Incidental Mutation 'R4704:Mical3'
ID 356289
Institutional Source Beutler Lab
Gene Symbol Mical3
Ensembl Gene ENSMUSG00000051586
Gene Name microtubule associated monooxygenase, calponin and LIM domain containing 3
Synonyms C130040D16Rik, MICAL-3
MMRRC Submission 041952-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.154) question?
Stock # R4704 (G1)
Quality Score 225
Status Validated
Chromosome 6
Chromosomal Location 120908668-121107959 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 120935649 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 1626 (S1626P)
Ref Sequence ENSEMBL: ENSMUSP00000146544 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000207889]
AlphaFold Q8CJ19
Predicted Effect noncoding transcript
Transcript: ENSMUST00000098457
SMART Domains Protein: ENSMUSP00000096056
Gene: ENSMUSG00000051586

DomainStartEndE-ValueType
low complexity region 33 45 N/A INTRINSIC
low complexity region 57 80 N/A INTRINSIC
coiled coil region 114 148 N/A INTRINSIC
low complexity region 191 225 N/A INTRINSIC
coiled coil region 238 265 N/A INTRINSIC
low complexity region 317 330 N/A INTRINSIC
low complexity region 374 383 N/A INTRINSIC
low complexity region 548 562 N/A INTRINSIC
low complexity region 582 592 N/A INTRINSIC
low complexity region 625 637 N/A INTRINSIC
low complexity region 794 824 N/A INTRINSIC
low complexity region 861 882 N/A INTRINSIC
low complexity region 911 929 N/A INTRINSIC
low complexity region 950 962 N/A INTRINSIC
DUF3585 968 1110 1.39e-65 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000124669
Predicted Effect noncoding transcript
Transcript: ENSMUST00000142924
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150503
SMART Domains Protein: ENSMUSP00000115131
Gene: ENSMUSG00000051586

DomainStartEndE-ValueType
SCOP:d1bjt__ 41 141 8e-3 SMART
coiled coil region 192 219 N/A INTRINSIC
low complexity region 271 284 N/A INTRINSIC
low complexity region 328 337 N/A INTRINSIC
low complexity region 502 516 N/A INTRINSIC
low complexity region 536 546 N/A INTRINSIC
low complexity region 579 591 N/A INTRINSIC
low complexity region 748 778 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000151602
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203013
Predicted Effect probably benign
Transcript: ENSMUST00000207889
AA Change: S1626P

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
Predicted Effect unknown
Transcript: ENSMUST00000212333
AA Change: S754P
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency 97% (89/92)
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057M21Rik A T 7: 130,959,259 (GRCm39) M147K probably damaging Het
Abca13 A G 11: 9,226,990 (GRCm39) D582G possibly damaging Het
Abca2 T C 2: 25,333,424 (GRCm39) L1683P probably damaging Het
Adam39 A G 8: 41,278,833 (GRCm39) H408R probably benign Het
Adcy4 A G 14: 56,012,482 (GRCm39) S554P possibly damaging Het
Ahnak T C 19: 8,990,545 (GRCm39) I3943T probably damaging Het
Ahnak T G 19: 8,989,622 (GRCm39) probably benign Het
Alkal2 T A 12: 30,937,195 (GRCm39) S109R probably damaging Het
Apobec4 A G 1: 152,632,001 (GRCm39) T10A probably benign Het
Arhgef40 A G 14: 52,239,767 (GRCm39) N1327S probably damaging Het
Arpc3 A G 5: 122,538,471 (GRCm39) M1V probably null Het
Ascc1 A G 10: 59,885,624 (GRCm39) Y225C probably damaging Het
Ascc3 A G 10: 50,535,110 (GRCm39) I668V probably benign Het
Bdnf T A 2: 109,554,037 (GRCm39) M137K possibly damaging Het
Cacna1b T C 2: 24,544,475 (GRCm39) D1231G probably damaging Het
