0 SMART
WD40 572 612 3.3e1 SMART
WD40 687 725 1.15e1 SMART
WD40 728 766 5.75e-1 SMART
WD40 768 808 9.24e-4 SMART
WD40 811 850 4.13e0 SMART
WD40 853 892 4.62e-1 SMART
WD40 950 993 1.07e1 SMART
WD40 996 1035 5.75e-1 SMART
WD40 1040 1077 1.58e-2 SMART
WD40 1290 1334 5.23e-3 SMART
WD40 1337 1378 1.27e-1 SMART
WD40 1384 1419 1.83e2 SMART
WD40 1422 1469 3.08e0 SMART
WD40 1472 1509 9.9e0 SMART
WD40 1568 1607 9.02e-7 SMART
WD40 1610 1655 5.75e-1 SMART
WD40 1659 1697 2.98e-1 SMART
WD40 1700 1749 6.14e1 SMART
WD40 1850 1888 1.92e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176170
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176575
Predicted Effect probably benign
Transcript: ENSMUST00000176678
Predicted Effect probably benign
Transcript: ENSMUST00000176923
AA Change: R658H

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000135420
Gene: ENSMUSG00000073434
AA Change: R658H

DomainStartEndE-ValueType
low complexity region 32 53 N/A INTRINSIC
Pfam:DUF667 60 252 5.1e-14 PFAM
low complexity region 363 378 N/A INTRINSIC
WD40 460 501 5.94e0 SMART
WD40 504 547 3.2e0 SMART
WD40 554 594 3.3e1 SMART
WD40 669 707 1.15e1 SMART
WD40 710 748 5.75e-1 SMART
WD40 750 790 9.24e-4 SMART
WD40 793 832 4.13e0 SMART
WD40 835 874 4.62e-1 SMART
WD40 932 975 1.07e1 SMART
WD40 978 1017 5.75e-1 SMART
WD40 1022 1059 1.58e-2 SMART
WD40 1272 1316 5.23e-3 SMART
WD40 1319 1360 1.27e-1 SMART
WD40 1366 1401 1.83e2 SMART
WD40 1404 1451 3.08e0 SMART
WD40 1454 1491 9.9e0 SMART
WD40 1550 1589 9.02e-7 SMART
WD40 1592 1637 5.75e-1 SMART
WD40 1641 1679 2.98e-1 SMART
WD40 1682 1731 6.14e1 SMART
WD40 1832 1870 1.92e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000176963
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177017
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177031
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177170
Predicted Effect noncoding transcript
Transcript: ENSMUST00000177340
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180868
Meta Mutation Damage Score 0.2449 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.5%
Validation Efficiency 96% (75/78)
Allele List at MGI
Other mutations in this stock
Total: 66 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m T C 6: 121,615,243 (GRCm39) M1T probably null Het
Aatf T A 11: 84,339,964 (GRCm39) D449V probably damaging Het
Acbd3 T A 1: 180,549,509 (GRCm39) probably benign Het
Bicc1 T A 10: 70,789,314 (GRCm39) I366F possibly damaging Het
Ccdc74a T C 16: 17,467,613 (GRCm39) S184P possibly damaging Het
Cntn4 T C 6: 106,502,446 (GRCm39) V401A probably damaging Het
Cux2 T C 5: 122,011,816 (GRCm39) T540A probably damaging Het
Disp2 G T 2: 118,622,165 (GRCm39) E966* probably null Het
Dpp7 A G 2: 25,244,931 (GRCm39) Y209H probably benign Het
Dstyk T A 1: 132,377,225 (GRCm39) F277Y probably damaging Het
Dtx1 A T 5: 120,832,473 (GRCm39) probably null Het
Ear-ps2 G A 14: 44,284,517 (GRCm39) noncoding transcript Het
Ednra T C 8: 78,391,624 (GRCm39) H422R probably benign Het
