Incidental Mutation 'R4698:Tmem238'
ID 355833
Institutional Source Beutler Lab
Gene Symbol Tmem238
Ensembl Gene ENSMUSG00000030431
Gene Name transmembrane protein 238
Accession Numbers
Essential gene? Probably non essential (E-score: 0.150) question?
Stock # R4698 (G1)
Quality Score 129
Status Not validated
Chromosome 7
Chromosomal Location 4784557-4789656 bp(-) (GRCm38)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 4789017 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Stop codon at position 19 (E19*)
Gene Model predicted gene model for transcript(s): [ENSMUST00000013235] [ENSMUST00000032597] [ENSMUST00000078432] [ENSMUST00000168578]
AlphaFold A9JSM3
Predicted Effect probably benign
Transcript: ENSMUST00000013235
SMART Domains Protein: ENSMUSP00000013235
Gene: ENSMUSG00000013091

low complexity region 3 18 N/A INTRINSIC
Pfam:TMEM190 21 147 3.3e-70 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000032597
SMART Domains Protein: ENSMUSP00000032597
Gene: ENSMUSG00000030432

Pfam:Ribosomal_L28e 5 120 3.3e-39 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000078432
SMART Domains Protein: ENSMUSP00000104217
Gene: ENSMUSG00000030432

Pfam:Ribosomal_L28e 5 121 2.5e-42 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000126794
SMART Domains Protein: ENSMUSP00000117699
Gene: ENSMUSG00000030432

Pfam:Ribosomal_L28e 8 68 1.2e-13 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129888
Predicted Effect probably null
Transcript: ENSMUST00000168578
AA Change: E176*
SMART Domains Protein: ENSMUSP00000130452
Gene: ENSMUSG00000030431
AA Change: E176*

