Incidental Mutation 'R4700:Obsl1'
| ID |
355880 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Obsl1
|
| Ensembl Gene |
ENSMUSG00000026211 |
| Gene Name |
obscurin-like 1 |
| Synonyms |
|
| MMRRC Submission |
041948-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly non essential
(E-score: 0.269)
|
| Stock # |
R4700 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
75462469-75483134 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 75480085 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 487
(V487E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000109197
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037330]
[ENSMUST00000113565]
[ENSMUST00000113567]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000037330
|
| SMART Domains |
Protein: ENSMUSP00000040310
Gene: ENSMUSG00000032968
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
low complexity region
|
189 |
199 |
N/A |
INTRINSIC |
|
TGFB
|
263 |
366 |
1.58e-25 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113565
AA Change: V487E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000109195
Gene: ENSMUSG00000026211
AA Change: V487E
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
24 |
91 |
1.23e-12 |
SMART |
|
IGc2
|
140 |
216 |
2.33e-13 |
SMART |
|
IGc2
|
258 |
326 |
1.48e-6 |
SMART |
|
IG
|
347 |
427 |
9.49e-5 |
SMART |
|
IG
|
435 |
511 |
1.04e-1 |
SMART |
|
FN3
|
518 |
601 |
6.6e-2 |
SMART |
|
PDB:2E6Q|A
|
608 |
714 |
5e-57 |
PDB |
|
Blast:IG_like
|
622 |
711 |
2e-50 |
BLAST |
|
IG
|
723 |
804 |
3.79e-4 |
SMART |
|
IG
|
814 |
893 |
2.58e-6 |
SMART |
|
IGc2
|
911 |
977 |
1.12e-6 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000113567
AA Change: V487E
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000109197
Gene: ENSMUSG00000026211
AA Change: V487E
| Domain | Start | End | E-Value | Type |
|---|
|
IGc2
|
24 |
91 |
1.23e-12 |
SMART |
|
IGc2
|
140 |
216 |
2.33e-13 |
SMART |
|
IGc2
|
258 |
326 |
1.48e-6 |
SMART |
|
IG
|
347 |
427 |
9.49e-5 |
SMART |
|
IG
|
435 |
511 |
1.04e-1 |
SMART |
|
FN3
|
518 |
601 |
6.6e-2 |
SMART |
|
PDB:2E6Q|A
|
608 |
714 |
8e-57 |
PDB |
|
Blast:IG_like
|
622 |
711 |
3e-50 |
BLAST |
|
IG
|
723 |
804 |
3.79e-4 |
SMART |
|
IG
|
814 |
893 |
2.58e-6 |
SMART |
|
IGc2
|
911 |
977 |
1.12e-6 |
SMART |
|
IG
|
996 |
1075 |
1.27e-5 |
SMART |
|
IGc2
|
1094 |
1160 |
4.07e-4 |
SMART |
|
IGc2
|
1186 |
1252 |
9.49e-5 |
SMART |
|
IG
|
1274 |
1353 |
7.41e-7 |
SMART |
|
IG
|
1363 |
1444 |
1.15e-3 |
SMART |
|
IG
|
1454 |
1533 |
8.33e-1 |
SMART |
|
IGc2
|
1549 |
1615 |
8.72e-4 |
SMART |
|
IG
|
1633 |
1712 |
1e-3 |
SMART |
|
IG
|
1723 |
1802 |
3.82e-9 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000127507
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000129403
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000145306
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000155084
AA Change: V292E
|
| SMART Domains |
Protein: ENSMUSP00000114553
Gene: ENSMUSG00000026211
AA Change: V292E
| Domain | Start | End | E-Value | Type |
|---|
|
SCOP:d1g1ca_
|
2 |
32 |
1e-3 |
SMART |
|
IGc2
|
64 |
132 |
1.48e-6 |
