Incidental Mutation 'R4703:Tnn'
ID 356178
Institutional Source Beutler Lab
Gene Symbol Tnn
Ensembl Gene ENSMUSG00000026725
Gene Name tenascin N
Synonyms tenascin-W, Tnw
MMRRC Submission 041951-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.396) question?
Stock # R4703 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 159912599-159981150 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 159943815 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 999 (D999E)
Ref Sequence ENSEMBL: ENSMUSP00000039452 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039178] [ENSMUST00000131919]
AlphaFold Q80Z71
Predicted Effect possibly damaging
Transcript: ENSMUST00000039178
AA Change: D999E

PolyPhen 2 Score 0.837 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000039452
Gene: ENSMUSG00000026725
AA Change: D999E

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
coiled coil region 100 132 N/A INTRINSIC
EGF_like 170 198 3.5e1 SMART
EGF 201 229 2.29e1 SMART
EGF_like 232 260 2.86e1 SMART
FN3 262 341 1.81e-8 SMART
FN3 351 432 1.08e-6 SMART
FN3 443 521 1.19e-8 SMART
FN3 531 608 2.64e-10 SMART
FN3 619 696 1.6e-9 SMART
FN3 707 784 9.04e-9 SMART
FN3 795 872 7.34e-9 SMART
FN3 883 960 9.04e-9 SMART
FN3 971 1048 1.07e-10 SMART
FN3 1059 1136 7.57e-11 SMART
FN3 1147 1224 4.59e-10 SMART
FN3 1235 1312 1.95e-4 SMART
FBG 1327 1539 1.16e-114 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000131919
SMART Domains Protein: ENSMUSP00000115685
Gene: ENSMUSG00000026725

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
coiled coil region 100 132 N/A INTRINSIC
EGF_like 170 198 3.5e1 SMART
EGF 201 229 2.29e1 SMART
EGF_like 232 260 2.86e1 SMART
FN3 262 341 1.81e-8 SMART
FN3 351 432 1.08e-6 SMART
FN3 443 521 1.19e-8 SMART
FN3 531 608 2.64e-10 SMART
FN3 619 696 1.6e-9 SMART
FN3 707 784 9.04e-9 SMART
FN3 795 872 7.57e-11 SMART
FN3 883 960 4.59e-10 SMART
FN3 971 1048 1.95e-4 SMART
FBG 1063 1275 1.16e-114 SMART
Meta Mutation Damage Score 0.2239 question?
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.5%
  • 10x: 97.0%
  • 20x: 94.6%
Validation Efficiency 97% (98/101)
Allele List at MGI

All alleles(2) : Targeted, other(2)

Other mutations in this stock
Total: 89 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4921517D22Rik T A 13: 59,837,342 (GRCm39) T248S possibly damaging Het
AA986860 T C 1: 130,671,092 (GRCm39) V438A probably benign Het
Adam25 G T 8: 41,207,163 (GRCm39) C143F probably damaging Het
Aox1 T A 1: 58,398,116 (GRCm39) F1286I possibly damaging Het
Apobec4 A G 1: 152,632,001 (GRCm39) T10A probably benign Het
Arhgap5 C T 12: 52,564,366 (GRCm39) P446S probably damaging Het
Arhgef40 A G 14: 52,239,767 (GRCm39) N1327S probably damaging Het
Armc12 A G 17: 28,751,336 (GRCm39) D110G probably benign Het
Ascc1 A G 10: 59,885,624 (GRCm39) Y225C probably damaging Het
Aspscr1 A T 11: 120,579,771 (GRCm39) K39N possibly damaging Het
B4galnt1 G T 10: 127,003,394 (GRCm39) V172F possibly damaging Het
B4galt1 A G 4: 40,823,569 (GRCm39) V174A probably benign Het
Bcl11a C A 11: 24,113,725 (GRCm39) A356E possibly damaging Het
