Mutagenetix > Incidental Mutation

Incidental Mutation 'R3735:Zfp629'

356343

Institutional Source

Beutler Lab

Gene Symbol

Zfp629

Ensembl Gene

ENSMUSG00000045639

Gene Name

zinc finger protein 629

Synonyms

9330199A09Rik

MMRRC Submission

040722-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.220) question?

Stock #

R3735 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

127206203-127214969 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

T to A at 127211950 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000114772 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000058038] [ENSMUST00000084564] [ENSMUST00000122066] [ENSMUST00000128731] [ENSMUST00000131318] [ENSMUST00000132524] [ENSMUST00000134446] [ENSMUST00000151107] [ENSMUST00000152315]

AlphaFold

Q6A085

Predicted Effect

probably benign
Transcript: ENSMUST00000058038

SMART Domains

Protein: ENSMUSP00000053760
Gene: ENSMUSG00000045639

Domain	Start	End	E-Value	Type
low complexity region	27	43	N/A	INTRINSIC
low complexity region	93	104	N/A	INTRINSIC
ZnF_C2H2	149	171	4.01e-5	SMART
ZnF_C2H2	177	199	2.09e-3	SMART
ZnF_C2H2	205	227	6.08e-5	SMART
ZnF_C2H2	233	255	2.99e-4	SMART
ZnF_C2H2	261	283	1.45e-2	SMART
ZnF_C2H2	289	311	1.13e-4	SMART
ZnF_C2H2	317	339	9.88e-5	SMART
ZnF_C2H2	345	367	9.73e-4	SMART
ZnF_C2H2	373	395	9.22e-5	SMART
ZnF_C2H2	401	423	6.08e-5	SMART
ZnF_C2H2	429	451	7.78e-3	SMART
ZnF_C2H2	457	479	3.95e-4	SMART
ZnF_C2H2	485	507	1.15e-5	SMART
ZnF_C2H2	513	535	2.91e-2	SMART
ZnF_C2H2	568	590	9.58e-3	SMART
ZnF_C2H2	661	683	3.16e-3	SMART
ZnF_C2H2	713	735	9.73e-4	SMART
low complexity region	737	754	N/A	INTRINSIC
ZnF_C2H2	766	788	2.57e-3	SMART
ZnF_C2H2	840	862	1.14e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000084564

SMART Domains

Protein: ENSMUSP00000081612
Gene: ENSMUSG00000045639

Domain	Start	End	E-Value	Type
low complexity region	27	43	N/A	INTRINSIC
low complexity region	93	104	N/A	INTRINSIC
ZnF_C2H2	149	171	4.01e-5	SMART
ZnF_C2H2	177	199	2.09e-3	SMART
ZnF_C2H2	205	227	6.08e-5	SMART
ZnF_C2H2	233	255	2.99e-4	SMART
ZnF_C2H2	261	283	1.45e-2	SMART
ZnF_C2H2	289	311	1.13e-4	SMART
ZnF_C2H2	317	339	9.88e-5	SMART
ZnF_C2H2	345	367	9.73e-4	SMART
ZnF_C2H2	373	395	9.22e-5	SMART
ZnF_C2H2	401	423	6.08e-5	SMART
ZnF_C2H2	429	451	7.78e-3	SMART
ZnF_C2H2	457	479	3.95e-4	SMART
ZnF_C2H2	485	507	1.15e-5	SMART
ZnF_C2H2	513	535	2.91e-2	SMART
ZnF_C2H2	568	590	9.58e-3	SMART
ZnF_C2H2	661	683	3.16e-3	SMART
ZnF_C2H2	713	735	9.73e-4	SMART
low complexity region	737	754	N/A	INTRINSIC
ZnF_C2H2	766	788	2.57e-3	SMART
ZnF_C2H2	840	862	1.14e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000122066