SMART |
|
IG
|
153 |
233 |
9.49e-5 |
SMART |
|
IG
|
241 |
317 |
1.04e-1 |
SMART |
|
FN3
|
324 |
407 |
6.6e-2 |
SMART |
|
PDB:2E6Q|A
|
414 |
520 |
4e-57 |
PDB |
|
Blast:IG_like
|
428 |
517 |
2e-50 |
BLAST |
|
IG
|
529 |
610 |
3.79e-4 |
SMART |
|
IG
|
620 |
699 |
2.58e-6 |
SMART |
|
IGc2
|
717 |
783 |
1.12e-6 |
SMART |
|
IG
|
802 |
881 |
1.27e-5 |
SMART |
|
IGc2
|
900 |
966 |
4.07e-4 |
SMART |
|
IGc2
|
992 |
1058 |
9.49e-5 |
SMART |
|
IG
|
1080 |
1159 |
7.41e-7 |
SMART |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
97% (127/131) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 112 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A530084C06Rik |
A |
G |
13: 31,742,795 (GRCm39) |
|
probably benign |
Het |
| Abca13 |
A |
G |
11: 9,242,306 (GRCm39) |
T1390A |
possibly damaging |
Het |
| Abca14 |
T |
A |
7: 119,911,928 (GRCm39) |
|
probably null |
Het |
| Abca8a |
A |
C |
11: 109,961,308 (GRCm39) |
V538G |
probably damaging |
Het |
| Acy1 |
C |
T |
9: 106,310,782 (GRCm39) |
G329R |
probably benign |
Het |
| Adamts17 |
T |
C |
7: 66,691,636 (GRCm39) |
C607R |
probably damaging |
Het |
| Adamts20 |
A |
T |
15: 94,292,503 (GRCm39) |
C202* |
probably null |
Het |
| Adcy5 |
A |
G |
16: 35,099,586 (GRCm39) |
N712S |
possibly damaging |
Het |
| Ahnak |
A |
G |
19: 8,982,045 (GRCm39) |
K1110E |
probably benign |
Het |
| Anks6 |
T |
A |
4: 47,033,127 (GRCm39) |
H578L |
possibly damaging |
Het |
| Appl1 |
C |
A |
14: 26,647,928 (GRCm39) |
L626F |
probably benign |
Het |
| Arl1 |
A |
G |
10: 88,566,499 (GRCm39) |
|
probably benign |
Het |
| Atf4 |
T |
A |
15: 80,141,618 (GRCm39) |
I336K |
probably damaging |
Het |
| Atp7b |
A |
T |
8: 22,490,137 (GRCm39) |
S1044T |
probably benign |
Het |
| Carm1 |
A |
G |
9: 21,498,480 (GRCm39) |
N466S |
probably benign |
Het |
| Cbl |
A |
G |
9: 44,084,677 (GRCm39) |
S153P |
probably damaging |
Het |
| Ccdc159 |
A |
G |
9: 21,839,027 (GRCm39) |
|
probably null |
Het |
| Cd109 |
CATTTATTTATTTATTTATTTATTTATTTATTTAT |
CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT |
9: 78,619,782 (GRCm39) |
|
probably benign |
Het |
| Cdc7 |
T |
C |
5: 107,121,707 (GRCm39) |
F207L |
probably benign |
Het |
| Celsr2 |
T |
C |
3: 108,304,547 (GRCm39) |
R2271G |
probably benign |
Het |
| Cep162 |
T |
C |
9: 87,088,915 (GRCm39) |
Q989R |
probably damaging |
Het |
| Cep89 |
A |
G |
7: 35,137,862 (GRCm39) |
T749A |
probably benign |
Het |
| Clcn5 |
T |
C |
X: 7,032,591 (GRCm39) |
|
probably null |
Het |
| Clu |
A |
T |
14: 66,217,313 (GRCm39) |
Y382F |
probably benign |
Het |
| Cnih4 |
A |
G |
1: 180,993,808 (GRCm39) |
|
probably benign |
Het |
| Crb1 |
A |
G |
1: 139,126,509 (GRCm39) |
L1340P |
probably damaging |
Het |
| Ddx4 |
T |
C |
13: 112,750,269 (GRCm39) |
T421A |
probably damaging |
Het |
| Dennd5a |
T |
C |
7: 109,520,405 (GRCm39) |
E484G |
probably benign |
Het |
| Dsg4 |
G |
T |
18: 20,589,965 (GRCm39) |
V372L |
possibly damaging |
Het |
| Dyrk2 |
T |
C |
10: 118,704,191 (GRCm39) |
D21G |
probably benign |
Het |
| E2f1 |
C |
G |
2: 154,405,942 (GRCm39) |
G144R |
probably damaging |
Het |
| Epb41l4a |
A |
T |
