Incidental Mutation 'R4701:Plxna4'
| ID |
356017 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Plxna4
|
| Ensembl Gene |
ENSMUSG00000029765 |
| Gene Name |
plexin A4 |
| Synonyms |
Plxa4 |
| MMRRC Submission |
041949-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.616)
|
| Stock # |
R4701 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
32121478-32565127 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 32493623 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glycine
at position 331
(D331G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000110748
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000115096]
|
| AlphaFold |
Q80UG2 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000115096
AA Change: D331G
PolyPhen 2
Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
|
| SMART Domains |
Protein: ENSMUSP00000110748
Gene: ENSMUSG00000029765
AA Change: D331G
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Sema
|
50 |
490 |
2.3e-131 |
SMART |
|
PSI
|
508 |
558 |
2.21e-14 |
SMART |
|
PSI
|
654 |
701 |
2.44e-7 |
SMART |
|
PSI
|
802 |
855 |
1.2e-6 |
SMART |
|
IPT
|
856 |
950 |
7.25e-16 |
SMART |
|
IPT
|
952 |
1036 |
4.1e-15 |
SMART |
|
IPT
|
1038 |
1138 |
2.86e-14 |
SMART |
|
IPT
|
1140 |
1229 |
6.88e-1 |
SMART |
|
transmembrane domain
|
1237 |
1259 |
N/A |
INTRINSIC |
|
Pfam:Plexin_cytopl
|
1310 |
1863 |
1.8e-264 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150314
|
| Meta Mutation Damage Score |
0.6358 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.0%
- 20x: 94.6%
|
| Validation Efficiency |
96% (108/112) |
| MGI Phenotype |
PHENOTYPE: Homozygous null mice exhibit defective trajecotory and projection of peripheral sensory axons and sympathetic ganglion axons and the formation of the anterior commissure and the barrels. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(2) : Targeted, knock-out(2) |
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aarsd1 |
T |
C |
11: 101,301,986 (GRCm39) |
I196V |
probably benign |
Het |
| Aass |
T |
A |
6: 23,075,855 (GRCm39) |
K761* |
probably null |
Het |
| Abca13 |
A |
G |
11: 9,242,306 (GRCm39) |
T1390A |
possibly damaging |
Het |
| Abhd16a |
T |
C |
17: 35,315,582 (GRCm39) |
|
probably null |
Het |
| Acad11 |
C |
T |
9: 103,972,764 (GRCm39) |
Q486* |
probably null |
Het |
| Actl9 |
T |
C |
17: 33,652,909 (GRCm39) |
L323P |
probably benign |
Het |
| Adam12 |
T |
A |
7: 133,518,191 (GRCm39) |
I650F |
possibly damaging |
Het |
| Adgre4 |
A |
T |
17: 56,091,971 (GRCm39) |
D77V |
probably damaging |
Het |
| Ankrd26 |
A |
G |
6: 118,483,446 (GRCm39) |
F1586S |
possibly damaging |
Het |
| Anpep |
T |
C |
7: 79,489,213 (GRCm39) |
T320A |
probably benign |
Het |
| Arl15 |
T |
A |
13: 114,104,261 (GRCm39) |
C133S |
probably benign |
Het |
| Ascc3 |
A |
G |
10: 50,596,760 (GRCm39) |
N1230S |
possibly damaging |
Het |
| Atf4 |
T |
A |
15: 80,141,618 (GRCm39) |
I336K |
probably damaging |
Het |
| Atp7b |
A |
T |
8: 22,490,137 (GRCm39) |
S1044T |
probably benign |
Het |
| Atp8b4 |
A |
G |
2: 126,256,213 (GRCm39) |
F249L |
probably damaging |
Het |
| AU021092 |
G |
T |
16: 5,030,057 (GRCm39) |
N319K |
probably benign |
Het |
| Bbs4 |
A |
G |
9: 59,230,802 (GRCm39) |
V440A |
probably benign |
Het |
| Bpifb4 |
G |
T |
2: 153,792,305 (GRCm39) |
G450C |
probably damaging |
Het |
| Cadm1 |
G |
A |