Cds2 T A 2: 132,142,522 (GRCm39) Y239* probably null Het
Cpped1 G A 16: 11,703,493 (GRCm39) probably benign Het
Ctu2 G A 8: 123,206,042 (GRCm39) R261Q probably damaging Het
Cux1 A G 5: 136,278,055 (GRCm39) V645A probably benign Het
Cyp4f13 A G 17: 33,144,709 (GRCm39) C401R probably damaging Het
Dpt T G 1: 164,646,518 (GRCm39) Y162* probably null Het
Ednra A G 8: 78,394,592 (GRCm39) probably benign Het
Eepd1 A G 9: 25,394,122 (GRCm39) T129A probably benign Het
Eif2s1 A G 12: 78,923,944 (GRCm39) T134A probably benign Het
Eloa A G 4: 135,738,525 (GRCm39) V145A probably benign Het
Enam T A 5: 88,651,650 (GRCm39) L1053* probably null Het
Eng T C 2: 32,568,924 (GRCm39) S484P probably benign Het
Eogt A T 6: 97,090,813 (GRCm39) V442E probably damaging Het
Fam185a C T 5: 21,685,471 (GRCm39) probably benign Het
Gm4922 C T 10: 18,660,567 (GRCm39) V52I probably benign Het
Gnao1 A G 8: 94,538,004 (GRCm39) E14G probably benign Het
Gpr75 C A 11: 30,841,110 (GRCm39) A5D probably benign Het
Hbq1b T A 11: 32,237,448 (GRCm39) probably benign Het
Hdac7 G A 15: 97,694,097 (GRCm39) T724M probably damaging Het
Ifi204 C A 1: 173,587,927 (GRCm39) probably benign Het
Ift88 A G 14: 57,718,307 (GRCm39) probably benign Het
Irak4 A G 15: 94,464,781 (GRCm39) probably null Het
Kalrn T C 16: 34,024,327 (GRCm39) D610G probably damaging Het
Kifc2 T C 15: 76,547,177 (GRCm39) probably null Het
Kmt2c G A 5: 25,519,025 (GRCm39) Q2362* probably null Het
Kntc1 G A 5: 123,949,496 (GRCm39) E1956K probably damaging Het
Lama3 T C 18: 12,686,280 (GRCm39) V2781A probably benign Het
Lipt2 A G 7: 99,809,534 (GRCm39) E207G probably damaging Het
Mag A T 7: 30,608,598 (GRCm39) L172Q probably damaging Het
Map1b A T 13: 99,566,983 (GRCm39) C1913S unknown Het
Mslnl G T 17: 25,957,952 (GRCm39) W65L possibly damaging Het
Muc20 G T 16: 32,599,448 (GRCm39) A3332S possibly damaging Het
Nadk C A 4: 155,669,684 (GRCm39) P157T probably benign Het
Nkx2-3 G A 19: 43,601,123 (GRCm39) E62K probably damaging Het
Or6c2 T C 10: 129,362,171 (GRCm39) L25P possibly damaging Het
Pclo A G 5: 14,726,494 (GRCm39) probably benign Het
Pcna-ps2 T A 19: 9,260,786 (GRCm39) V15E possibly damaging Het
Plekhg3 G T 12: 76,625,012 (GRCm39) G1285W probably damaging Het
Pramel29 A T 4: 143,935,162 (GRCm39) I193N probably damaging Het
Procr A G 2: 155,596,258 (GRCm39) S142G probably damaging Het
Ptpn3 A T 4: 57,270,119 (GRCm39) N14K possibly damaging Het
Rin1 C A 19: 5,105,018 (GRCm39) L693I probably damaging Het
Ripk4 C A 16: 97,547,204 (GRCm39) E290* probably null Het
Rnf213 A G 11: 119,331,175 (GRCm39) Y2128C probably damaging Het
Saal1 T C 7: 46,349,164 (GRCm39) probably benign Het
Selplg T C 5: 113,957,094 (GRCm39) D404G probably benign Het
Serpinf1 C A 11: 75,301,867 (GRCm39) A263S probably damaging Het
Sgo2b A T 8: 64,380,824 (GRCm39) D669E probably damaging Het
Slc30a9 T C 5: 67,499,616 (GRCm39) probably benign Het
Sri A T 5: 8,112,430 (GRCm39) probably null Het
Sspo G A 6: 48,475,638 (GRCm39) C4918Y probably damaging Het
Szt2 A G 4: 118,251,026 (GRCm39) Y361H probably damaging Het
Tbc1d12 T A 19: 38,889,781 (GRCm39) W404R probably damaging Het
Tcf20 T C 15: 82,735,928 (GRCm39) E1841G possibly damaging Het
Tep1 T C 14: 51,074,530 (GRCm39) T1832A probably benign Het
Tmem132e G A 11: 82,334,357 (GRCm39) A623T probably damaging Het
Tmem201 A T 4: 149,811,774 (GRCm39) F357Y possibly damaging Het
Trappc13 T G 13: 104,303,329 (GRCm39) probably benign Het
Trav6-5 C T 14: 53,728,883 (GRCm39) Q47* probably null Het
