Incidental Mutation 'R4700:Ttc28'
| ID |
355904 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc28
|
| Ensembl Gene |
ENSMUSG00000033209 |
| Gene Name |
tetratricopeptide repeat domain 28 |
| Synonyms |
TPRBK, 2310015L07Rik |
| MMRRC Submission |
041948-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4700 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
111027669-111437646 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 111424909 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Proline
at position 1547
(L1547P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000137609
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040111]
[ENSMUST00000156290]
|
| AlphaFold |
Q80XJ3 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000040111
AA Change: L1578P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000136116
Gene: ENSMUSG00000033209
AA Change: L1578P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
TPR
|
52 |
85 |
2.84e1 |
SMART |
|
TPR
|
86 |
119 |
5.03e-1 |
SMART |
|
TPR
|
120 |
153 |
2.11e-3 |
SMART |
|
TPR
|
268 |
301 |
8.51e0 |
SMART |
|
TPR
|
339 |
372 |
1.78e-1 |
SMART |
|
TPR
|
379 |
412 |
2.82e-4 |
SMART |
|
TPR
|
419 |
452 |
9.98e-5 |
SMART |
|
TPR
|
459 |
492 |
1.88e0 |
SMART |
|
TPR
|
499 |
532 |
1.11e1 |
SMART |
|
TPR
|
539 |
572 |
2.93e-2 |
SMART |
|
TPR
|
579 |
612 |
1.21e-3 |
SMART |
|
TPR
|
619 |
652 |
4.91e-4 |
SMART |
|
TPR
|
659 |
692 |
7.56e-5 |
SMART |
|
TPR
|
699 |
732 |
8.29e0 |
SMART |
|
TPR
|
739 |
772 |
1.63e0 |
SMART |
|
TPR
|
779 |
812 |
1.24e0 |
SMART |
|
TPR
|
819 |
852 |
7.98e-4 |
SMART |
|
TPR
|
859 |
892 |
8.74e0 |
SMART |
|
TPR
|
902 |
935 |
5.43e-6 |
SMART |
|
TPR
|
942 |
975 |
4.09e-1 |
SMART |
|
TPR
|
982 |
1015 |
9.98e-5 |
SMART |
|
TPR
|
1022 |
1055 |
7.12e-1 |
SMART |
|
TPR
|
1062 |
1095 |
5.69e0 |
SMART |
|
TPR
|
1102 |
1135 |
3.14e-2 |
SMART |
|
TPR
|
1142 |
1175 |
2.84e1 |
SMART |
|
low complexity region
|
1259 |
1277 |
N/A |
INTRINSIC |
|
Pfam:CHAT
|
1415 |
1738 |
7.3e-77 |
PFAM |
|
low complexity region
|
1972 |
1990 |
N/A |
INTRINSIC |
|
low complexity region
|
2014 |
2031 |
N/A |
INTRINSIC |
|
low complexity region
|
2033 |
2045 |
N/A |
INTRINSIC |
|
low complexity region
|
2155 |
2171 |
N/A |
INTRINSIC |
|
low complexity region
|
2283 |
2293 |
N/A |
INTRINSIC |
|
low complexity region
|
2327 |
2352 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000156290
AA Change: L1547P
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000137609
Gene: ENSMUSG00000033209
AA Change: L1547P
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
TPR
|
52 |
85 |
2.84e1 |
SMART |
|
TPR
|
86 |
119 |
5.03e-1 |
SMART |
|
TPR
|
120 |
153 |
2.11e-3 |
SMART |
|
TPR
|
268 |
301 |
8.51e0 |
SMART |
|
TPR
|
308 |
341 |
1.78e-1 |
SMART |
|
TPR
|
348 |
381 |
2.82e-4 |
SMART |
|
TPR
|
388 |
421 |
9.98e-5 |
SMART |
|
TPR
|
428 |
461 |
1.88e0 |
SMART |
|
TPR
|
468 |
501 |
1.11e1 |
SMART |
|
TPR
|
508 |
541 |
2.93e-2 |
SMART |
|
TPR
|
548 |
581 |
1.21e-3 |
SMART |
|
TPR
|
588 |
621 |
4.91e-4 |
SMART |
|
TPR
|
628 |
661 |
7.56e-5 |
SMART |
|
TPR
|
668 |
701 |
8.29e0 |
SMART |
|
TPR
|
708 |
741 |
1.63e0 |
SMART |
|
TPR
|
748 |
781 |
1.24e0 |
SMART |
|
TPR
|
788 |
821 |
7.98e-4 |
SMART |
|
TPR
|
828 |
861 |
8.74e0 |
SMART |
|
TPR
|
871 |
904 |
5.43e-6 |
SMART |
|
TPR
|
911 |
944 |
4.09e-1 |
SMART |
|
TPR
|
951 |
984 |
9.98e-5 |
