Mutagenetix > Incidental Mutation

Incidental Mutation 'R0402:Zfp1005'

35600

Institutional Source

Beutler Lab

Gene Symbol

Zfp1005

Ensembl Gene

ENSMUSG00000079008

Gene Name

zinc finger protein 1005

Synonyms

Gm10749, EG640962, Gm14124

MMRRC Submission

038607-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.070) question?

Stock #

R0402 (G1)

Quality Score

Status

Validated

Chromosome

Chromosomal Location

150099437-150112220 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 150111136 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 609 (C609S)

Ref Sequence

ENSEMBL: ENSMUSP00000105548 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000109922]

AlphaFold

A2AU83

Predicted Effect

possibly damaging
Transcript: ENSMUST00000109922
AA Change: C609S

PolyPhen 2 Score 0.934 (Sensitivity: 0.80; Specificity: 0.94)

SMART Domains

Protein: ENSMUSP00000105548
Gene: ENSMUSG00000079008
AA Change: C609S

Domain	Start	End	E-Value	Type
KRAB	4	66	9.26e-19	SMART
ZnF_C2H2	103	125	7.49e-5	SMART
ZnF_C2H2	131	151	9.46e0	SMART
ZnF_C2H2	159	181	5.9e-3	SMART
ZnF_C2H2	187	209	6.67e-2	SMART
ZnF_C2H2	215	237	4.87e-4	SMART
ZnF_C2H2	243	265	2.82e0	SMART
ZnF_C2H2	271	293	2.2e2	SMART
ZnF_C2H2	299	321	1.4e-4	SMART
ZnF_C2H2	327	349	1.6e-4	SMART
ZnF_C2H2	355	377	1.18e-2	SMART
ZnF_C2H2	383	405	1.38e-3	SMART
ZnF_C2H2	411	433	9.56e1	SMART
ZnF_C2H2	439	461	6.99e-5	SMART
ZnF_C2H2	467	489	2.99e-4	SMART
ZnF_C2H2	495	517	7.78e-3	SMART
ZnF_C2H2	523	545	1.04e-3	SMART
ZnF_C2H2	551	573	1.6e-4	SMART
ZnF_C2H2	579	601	1.18e-2	SMART
ZnF_C2H2	607	629	4.54e-4	SMART
ZnF_C2H2	635	657	4.24e-4	SMART
ZnF_C2H2	663	685	1.2e-3	SMART
ZnF_C2H2	691	713	8.47e-4	SMART

Meta Mutation Damage Score

0.1795

Coding Region Coverage

1x: 98.2%
3x: 97.0%
10x: 94.5%
20x: 88.7%

Validation Efficiency

100% (74/74)