Pfam:TMEM238 32 100 1.2e-32 PFAM
low complexity region 124 135 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000206315
AA Change: E19*
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206617
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 96.9%
  • 20x: 94.3%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700122O11Rik A G 17: 48,038,240 (GRCm38) V11A possibly damaging Het
6030452D12Rik T C 8: 106,504,347 (GRCm38) I55T unknown Het
Aadacl2 A G 3: 60,025,039 (GRCm38) D325G probably benign Het
Adh1 A G 3: 138,282,513 (GRCm38) S113G probably benign Het
Agxt2 T C 15: 10,392,044 (GRCm38) probably null Het
Aicda C T 6: 122,553,888 (GRCm38) probably benign Het
Aifm2 T C 10: 61,727,756 (GRCm38) M135T probably benign Het
Asah2 T C 19: 32,054,471 (GRCm38) probably null Het
Btbd17 T C 11: 114,791,717 (GRCm38) R390G probably damaging Het
Cadps T C 14: 12,705,654 (GRCm38) E247G possibly damaging Het
Cds2 T C 2: 132,304,953 (GRCm38) I383T probably damaging Het
Celf3 T A 3: 94,484,867 (GRCm38) probably null Het
Crhr2 T C 6: 55,102,867 (GRCm38) S162G possibly damaging Het
Dapl1 A T 2: 59,504,774 (GRCm38) K91* probably null Het
Ddx60 A C 8: 62,012,424 (GRCm38) M1372L probably benign Het
Dnah2 A T 11: 69,498,532 (GRCm38) F845I probably damaging Het
Dscam T C 16: 96,610,324 (GRCm38) D1784G probably damaging Het
Ech1 T C 7: 28,832,053 (GRCm38) V310A probably benign Het
Eef1g A G 19: 8,977,966 (GRCm38) D393G possibly damaging Het
Eif3k T C 7: 28,972,544 (GRCm38) I172V possibly damaging Het
Foxd4 A G 19: 24,900,261 (GRCm38) F192L probably damaging Het
Gpr153 T A 4: 152,281,783 (GRCm38) S268R probably damaging Het
H3c13 C A 3: 96,269,078 (GRCm38) R129S probably damaging Het
Ivl T C 3: 92,571,391 (GRCm38) K456E unknown Het
Kif20b A T 19: 34,951,544 (GRCm38) D1190V probably damaging Het
Kif21a T A 15: 90,956,305 (GRCm38) I1223L possibly damaging Het
Lmf1 T C 17: 25,579,350 (GRCm38) V55A probably damaging Het
Loxhd1 A G 18: 77,372,291 (GRCm38) E659G possibly damaging Het
Lrrc37a T C 11: 103,504,104 (GRCm38) E165G possibly damaging Het
Mios T C 6: 8,228,113 (GRCm38) Y677H possibly damaging Het
Mnx1 T A 5: 29,474,059 (GRCm38) K342M unknown Het
Mtpap A T 18: 4,375,724 (GRCm38) T35S possibly damaging Het
Ndc1 C G 4: 107,411,137 (GRCm38) D623E probably benign Het
Nedd4l A G 18: 65,203,880 (GRCm38) Y666C probably damaging Het
Or52s6 T A 7: 103,442,635 (GRCm38) I163F possibly damaging Het
Or5ac22 T C 16: 59,315,357 (GRCm38) T17A probably damaging Het
Or5b12b T G 19: 12,884,621 (GRCm38) F247V probably benign Het
Or5m10b A G 2: 85,869,252 (GRCm38) Y220C possibly damaging Het
Papss1 G T 3: 131,607,331 (GRCm38) V369F probably damaging Het
Pcdhac2 T A 18: 37,145,769 (GRCm38) Y601N probably damaging Het
Pde7a C T 3: 19,310,931 (GRCm38) R24Q probably damaging Het
Phf21a A G 2: 92,356,952 (GRCm38) D445G probably damaging Het
Plekho1 T A 3: 95,995,652 (GRCm38) N15I possibly damaging Het
Pprc1 T C 19: 46,069,195 (GRCm38) probably benign Het
Ralgapa1 A T 12: 55,677,276 (GRCm38) probably null Het
Rrp12 T C 19: 41,873,042 (GRCm38) E942G probably benign Het
Skor1 T C 9: 63,144,548 (GRCm38) D685G probably benign Het
Smim23 A T 11: 32,824,510 (GRCm38) I3N possibly damaging Het
Spata7 A T 12: 98,664,277 (GRCm38) I333F probably damaging Het
Sppl2c T C 11: 104,188,315 (GRCm38) I647T probably benign Het
Srgap1 C A 10: 121,792,487 (GRCm38) R837L probably benign Het
Stpg2 C A 3: 139,309,229 (GRCm38) P385H probably damaging Het
Top2b A T 14: 16,387,331 (GRCm38) K140* probably null Het
Trp53 T A 11: 69,588,422 (GRCm38) L142* probably null Het
Tyro3 A T 2: 119,803,270 (GRCm38) D133V probably damaging Het
Virma T A 4: 11,528,636 (GRCm38) I1291N probably damaging Het
Vmn1r213 A G 13: 23,011,337 (GRCm38) probably benign Het
Zbtb10 T C 3: 9,264,550 (GRCm38) S323P possibly damaging Het
Zfp521 A T 18: 13,845,603 (GRCm38) N584K probably damaging Het
Zfp944 A G 17: 22,339,199 (GRCm38) C356R probably damaging Het
Other mutations in Tmem238
AlleleSourceChrCoordTypePredicted EffectPPH Score
R3834:Tmem238 UTSW 7 4,789,079 (GRCm38) missense possibly damaging 0.48
R7140:Tmem238 UTSW 7 4,789,073 (GRCm38) missense possibly damaging 0.85
R7657:Tmem238 UTSW 7 4,789,227 (GRCm38) missense probably damaging 1.00
R8836:Tmem238 UTSW 7 4,789,521 (GRCm38) missense possibly damaging 0.96
Predicted Primers PCR Primer

Sequencing Primer
Posted On 2015-10-21