Bri3bp C T 5: 125,528,830 (GRCm39) L110F probably damaging Het
Cacna1b T C 2: 24,544,475 (GRCm39) D1231G probably damaging Het
Ccdc33 T A 9: 57,940,953 (GRCm39) I430F possibly damaging Het
Cgn A G 3: 94,683,405 (GRCm39) probably benign Het
Crbn T A 6: 106,759,883 (GRCm39) I317F possibly damaging Het
Cyp2d22 A C 15: 82,260,118 (GRCm39) L22R probably damaging Het
Dnah7a C T 1: 53,486,476 (GRCm39) probably null Het
Dnajc12 A G 10: 63,222,429 (GRCm39) probably null Het
Dntt T A 19: 41,028,242 (GRCm39) D179E probably benign Het
Enam T A 5: 88,651,650 (GRCm39) L1053* probably null Het
Epn1 T A 7: 5,098,147 (GRCm39) D319E probably damaging Het
Evpl C G 11: 116,113,331 (GRCm39) R1453P probably damaging Het
Focad T A 4: 88,260,558 (GRCm39) probably null Het
Foxp2 A T 6: 15,411,247 (GRCm39) M542L probably benign Het
Gak T A 5: 108,717,743 (GRCm39) Q1299L probably damaging Het
Galnt5 G T 2: 57,888,919 (GRCm39) R173I possibly damaging Het
Gli1 G T 10: 127,166,724 (GRCm39) P843Q possibly damaging Het
Gm5422 G T 10: 31,125,608 (GRCm39) noncoding transcript Het
Gna14 T G 19: 16,576,344 (GRCm39) V117G possibly damaging Het
Gpr6 T C 10: 40,947,037 (GRCm39) T182A probably damaging Het
Ifi204 C A 1: 173,587,927 (GRCm39) probably benign Het
Ifih1 A T 2: 62,429,220 (GRCm39) L906H probably benign Het
Ift88 A G 14: 57,718,307 (GRCm39) probably benign Het
Ighd A G 12: 113,379,661 (GRCm39) probably benign Het
Ighv11-1 A C 12: 113,945,622 (GRCm39) I77R possibly damaging Het
Il22 A T 10: 118,041,511 (GRCm39) I75F probably damaging Het
Il23r A T 6: 67,467,686 (GRCm39) I27K probably damaging Het
Inpp5a A C 7: 139,138,839 (GRCm39) N261T probably damaging Het
Ints8 T G 4: 11,223,785 (GRCm39) Q686P possibly damaging Het
Iqcf4 T C 9: 106,445,519 (GRCm39) probably null Het
Irf2bp1 C T 7: 18,739,496 (GRCm39) R379C possibly damaging Het
Iws1 C T 18: 32,213,066 (GRCm39) P165S probably benign Het
Kalrn T C 16: 34,024,327 (GRCm39) D610G probably damaging Het
Kcna10 A T 3: 107,101,926 (GRCm39) I186F probably benign Het
Limk2 C A 11: 3,297,586 (GRCm39) E329* probably null Het
Nadk C A 4: 155,669,684 (GRCm39) P157T probably benign Het
Notch1 T G 2: 26,361,170 (GRCm39) K1107Q probably benign Het
Nsd1 T A 13: 55,361,876 (GRCm39) D281E probably damaging Het
Obi1 A G 14: 104,743,644 (GRCm39) L145P probably benign Het
Olfml2a T A 2: 38,841,250 (GRCm39) L262Q probably damaging Het
Or1ab2 T A 8: 72,864,044 (GRCm39) F211L probably damaging Het
Or4k44 T A 2: 111,368,113 (GRCm39) I174L probably benign Het
Or51d1 A T 7: 102,347,477 (GRCm39) T11S probably benign Het
Or6k6 A G 1: 173,944,964 (GRCm39) I206T possibly damaging Het
Or7c19 A G 8: 85,957,237 (GRCm39) T38A possibly damaging Het
Otogl A C 10: 107,657,785 (GRCm39) D1048E probably damaging Het
Oxnad1 T C 14: 31,817,427 (GRCm39) W96R probably damaging Het
Pcdh15 A T 10: 74,285,995 (GRCm39) D743V probably damaging Het
Pclo A G 5: 14,726,494 (GRCm39) probably benign Het
Pcnx1 C T 12: 81,941,938 (GRCm39) T112I probably benign Het