SMART |
|
TPR
|
991 |
1024 |
7.12e-1 |
SMART |
|
TPR
|
1031 |
1064 |
5.69e0 |
SMART |
|
TPR
|
1071 |
1104 |
3.14e-2 |
SMART |
|
TPR
|
1111 |
1144 |
2.84e1 |
SMART |
|
low complexity region
|
1228 |
1246 |
N/A |
INTRINSIC |
|
Pfam:CHAT
|
1384 |
1707 |
1.1e-76 |
PFAM |
|
low complexity region
|
1941 |
1959 |
N/A |
INTRINSIC |
|
low complexity region
|
1983 |
2000 |
N/A |
INTRINSIC |
|
low complexity region
|
2002 |
2014 |
N/A |
INTRINSIC |
|
low complexity region
|
2124 |
2140 |
N/A |
INTRINSIC |
|
low complexity region
|
2252 |
2262 |
N/A |
INTRINSIC |
|
low complexity region
|
2296 |
2321 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000183861
|
| Meta Mutation Damage Score |
0.2702 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.8%
- 20x: 94.0%
|
| Validation Efficiency |
97% (127/131) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 112 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A530084C06Rik |
A |
G |
13: 31,742,795 (GRCm39) |
|
probably benign |
Het |
| Abca13 |
A |
G |
11: 9,242,306 (GRCm39) |
T1390A |
possibly damaging |
Het |
| Abca14 |
T |
A |
7: 119,911,928 (GRCm39) |
|
probably null |
Het |
| Abca8a |
A |
C |
11: 109,961,308 (GRCm39) |
V538G |
probably damaging |
Het |
| Acy1 |
C |
T |
9: 106,310,782 (GRCm39) |
G329R |
probably benign |
Het |
| Adamts17 |
T |
C |
7: 66,691,636 (GRCm39) |
C607R |
probably damaging |
Het |
| Adamts20 |
A |
T |
15: 94,292,503 (GRCm39) |
C202* |
probably null |
Het |
| Adcy5 |
A |
G |
16: 35,099,586 (GRCm39) |
N712S |
possibly damaging |
Het |
| Ahnak |
A |
G |
19: 8,982,045 (GRCm39) |
K1110E |
probably benign |
Het |
| Anks6 |
T |
A |
4: 47,033,127 (GRCm39) |
H578L |
possibly damaging |
Het |
| Appl1 |
C |
A |
14: 26,647,928 (GRCm39) |
L626F |
probably benign |
Het |
| Arl1 |
A |
G |
10: 88,566,499 (GRCm39) |
|
probably benign |
Het |
| Atf4 |
T |
A |
15: 80,141,618 (GRCm39) |
I336K |
probably damaging |
Het |
| Atp7b |
A |
T |
8: 22,490,137 (GRCm39) |
S1044T |
probably benign |
Het |
| Carm1 |
A |
G |
9: 21,498,480 (GRCm39) |
N466S |
probably benign |
Het |
| Cbl |
A |
G |
9: 44,084,677 (GRCm39) |
S153P |
probably damaging |
Het |
| Ccdc159 |
A |
G |
9: 21,839,027 (GRCm39) |
|
probably null |
Het |
| Cd109 |
CATTTATTTATTTATTTATTTATTTATTTATTTAT |
CATTTATTTATTTATTTATTTATTTATTTATTTATTTAT |
9: 78,619,782 (GRCm39) |
|
probably benign |
Het |
| Cdc7 |
T |
C |
5: 107,121,707 (GRCm39) |
F207L |
probably benign |
Het |
| Celsr2 |
T |
C |
3: 108,304,547 (GRCm39) |
R2271G |
probably benign |
Het |
| Cep162 |
T |
C |
9: 87,088,915 (GRCm39) |
Q989R |
probably damaging |
Het |
| Cep89 |
A |
G |
7: 35,137,862 (GRCm39) |
T749A |
probably benign |
Het |
| Clcn5 |
T |
C |
X: 7,032,591 (GRCm39) |
|
probably null |
Het |
| Clu |
A |
T |
14: 66,217,313 (GRCm39) |
Y382F |
probably benign |
Het |
| Cnih4 |
A |
G |
1: 180,993,808 (GRCm39) |
|
probably benign |
Het |
| Crb1 |
A |
G |
1: 139,126,509 (GRCm39) |
L1340P |
probably damaging |
Het |
| Ddx4 |
T |
C |
13: 112,750,269 (GRCm39) |
T421A |
probably damaging |
Het |
| Dennd5a |
T |
C |
7: 109,520,405 (GRCm39) |
E484G |
probably benign |
Het |
| Dsg4 |
G |
T |
18: 20,589,965 (GRCm39) |
V372L |
possibly damaging |
Het |
| Dyrk2 |
T |
C |
10: 118,704,191 (GRCm39) |
D21G |
probably benign |
Het |
| E2f1 |
C |
G |
2: 154,405,942 (GRCm39) |
G144R |
probably damaging |
Het |
| Epb41l4a |
A |