18: 33,935,560 (GRCm39) |
|
probably null |
Het |
| F10 |
G |
T |
8: 13,089,621 (GRCm39) |
V67F |
possibly damaging |
Het |
| Fat3 |
A |
G |
9: 15,942,469 (GRCm39) |
I1301T |
probably damaging |
Het |
| Filip1l |
A |
G |
16: 57,391,058 (GRCm39) |
T549A |
probably benign |
Het |
| Flt4 |
C |
A |
11: 49,517,271 (GRCm39) |
|
probably benign |
Het |
| Fndc1 |
G |
A |
17: 7,990,312 (GRCm39) |
T1128I |
unknown |
Het |
| Fos |
T |
C |
12: 85,522,936 (GRCm39) |
S283P |
probably benign |
Het |
| Fryl |
T |
C |
5: 73,222,881 (GRCm39) |
Y1900C |
possibly damaging |
Het |
| Fsip2 |
C |
A |
2: 82,817,373 (GRCm39) |
Q4369K |
probably benign |
Het |
| Gad2 |
A |
T |
2: 22,563,982 (GRCm39) |
H395L |
probably damaging |
Het |
| Grm2 |
T |
A |
9: 106,531,130 (GRCm39) |
I120F |
probably benign |
Het |
| Hjurp |
GT |
GTT |
1: 88,194,246 (GRCm39) |
|
probably null |
Het |
| Igsf10 |
A |
T |
3: 59,227,751 (GRCm39) |
I1974N |
probably damaging |
Het |
| Il23r |
T |
C |
6: 67,450,834 (GRCm39) |
N215S |
probably damaging |
Het |
| Jph1 |
T |
A |
1: 17,161,928 (GRCm39) |
M245L |
possibly damaging |
Het |
| Loxl4 |
G |
A |
19: 42,596,052 (GRCm39) |
H147Y |
probably benign |
Het |
| Lsg1 |
A |
G |
16: 30,384,267 (GRCm39) |
I521T |
probably damaging |
Het |
| Ltc4s |
C |
T |
11: 50,127,908 (GRCm39) |
G83R |
probably damaging |
Het |
| Map2 |
A |
G |
1: 66,449,796 (GRCm39) |
E173G |
probably damaging |
Het |
| Med29 |
T |
A |
7: 28,086,352 (GRCm39) |
D152V |
possibly damaging |
Het |
| Megf8 |
A |
G |
7: 25,062,940 (GRCm39) |
D2432G |
probably damaging |
Het |
| Mrpl38 |
G |
A |
11: 116,025,978 (GRCm39) |
|
probably benign |
Het |
| Myh7 |
A |
G |
14: 55,225,778 (GRCm39) |
I521T |
possibly damaging |
Het |
| Mylk |
G |
T |
16: 34,742,805 (GRCm39) |
V1106L |
probably benign |
Het |
| Myo15b |
A |
T |
11: 115,752,761 (GRCm39) |
D753V |
possibly damaging |
Het |
| Myo1g |
T |
C |
11: 6,466,785 (GRCm39) |
|
probably null |
Het |
| Myrfl |
A |
G |
10: 116,613,247 (GRCm39) |
|
probably null |
Het |
| Naip5 |
A |
G |
13: 100,359,922 (GRCm39) |
V438A |
possibly damaging |
Het |
| Nav3 |
A |
G |
10: 109,600,796 (GRCm39) |
V1277A |
probably benign |
Het |
| Nek10 |
T |
A |
14: 14,842,841 (GRCm38) |
V182E |
possibly damaging |
Het |
| Ngly1 |
T |
C |
14: 16,281,809 (GRCm38) |
V355A |
probably benign |
Het |
| Nol6 |
T |
C |
4: 41,118,944 (GRCm39) |
E683G |
possibly damaging |
Het |
| Oc90 |
T |
A |
15: 65,753,354 (GRCm39) |
R322W |
possibly damaging |
Het |
| Or1q1 |
C |
A |
2: 36,887,515 (GRCm39) |
A231D |
probably benign |
Het |
| Or4f60 |
A |
G |
2: 111,902,097 (GRCm39) |
V277A |
possibly damaging |
Het |
| Or52e4 |
A |
T |
7: 104,705,483 (GRCm39) |
H10L |
possibly damaging |
Het |
| Or8b4 |
A |
G |
9: 37,830,217 (GRCm39) |
E93G |
possibly damaging |
Het |
| Osbp2 |
T |
C |
11: 3,662,160 (GRCm39) |
H231R |
probably damaging |
Het |
| Pate6 |
A |
T |
9: 35,701,021 (GRCm39) |
C22S |
probably damaging |
Het |
| Pdzph1 |
T |
C |
17: 59,281,541 (GRCm39) |
H247R |
probably damaging |
Het |
| Pidd1 |
T |
C |
7: 141,022,162 (GRCm39) |
N209S |
probably damaging |
Het |
| Pknox1 |
C |