Pctp T C 11: 89,878,099 (GRCm39) E145G possibly damaging Het
Pip5k1b T C 19: 24,332,517 (GRCm39) K389R probably damaging Het
Pla2g15 T A 8: 106,889,691 (GRCm39) M321K probably benign Het
Pnlip T A 19: 58,664,899 (GRCm39) D242E probably damaging Het
Ptpn21 T C 12: 98,645,651 (GRCm39) T1096A probably benign Het
Rims3 A T 4: 120,740,494 (GRCm39) probably benign Het
Scfd2 T A 5: 74,680,256 (GRCm39) Q299L probably benign Het
Selplg T C 5: 113,957,094 (GRCm39) D404G probably benign Het
Slc15a5 T C 6: 138,032,643 (GRCm39) D237G probably benign Het
Slc16a12 T A 19: 34,652,291 (GRCm39) H285L possibly damaging Het
Sox2 C A 3: 34,704,862 (GRCm39) R100S probably damaging Het
Sspo G A 6: 48,477,387 (GRCm39) C4969Y probably damaging Het
Stxbp2 A G 8: 3,682,521 (GRCm39) S37G probably damaging Het
Tbxas1 T C 6: 39,060,791 (GRCm39) probably null Het
Tcf4 A G 18: 69,790,981 (GRCm39) Y307C probably damaging Het
Thsd7b A T 1: 129,977,646 (GRCm39) probably benign Het
Trmt13 C A 3: 116,388,247 (GRCm39) W63L probably benign Het
Tsc2 T C 17: 24,823,883 (GRCm39) N915S probably benign Het
Tyrp1 T A 4: 80,759,043 (GRCm39) probably null Het
Uvrag A T 7: 98,638,794 (GRCm39) I315N probably damaging Het
Vmn1r31 C A 6: 58,448,953 (GRCm39) *304L probably null Het
Vmn2r59 T A 7: 41,661,686 (GRCm39) I710L probably benign Het
Vmn2r82 A T 10: 79,214,641 (GRCm39) H208L probably damaging Het
Wtap T C 17: 13,199,711 (GRCm39) T91A probably benign Het
Xirp1 A T 9: 119,846,093 (GRCm39) V930E probably damaging Het
Xpo4 T G 14: 57,827,565 (GRCm39) H877P probably benign Het
Other mutations in Tnn
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00095:Tnn APN 1 159,953,021 (GRCm39) missense possibly damaging 0.65
IGL00433:Tnn APN 1 159,925,776 (GRCm39) splice site probably benign
IGL00858:Tnn APN 1 159,915,962 (GRCm39) critical splice donor site probably null
IGL00939:Tnn APN 1 159,975,100 (GRCm39) missense probably damaging 1.00
IGL01569:Tnn APN 1 159,948,124 (GRCm39) missense possibly damaging 0.51
IGL01591:Tnn APN 1 159,953,144 (GRCm39) missense probably damaging 1.00
IGL01628:Tnn APN 1 159,975,172 (GRCm39) missense possibly damaging 0.89
IGL01811:Tnn APN 1 159,934,705 (GRCm39) missense probably damaging 1.00
IGL01813:Tnn APN 1 159,916,008 (GRCm39) missense probably damaging 1.00
IGL02340:Tnn APN 1 159,972,775 (GRCm39) missense probably benign 0.00
IGL02488:Tnn APN 1 159,968,163 (GRCm39) missense probably benign 0.21
IGL02535:Tnn APN 1 159,950,222 (GRCm39) splice site probably null
IGL02563:Tnn APN 1 159,942,123 (GRCm39) missense probably damaging 1.00
IGL02572:Tnn APN 1 159,913,677 (GRCm39) missense probably damaging 1.00
IGL02740:Tnn APN 1 159,968,347 (GRCm39) splice site probably benign
IGL02818:Tnn APN 1 159,943,848 (GRCm39) missense possibly damaging 0.86
IGL03284:Tnn APN 1 159,953,022 (GRCm39) missense probably benign 0.01
1mM(1):Tnn UTSW 1 159,924,911 (GRCm39) missense probably damaging 1.00
PIT4305001:Tnn UTSW 1 159,913,647 (GRCm39) missense possibly damaging 0.91
R0023:Tnn UTSW 1 159,932,498 (GRCm39) missense probably benign 0.00