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017N19Rik	A	T	10: 100,445,115 (GRCm39)	K165N	probably damaging	Het
Adam6b	T	A	12: 113,453,615 (GRCm39)	M144K	probably damaging	Het
Arhgap44	T	C	11: 64,922,903 (GRCm39)		probably benign	Het
Arl5c	T	A	11: 97,885,939 (GRCm39)	I21F	probably damaging	Het
Bglap2	C	T	3: 88,285,552 (GRCm39)	G40D	probably damaging	Het
Bptf	T	C	11: 106,964,940 (GRCm39)	E1303G	probably damaging	Het
Calhm1	T	C	19: 47,129,896 (GRCm39)	T209A	probably damaging	Het
Ccr8	A	G	9: 119,923,976 (GRCm39)		probably null	Het
Chkb	C	T	15: 89,313,610 (GRCm39)	R65Q	probably benign	Het
Col4a1	T	C	8: 11,249,838 (GRCm39)		probably benign	Het
Cryzl2	A	G	1: 157,292,014 (GRCm39)	T98A	probably benign	Het
D430041D05Rik	T	C	2: 103,998,509 (GRCm39)	T1080A	probably damaging	Het
Dhx8	C	A	11: 101,643,223 (GRCm39)	T765N	probably damaging	Het
Dicer1	T	C	12: 104,697,323 (GRCm39)	D78G	probably benign	Het
Drd2	A	G	9: 49,316,271 (GRCm39)	I344V	probably benign	Het
Edil3	A	T	13: 89,347,570 (GRCm39)		probably benign	Het
Fbxw19	C	T	9: 109,313,493 (GRCm39)	G235D	probably benign	Het
Fzd1	T	C	5: 4,805,702 (GRCm39)	K627E	possibly damaging	Het
Garin1b	A	G	6: 29,323,901 (GRCm39)	T209A	probably benign	Het
Garin4	T	C	1: 190,896,637 (GRCm39)	D2G	probably benign	Het
Gm10638	A	G	8: 87,472,828 (GRCm39)		probably benign	Het
H6pd	G	T	4: 150,080,773 (GRCm39)	A24E	probably damaging	Het
Hectd2	G	T	19: 36,578,929 (GRCm39)		probably null	Het
Hps5	A	G	7: 46,440,333 (GRCm39)		probably benign	Het
Irx3	T	C	8: 92,527,296 (GRCm39)	N136S	possibly damaging	Het
Kcmf1	T	C	6: 72,826,568 (GRCm39)	M1V	probably null	Het
Klrb1	A	T	6: 128,687,583 (GRCm39)	F104I	probably benign	Het
Lrfn5	T	C	12: 61,886,803 (GRCm39)	M197T	probably benign	Het
Mpdz	A	C	4: 81,279,677 (GRCm39)	M51R	possibly damaging	Het
Mtbp	G	T	15: 55,432,466 (GRCm39)	E258*	probably null	Het
Mylk3	T	A	8: 86,079,539 (GRCm39)	H373L	probably damaging	Het
Myrfl	A	G	10: 116,664,882 (GRCm39)	S383P	probably damaging	Het
Nt5c	T	C	11: 115,381,468 (GRCm39)	*195W	probably null	Het
Ocstamp	A	G	2: 165,238,184 (GRCm39)	V360A	possibly damaging	Het
Or10ak16	A	T	4: 118,750,426 (GRCm39)	I49F	possibly damaging	Het
Or10al6	T	A	17: 38,083,284 (GRCm39)	C247S	probably damaging	Het
Or4k35	A	G	2: 111,100,208 (GRCm39)	F168S	probably damaging	Het
Or4p19	A	T	2: 88,242,378 (GRCm39)	V208D	probably damaging	Het
Or5an9	A	G	19: 12,186,953 (GRCm39)	T8A	probably damaging	Het
Otop2	T	C	11: 115,217,234 (GRCm39)		probably benign	Het
Pom121l2	A	T	13: 22,172,649 (GRCm39)		probably benign	Het
Pon2	T	A	6: 5,272,410 (GRCm39)	K137*	probably null	Het
Ppip5k2	T	A	1: 97,647,579 (GRCm39)	Q1049L	probably benign	Het
Ralgapa2	C	T	2: 146,276,729 (GRCm39)	V504M	probably damaging	Het
Rph3a	G	A	5: 121,080,317 (GRCm39)	H654Y	probably damaging	Het
Sh2d1b1	T	C	1: 170,107,342 (GRCm39)		probably benign	Het
Slc15a2	G	A	16: 36,595,960 (GRCm39)	T154I	probably benign	Het
Slc45a3	T	C	1: 131,905,265 (GRCm39)	V96A	possibly damaging	Het
Slc7a4	A	G	16: 17,393,497 (GRCm39)	S101P	probably damaging	Het
Smco2	T	C	6: 146,772,633 (GRCm39)		probably benign	Het
Spata2	A	T	2: 167,325,580 (GRCm39)	V413E	probably benign	Het
Specc1l	A	G	10: 75,082,260 (GRCm39)	E552G	probably damaging	Het
Sstr5	C	T	17: 25,711,008 (GRCm39)	V74M	probably benign	Het
Timm50	G	A	7: 28,006,280 (GRCm39)	R274W	probably damaging	Het
Tll2	A	G	19: 41,087,132 (GRCm39)	V573A	possibly damaging	Het
Tm7sf3	C	A	6: 146,507,685 (GRCm39)	R459M	possibly damaging	Het
Txk	A	G	5: 72,889,105 (GRCm39)		probably null	Het
Uroc1	A	G	6: 90,324,284 (GRCm39)	D436G	probably damaging	Het
Vmn1r13	T	A	6: 57,187,083 (GRCm39)	Y81N	possibly damaging	Het
Vmn2r19	A	G	6: 123,313,141 (GRCm39)	E737G	probably damaging	Het
Wfs1	A	G	5: 37,134,324 (GRCm39)		probably benign	Het
Zfp1	G	A	8: 112,396,875 (GRCm39)	E285K	probably damaging	Het
Zfp661	G	A	2: 127,419,640 (GRCm39)	Q167*	probably null	Het
Zswim8	T	C	14: 20,760,834 (GRCm39)	F36S	probably damaging	Het
Zw10	A	G	9: 48,980,023 (GRCm39)	T385A	probably benign	Het