T |
18: 33,935,560 (GRCm39) |
|
probably null |
Het |
| F10 |
G |
T |
8: 13,089,621 (GRCm39) |
V67F |
possibly damaging |
Het |
| Fat3 |
A |
G |
9: 15,942,469 (GRCm39) |
I1301T |
probably damaging |
Het |
| Filip1l |
A |
G |
16: 57,391,058 (GRCm39) |
T549A |
probably benign |
Het |
| Flt4 |
C |
A |
11: 49,517,271 (GRCm39) |
|
probably benign |
Het |
| Fndc1 |
G |
A |
17: 7,990,312 (GRCm39) |
T1128I |
unknown |
Het |
| Fos |
T |
C |
12: 85,522,936 (GRCm39) |
S283P |
probably benign |
Het |
| Fryl |
T |
C |
5: 73,222,881 (GRCm39) |
Y1900C |
possibly damaging |
Het |
| Fsip2 |
C |
A |
2: 82,817,373 (GRCm39) |
Q4369K |
probably benign |
Het |
| Gad2 |
A |
T |
2: 22,563,982 (GRCm39) |
H395L |
probably damaging |
Het |
| Grm2 |
T |
A |
9: 106,531,130 (GRCm39) |
I120F |
probably benign |
Het |
| Hjurp |
GT |
GTT |
1: 88,194,246 (GRCm39) |
|
probably null |
Het |
| Igsf10 |
A |
T |
3: 59,227,751 (GRCm39) |
I1974N |
probably damaging |
Het |
| Il23r |
T |
C |
6: 67,450,834 (GRCm39) |
N215S |
probably damaging |
Het |
| Jph1 |
T |
A |
1: 17,161,928 (GRCm39) |
M245L |
possibly damaging |
Het |
| Loxl4 |
G |
A |
19: 42,596,052 (GRCm39) |
H147Y |
probably benign |
Het |
| Lsg1 |
A |
G |
16: 30,384,267 (GRCm39) |
I521T |
probably damaging |
Het |
| Ltc4s |
C |
T |
11: 50,127,908 (GRCm39) |
G83R |
probably damaging |
Het |
| Map2 |
A |
G |
1: 66,449,796 (GRCm39) |
E173G |
probably damaging |
Het |
| Med29 |
T |
A |
7: 28,086,352 (GRCm39) |
D152V |
possibly damaging |
Het |
| Megf8 |
A |
G |
7: 25,062,940 (GRCm39) |
D2432G |
probably damaging |
Het |
| Mrpl38 |
G |
A |
11: 116,025,978 (GRCm39) |
|
probably benign |
Het |
| Myh7 |
A |
G |
14: 55,225,778 (GRCm39) |
I521T |
possibly damaging |
Het |
| Mylk |
G |
T |
16: 34,742,805 (GRCm39) |
V1106L |
probably benign |
Het |
| Myo15b |
A |
T |
11: 115,752,761 (GRCm39) |
D753V |
possibly damaging |
Het |
| Myo1g |
T |
C |
11: 6,466,785 (GRCm39) |
|
probably null |
Het |
| Myrfl |
A |
G |
10: 116,613,247 (GRCm39) |
|
probably null |
Het |
| Naip5 |
A |
G |
13: 100,359,922 (GRCm39) |
V438A |
possibly damaging |
Het |
| Nav3 |
A |
G |
10: 109,600,796 (GRCm39) |
V1277A |
probably benign |
Het |
| Nek10 |
T |
A |
14: 14,842,841 (GRCm38) |
V182E |
possibly damaging |
Het |
| Ngly1 |
T |
C |
14: 16,281,809 (GRCm38) |
V355A |
probably benign |
Het |
| Nol6 |
T |
C |
4: 41,118,944 (GRCm39) |
E683G |
possibly damaging |
Het |
| Obsl1 |
A |
T |
1: 75,480,085 (GRCm39) |
V487E |
probably damaging |
Het |
| Oc90 |
T |
A |
15: 65,753,354 (GRCm39) |
R322W |
possibly damaging |
Het |
| Or1q1 |
C |
A |
2: 36,887,515 (GRCm39) |
A231D |
probably benign |
Het |
| Or4f60 |
A |
G |
2: 111,902,097 (GRCm39) |
V277A |
possibly damaging |
Het |
| Or52e4 |
A |
T |
7: 104,705,483 (GRCm39) |
H10L |
possibly damaging |
Het |
| Or8b4 |
A |
G |
9: 37,830,217 (GRCm39) |
E93G |
possibly damaging |
Het |
| Osbp2 |
T |
C |
11: 3,662,160 (GRCm39) |
H231R |
probably damaging |
Het |
| Pate6 |
A |
T |
9: 35,701,021 (GRCm39) |
C22S |
probably damaging |
Het |
| Pdzph1 |
T |
C |
17: 59,281,541 (GRCm39) |
H247R |
probably damaging |
Het |
| Pidd1 |
T |
C |
7: 141,022,162 (GRCm39) |
N209S |
probably damaging |
Het |
| Pknox1 |
C |
T |
17: 31,822,286 (GRCm39) |
A351V |
probably damaging |
Het |
| Plxnd1 |
C |
A |
6: 115,935,576 (GRCm39) |
V1737F |
probably damaging |
Het |
| Prkdc |
A |
T |