9: 47,730,120 (GRCm39) |
|
probably benign |
Het |
| Ccser2 |
G |
A |
14: 36,660,654 (GRCm39) |
L500F |
probably damaging |
Het |
| Cd22 |
T |
A |
7: 30,575,578 (GRCm39) |
I155F |
probably damaging |
Het |
| Cdkl4 |
A |
T |
17: 80,851,081 (GRCm39) |
V207E |
probably damaging |
Het |
| Cfap251 |
A |
G |
5: 123,460,676 (GRCm39) |
K1213E |
probably benign |
Het |
| Cfap65 |
T |
C |
1: 74,958,067 (GRCm39) |
D947G |
probably damaging |
Het |
| Cntn6 |
T |
C |
6: 104,781,321 (GRCm39) |
V397A |
probably benign |
Het |
| Cpox |
T |
A |
16: 58,498,332 (GRCm39) |
Y388* |
probably null |
Het |
| Dab1 |
C |
T |
4: 104,588,948 (GRCm39) |
A524V |
probably benign |
Het |
| Dda1 |
T |
A |
8: 71,926,454 (GRCm39) |
Y58N |
probably damaging |
Het |
| Dennd4a |
C |
T |
9: 64,804,639 (GRCm39) |
T1326I |
possibly damaging |
Het |
| Eps8l2 |
A |
T |
7: 140,937,173 (GRCm39) |
I338F |
probably damaging |
Het |
| Fbxo42 |
A |
G |
4: 140,927,120 (GRCm39) |
T467A |
probably benign |
Het |
| Flt4 |
T |
C |
11: 49,517,635 (GRCm39) |
F319S |
possibly damaging |
Het |
| Fmn1 |
A |
T |
2: 113,414,416 (GRCm39) |
Y895F |
possibly damaging |
Het |
| Gm6887 |
C |
A |
7: 42,114,517 (GRCm39) |
|
noncoding transcript |
Het |
| Grid2 |
A |
G |
6: 64,642,899 (GRCm39) |
D887G |
probably benign |
Het |
| Grm6 |
C |
T |
11: 50,753,837 (GRCm39) |
P714S |
probably damaging |
Het |
| Gsto2 |
A |
G |
19: 47,873,095 (GRCm39) |
I157V |
probably benign |
Het |
| Il15ra |
A |
G |
2: 11,723,156 (GRCm39) |
|
probably null |
Het |
| Impg1 |
A |
G |
9: 80,221,682 (GRCm39) |
F713L |
probably benign |
Het |
| Jag1 |
T |
A |
2: 136,936,376 (GRCm39) |
T373S |
probably benign |
Het |
| Kcnh3 |
T |
A |
15: 99,139,826 (GRCm39) |
L904Q |
probably benign |
Het |
| Kctd19 |
C |
A |
8: 106,117,061 (GRCm39) |
G356V |
possibly damaging |
Het |
| Kdm5b |
T |
A |
1: 134,533,750 (GRCm39) |
|
probably benign |
Het |
| Kif1a |
T |
C |
1: 93,006,557 (GRCm39) |
I37V |
probably damaging |
Het |
| Lama5 |
G |
A |
2: 179,833,489 (GRCm39) |
R1508C |
probably damaging |
Het |
| Lamb1 |
T |
A |
12: 31,316,847 (GRCm39) |
C65* |
probably null |
Het |
| Lingo1 |
A |
G |
9: 56,527,542 (GRCm39) |
F349S |
probably damaging |
Het |
| Loxl4 |
G |
A |
19: 42,596,052 (GRCm39) |
H147Y |
probably benign |
Het |
| Lrrn4cl |
T |
A |
19: 8,829,419 (GRCm39) |
N132K |
probably damaging |
Het |
| Med17 |
A |
T |
9: 15,181,656 (GRCm39) |
H31Q |
probably damaging |
Het |
| Med23 |
A |
T |
10: 24,769,546 (GRCm39) |
L476F |
probably damaging |
Het |
| Mgst1 |
A |
T |
6: 138,127,836 (GRCm39) |
D66V |
probably damaging |
Het |
| Mroh2a |
T |
C |
1: 88,162,334 (GRCm39) |
|
probably null |
Het |
| Mroh2a |
A |
C |
1: 88,169,340 (GRCm39) |
I672L |
probably benign |
Het |
| Muc4 |
A |
T |
16: 32,576,220 (GRCm39) |
|
probably benign |
Het |
| Myo18a |
C |
T |
11: 77,708,491 (GRCm39) |
T30M |
probably damaging |
Het |
| Ncapg2 |
G |
T |
12: 116,404,238 (GRCm39) |
R903L |
probably benign |
Het |
| Nme1 |
A |
G |
11: 93,856,734 (GRCm39) |
I9T |
probably damaging |
Het |
| Nmt2 |
T |
A |
2: 3,323,678 (GRCm39) |
I357N |
probably benign |
Het |
| Nphp4 |
T |
C |
4: 152,581,116 (GRCm39) |
F100S |
probably damaging |
Het |
| Oca2 |
C |
A |
7: 55,904,750 (GRCm39) |
T72K |
probably benign |
Het |
| Or52e4 |
A |
T |
7: 104,706,086 (GRCm39) |
D211V |
probably damaging |
Het |
| Or52e7 |
A |
T |
7: 104,684,798 (GRCm39) |