SMART Domains

Protein: ENSMUSP00000113903
Gene: ENSMUSG00000045639

Domain	Start	End	E-Value	Type
low complexity region	27	43	N/A	INTRINSIC
low complexity region	93	104	N/A	INTRINSIC
ZnF_C2H2	149	171	4.01e-5	SMART
ZnF_C2H2	177	199	2.09e-3	SMART
ZnF_C2H2	205	227	6.08e-5	SMART
ZnF_C2H2	233	255	2.99e-4	SMART
ZnF_C2H2	261	283	1.45e-2	SMART
ZnF_C2H2	289	311	1.13e-4	SMART
ZnF_C2H2	317	339	9.88e-5	SMART
ZnF_C2H2	345	367	9.73e-4	SMART
ZnF_C2H2	373	395	9.22e-5	SMART
ZnF_C2H2	401	423	6.08e-5	SMART
ZnF_C2H2	429	451	7.78e-3	SMART
ZnF_C2H2	457	479	3.95e-4	SMART
ZnF_C2H2	485	507	1.15e-5	SMART
ZnF_C2H2	513	535	2.91e-2	SMART
ZnF_C2H2	568	590	9.58e-3	SMART
ZnF_C2H2	661	683	3.16e-3	SMART
ZnF_C2H2	713	735	9.73e-4	SMART
low complexity region	737	754	N/A	INTRINSIC
ZnF_C2H2	766	788	2.57e-3	SMART
ZnF_C2H2	840	862	1.14e0	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000128731

SMART Domains

Protein: ENSMUSP00000140505
Gene: ENSMUSG00000045639

Domain	Start	End	E-Value	Type
low complexity region	78	90	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000131318

SMART Domains

Protein: ENSMUSP00000116375
Gene: ENSMUSG00000045639

Domain	Start	End	E-Value	Type
low complexity region	27	43	N/A	INTRINSIC
low complexity region	93	104	N/A	INTRINSIC
ZnF_C2H2	149	171	4.01e-5	SMART
ZnF_C2H2	177	199	2.09e-3	SMART
ZnF_C2H2	205	227	6.08e-5	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000132524

Predicted Effect

probably benign
Transcript: ENSMUST00000134446

Predicted Effect

probably benign
Transcript: ENSMUST00000151107

Predicted Effect

probably benign
Transcript: ENSMUST00000152315

SMART Domains

Protein: ENSMUSP00000114772
Gene: ENSMUSG00000045639

Domain	Start	End	E-Value	Type
low complexity region	27	43	N/A	INTRINSIC
low complexity region	93	104	N/A	INTRINSIC
ZnF_C2H2	149	171	4.01e-5	SMART
ZnF_C2H2	177	195	1.24e2	SMART

Meta Mutation Damage Score

0.0898

Coding Region Coverage

1x: 99.1%
3x: 98.5%
10x: 97.1%
20x: 94.3%

Validation Efficiency

100% (71/71)