16: 15,519,976 (GRCm39) |
K1138M |
probably damaging |
Het |
| Rad54l2 |
T |
C |
9: 106,631,224 (GRCm39) |
D21G |
possibly damaging |
Het |
| Recql4 |
C |
T |
15: 76,592,785 (GRCm39) |
C302Y |
probably damaging |
Het |
| Scgb2b6 |
T |
C |
7: 31,318,908 (GRCm39) |
|
noncoding transcript |
Het |
| Sdc1 |
A |
G |
12: 8,840,541 (GRCm39) |
E106G |
possibly damaging |
Het |
| Slc10a5 |
T |
G |
3: 10,400,360 (GRCm39) |
Q100P |
probably damaging |
Het |
| Slc10a5 |
C |
A |
3: 10,400,359 (GRCm39) |
Q100H |
probably damaging |
Het |
| Slc5a9 |
A |
T |
4: 111,748,134 (GRCm39) |
L226Q |
possibly damaging |
Het |
| Slfn1 |
T |
C |
11: 83,012,475 (GRCm39) |
V197A |
probably benign |
Het |
| Spire1 |
T |
C |
18: 67,645,935 (GRCm39) |
M244V |
probably benign |
Het |
| St3gal3 |
C |
T |
4: 117,817,232 (GRCm39) |
V141I |
probably benign |
Het |
| St6galnac4 |
G |
T |
2: 32,477,172 (GRCm39) |
|
probably benign |
Het |
| Svep1 |
T |
C |
4: 58,097,323 (GRCm39) |
K1407E |
possibly damaging |
Het |
| Tbc1d32 |
A |
G |
10: 56,100,745 (GRCm39) |
C78R |
probably damaging |
Het |
| Tcstv5 |
T |
C |
13: 120,411,378 (GRCm39) |
Y76C |
probably benign |
Het |
| Tln2 |
A |
G |
9: 67,253,809 (GRCm39) |
V754A |
probably benign |
Het |
| Tmeff1 |
A |
T |
4: 48,636,869 (GRCm39) |
Y189F |
possibly damaging |
Het |
| Tmem131l |
C |
T |
3: 83,806,519 (GRCm39) |
A1433T |
probably benign |
Het |
| Tnfrsf8 |
T |
C |
4: 145,029,692 (GRCm39) |
Y36C |
probably damaging |
Het |
| Trp53i11 |
G |
T |
2: 93,030,245 (GRCm39) |
R184L |
probably damaging |
Het |
| Trpv1 |
A |
T |
11: 73,142,110 (GRCm39) |
M214L |
possibly damaging |
Het |
| Tsnax |
T |
A |
8: 125,755,533 (GRCm39) |
S132T |
probably benign |
Het |
| Ttc3 |
A |
G |
16: 94,240,100 (GRCm39) |
|
probably null |
Het |
| Tubal3 |
T |
A |
13: 3,983,514 (GRCm39) |
D431E |
probably damaging |
Het |
| Ugt2b36 |
A |
T |
5: 87,240,301 (GRCm39) |
|
probably null |
Het |
| Vmn1r23 |
A |
T |
6: 57,903,190 (GRCm39) |
I196K |
probably benign |
Het |
| Vmn1r55 |
A |
C |
7: 5,149,586 (GRCm39) |
L279R |
probably damaging |
Het |
| Vmn1r55 |
G |
T |
7: 5,149,587 (GRCm39) |
L279M |
probably damaging |
Het |
| Vmn2r89 |
G |
A |
14: 51,694,942 (GRCm39) |
G474E |
probably damaging |
Het |
| Vps26b |
T |
C |
9: 26,926,511 (GRCm39) |
K163E |
probably damaging |
Het |
| Zfp142 |
A |
G |
1: 74,609,431 (GRCm39) |
F1352L |
probably damaging |
Het |
| Zfp422 |
C |
T |
6: 116,603,844 (GRCm39) |
E52K |
possibly damaging |
Het |
| Zfp423 |
T |
A |
8: 88,508,338 (GRCm39) |
|
probably null |
Het |
| Zfp493 |
T |
C |
13: 67,934,736 (GRCm39) |
F230L |
probably damaging |
Het |
| Zfp760 |
T |
C |
17: 21,941,388 (GRCm39) |
C188R |
probably benign |
Het |
| Zfyve28 |
G |
T |
5: 34,375,189 (GRCm39) |
T275K |
probably damaging |
Het |
| Znhit3 |
T |
C |
11: 84,807,155 (GRCm39) |
N5D |
probably benign |
Het |
|
| Other mutations in Ttc28 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Ttc28
|
APN |
5 |
111,373,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00963:Ttc28
|
APN |
5 |
111,434,255 (GRCm39) |
nonsense |
probably null |
|
|
IGL00969:Ttc28
|
APN |
5 |
111,373,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01366:Ttc28
|
APN |
5 |
111,233,037 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01528:Ttc28
|
APN |
5 |
111,249,826 (GRCm39) |
splice site |
probably benign |
|
|
IGL01558:Ttc28
|