T |
17: 31,822,286 (GRCm39) |
A351V |
probably damaging |
Het |
| Plxnd1 |
C |
A |
6: 115,935,576 (GRCm39) |
V1737F |
probably damaging |
Het |
| Prkdc |
A |
T |
16: 15,519,976 (GRCm39) |
K1138M |
probably damaging |
Het |
| Rad54l2 |
T |
C |
9: 106,631,224 (GRCm39) |
D21G |
possibly damaging |
Het |
| Recql4 |
C |
T |
15: 76,592,785 (GRCm39) |
C302Y |
probably damaging |
Het |
| Scgb2b6 |
T |
C |
7: 31,318,908 (GRCm39) |
|
noncoding transcript |
Het |
| Sdc1 |
A |
G |
12: 8,840,541 (GRCm39) |
E106G |
possibly damaging |
Het |
| Slc10a5 |
T |
G |
3: 10,400,360 (GRCm39) |
Q100P |
probably damaging |
Het |
| Slc10a5 |
C |
A |
3: 10,400,359 (GRCm39) |
Q100H |
probably damaging |
Het |
| Slc5a9 |
A |
T |
4: 111,748,134 (GRCm39) |
L226Q |
possibly damaging |
Het |
| Slfn1 |
T |
C |
11: 83,012,475 (GRCm39) |
V197A |
probably benign |
Het |
| Spire1 |
T |
C |
18: 67,645,935 (GRCm39) |
M244V |
probably benign |
Het |
| St3gal3 |
C |
T |
4: 117,817,232 (GRCm39) |
V141I |
probably benign |
Het |
| St6galnac4 |
G |
T |
2: 32,477,172 (GRCm39) |
|
probably benign |
Het |
| Svep1 |
T |
C |
4: 58,097,323 (GRCm39) |
K1407E |
possibly damaging |
Het |
| Tbc1d32 |
A |
G |
10: 56,100,745 (GRCm39) |
C78R |
probably damaging |
Het |
| Tcstv5 |
T |
C |
13: 120,411,378 (GRCm39) |
Y76C |
probably benign |
Het |
| Tln2 |
A |
G |
9: 67,253,809 (GRCm39) |
V754A |
probably benign |
Het |
| Tmeff1 |
A |
T |
4: 48,636,869 (GRCm39) |
Y189F |
possibly damaging |
Het |
| Tmem131l |
C |
T |
3: 83,806,519 (GRCm39) |
A1433T |
probably benign |
Het |
| Tnfrsf8 |
T |
C |
4: 145,029,692 (GRCm39) |
Y36C |
probably damaging |
Het |
| Trp53i11 |
G |
T |
2: 93,030,245 (GRCm39) |
R184L |
probably damaging |
Het |
| Trpv1 |
A |
T |
11: 73,142,110 (GRCm39) |
M214L |
possibly damaging |
Het |
| Tsnax |
T |
A |
8: 125,755,533 (GRCm39) |
S132T |
probably benign |
Het |
| Ttc28 |
T |
C |
5: 111,424,909 (GRCm39) |
L1547P |
probably damaging |
Het |
| Ttc3 |
A |
G |
16: 94,240,100 (GRCm39) |
|
probably null |
Het |
| Tubal3 |
T |
A |
13: 3,983,514 (GRCm39) |
D431E |
probably damaging |
Het |
| Ugt2b36 |
A |
T |
5: 87,240,301 (GRCm39) |
|
probably null |
Het |
| Vmn1r23 |
A |
T |
6: 57,903,190 (GRCm39) |
I196K |
probably benign |
Het |
| Vmn1r55 |
A |
C |
7: 5,149,586 (GRCm39) |
L279R |
probably damaging |
Het |
| Vmn1r55 |
G |
T |
7: 5,149,587 (GRCm39) |
L279M |
probably damaging |
Het |
| Vmn2r89 |
G |
A |
14: 51,694,942 (GRCm39) |
G474E |
probably damaging |
Het |
| Vps26b |
T |
C |
9: 26,926,511 (GRCm39) |
K163E |
probably damaging |
Het |
| Zfp142 |
A |
G |
1: 74,609,431 (GRCm39) |
F1352L |
probably damaging |
Het |
| Zfp422 |
C |
T |
6: 116,603,844 (GRCm39) |
E52K |
possibly damaging |
Het |
| Zfp423 |
T |
A |
8: 88,508,338 (GRCm39) |
|
probably null |
Het |
| Zfp493 |
T |
C |
13: 67,934,736 (GRCm39) |
F230L |
probably damaging |
Het |
| Zfp760 |
T |
C |
17: 21,941,388 (GRCm39) |
C188R |
probably benign |
Het |
| Zfyve28 |
G |
T |
5: 34,375,189 (GRCm39) |
T275K |
probably damaging |
Het |
| Znhit3 |
T |
C |
11: 84,807,155 (GRCm39) |
N5D |
probably benign |
Het |
|