Allele List at MGI

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4921539E11Rik	C	G	4: 103,123,603 (GRCm39)	E90Q	probably damaging	Het
Acadl	G	A	1: 66,892,448 (GRCm39)	A125V	probably benign	Het
Acot12	T	A	13: 91,932,465 (GRCm39)	I487N	probably benign	Het
Acox3	A	G	5: 35,768,497 (GRCm39)	K686R	probably benign	Het
Adam17	T	C	12: 21,375,413 (GRCm39)	D802G	probably benign	Het
Aoc3	A	T	11: 101,223,045 (GRCm39)	D427V	probably damaging	Het
Bivm	C	T	1: 44,165,594 (GRCm39)	H15Y	probably benign	Het
C8a	T	C	4: 104,674,812 (GRCm39)	E509G	probably benign	Het
Ccdc158	A	C	5: 92,780,283 (GRCm39)	L930R	possibly damaging	Het
Cdca7	T	A	2: 72,314,209 (GRCm39)		probably null	Het
Cep170b	A	T	12: 112,707,438 (GRCm39)	I395F	probably damaging	Het
Champ1	T	C	8: 13,928,735 (GRCm39)	S298P	probably damaging	Het
Cimip2c	A	T	5: 30,639,442 (GRCm39)	Y123F	probably benign	Het
Cyp2j8	T	A	4: 96,332,836 (GRCm39)	R503S	probably damaging	Het
Dcaf10	C	T	4: 45,348,117 (GRCm39)	T191I	probably benign	Het
Dido1	A	G	2: 180,325,829 (GRCm39)		probably benign	Het
Dnah7b	C	T	1: 46,339,035 (GRCm39)	T3361I	probably benign	Het
Dync1h1	G	A	12: 110,598,109 (GRCm39)	V1767I	probably benign	Het
Eml5	G	A	12: 98,822,248 (GRCm39)	T721I	possibly damaging	Het
F8	G	A	X: 74,254,981 (GRCm39)	P2138S	probably damaging	Het
Fam169b	G	T	7: 68,000,049 (GRCm39)	R198S	probably damaging	Het
Gm7694	A	G	1: 170,130,330 (GRCm39)	S23P	probably damaging	Het
Grk3	T	A	5: 113,101,697 (GRCm39)	T248S	probably benign	Het
Helq	T	G	5: 100,938,054 (GRCm39)	D464A	possibly damaging	Het
Ido2	C	T	8: 25,025,209 (GRCm39)	V273M	probably damaging	Het
Il12rb1	T	C	8: 71,269,862 (GRCm39)	L518P	probably damaging	Het
Irag2	G	A	6: 145,106,596 (GRCm39)		probably benign	Het
Kansl1l	A	G	1: 66,840,409 (GRCm39)	V297A	possibly damaging	Het
Kcnj10	A	G	1: 172,197,533 (GRCm39)	Y349C	possibly damaging	Het
Krt18	A	G	15: 101,936,936 (GRCm39)	T75A	probably benign	Het
Lrp4	A	T	2: 91,328,716 (GRCm39)	I1539F	probably damaging	Het
Map3k6	T	C	4: 132,973,683 (GRCm39)	V458A	probably benign	Het
Med12l	T	A	3: 58,998,916 (GRCm39)	H614Q	probably damaging	Het
Med13	A	C	11: 86,170,484 (GRCm39)	M1850R	probably benign	Het
Mfsd13a	A	G	19: 46,356,767 (GRCm39)	Y256C	probably damaging	Het
Mogs	C	A	6: 83,093,757 (GRCm39)	T242K	possibly damaging	Het
Myo9b	T	C	8: 71,801,241 (GRCm39)	V1133A	probably benign	Het
Myom2	A	T	8: 15,119,676 (GRCm39)	H144L	probably benign	Het
Ncapg	A	T	5: 45,853,469 (GRCm39)	Q906L	probably benign	Het
Nkx1-1	C	T	5: 33,591,074 (GRCm39)	V83I	unknown	Het
Npy4r	T	A	14: 33,869,226 (GRCm39)	T21S	probably benign	Het
Nup88	A	G	11: 70,847,018 (GRCm39)	S331P	probably damaging	Het
Olr1	T	A	6: 129,476,838 (GRCm39)		probably benign	Het
Or4k44	T	A	2: 111,368,241 (GRCm39)	H131L	probably damaging	Het
Osmr	A	T	15: 6,851,561 (GRCm39)	Y656N	probably damaging	Het
Otogl	A	T	10: 107,735,390 (GRCm39)	Y131*	probably null	Het
Pgr	G	A	9: 8,901,534 (GRCm39)	G356S	probably damaging	Het
Prdm2	T	C	4: 142,860,929 (GRCm39)	E787G	probably damaging	Het
Prpf18	A	G	2: 4,648,484 (GRCm39)	I114T	probably benign	Het
R3hdm2	T	A	10: 127,300,879 (GRCm39)	I280N	probably benign	Het
Rims4	T	C	2: 163,705,905 (GRCm39)	D243G	possibly damaging	Het
Rmnd5a	T	C	6: 71,373,846 (GRCm39)	D316G	possibly damaging	Het
Rpap2	T	C	5: 107,803,017 (GRCm39)		probably benign	Het
Sdr16c5	G	A	4: 4,005,614 (GRCm39)	T240I	probably benign	Het
Shroom3	T	C	5: 93,112,303 (GRCm39)	V1888A	possibly damaging	Het
Slc36a4	T	A	9: 15,649,569 (GRCm39)	Y466*	probably null	Het
Slco3a1	A	G	7: 74,154,245 (GRCm39)	I80T	probably damaging	Het
Sptlc2	G	A	12: 87,388,339 (GRCm39)	A381V	probably benign	Het
Stam	A	T	2: 14,133,823 (GRCm39)	Q190L	probably damaging	Het
Suclg2	T	A	6: 95,474,677 (GRCm39)	I363F	probably damaging	Het
Tacstd2	A	G	6: 67,511,843 (GRCm39)	V283A	probably damaging	Het
Tln1	G	T	4: 43,549,370 (GRCm39)	A616E	probably damaging	Het
Trdmt1	A	T	2: 13,524,684 (GRCm39)	F257Y	possibly damaging	Het
Trip12	TATACATACATACATACATACATACATACATAC	TATACATACATACATACATACATACATACATACATAC	1: 84,792,511 (GRCm39)		probably null	Het
Trps1	A	G	15: 50,709,456 (GRCm39)	I298T	possibly damaging	Het
Tti2	T	C	8: 31,645,925 (GRCm39)	L413P	probably damaging	Het
Utrn	A	G	10: 12,354,228 (GRCm39)	V343A	probably damaging	Het
Vwf	G	T	6: 125,565,576 (GRCm39)	W288L	probably damaging	Het
Zfp873	G	A	10: 81,897,015 (GRCm39)	S582N	probably benign	Het
Zfp979	A	G	4: 147,697,939 (GRCm39)	Y257H	possibly damaging	Het
Zfpm1	G	A	8: 123,050,475 (GRCm39)	C117Y	possibly damaging	Het