D131V |
probably damaging |
Het |
| Or52z15 |
G |
A |
7: 103,332,269 (GRCm39) |
V105M |
probably damaging |
Het |
| Or7h8 |
T |
C |
9: 20,123,921 (GRCm39) |
I92T |
probably damaging |
Het |
| Or9s15 |
C |
A |
1: 92,525,160 (GRCm39) |
D306E |
probably benign |
Het |
| Plce1 |
A |
T |
19: 38,713,451 (GRCm39) |
T1240S |
probably benign |
Het |
| Plch1 |
A |
T |
3: 63,606,917 (GRCm39) |
|
probably null |
Het |
| Ppp1r3a |
T |
C |
6: 14,718,992 (GRCm39) |
T641A |
probably benign |
Het |
| Rab32 |
A |
G |
10: 10,426,598 (GRCm39) |
L116P |
probably benign |
Het |
| Recql4 |
C |
T |
15: 76,592,785 (GRCm39) |
C302Y |
probably damaging |
Het |
| Rorc |
G |
C |
3: 94,299,017 (GRCm39) |
E391Q |
probably null |
Het |
| Saa4 |
A |
T |
7: 46,381,051 (GRCm39) |
F24I |
possibly damaging |
Het |
| Sall1 |
T |
A |
8: 89,757,788 (GRCm39) |
K772M |
probably damaging |
Het |
| Sdk1 |
T |
G |
5: 142,170,986 (GRCm39) |
L1950V |
probably damaging |
Het |
| Sil1 |
T |
C |
18: 35,399,949 (GRCm39) |
E352G |
probably benign |
Het |
| Slc26a3 |
C |
T |
12: 31,497,773 (GRCm39) |
P59L |
probably damaging |
Het |
| Smco2 |
T |
C |
6: 146,763,440 (GRCm39) |
|
probably benign |
Het |
| Sppl3 |
A |
G |
5: 115,241,372 (GRCm39) |
|
probably null |
Het |
| St6gal2 |
T |
A |
17: 55,803,345 (GRCm39) |
V360D |
probably damaging |
Het |
| Stard9 |
G |
A |
2: 120,536,194 (GRCm39) |
R345Q |
possibly damaging |
Het |
| Susd4 |
T |
A |
1: 182,719,626 (GRCm39) |
Y414N |
probably damaging |
Het |
| Tenm4 |
T |
C |
7: 96,544,556 (GRCm39) |
Y2191H |
probably damaging |
Het |
| Tln2 |
A |
G |
9: 67,253,809 (GRCm39) |
V754A |
probably benign |
Het |
| Tmem132c |
T |
A |
5: 127,641,560 (GRCm39) |
|
probably benign |
Het |
| Tnn |
A |
T |
1: 159,975,338 (GRCm39) |
S30T |
possibly damaging |
Het |
| Trpd52l3 |
G |
T |
19: 29,981,895 (GRCm39) |
V217F |
probably damaging |
Het |
| Trpm1 |
G |
T |
7: 63,893,248 (GRCm39) |
L1033F |
probably damaging |
Het |
| Tulp2 |
A |
G |
7: 45,167,348 (GRCm39) |
E182G |
probably damaging |
Het |
| Ubr4 |
A |
G |
4: 139,198,647 (GRCm39) |
K4490R |
possibly damaging |
Het |
| Usp17la |
A |
T |
7: 104,509,856 (GRCm39) |
R154* |
probably null |
Het |
| Vmn2r17 |
T |
G |
5: 109,575,849 (GRCm39) |
M240R |
probably damaging |
Het |
| Vmn2r22 |
T |
A |
6: 123,627,428 (GRCm39) |
N56I |
probably benign |
Het |
| Zdhhc21 |
A |
T |
4: 82,738,571 (GRCm39) |
I206N |
possibly damaging |
Het |
| Zfp148 |
T |
A |
16: 33,277,278 (GRCm39) |
D122E |
probably benign |
Het |
| Zfp804a |
A |
T |
2: 82,086,926 (GRCm39) |
S252C |
probably damaging |
Het |
| Zgrf1 |
C |
T |
3: 127,392,353 (GRCm39) |
T1291I |
probably benign |
Het |
|
| Other mutations in Plxna4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00429:Plxna4
|
APN |
6 |
32,139,026 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01395:Plxna4
|
APN |
6 |
32,216,368 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01506:Plxna4
|
APN |
6 |
32,493,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01606:Plxna4
|
APN |
6 |
32,134,936 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01753:Plxna4
|
APN |
6 |
32,287,413 (GRCm39) |
missense |
probably benign |
0.06 |
|
IGL01767:Plxna4
|
APN |
6 |
32,214,613 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL01968:Plxna4
|
APN |
6 |
32,192,139 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02109:Plxna4
