Incidental Mutation 'R4702:Stk10'
ID 356149
Institutional Source Beutler Lab
Gene Symbol Stk10
Ensembl Gene ENSMUSG00000020272
Gene Name serine/threonine kinase 10
Synonyms Lok, Gek1
MMRRC Submission 041950-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.145) question?
Stock # R4702 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 32483305-32574587 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 32505172 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Serine at position 69 (T69S)
Ref Sequence ENSEMBL: ENSMUSP00000099885 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000102821]
AlphaFold O55098
Predicted Effect probably benign
Transcript: ENSMUST00000102821
AA Change: T69S

PolyPhen 2 Score 0.282 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000099885
Gene: ENSMUSG00000020272
AA Change: T69S

DomainStartEndE-ValueType
S_TKc 36 294 8.66e-92 SMART
low complexity region 316 334 N/A INTRINSIC
low complexity region 544 577 N/A INTRINSIC
Pfam:PKK 586 724 1.9e-41 PFAM
Pfam:PKK 754 894 2.2e-37 PFAM
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.1%
Validation Efficiency
MGI Phenotype FUNCTION: This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. Mice deficient for this gene product are viable, but exhibit altered integrin-mediated lymphocyte adhesion characteristics. The orthologous gene product in humans can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. [provided by RefSeq, Jul 2008]
PHENOTYPE: Targeted disruption of this gene results in enhanced cell adhesion in mitogen-stimulated T cells. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 75 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921509C19Rik T C 2: 151,314,509 (GRCm39) T390A probably benign Het
Adam25 G T 8: 41,207,163 (GRCm39) C143F probably damaging Het
Adra1a T C 14: 66,875,008 (GRCm39) probably benign Het
Aff1 T C 5: 103,958,935 (GRCm39) Y343H probably damaging Het
Antxr2 C T 5: 98,097,028 (GRCm39) probably null Het
Ap1m2 A G 9: 21,209,591 (GRCm39) F362L probably benign Het
Apobec4 A G 1: 152,632,001 (GRCm39) T10A probably benign Het
Armc3 A G 2: 19,314,792 (GRCm39) N822S probably damaging Het
Atr A C 9: 95,802,408 (GRCm39) T1767P possibly damaging Het
B4galnt1 G T 10: 127,003,394 (GRCm39) V172F possibly damaging Het
Bloc1s1 T A 10: 128,759,267 (GRCm39) Q13L probably damaging Het
Blvra A C 2: 126,933,982 (GRCm39) I125L probably benign Het
Caps2 T C 10: 112,044,252 (GRCm39) F484L probably damaging Het
Cep76 A T 18: 67,767,968 (GRCm39) I188K possibly damaging Het
Cidea T A 18: 67,500,498 (GRCm39) F187I probably benign Het
Cntn3 T A 6: 102,142,292 (GRCm39) N1025I probably benign Het
Cntnap3 A T 13: 64,926,676 (GRCm39) C565S probably benign Het
Cyp2d22 A C 15: 82,260,118 (GRCm39) L22R probably damaging Het
Cyp2d26 C T 15: 82,676,648 (GRCm39) probably benign Het
Cyp2j12 A T 4: 96,021,230 (GRCm39) probably null Het
Dnajb13 T C 7: 100,153,748 (GRCm39) N229S probably benign Het
Dpys A G 15: 39,656,798 (GRCm39) V423A possibly damaging Het
Eif4e1b A T 13: 54,935,138 (GRCm39) I222F probably damaging Het
Eif5b A T 1: 38,057,958 (GRCm39) N87Y unknown Het