Ubxn1 T A 19: 8,849,399 (GRCm39) D47E probably benign Het
Vmn2r45 G T 7: 8,486,535 (GRCm39) S251* probably null Het
Wnk1 A G 6: 119,942,705 (GRCm39) L774S possibly damaging Het
Zfp189 T C 4: 49,530,081 (GRCm39) S395P probably damaging Het
Other mutations in Mical3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00569:Mical3 APN 6 120,938,585 (GRCm39) missense possibly damaging 0.73
IGL00718:Mical3 APN 6 121,017,410 (GRCm39) missense probably damaging 0.98
IGL00940:Mical3 APN 6 120,999,371 (GRCm39) missense possibly damaging 0.55
IGL00973:Mical3 APN 6 120,911,885 (GRCm39) splice site probably benign
IGL01503:Mical3 APN 6 120,935,537 (GRCm39) missense probably benign 0.09
IGL01991:Mical3 APN 6 120,912,172 (GRCm39) missense probably damaging 0.98
IGL02794:Mical3 APN 6 120,984,270 (GRCm39) missense probably damaging 0.99
IGL02996:Mical3 APN 6 120,935,519 (GRCm39) missense probably damaging 1.00
IGL03105:Mical3 APN 6 121,019,199 (GRCm39) missense probably benign 0.01
IGL03109:Mical3 APN 6 120,986,085 (GRCm39) missense probably damaging 1.00
IGL03236:Mical3 APN 6 120,946,345 (GRCm39) missense probably benign 0.00
P0028:Mical3 UTSW 6 121,001,650 (GRCm39) missense probably benign 0.33
R0244:Mical3 UTSW 6 120,934,683 (GRCm39) missense probably benign 0.00
R0494:Mical3 UTSW 6 120,936,162 (GRCm39) missense possibly damaging 0.94
R0586:Mical3 UTSW 6 121,006,602 (GRCm39) unclassified probably benign
R1029:Mical3 UTSW 6 120,911,639 (GRCm39) missense probably benign 0.02
R1263:Mical3 UTSW 6 120,929,430 (GRCm39) missense probably damaging 0.99
R1507:Mical3 UTSW 6 121,019,199 (GRCm39) missense probably benign 0.36
R1527:Mical3 UTSW 6 121,001,740 (GRCm39) missense probably damaging 0.99
R1623:Mical3 UTSW 6 121,001,768 (GRCm39) missense probably damaging 0.99
R1680:Mical3 UTSW 6 120,936,604 (GRCm39) missense probably benign 0.09
R1697:Mical3 UTSW 6 120,984,369 (GRCm39) missense possibly damaging 0.84
R1817:Mical3 UTSW 6 121,019,196 (GRCm39) missense probably benign 0.06
R1875:Mical3 UTSW 6 121,019,025 (GRCm39) missense probably damaging 1.00
R1961:Mical3 UTSW 6 120,959,568 (GRCm39) missense possibly damaging 0.94
R2004:Mical3 UTSW 6 120,928,283 (GRCm39) missense probably damaging 1.00
R2093:Mical3 UTSW 6 121,017,347 (GRCm39) missense probably damaging 1.00
R2141:Mical3 UTSW 6 121,008,095 (GRCm39) splice site probably null
R2142:Mical3 UTSW 6 121,008,095 (GRCm39) splice site probably null
R2257:Mical3 UTSW 6 121,010,696 (GRCm39) missense possibly damaging 0.94
R2404:Mical3 UTSW 6 120,936,789 (GRCm39) missense probably benign 0.01
R2419:Mical3 UTSW 6 120,936,884 (GRCm39) missense probably benign
R2509:Mical3 UTSW 6 121,011,118 (GRCm39) missense probably damaging 1.00
R3784:Mical3 UTSW 6 120,998,298 (GRCm39) missense probably benign 0.00
R4342:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4343:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4579:Mical3 UTSW 6 120,935,660 (GRCm39) missense probably benign
R4603:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4605:Mical3 UTSW 6 121,011,041 (GRCm39) nonsense probably null
R4610:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4611:Mical3 UTSW 6 120,911,799 (GRCm39) nonsense probably null
R4623:Mical3 UTSW 6 120,938,586 (GRCm39) nonsense probably null
R4669:Mical3 UTSW 6 120,934,664 (GRCm39) missense probably damaging 0.98
R4722:Mical3 UTSW 6 121,015,486 (GRCm39) missense probably benign 0.00
R4863:Mical3 UTSW 6 121,010,748 (GRCm39) missense probably damaging 0.99