|
APN |
6 |
32,192,576 (GRCm39) |
missense |
probably benign |
|
|
IGL02299:Plxna4
|
APN |
6 |
32,142,091 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02306:Plxna4
|
APN |
6 |
32,183,059 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02312:Plxna4
|
APN |
6 |
32,142,052 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
IGL02326:Plxna4
|
APN |
6 |
32,129,840 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02658:Plxna4
|
APN |
6 |
32,162,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02683:Plxna4
|
APN |
6 |
32,494,541 (GRCm39) |
missense |
probably benign |
0.03 |
|
IGL02701:Plxna4
|
APN |
6 |
32,494,494 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02995:Plxna4
|
APN |
6 |
32,493,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03030:Plxna4
|
APN |
6 |
32,179,160 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL03264:Plxna4
|
APN |
6 |
32,155,337 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
IGL03304:Plxna4
|
APN |
6 |
32,141,986 (GRCm39) |
splice site |
probably benign |
|
|
IGL03382:Plxna4
|
APN |
6 |
32,179,129 (GRCm39) |
missense |
probably benign |
0.23 |
|
corona
|
UTSW |
6 |
32,494,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Disposed
|
UTSW |
6 |
32,493,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
inclined
|
UTSW |
6 |
32,214,658 (GRCm39) |
nonsense |
probably null |
|
|
Slope
|
UTSW |
6 |
32,211,541 (GRCm39) |
missense |
probably benign |
0.00 |
|
G4846:Plxna4
|
UTSW |
6 |
32,169,207 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0133:Plxna4
|
UTSW |
6 |
32,174,009 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0200:Plxna4
|
UTSW |
6 |
32,174,023 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0308:Plxna4
|
UTSW |
6 |
32,214,703 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0468:Plxna4
|
UTSW |
6 |
32,192,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0505:Plxna4
|
UTSW |
6 |
32,179,054 (GRCm39) |
missense |
probably benign |
|
|
R0542:Plxna4
|
UTSW |
6 |
32,169,232 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0548:Plxna4
|
UTSW |
6 |
32,134,950 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0652:Plxna4
|
UTSW |
6 |
32,162,436 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1144:Plxna4
|
UTSW |
6 |
32,174,091 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R1190:Plxna4
|
UTSW |
6 |
32,228,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1228:Plxna4
|
UTSW |
6 |
32,201,087 (GRCm39) |
splice site |
probably null |
|
|
R1569:Plxna4
|
UTSW |
6 |
32,162,410 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R1803:Plxna4
|
UTSW |
6 |
32,494,379 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1832:Plxna4
|
UTSW |
6 |
32,174,761 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2068:Plxna4
|
UTSW |
6 |
32,494,551 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R2157:Plxna4
|
UTSW |
6 |
32,493,909 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2842:Plxna4
|
UTSW |
6 |
32,192,566 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2849:Plxna4
|
UTSW |
6 |
32,162,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2892:Plxna4
|
UTSW |
6 |
32,493,972 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2930:Plxna4
|
UTSW |
6 |
32,142,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3892:Plxna4
|
UTSW |
6 |