R0234:Tnn UTSW 1 159,916,036 (GRCm39) missense probably damaging 1.00
R0234:Tnn UTSW 1 159,916,036 (GRCm39) missense probably damaging 1.00
R0316:Tnn UTSW 1 159,948,137 (GRCm39) missense possibly damaging 0.93
R0492:Tnn UTSW 1 159,948,327 (GRCm39) missense probably damaging 0.99
R0547:Tnn UTSW 1 159,943,907 (GRCm39) intron probably benign
R1067:Tnn UTSW 1 159,952,968 (GRCm39) missense probably damaging 1.00
R1563:Tnn UTSW 1 159,952,985 (GRCm39) missense probably damaging 1.00
R1565:Tnn UTSW 1 159,924,835 (GRCm39) missense probably damaging 1.00
R1615:Tnn UTSW 1 159,945,978 (GRCm39) missense possibly damaging 0.93
R1637:Tnn UTSW 1 159,975,170 (GRCm39) missense probably damaging 1.00
R1707:Tnn UTSW 1 159,972,714 (GRCm39) missense probably damaging 1.00
R1758:Tnn UTSW 1 159,975,154 (GRCm39) missense possibly damaging 0.61
R1797:Tnn UTSW 1 159,968,258 (GRCm39) missense probably damaging 1.00
R1847:Tnn UTSW 1 159,943,752 (GRCm39) missense possibly damaging 0.51
R1925:Tnn UTSW 1 159,924,799 (GRCm39) missense probably damaging 1.00
R2182:Tnn UTSW 1 159,968,170 (GRCm39) splice site probably null
R2196:Tnn UTSW 1 159,924,798 (GRCm39) nonsense probably null
R2225:Tnn UTSW 1 159,975,035 (GRCm39) missense probably damaging 1.00
R2227:Tnn UTSW 1 159,975,035 (GRCm39) missense probably damaging 1.00
R2286:Tnn UTSW 1 159,938,079 (GRCm39) missense possibly damaging 0.89
R2850:Tnn UTSW 1 159,966,857 (GRCm39) missense probably benign 0.00
R3110:Tnn UTSW 1 159,943,856 (GRCm39) missense possibly damaging 0.71
R3111:Tnn UTSW 1 159,934,625 (GRCm39) missense probably damaging 0.98
R3112:Tnn UTSW 1 159,943,856 (GRCm39) missense possibly damaging 0.71
R3729:Tnn UTSW 1 159,973,810 (GRCm39) missense probably damaging 1.00
R4183:Tnn UTSW 1 159,924,925 (GRCm39) missense probably damaging 1.00
R4439:Tnn UTSW 1 159,943,650 (GRCm39) missense probably benign
R4441:Tnn UTSW 1 159,943,650 (GRCm39) missense probably benign
R4588:Tnn UTSW 1 159,972,681 (GRCm39) missense probably benign 0.25
R4646:Tnn UTSW 1 159,973,612 (GRCm39) missense probably benign
R4647:Tnn UTSW 1 159,973,612 (GRCm39) missense probably benign
R4648:Tnn UTSW 1 159,973,612 (GRCm39) missense probably benign
R4701:Tnn UTSW 1 159,975,338 (GRCm39) missense possibly damaging 0.72
R4737:Tnn UTSW 1 159,973,659 (GRCm39) missense probably damaging 1.00
R4801:Tnn UTSW 1 159,972,603 (GRCm39) missense possibly damaging 0.90
R4802:Tnn UTSW 1 159,972,603 (GRCm39) missense possibly damaging 0.90
R4868:Tnn UTSW 1 159,958,443 (GRCm39) missense possibly damaging 0.64
R4977:Tnn UTSW 1 159,948,188 (GRCm39) missense probably damaging 1.00
R5011:Tnn UTSW 1 159,953,949 (GRCm39) missense possibly damaging 0.89
R5026:Tnn UTSW 1 159,973,707 (GRCm39) missense probably benign 0.00
R5027:Tnn UTSW 1 159,972,781 (GRCm39) missense probably damaging 1.00
R5049:Tnn UTSW 1 159,968,308 (GRCm39) missense probably benign 0.00
R5119:Tnn UTSW 1 159,948,122 (GRCm39) missense probably damaging 0.98
R5128:Tnn UTSW 1 159,950,464 (GRCm39) missense probably damaging 0.98
R5234:Tnn UTSW 1 159,972,569 (GRCm39) missense possibly damaging 0.95