APN |
5 |
111,431,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01973:Ttc28
|
APN |
5 |
111,372,101 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02040:Ttc28
|
APN |
5 |
111,040,802 (GRCm39) |
nonsense |
probably null |
|
|
IGL02432:Ttc28
|
APN |
5 |
111,371,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02531:Ttc28
|
APN |
5 |
111,373,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02819:Ttc28
|
APN |
5 |
111,414,449 (GRCm39) |
missense |
probably benign |
|
|
IGL02830:Ttc28
|
APN |
5 |
111,434,105 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02893:Ttc28
|
APN |
5 |
111,433,251 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03387:Ttc28
|
APN |
5 |
111,381,208 (GRCm39) |
missense |
probably benign |
0.07 |
|
PIT4131001:Ttc28
|
UTSW |
5 |
111,040,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0142:Ttc28
|
UTSW |
5 |
111,425,323 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0166:Ttc28
|
UTSW |
5 |
111,373,500 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0328:Ttc28
|
UTSW |
5 |
111,431,933 (GRCm39) |
splice site |
probably benign |
|
|
R0582:Ttc28
|
UTSW |
5 |
111,331,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0744:Ttc28
|
UTSW |
5 |
111,378,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0811:Ttc28
|
UTSW |
5 |
111,383,366 (GRCm39) |
missense |
probably benign |
0.24 |
|
R0812:Ttc28
|
UTSW |
5 |
111,383,366 (GRCm39) |
missense |
probably benign |
0.24 |
|
R0828:Ttc28
|
UTSW |
5 |
111,371,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0833:Ttc28
|
UTSW |
5 |
111,378,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1013:Ttc28
|
UTSW |
5 |
111,424,831 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1168:Ttc28
|
UTSW |
5 |
111,378,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1194:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1205:Ttc28
|
UTSW |
5 |
111,433,635 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1386:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Ttc28
|
UTSW |
5 |
111,433,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1467:Ttc28
|
UTSW |
5 |
111,433,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1537:Ttc28
|
UTSW |
5 |
111,433,184 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1539:Ttc28
|
UTSW |
5 |
111,248,677 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1558:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1560:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1561:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1566:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1768:Ttc28
|
UTSW |
5 |
111,425,034 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1775:Ttc28
|
UTSW |
5 |
111,424,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1909:Ttc28
|
UTSW |
5 |
111,431,920 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1911:Ttc28
|
UTSW |
5 |
111,428,616 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1970:Ttc28
|
UTSW |
5 |
111,383,501 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1990:Ttc28
|
UTSW |
5 |
111,424,188 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1992:Ttc28
|
UTSW |
5 |
111,424,188 (GRCm39) |
missense |
probably benign |
0.37 |
|
R2066:Ttc28
|
UTSW |
5 |
111,373,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2112:Ttc28
|
UTSW |
5 |
111,424,139 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2158:Ttc28