Other mutations in Zfp1005

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01550:Zfp1005	APN	2	150,108,363 (GRCm39)	splice site	probably benign
R0220:Zfp1005	UTSW	2	150,110,595 (GRCm39)	missense	unknown
R0396:Zfp1005	UTSW	2	150,109,973 (GRCm39)	missense	probably damaging	1.00
R0446:Zfp1005	UTSW	2	150,109,993 (GRCm39)	missense	possibly damaging	0.71
R0462:Zfp1005	UTSW	2	150,111,122 (GRCm39)	missense	possibly damaging	0.80
R0507:Zfp1005	UTSW	2	150,110,044 (GRCm39)	missense	possibly damaging	0.69
R0605:Zfp1005	UTSW	2	150,110,523 (GRCm39)	missense	unknown
R0838:Zfp1005	UTSW	2	150,111,220 (GRCm39)	missense	possibly damaging	0.74
R1327:Zfp1005	UTSW	2	150,108,070 (GRCm39)	missense	possibly damaging	0.71
R1405:Zfp1005	UTSW	2	150,109,620 (GRCm39)	nonsense	probably null
R1405:Zfp1005	UTSW	2	150,109,620 (GRCm39)	nonsense	probably null
R2114:Zfp1005	UTSW	2	150,109,819 (GRCm39)	missense	unknown
R2140:Zfp1005	UTSW	2	150,111,281 (GRCm39)	missense	probably benign	0.33
R3683:Zfp1005	UTSW	2	150,109,976 (GRCm39)	missense	probably benign	0.41
R3917:Zfp1005	UTSW	2	150,108,039 (GRCm39)	splice site	probably benign
R4084:Zfp1005	UTSW	2	150,108,122 (GRCm39)	missense	possibly damaging	0.85
R4499:Zfp1005	UTSW	2	150,111,362 (GRCm39)	missense	possibly damaging	0.93
R4683:Zfp1005	UTSW	2	150,108,390 (GRCm39)	missense	possibly damaging	0.53
R4762:Zfp1005	UTSW	2	150,109,549 (GRCm39)	missense	possibly damaging	0.53
R4937:Zfp1005	UTSW	2	150,110,680 (GRCm39)	missense	unknown
R5678:Zfp1005	UTSW	2	150,110,425 (GRCm39)	nonsense	probably null
R5696:Zfp1005	UTSW	2	150,111,394 (GRCm39)	missense	possibly damaging	0.52
R5697:Zfp1005	UTSW	2	150,111,394 (GRCm39)	missense	possibly damaging	0.52
R5698:Zfp1005	UTSW	2	150,111,394 (GRCm39)	missense	possibly damaging	0.52
R5769:Zfp1005	UTSW	2	150,110,198 (GRCm39)	missense	possibly damaging	0.87
R5780:Zfp1005	UTSW	2	150,108,139 (GRCm39)	missense	probably benign	0.05
R5973:Zfp1005	UTSW	2	150,109,855 (GRCm39)	missense	unknown
R6662:Zfp1005	UTSW	2	150,108,172 (GRCm39)	critical splice donor site	probably null
R6878:Zfp1005	UTSW	2	150,108,406 (GRCm39)	missense	possibly damaging	0.86
R7037:Zfp1005	UTSW	2	150,108,376 (GRCm39)	missense	possibly damaging	0.86
R7081:Zfp1005	UTSW	2	150,110,189 (GRCm39)	missense	possibly damaging	0.66
R7413:Zfp1005	UTSW	2	150,108,081 (GRCm39)	missense	possibly damaging	0.93
R7725:Zfp1005	UTSW	2	150,110,468 (GRCm39)	missense	unknown
R7781:Zfp1005	UTSW	2	150,109,577 (GRCm39)	missense	possibly damaging	0.53
R8197:Zfp1005	UTSW	2	150,109,577 (GRCm39)	missense	possibly damaging	0.53
R8355:Zfp1005	UTSW	2	150,109,876 (GRCm39)	missense	unknown
R8517:Zfp1005	UTSW	2	150,110,043 (GRCm39)	missense	probably benign	0.33
R8812:Zfp1005	UTSW	2	150,109,624 (GRCm39)	missense	possibly damaging	0.83
R9108:Zfp1005	UTSW	2	150,109,969 (GRCm39)	missense	possibly damaging	0.61
R9488:Zfp1005	UTSW	2	150,110,477 (GRCm39)	missense	unknown
R9499:Zfp1005	UTSW	2	150,109,856 (GRCm39)	missense	unknown
R9551:Zfp1005	UTSW	2	150,109,856 (GRCm39)	missense	unknown
R9567:Zfp1005	UTSW	2	150,109,517 (GRCm39)	missense	possibly damaging	0.53
R9646:Zfp1005	UTSW	2	150,110,104 (GRCm39)	missense	probably benign	0.43
R9709:Zfp1005	UTSW	2	150,110,305 (GRCm39)	missense	possibly damaging	0.47
R9719:Zfp1005	UTSW	2	150,111,304 (GRCm39)	missense	possibly damaging	0.74
R9779:Zfp1005	UTSW	2	150,108,064 (GRCm39)	missense	possibly damaging	0.92
X0022:Zfp1005	UTSW	2	150,109,578 (GRCm39)	missense	possibly damaging	0.53
Z1177:Zfp1005	UTSW	2	150,110,244 (GRCm39)	missense	possibly damaging	0.94
Z1177:Zfp1005	UTSW	2	150,110,237 (GRCm39)	missense	possibly damaging	0.84

Predicted Primers

Posted On

2013-05-09