Enam T A 5: 88,651,650 (GRCm39) L1053* probably null Het
Epha7 T A 4: 28,961,425 (GRCm39) L890Q probably damaging Het
Fancm T A 12: 65,168,826 (GRCm39) S1730T possibly damaging Het
Flrt3 A G 2: 140,503,575 (GRCm39) F18L probably benign Het
Git2 A G 5: 114,883,543 (GRCm39) S396P probably damaging Het
H2-M10.4 A G 17: 36,772,874 (GRCm39) I36T probably benign Het
Igfn1 G A 1: 135,894,947 (GRCm39) S1873L possibly damaging Het
Ints12 A T 3: 132,802,546 (GRCm39) D10V probably damaging Het
Kbtbd2 A G 6: 56,756,288 (GRCm39) S483P probably benign Het
Kcnv2 G C 19: 27,300,967 (GRCm39) A273P probably damaging Het
Klc3 T G 7: 19,129,756 (GRCm39) D371A probably damaging Het
Lama3 T A 18: 12,711,086 (GRCm39) L1567* probably null Het
Ldhal6b G T 17: 5,468,582 (GRCm39) H117Q probably damaging Het
Lrriq1 G T 10: 103,051,610 (GRCm39) Q381K possibly damaging Het
Mrps31 T A 8: 22,909,754 (GRCm39) L140Q probably damaging Het
Myo15b A G 11: 115,774,834 (GRCm39) T2119A probably benign Het
Nkx6-2 T C 7: 139,161,456 (GRCm39) D243G probably damaging Het
Or1ab2 T A 8: 72,864,044 (GRCm39) F211L probably damaging Het
Or8b3b A T 9: 38,584,776 (GRCm39) M1K probably null Het
Papln C T 12: 83,828,757 (GRCm39) T821I probably benign Het
Pitpnb T G 5: 111,519,218 (GRCm39) V166G probably benign Het
Pla2g15 T A 8: 106,889,691 (GRCm39) M321K probably benign Het
Plcxd3 C A 15: 4,405,269 (GRCm39) S25R probably benign Het
Ppargc1a T C 5: 51,653,038 (GRCm39) I175V possibly damaging Het
Ppp1r13b T A 12: 111,799,715 (GRCm39) Q687H probably benign Het
Prpf3 A G 3: 95,741,404 (GRCm39) V584A probably damaging Het
Psen2 A G 1: 180,055,289 (GRCm39) L399S probably damaging Het
Ptchd3 G A 11: 121,727,235 (GRCm39) V370I probably damaging Het
Rasa3 G T 8: 13,620,394 (GRCm39) D758E probably benign Het
Reck T C 4: 43,898,060 (GRCm39) C113R probably damaging Het
Resf1 A G 6: 149,230,901 (GRCm39) T1316A probably benign Het
Ric1 T A 19: 29,575,417 (GRCm39) F1009I possibly damaging Het
Rrp12 T C 19: 41,859,975 (GRCm39) N1035S probably damaging Het
Rtel1 T A 2: 180,993,962 (GRCm39) S849T probably benign Het
Scn10a A T 9: 119,462,857 (GRCm39) Y1060N possibly damaging Het
Selenov A G 7: 27,987,436 (GRCm39) L314P probably damaging Het
Selplg T C 5: 113,957,094 (GRCm39) D404G probably benign Het
Slc7a14 T A 3: 31,284,547 (GRCm39) Y263F probably damaging Het
Slco3a1 A G 7: 73,970,315 (GRCm39) S431P probably damaging Het
Speer3 C G 5: 13,846,394 (GRCm39) A238G possibly damaging Het
Spopl A T 2: 23,405,309 (GRCm39) probably null Het
Tbxas1 T C 6: 39,060,791 (GRCm39) probably null Het
Tec G A 5: 72,941,074 (GRCm39) P161L possibly damaging Het
Tnip1 A G 11: 54,815,228 (GRCm39) S339P probably benign Het
Tsen34 T A 7: 3,703,632 (GRCm39) V290D probably damaging Het
Tuba1a T A 15: 98,849,563 (GRCm39) I5F possibly damaging Het
Vmn1r31 C A 6: 58,448,953 (GRCm39) *304L probably null Het
Vmn1r63 T C 7: 5,806,516 (GRCm39) R39G possibly damaging Het
Xylt2 A G 11: 94,560,355 (GRCm39) Y307H possibly damaging Het
Zfp65 A G 13: 67,872,341 (GRCm39) M1T probably null Het
Zmym4 T C 4: 126,816,958 (GRCm39) I247V probably benign Het