|
UTSW |
5 |
111,325,483 (GRCm39) |
intron |
probably benign |
|
|
R2192:Ttc28
|
UTSW |
5 |
111,371,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2267:Ttc28
|
UTSW |
5 |
111,373,869 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2384:Ttc28
|
UTSW |
5 |
111,424,074 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2989:Ttc28
|
UTSW |
5 |
111,371,881 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3881:Ttc28
|
UTSW |
5 |
111,331,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3919:Ttc28
|
UTSW |
5 |
111,433,245 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4455:Ttc28
|
UTSW |
5 |
111,371,924 (GRCm39) |
frame shift |
probably null |
|
|
R4456:Ttc28
|
UTSW |
5 |
111,371,924 (GRCm39) |
frame shift |
probably null |
|
|
R4522:Ttc28
|
UTSW |
5 |
111,428,038 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4548:Ttc28
|
UTSW |
5 |
111,419,090 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4591:Ttc28
|
UTSW |
5 |
111,371,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4633:Ttc28
|
UTSW |
5 |
111,371,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4714:Ttc28
|
UTSW |
5 |
111,433,095 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4790:Ttc28
|
UTSW |
5 |
111,372,083 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4803:Ttc28
|
UTSW |
5 |
111,425,329 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4840:Ttc28
|
UTSW |
5 |
111,433,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4969:Ttc28
|
UTSW |
5 |
111,424,121 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5019:Ttc28
|
UTSW |
5 |
111,249,930 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5130:Ttc28
|
UTSW |
5 |
111,040,722 (GRCm39) |
missense |
probably benign |
|
|
R5150:Ttc28
|
UTSW |
5 |
111,373,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5214:Ttc28
|
UTSW |
5 |
111,325,489 (GRCm39) |
intron |
probably benign |
|
|
R5254:Ttc28
|
UTSW |
5 |
111,419,104 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5518:Ttc28
|
UTSW |
5 |
111,373,794 (GRCm39) |
missense |
probably benign |
0.17 |
|
R5851:Ttc28
|
UTSW |
5 |
111,383,335 (GRCm39) |
splice site |
probably benign |
|
|
R5931:Ttc28
|
UTSW |
5 |
111,232,975 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6011:Ttc28
|
UTSW |
5 |
111,434,309 (GRCm39) |
missense |
probably benign |
|
|
R6176:Ttc28
|
UTSW |
5 |
111,371,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6221:Ttc28
|
UTSW |
5 |
111,419,114 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6398:Ttc28
|
UTSW |
5 |
111,424,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6717:Ttc28
|
UTSW |
5 |
111,433,302 (GRCm39) |
missense |
probably benign |
|
|
R6770:Ttc28
|
UTSW |
5 |
111,434,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6901:Ttc28
|
UTSW |
5 |
111,424,891 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7038:Ttc28
|
UTSW |
5 |
111,414,445 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7073:Ttc28
|
UTSW |
5 |
111,371,282 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R7101:Ttc28
|
UTSW |
5 |
111,232,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7135:Ttc28
|
UTSW |
5 |
111,427,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Ttc28
|
UTSW |
5 |
111,373,903 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7454:Ttc28
|
UTSW |
5 |