Erlec1 T A 11: 30,902,640 (GRCm39) I67F probably benign Het
Fam161b G A 12: 84,395,332 (GRCm39) probably benign Het
Gata5 A T 2: 179,969,172 (GRCm39) C345* probably null Het
Glmp T C 3: 88,235,581 (GRCm39) V47A probably damaging Het
Gm9762 T A 3: 78,873,857 (GRCm39) noncoding transcript Het
Gnas A T 2: 174,139,873 (GRCm39) D14V probably damaging Het
Gnl3 T C 14: 30,739,286 (GRCm39) S53G probably damaging Het
Grhl3 C T 4: 135,275,777 (GRCm39) V527M probably damaging Het
Hoxd10 T A 2: 74,524,531 (GRCm39) L281* probably null Het
Kif16b T G 2: 142,532,614 (GRCm39) Y1175S probably benign Het
Kif2b A G 11: 91,467,672 (GRCm39) S204P probably benign Het
Klhl40 T A 9: 121,607,800 (GRCm39) I320N probably damaging Het
Ksr2 G A 5: 117,846,212 (GRCm39) R693Q probably damaging Het
Mis12 A G 11: 70,916,152 (GRCm39) K62E possibly damaging Het
Mlc1 A G 15: 88,858,980 (GRCm39) C102R probably damaging Het
Muc5b T C 7: 141,411,098 (GRCm39) I1348T unknown Het
Myh7b A G 2: 155,471,242 (GRCm39) E1130G probably damaging Het
Nat8f4 T C 6: 85,878,368 (GRCm39) T52A probably benign Het
Nxpe2 C A 9: 48,231,821 (GRCm39) V379L probably benign Het
Or10ad1c G A 15: 98,084,749 (GRCm39) R310W probably damaging Het
Or4c1 C A 2: 89,133,246 (GRCm39) S230I possibly damaging Het
Or4c1 T A 2: 89,133,247 (GRCm39) S230C probably damaging Het
Or5b111 A T 19: 13,291,081 (GRCm39) D189E probably benign Het
Or5b12 C T 19: 12,897,298 (GRCm39) C125Y probably damaging Het
Pcdhga7 A T 18: 37,850,261 (GRCm39) Y756F probably damaging Het
Pcsk6 T A 7: 65,608,989 (GRCm39) Y284N probably damaging Het
Pdcd11 T C 19: 47,114,786 (GRCm39) V1367A possibly damaging Het
Postn T A 3: 54,282,492 (GRCm39) N484K probably damaging Het
Prkd3 C T 17: 79,268,600 (GRCm39) V572I probably benign Het
Qser1 T C 2: 104,617,528 (GRCm39) S1005G probably benign Het
Radil G T 5: 142,472,556 (GRCm39) D951E probably benign Het
Ripk1 C T 13: 34,211,925 (GRCm39) R352* probably null Het
Sacs T C 14: 61,450,196 (GRCm39) F4081L probably benign Het
Sbf1 A G 15: 89,199,288 (GRCm39) V11A possibly damaging Het
Sgip1 T A 4: 102,791,784 (GRCm39) F536I probably damaging Het
Slc45a1 A G 4: 150,722,741 (GRCm39) L381P probably damaging Het
Smarcad1 C T 6: 65,029,625 (GRCm39) P71L probably benign Het
Spns1 T A 7: 125,976,209 (GRCm39) D14V probably damaging Het
Sv2c T A 13: 96,122,526 (GRCm39) I417F possibly damaging Het
Tas2r113 T A 6: 132,870,479 (GRCm39) M169K probably benign Het
Tgm1 A T 14: 55,943,138 (GRCm39) N567K probably benign Het
Thoc2l A G 5: 104,670,106 (GRCm39) K1543E probably benign Het
Tln2 C T 9: 67,302,743 (GRCm39) R76Q probably damaging Het
Trpm6 T C 19: 18,831,155 (GRCm39) V1340A probably benign Het
Tspan18 A T 2: 93,142,375 (GRCm39) probably null Het
Txndc11 C T 16: 10,902,178 (GRCm39) V679I probably damaging Het
Usf1 G T 1: 171,244,532 (GRCm39) G144V possibly damaging Het
Vmn1r59 T C 7: 5,457,451 (GRCm39) Y103C probably damaging Het
Vmn2r23 A T 6: 123,718,785 (GRCm39) I713F probably damaging Het