Other mutations in Stk10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01105:Stk10 APN 11 32,527,740 (GRCm39) missense probably benign 0.33
IGL01285:Stk10 APN 11 32,560,653 (GRCm39) missense possibly damaging 0.91
IGL01983:Stk10 APN 11 32,539,460 (GRCm39) missense probably benign 0.05
IGL03177:Stk10 APN 11 32,564,592 (GRCm39) missense probably damaging 1.00
IGL03183:Stk10 APN 11 32,554,143 (GRCm39) missense possibly damaging 0.50
coquet UTSW 11 32,527,764 (GRCm39) missense
legacy UTSW 11 32,554,166 (GRCm39) nonsense probably null
mignon UTSW 11 32,537,363 (GRCm39) missense probably damaging 1.00
R0481_stk10_383 UTSW 11 32,564,708 (GRCm39) missense probably damaging 1.00
FR4976:Stk10 UTSW 11 32,564,520 (GRCm39) critical splice acceptor site probably benign
R0003:Stk10 UTSW 11 32,539,460 (GRCm39) missense probably benign 0.05
R0008:Stk10 UTSW 11 32,537,305 (GRCm39) splice site probably benign
R0056:Stk10 UTSW 11 32,567,851 (GRCm39) missense possibly damaging 0.95
R0076:Stk10 UTSW 11 32,553,722 (GRCm39) missense probably benign
R0227:Stk10 UTSW 11 32,567,859 (GRCm39) missense probably damaging 1.00
R0440:Stk10 UTSW 11 32,554,190 (GRCm39) missense probably damaging 1.00
R0454:Stk10 UTSW 11 32,546,724 (GRCm39) missense probably damaging 0.99
R0481:Stk10 UTSW 11 32,564,708 (GRCm39) missense probably damaging 1.00
R0504:Stk10 UTSW 11 32,567,882 (GRCm39) missense probably benign 0.04
R0790:Stk10 UTSW 11 32,548,653 (GRCm39) missense probably benign 0.00
R1439:Stk10 UTSW 11 32,567,919 (GRCm39) missense probably damaging 0.98
R1539:Stk10 UTSW 11 32,483,440 (GRCm39) missense possibly damaging 0.85
R1770:Stk10 UTSW 11 32,572,464 (GRCm39) missense possibly damaging 0.94
R4304:Stk10 UTSW 11 32,560,634 (GRCm39) missense probably damaging 0.97
R4430:Stk10 UTSW 11 32,483,552 (GRCm39) missense possibly damaging 0.81
R4797:Stk10 UTSW 11 32,548,471 (GRCm39) missense probably benign 0.01
R5447:Stk10 UTSW 11 32,554,166 (GRCm39) nonsense probably null
R5801:Stk10 UTSW 11 32,546,748 (GRCm39) missense probably benign 0.01
R5802:Stk10 UTSW 11 32,546,748 (GRCm39) missense probably benign 0.01
R6129:Stk10 UTSW 11 32,565,871 (GRCm39) missense probably damaging 1.00
R6154:Stk10 UTSW 11 32,553,654 (GRCm39) splice site probably null
R6175:Stk10 UTSW 11 32,553,761 (GRCm39) missense possibly damaging 0.46
R6185:Stk10 UTSW 11 32,527,749 (GRCm39) missense probably benign 0.13
R6520:Stk10 UTSW 11 32,538,839 (GRCm39) missense probably damaging 1.00
R6824:Stk10 UTSW 11 32,537,363 (GRCm39) missense probably damaging 1.00
R7259:Stk10 UTSW 11 32,548,497 (GRCm39) missense probably benign 0.00
R7649:Stk10 UTSW 11 32,527,764 (GRCm39) missense
R8331:Stk10 UTSW 11 32,538,928 (GRCm39) missense
R8847:Stk10 UTSW 11 32,539,427 (GRCm39) missense
R9252:Stk10 UTSW 11 32,538,915 (GRCm39) missense
R9367:Stk10 UTSW 11 32,538,878 (GRCm39) missense
X0027:Stk10 UTSW 11 32,537,361 (GRCm39) missense probably benign 0.01
Predicted Primers PCR Primer
(F):5'- GAATGTTCTCTCTGGTCTGAGCTC -3'
(R):5'- TTTACCAGGGAGCCCACTTC -3'

Sequencing Primer
(F):5'- TGAGCTCCCCAGTGTTGACAC -3'
(R):5'- AGGGAGCCCACTTCACCTTC -3'
Posted On 2015-10-21