| Other mutations in Obsl1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00504:Obsl1
|
APN |
1 |
75,467,518 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL01111:Obsl1
|
APN |
1 |
75,473,789 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL01140:Obsl1
|
APN |
1 |
75,466,400 (GRCm39) |
unclassified |
probably benign |
|
|
IGL02149:Obsl1
|
APN |
1 |
75,480,464 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02225:Obsl1
|
APN |
1 |
75,480,442 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02269:Obsl1
|
APN |
1 |
75,464,357 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02296:Obsl1
|
APN |
1 |
75,474,793 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02386:Obsl1
|
APN |
1 |
75,469,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02408:Obsl1
|
APN |
1 |
75,481,890 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02601:Obsl1
|
APN |
1 |
75,466,264 (GRCm39) |
missense |
probably benign |
|
|
IGL03053:Obsl1
|
APN |
1 |
75,469,723 (GRCm39) |
missense |
probably benign |
|
|
IGL03181:Obsl1
|
APN |
1 |
75,469,228 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03402:Obsl1
|
APN |
1 |
75,463,443 (GRCm39) |
missense |
probably benign |
0.00 |
|
Jude
|
UTSW |
1 |
75,474,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT1430001:Obsl1
|
UTSW |
1 |
75,482,811 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4382001:Obsl1
|
UTSW |
1 |
75,464,607 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0281:Obsl1
|
UTSW |
1 |
75,469,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1343:Obsl1
|
UTSW |
1 |
75,469,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1394:Obsl1
|
UTSW |
1 |
75,469,309 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1395:Obsl1
|
UTSW |
1 |
75,469,309 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1439:Obsl1
|
UTSW |
1 |
75,463,428 (GRCm39) |
nonsense |
probably null |
|
|
R1456:Obsl1
|
UTSW |
1 |
75,464,300 (GRCm39) |
nonsense |
probably null |
|
|
R1728:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1729:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1730:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1739:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1757:Obsl1
|
UTSW |
1 |
75,470,527 (GRCm39) |
missense |
probably benign |
|
|
R1762:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1783:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1784:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1785:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R1851:Obsl1
|
UTSW |
1 |
75,469,537 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1864:Obsl1
|
UTSW |
1 |
75,469,753 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1873:Obsl1
|
UTSW |
1 |
75,474,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1875:Obsl1
|
UTSW |
1 |
75,474,877 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1980:Obsl1
|
UTSW |
1 |
75,482,480 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1985:Obsl1
|
UTSW |
1 |
75,482,244 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2049:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R2069:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R2122:Obsl1