Vmn2r79 A T 7: 86,687,168 (GRCm39) I850F probably damaging Het
Vps35l T A 7: 118,390,671 (GRCm39) I455N probably damaging Het
Zfp867 G A 11: 59,354,487 (GRCm39) R281W probably damaging Het
Zfp939 T C 7: 39,122,366 (GRCm39) noncoding transcript Het
Other mutations in Wdr90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00418:Wdr90 APN 17 26,068,338 (GRCm39) missense probably damaging 1.00
IGL01118:Wdr90 APN 17 26,073,661 (GRCm39) missense probably damaging 1.00
IGL01964:Wdr90 APN 17 26,067,383 (GRCm39) missense probably benign
IGL02116:Wdr90 APN 17 26,078,466 (GRCm39) missense probably benign 0.12
IGL02172:Wdr90 APN 17 26,069,408 (GRCm39) missense probably benign 0.22
IGL02716:Wdr90 APN 17 26,076,194 (GRCm39) missense probably damaging 0.96
IGL02961:Wdr90 APN 17 26,067,649 (GRCm39) nonsense probably null
IGL03229:Wdr90 APN 17 26,064,437 (GRCm39) splice site probably benign
IGL03367:Wdr90 APN 17 26,066,765 (GRCm39) splice site probably benign
IGL03098:Wdr90 UTSW 17 26,078,961 (GRCm39) intron probably benign
R0111:Wdr90 UTSW 17 26,067,418 (GRCm39) splice site probably benign
R0454:Wdr90 UTSW 17 26,079,023 (GRCm39) missense probably damaging 0.96
R0457:Wdr90 UTSW 17 26,079,459 (GRCm39) missense probably benign 0.00
R0488:Wdr90 UTSW 17 26,067,591 (GRCm39) missense probably damaging 1.00
R0622:Wdr90 UTSW 17 26,074,632 (GRCm39) missense probably damaging 1.00
R0671:Wdr90 UTSW 17 26,065,367 (GRCm39) missense probably benign 0.04
R0799:Wdr90 UTSW 17 26,079,104 (GRCm39) missense probably benign 0.38
R1177:Wdr90 UTSW 17 26,065,028 (GRCm39) missense possibly damaging 0.85
R1460:Wdr90 UTSW 17 26,079,422 (GRCm39) missense possibly damaging 0.82
R1468:Wdr90 UTSW 17 26,073,027 (GRCm39) missense probably damaging 1.00
R1468:Wdr90 UTSW 17 26,073,027 (GRCm39) missense probably damaging 1.00
R1544:Wdr90 UTSW 17 26,068,284 (GRCm39) missense possibly damaging 0.69
R2057:Wdr90 UTSW 17 26,074,173 (GRCm39) missense probably benign 0.05
R2087:Wdr90 UTSW 17 26,065,577 (GRCm39) missense probably damaging 1.00
R2159:Wdr90 UTSW 17 26,070,715 (GRCm39) missense probably benign
R2208:Wdr90 UTSW 17 26,079,362 (GRCm39) missense probably damaging 1.00
R2345:Wdr90 UTSW 17 26,078,136 (GRCm39) missense probably benign 0.05
R2391:Wdr90 UTSW 17 26,070,429 (GRCm39) missense probably damaging 1.00
R2394:Wdr90 UTSW 17 26,070,429 (GRCm39) missense probably damaging 1.00
R2520:Wdr90 UTSW 17 26,074,326 (GRCm39) missense probably damaging 1.00
R3798:Wdr90 UTSW 17 26,069,472 (GRCm39) missense probably benign 0.01
R3979:Wdr90 UTSW 17 26,078,252 (GRCm39) missense probably benign 0.00
R4111:Wdr90 UTSW 17 26,068,342 (GRCm39) missense possibly damaging 0.94
R4326:Wdr90 UTSW 17 26,072,705 (GRCm39) missense probably benign 0.25
R4459:Wdr90 UTSW 17 26,079,976 (GRCm39) missense possibly damaging 0.95
R4735:Wdr90 UTSW 17 26,078,424 (GRCm39) missense probably benign
R4907:Wdr90 UTSW 17 26,079,624 (GRCm39) intron probably benign