R4878:Mical3 UTSW 6 120,946,348 (GRCm39) missense possibly damaging 0.51
R4885:Mical3 UTSW 6 120,912,214 (GRCm39) missense probably damaging 1.00
R4907:Mical3 UTSW 6 120,984,259 (GRCm39) missense probably benign 0.00
R5007:Mical3 UTSW 6 121,015,030 (GRCm39) missense probably damaging 0.98
R5299:Mical3 UTSW 6 120,936,473 (GRCm39) missense possibly damaging 0.71
R5303:Mical3 UTSW 6 120,936,941 (GRCm39) missense probably benign
R5368:Mical3 UTSW 6 120,936,434 (GRCm39) missense probably damaging 1.00
R5955:Mical3 UTSW 6 121,010,711 (GRCm39) missense probably damaging 0.99
R5970:Mical3 UTSW 6 120,935,232 (GRCm39) nonsense probably null
R6000:Mical3 UTSW 6 120,998,281 (GRCm39) missense probably benign 0.06
R6101:Mical3 UTSW 6 121,010,671 (GRCm39) missense probably damaging 1.00
R6195:Mical3 UTSW 6 120,993,796 (GRCm39) intron probably benign
R6210:Mical3 UTSW 6 121,017,478 (GRCm39) splice site probably null
R6225:Mical3 UTSW 6 120,935,684 (GRCm39) missense probably damaging 0.98
R6258:Mical3 UTSW 6 120,985,991 (GRCm39) missense probably damaging 1.00
R6260:Mical3 UTSW 6 120,985,991 (GRCm39) missense probably damaging 1.00
R6349:Mical3 UTSW 6 120,936,486 (GRCm39) missense probably benign
R6352:Mical3 UTSW 6 120,929,434 (GRCm39) missense probably damaging 0.97
R6480:Mical3 UTSW 6 121,011,236 (GRCm39) missense possibly damaging 0.76
R6704:Mical3 UTSW 6 120,986,761 (GRCm39) intron probably benign
R6783:Mical3 UTSW 6 120,935,786 (GRCm39) missense possibly damaging 0.85
R6925:Mical3 UTSW 6 120,936,351 (GRCm39) missense probably benign 0.05
R6960:Mical3 UTSW 6 120,935,504 (GRCm39) missense probably damaging 1.00
R7170:Mical3 UTSW 6 120,950,694 (GRCm39) splice site probably null
R7344:Mical3 UTSW 6 121,013,505 (GRCm39) nonsense probably null
R7414:Mical3 UTSW 6 121,011,074 (GRCm39) missense probably damaging 1.00
R7455:Mical3 UTSW 6 120,935,705 (GRCm39) missense probably damaging 1.00
R7649:Mical3 UTSW 6 120,911,909 (GRCm39) missense probably damaging 1.00
R8236:Mical3 UTSW 6 120,989,504 (GRCm39) missense
R8286:Mical3 UTSW 6 120,998,149 (GRCm39) missense possibly damaging 0.68
R8316:Mical3 UTSW 6 120,911,944 (GRCm39) missense probably damaging 1.00
R8328:Mical3 UTSW 6 120,912,138 (GRCm39) missense probably damaging 0.98
R8354:Mical3 UTSW 6 120,950,381 (GRCm39) missense probably damaging 0.99
R8511:Mical3 UTSW 6 121,015,513 (GRCm39) missense possibly damaging 0.78
R8687:Mical3 UTSW 6 120,936,438 (GRCm39) missense probably benign 0.19
R8728:Mical3 UTSW 6 120,950,514 (GRCm39) missense probably damaging 0.99
R8925:Mical3 UTSW 6 120,984,325 (GRCm39) missense probably benign 0.00
R8927:Mical3 UTSW 6 120,984,325 (GRCm39) missense probably benign 0.00
R8986:Mical3 UTSW 6 120,991,822 (GRCm39) missense
R9026:Mical3 UTSW 6 120,986,848 (GRCm39) splice site probably benign
R9415:Mical3 UTSW 6 120,934,712 (GRCm39) missense probably damaging 1.00
R9515:Mical3 UTSW 6 121,001,758 (GRCm39) missense probably damaging 1.00
R9720:Mical3 UTSW 6 120,935,238 (GRCm39) missense probably damaging 0.99
R9777:Mical3 UTSW 6 120,959,529 (GRCm39) missense possibly damaging 0.91
U24488:Mical3 UTSW 6 120,978,457 (GRCm39) missense possibly damaging 0.90
Z1177:Mical3 UTSW 6 120,936,689 (GRCm39) missense possibly damaging 0.71
Z1190:Mical3 UTSW 6 120,998,319 (GRCm39) critical splice acceptor site probably null
Predicted Primers PCR Primer
(F):5'- TACCACATCTTCTGGGAGGC -3'
(R):5'- AGGAGAAGTTCTTCACACCCC -3'

Sequencing Primer
(F):5'- AGAAGAGCGACGACCTCTTTTTG -3'
(R):5'- GAAGCTCCAGGCCAAGG -3'
Posted On 2015-10-21