|
UTSW |
1 |
75,470,527 (GRCm39) |
missense |
probably benign |
|
|
R2141:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R2142:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
R2184:Obsl1
|
UTSW |
1 |
75,478,861 (GRCm39) |
missense |
probably benign |
0.26 |
|
R2267:Obsl1
|
UTSW |
1 |
75,482,342 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2883:Obsl1
|
UTSW |
1 |
75,473,155 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R3079:Obsl1
|
UTSW |
1 |
75,467,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3749:Obsl1
|
UTSW |
1 |
75,474,890 (GRCm39) |
missense |
probably benign |
|
|
R4002:Obsl1
|
UTSW |
1 |
75,476,743 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4365:Obsl1
|
UTSW |
1 |
75,464,693 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4366:Obsl1
|
UTSW |
1 |
75,464,693 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4414:Obsl1
|
UTSW |
1 |
75,467,546 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4799:Obsl1
|
UTSW |
1 |
75,466,145 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R5081:Obsl1
|
UTSW |
1 |
75,464,607 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R5389:Obsl1
|
UTSW |
1 |
75,479,905 (GRCm39) |
intron |
probably benign |
|
|
R5757:Obsl1
|
UTSW |
1 |
75,469,699 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5890:Obsl1
|
UTSW |
1 |
75,470,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5946:Obsl1
|
UTSW |
1 |
75,467,851 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6005:Obsl1
|
UTSW |
1 |
75,468,859 (GRCm39) |
splice site |
probably null |
|
|
R6118:Obsl1
|
UTSW |
1 |
75,468,722 (GRCm39) |
intron |
probably benign |
|
|
R6154:Obsl1
|
UTSW |
1 |
75,476,788 (GRCm39) |
missense |
probably benign |
0.19 |
|
R6317:Obsl1
|
UTSW |
1 |
75,466,273 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
R6379:Obsl1
|
UTSW |
1 |
75,479,787 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6387:Obsl1
|
UTSW |
1 |
75,468,006 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7084:Obsl1
|
UTSW |
1 |
75,464,394 (GRCm39) |
missense |
probably benign |
|
|
R7123:Obsl1
|
UTSW |
1 |
75,466,313 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7202:Obsl1
|
UTSW |
1 |
75,466,360 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7291:Obsl1
|
UTSW |
1 |
75,466,161 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7305:Obsl1
|
UTSW |
1 |
75,470,590 (GRCm39) |
nonsense |
probably null |
|
|
R7366:Obsl1
|
UTSW |
1 |
75,479,608 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7402:Obsl1
|
UTSW |
1 |
75,464,348 (GRCm39) |
missense |
probably benign |
|
|
R7474:Obsl1
|
UTSW |
1 |
75,474,828 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7611:Obsl1
|
UTSW |
1 |
75,482,024 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7672:Obsl1
|
UTSW |
1 |
75,469,365 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7715:Obsl1
|
UTSW |
1 |
75,478,680 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7762:Obsl1
|
UTSW |
1 |
75,480,167 (GRCm39) |
missense |
probably benign |
|
|
R8005:Obsl1
|
UTSW |
1 |