32,192,589 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4065:Plxna4
|
UTSW |
6 |
32,213,300 (GRCm39) |
nonsense |
probably null |
|
|
R4276:Plxna4
|
UTSW |
6 |
32,177,883 (GRCm39) |
missense |
probably benign |
0.29 |
|
R4307:Plxna4
|
UTSW |
6 |
32,140,444 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4331:Plxna4
|
UTSW |
6 |
32,127,480 (GRCm39) |
nonsense |
probably null |
|
|
R4478:Plxna4
|
UTSW |
6 |
32,173,068 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4529:Plxna4
|
UTSW |
6 |
32,473,831 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R4566:Plxna4
|
UTSW |
6 |
32,494,338 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4568:Plxna4
|
UTSW |
6 |
32,129,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4664:Plxna4
|
UTSW |
6 |
32,493,885 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4685:Plxna4
|
UTSW |
6 |
32,142,779 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4939:Plxna4
|
UTSW |
6 |
32,142,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5153:Plxna4
|
UTSW |
6 |
32,201,094 (GRCm39) |
splice site |
probably null |
|
|
R5181:Plxna4
|
UTSW |
6 |
32,493,932 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5256:Plxna4
|
UTSW |
6 |
32,228,007 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5259:Plxna4
|
UTSW |
6 |
32,493,956 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R5306:Plxna4
|
UTSW |
6 |
32,183,056 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5487:Plxna4
|
UTSW |
6 |
32,494,218 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5510:Plxna4
|
UTSW |
6 |
32,155,293 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5542:Plxna4
|
UTSW |
6 |
32,183,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5567:Plxna4
|
UTSW |
6 |
32,134,915 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R5634:Plxna4
|
UTSW |
6 |
32,214,658 (GRCm39) |
nonsense |
probably null |
|
|
R5653:Plxna4
|
UTSW |
6 |
32,494,551 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R5665:Plxna4
|
UTSW |
6 |
32,192,657 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5845:Plxna4
|
UTSW |
6 |
32,214,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5909:Plxna4
|
UTSW |
6 |
32,494,181 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5938:Plxna4
|
UTSW |
6 |
32,211,541 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5973:Plxna4
|
UTSW |
6 |
32,228,000 (GRCm39) |
splice site |
probably null |
|
|
R6433:Plxna4
|
UTSW |
6 |
32,192,613 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6482:Plxna4
|
UTSW |
6 |
32,493,672 (GRCm39) |
missense |
probably benign |
|
|
R6560:Plxna4
|
UTSW |
6 |
32,192,613 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6721:Plxna4
|
UTSW |
6 |
32,177,794 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6810:Plxna4
|
UTSW |
6 |
32,287,457 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6985:Plxna4
|
UTSW |
6 |
32,214,643 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7024:Plxna4
|
UTSW |
6 |
32,169,204 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7046:Plxna4
|
UTSW |
6 |
32,493,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7137:Plxna4
|
UTSW |
6 |
32,494,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7163:Plxna4
|
UTSW |
6 |
32,473,691 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7199:Plxna4
|
UTSW |
6 |
32,192,113 (GRCm39) |
nonsense |
probably null |
|
|
R7248:Plxna4