111,433,350 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7461:Ttc28
|
UTSW |
5 |
111,371,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7596:Ttc28
|
UTSW |
5 |
111,427,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7613:Ttc28
|
UTSW |
5 |
111,371,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7625:Ttc28
|
UTSW |
5 |
111,433,085 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7648:Ttc28
|
UTSW |
5 |
111,331,258 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7735:Ttc28
|
UTSW |
5 |
111,414,544 (GRCm39) |
splice site |
probably null |
|
|
R8030:Ttc28
|
UTSW |
5 |
111,433,922 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8205:Ttc28
|
UTSW |
5 |
111,373,596 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8246:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8247:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8269:Ttc28
|
UTSW |
5 |
111,425,325 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8292:Ttc28
|
UTSW |
5 |
111,371,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8346:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8356:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8423:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8424:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8426:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8441:Ttc28
|
UTSW |
5 |
111,325,507 (GRCm39) |
nonsense |
probably null |
|
|
R8494:Ttc28
|
UTSW |
5 |
111,383,506 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8508:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8510:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8729:Ttc28
|
UTSW |
5 |
111,383,509 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8845:Ttc28
|
UTSW |
5 |
111,372,041 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9003:Ttc28
|
UTSW |
5 |
111,424,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9185:Ttc28
|
UTSW |
5 |
111,371,342 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9187:Ttc28
|
UTSW |
5 |
111,249,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Ttc28
|
UTSW |
5 |
111,325,525 (GRCm39) |
missense |
unknown |
|
|
R9251:Ttc28
|
UTSW |
5 |
111,040,698 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R9372:Ttc28
|
UTSW |
5 |
111,331,073 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9466:Ttc28
|
UTSW |
5 |
111,330,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9563:Ttc28
|
UTSW |
5 |
111,371,092 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9606:Ttc28
|
UTSW |
5 |
111,433,140 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9691:Ttc28
|
UTSW |
5 |
111,431,879 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9709:Ttc28
|
UTSW |
5 |
111,433,637 (GRCm39) |
missense |
probably damaging |
0.97 |
|
V8831:Ttc28
|
UTSW |
5 |
111,248,578 (GRCm39) |
missense |
probably benign |
0.11 |
|
Z1088:Ttc28
|
UTSW |
5 |
111,434,181 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Ttc28
|
UTSW |
5 |
111,414,432 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
Z1177:Ttc28
|
UTSW |
5 |
111,433,605 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1177:Ttc28
|
UTSW |
5 |
111,426,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- CTAAACTCCCATCGGCAGTGATG -3'
(R):5'- AACATCTTGGAAGCCGCGAC -3'
Sequencing Primer
(F):5'- CATCGGCAGTGATGGACAG -3'
(R):5'- TTCACTGACAGCCGCAG -3'
|
| Posted On |
2015-10-21 |
Incidental Mutation