75,482,096 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8012:Obsl1
|
UTSW |
1 |
75,469,317 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8379:Obsl1
|
UTSW |
1 |
75,480,501 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8381:Obsl1
|
UTSW |
1 |
75,480,501 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8383:Obsl1
|
UTSW |
1 |
75,480,501 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R8396:Obsl1
|
UTSW |
1 |
75,480,350 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8465:Obsl1
|
UTSW |
1 |
75,480,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8506:Obsl1
|
UTSW |
1 |
75,482,300 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8710:Obsl1
|
UTSW |
1 |
75,469,326 (GRCm39) |
missense |
probably benign |
|
|
R8877:Obsl1
|
UTSW |
1 |
75,473,167 (GRCm39) |
nonsense |
probably null |
|
|
R8903:Obsl1
|
UTSW |
1 |
75,463,917 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R8913:Obsl1
|
UTSW |
1 |
75,467,892 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8924:Obsl1
|
UTSW |
1 |
75,482,841 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8955:Obsl1
|
UTSW |
1 |
75,480,493 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9008:Obsl1
|
UTSW |
1 |
75,482,027 (GRCm39) |
missense |
probably benign |
|
|
R9121:Obsl1
|
UTSW |
1 |
75,482,636 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R9295:Obsl1
|
UTSW |
1 |
75,476,721 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9362:Obsl1
|
UTSW |
1 |
75,482,391 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9367:Obsl1
|
UTSW |
1 |
75,466,177 (GRCm39) |
missense |
probably benign |
0.18 |
|
R9459:Obsl1
|
UTSW |
1 |
75,474,884 (GRCm39) |
missense |
probably benign |
0.16 |
|
R9496:Obsl1
|
UTSW |
1 |
75,467,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9497:Obsl1
|
UTSW |
1 |
75,467,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9498:Obsl1
|
UTSW |
1 |
75,467,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9502:Obsl1
|
UTSW |
1 |
75,466,267 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9546:Obsl1
|
UTSW |
1 |
75,482,030 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9550:Obsl1
|
UTSW |
1 |
75,474,910 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9561:Obsl1
|
UTSW |
1 |
75,480,157 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9687:Obsl1
|
UTSW |
1 |
75,479,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
V8831:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
X0061:Obsl1
|
UTSW |
1 |
75,463,412 (GRCm39) |
missense |
probably benign |
|
|
Z1088:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
Z1176:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
Z1177:Obsl1
|
UTSW |
1 |
75,467,656 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
Z1177:Obsl1
|
UTSW |
1 |
75,486,756 (GRCm38) |
missense |
probably benign |
|
|
Z1177:Obsl1
|
UTSW |
1 |
75,480,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ACCTAAGATAAAGGTGGGATCTTCAC -3'
(R):5'- CATCCTGAAGCGTTTACCCC -3'
Sequencing Primer
(F):5'- GGGATCTTCACCTGAGCCTTG -3'
(R):5'- TGAAGCGTTTACCCCGGAAG -3'
|
| Posted On |
2015-10-21 |
Incidental Mutation