|
UTSW |
6 |
32,139,095 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7260:Plxna4
|
UTSW |
6 |
32,216,455 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7361:Plxna4
|
UTSW |
6 |
32,173,057 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7383:Plxna4
|
UTSW |
6 |
32,129,734 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7405:Plxna4
|
UTSW |
6 |
32,173,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7516:Plxna4
|
UTSW |
6 |
32,214,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7635:Plxna4
|
UTSW |
6 |
32,473,676 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7754:Plxna4
|
UTSW |
6 |
32,129,807 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7763:Plxna4
|
UTSW |
6 |
32,200,915 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7789:Plxna4
|
UTSW |
6 |
32,183,168 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8167:Plxna4
|
UTSW |
6 |
32,493,981 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8191:Plxna4
|
UTSW |
6 |
32,493,885 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R8225:Plxna4
|
UTSW |
6 |
32,139,038 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8284:Plxna4
|
UTSW |
6 |
32,129,789 (GRCm39) |
missense |
probably benign |
0.25 |
|
R8305:Plxna4
|
UTSW |
6 |
32,188,000 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8438:Plxna4
|
UTSW |
6 |
32,179,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8493:Plxna4
|
UTSW |
6 |
32,192,647 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8714:Plxna4
|
UTSW |
6 |
32,140,379 (GRCm39) |
nonsense |
probably null |
|
|
R8759:Plxna4
|
UTSW |
6 |
32,169,276 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8822:Plxna4
|
UTSW |
6 |
32,127,431 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8844:Plxna4
|
UTSW |
6 |
32,174,026 (GRCm39) |
missense |
probably benign |
0.11 |
|
R8974:Plxna4
|
UTSW |
6 |
32,216,447 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R9020:Plxna4
|
UTSW |
6 |
32,211,497 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9144:Plxna4
|
UTSW |
6 |
32,162,496 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9206:Plxna4
|
UTSW |
6 |
32,494,379 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9208:Plxna4
|
UTSW |
6 |
32,494,379 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9257:Plxna4
|
UTSW |
6 |
32,139,018 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9269:Plxna4
|
UTSW |
6 |
32,155,315 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9411:Plxna4
|
UTSW |
6 |
32,159,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9469:Plxna4
|
UTSW |
6 |
32,494,526 (GRCm39) |
missense |
probably benign |
|
|
R9583:Plxna4
|
UTSW |
6 |
32,192,169 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9647:Plxna4
|
UTSW |
6 |
32,228,044 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9695:Plxna4
|
UTSW |
6 |
32,183,056 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9801:Plxna4
|
UTSW |
6 |
32,140,526 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
V1024:Plxna4
|
UTSW |
6 |
32,211,509 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0027:Plxna4
|
UTSW |
6 |
32,493,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGTCCTTCACCTTGAGCCAG -3'
(R):5'- TTTTGACCCTTCAGCCAGAG -3'
Sequencing Primer
(F):5'- AGGCCAGGTCTAGTGTTCC -3'
(R):5'- CTTCAGCCAGAGATGGTGTC -3'
|
| Posted On |
2015-10-21 |
Incidental Mutation