R5398:Tnn UTSW 1 159,975,092 (GRCm39) missense probably benign 0.00
R5424:Tnn UTSW 1 159,950,272 (GRCm39) missense possibly damaging 0.69
R5452:Tnn UTSW 1 159,937,831 (GRCm39) missense probably benign 0.13
R5466:Tnn UTSW 1 159,948,106 (GRCm39) missense possibly damaging 0.93
R6022:Tnn UTSW 1 159,937,928 (GRCm39) missense probably benign 0.00
R6062:Tnn UTSW 1 159,925,848 (GRCm39) missense probably damaging 1.00
R6086:Tnn UTSW 1 159,913,690 (GRCm39) missense probably damaging 1.00
R6132:Tnn UTSW 1 159,973,641 (GRCm39) missense probably damaging 0.96
R6324:Tnn UTSW 1 159,972,774 (GRCm39) missense probably damaging 0.96
R6455:Tnn UTSW 1 159,942,289 (GRCm39) missense probably damaging 1.00
R6563:Tnn UTSW 1 159,915,968 (GRCm39) missense probably damaging 1.00
R6650:Tnn UTSW 1 159,942,153 (GRCm39) missense probably damaging 1.00
R6806:Tnn UTSW 1 159,948,278 (GRCm39) missense possibly damaging 0.95
R6810:Tnn UTSW 1 159,932,412 (GRCm39) missense probably damaging 1.00
R7157:Tnn UTSW 1 159,953,947 (GRCm39) nonsense probably null
R7243:Tnn UTSW 1 159,934,687 (GRCm39) missense probably benign 0.07
R7340:Tnn UTSW 1 159,973,592 (GRCm39) missense probably damaging 0.98
R7472:Tnn UTSW 1 159,937,917 (GRCm39) missense probably benign 0.12
R7502:Tnn UTSW 1 159,937,929 (GRCm39) missense probably benign 0.00
R7527:Tnn UTSW 1 159,946,074 (GRCm39) missense possibly damaging 0.51
R7608:Tnn UTSW 1 159,915,984 (GRCm39) nonsense probably null
R7746:Tnn UTSW 1 159,942,255 (GRCm39) missense probably damaging 0.97
R8096:Tnn UTSW 1 159,950,411 (GRCm39) missense probably damaging 1.00
R8136:Tnn UTSW 1 159,934,630 (GRCm39) missense probably damaging 0.96
R8191:Tnn UTSW 1 159,953,088 (GRCm39) missense probably damaging 1.00
R8334:Tnn UTSW 1 159,946,053 (GRCm39) missense probably damaging 1.00
R8335:Tnn UTSW 1 159,946,053 (GRCm39) missense probably damaging 1.00
R8337:Tnn UTSW 1 159,946,053 (GRCm39) missense probably damaging 1.00
R8338:Tnn UTSW 1 159,946,053 (GRCm39) missense probably damaging 1.00
R8427:Tnn UTSW 1 159,958,256 (GRCm39) missense probably damaging 0.99
R8433:Tnn UTSW 1 159,924,790 (GRCm39) missense possibly damaging 0.81
R8479:Tnn UTSW 1 159,950,397 (GRCm39) missense probably benign 0.06
R8505:Tnn UTSW 1 159,973,593 (GRCm39) missense probably damaging 0.98
R8554:Tnn UTSW 1 159,937,986 (GRCm39) missense probably damaging 1.00
R8717:Tnn UTSW 1 159,943,846 (GRCm39) missense possibly damaging 0.51
R8850:Tnn UTSW 1 159,937,814 (GRCm39) critical splice donor site probably null
R8928:Tnn UTSW 1 159,953,099 (GRCm39) missense probably damaging 1.00
R9209:Tnn UTSW 1 159,953,986 (GRCm39) missense probably benign 0.02
X0019:Tnn UTSW 1 159,913,716 (GRCm39) missense probably damaging 1.00
Z1176:Tnn UTSW 1 159,973,863 (GRCm39) missense probably benign
Z1177:Tnn UTSW 1 159,954,097 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- ATTACCTGTGTGACCTTCGGTG -3'
(R):5'- TGTGGAACCAAGAGTCTCTGTC -3'

Sequencing Primer
(F):5'- ACCTTCGGTGTTGGCTTTC -3'
(R):5'- CCAAGAGTCTCTGTCTATGAGATCAC -3'
Posted On 2015-10-21