R5070:Wdr90 UTSW 17 26,065,307 (GRCm39) missense probably damaging 1.00
R5230:Wdr90 UTSW 17 26,074,277 (GRCm39) missense probably benign 0.01
R5268:Wdr90 UTSW 17 26,069,819 (GRCm39) missense probably damaging 1.00
R5287:Wdr90 UTSW 17 26,080,441 (GRCm39) utr 5 prime probably benign
R5382:Wdr90 UTSW 17 26,064,572 (GRCm39) missense probably damaging 1.00
R5511:Wdr90 UTSW 17 26,063,995 (GRCm39) unclassified probably benign
R5545:Wdr90 UTSW 17 26,064,830 (GRCm39) missense probably damaging 1.00
R5707:Wdr90 UTSW 17 26,076,166 (GRCm39) missense probably benign 0.00
R5973:Wdr90 UTSW 17 26,065,381 (GRCm39) missense probably damaging 1.00
R5973:Wdr90 UTSW 17 26,064,107 (GRCm39) missense probably damaging 0.99
R6385:Wdr90 UTSW 17 26,067,504 (GRCm39) missense probably damaging 1.00
R6481:Wdr90 UTSW 17 26,064,885 (GRCm39) missense probably damaging 0.99
R7078:Wdr90 UTSW 17 26,068,623 (GRCm39) missense probably damaging 1.00
R7214:Wdr90 UTSW 17 26,064,367 (GRCm39) missense probably benign 0.00
R7288:Wdr90 UTSW 17 26,065,286 (GRCm39) missense probably benign 0.03
R7304:Wdr90 UTSW 17 26,070,480 (GRCm39) missense probably benign 0.10
R7309:Wdr90 UTSW 17 26,079,676 (GRCm39) missense probably benign 0.02
R7391:Wdr90 UTSW 17 26,065,502 (GRCm39) missense probably benign 0.08
R7622:Wdr90 UTSW 17 26,073,083 (GRCm39) missense probably benign 0.00
R7646:Wdr90 UTSW 17 26,079,104 (GRCm39) missense probably benign 0.38
R7772:Wdr90 UTSW 17 26,080,465 (GRCm39) start gained probably benign
R7779:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7780:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7781:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7782:Wdr90 UTSW 17 26,065,300 (GRCm39) missense probably damaging 1.00
R7812:Wdr90 UTSW 17 26,071,532 (GRCm39) missense probably damaging 1.00
R7870:Wdr90 UTSW 17 26,079,513 (GRCm39) missense probably damaging 0.96
R7911:Wdr90 UTSW 17 26,069,723 (GRCm39) missense probably benign 0.00
R8126:Wdr90 UTSW 17 26,067,951 (GRCm39) missense possibly damaging 0.48
R8260:Wdr90 UTSW 17 26,064,141 (GRCm39) missense probably damaging 1.00
R8315:Wdr90 UTSW 17 26,064,399 (GRCm39) missense probably benign 0.21
R8919:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R8938:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R8940:Wdr90 UTSW 17 26,076,146 (GRCm39) missense
R9038:Wdr90 UTSW 17 26,076,200 (GRCm39) missense
R9079:Wdr90 UTSW 17 26,076,403 (GRCm39) missense
R9401:Wdr90 UTSW 17 26,064,750 (GRCm39) small insertion probably benign
R9471:Wdr90 UTSW 17 26,080,015 (GRCm39) missense possibly damaging 0.72
R9642:Wdr90 UTSW 17 26,072,694 (GRCm39) critical splice donor site probably null
X0064:Wdr90 UTSW 17 26,067,537 (GRCm39) missense probably damaging 1.00
Z1176:Wdr90 UTSW 17 26,079,470 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- CATGTGGCAGTAGAGACACTG -3'
(R):5'- GGAGTACTGTTCACTGGAGC -3'

Sequencing Primer
(F):5'- CAGTAGAGACACTGAGGCTACTG -3'
(R):5'- AGTACTGTTCACTGGAGCTCACTG -3'
Posted On 2015-10-21