Other mutations in Zfp629

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00957:Zfp629	APN	7	127,211,896 (GRCm39)	missense	probably damaging	0.97
IGL01541:Zfp629	APN	7	127,211,917 (GRCm39)	utr 5 prime	probably benign
IGL02116:Zfp629	APN	7	127,211,890 (GRCm39)	missense	probably damaging	1.00
IGL02134:Zfp629	APN	7	127,211,042 (GRCm39)	missense	probably benign	0.22
IGL02547:Zfp629	APN	7	127,210,846 (GRCm39)	splice site	probably null
IGL02858:Zfp629	APN	7	127,209,484 (GRCm39)	missense	probably damaging	1.00
IGL02867:Zfp629	APN	7	127,209,203 (GRCm39)	unclassified	probably benign
IGL02889:Zfp629	APN	7	127,209,203 (GRCm39)	unclassified	probably benign
R6768_Zfp629_044	UTSW	7	127,209,997 (GRCm39)	missense	probably benign	0.03
R0020:Zfp629	UTSW	7	127,210,341 (GRCm39)	missense	probably benign	0.02
R0137:Zfp629	UTSW	7	127,210,858 (GRCm39)	missense	probably damaging	1.00
R0219:Zfp629	UTSW	7	127,211,255 (GRCm39)	missense	probably damaging	1.00
R1061:Zfp629	UTSW	7	127,211,161 (GRCm39)	missense	probably damaging	1.00
R1182:Zfp629	UTSW	7	127,209,274 (GRCm39)	missense	probably damaging	1.00
R1187:Zfp629	UTSW	7	127,209,401 (GRCm39)	missense	probably benign
R1187:Zfp629	UTSW	7	127,211,059 (GRCm39)	missense	probably damaging	1.00
R1217:Zfp629	UTSW	7	127,211,916 (GRCm39)	start gained	probably benign
R1507:Zfp629	UTSW	7	127,211,033 (GRCm39)	nonsense	probably null
R1526:Zfp629	UTSW	7	127,209,931 (GRCm39)	missense	possibly damaging	0.69
R1622:Zfp629	UTSW	7	127,211,012 (GRCm39)	missense	probably damaging	1.00
R1704:Zfp629	UTSW	7	127,210,036 (GRCm39)	missense	probably benign	0.06
R1918:Zfp629	UTSW	7	127,211,172 (GRCm39)	missense	probably damaging	1.00
R2147:Zfp629	UTSW	7	127,209,616 (GRCm39)	missense	probably damaging	1.00
R2156:Zfp629	UTSW	7	127,211,551 (GRCm39)	missense	probably benign	0.00
R2258:Zfp629	UTSW	7	127,210,963 (GRCm39)	missense	probably damaging	1.00
R2994:Zfp629	UTSW	7	127,210,228 (GRCm39)	missense	probably damaging	0.99
R4287:Zfp629	UTSW	7	127,211,110 (GRCm39)	missense	probably damaging	1.00
R4610:Zfp629	UTSW	7	127,211,492 (GRCm39)	missense	probably benign	0.26
R4758:Zfp629	UTSW	7	127,209,758 (GRCm39)	missense	probably damaging	1.00
R4899:Zfp629	UTSW	7	127,210,190 (GRCm39)	missense	possibly damaging	0.69
R4922:Zfp629	UTSW	7	127,211,299 (GRCm39)	missense	probably damaging	1.00
R5414:Zfp629	UTSW	7	127,210,454 (GRCm39)	missense	probably damaging	0.97
R5772:Zfp629	UTSW	7	127,210,307 (GRCm39)	missense	probably damaging	1.00
R5907:Zfp629	UTSW	7	127,209,542 (GRCm39)	missense	probably damaging	1.00
R6768:Zfp629	UTSW	7	127,209,997 (GRCm39)	missense	probably benign	0.03
R7122:Zfp629	UTSW	7	127,210,484 (GRCm39)	missense	probably damaging	0.99
R7156:Zfp629	UTSW	7	127,211,463 (GRCm39)	nonsense	probably null
R7407:Zfp629	UTSW	7	127,209,415 (GRCm39)	missense	probably benign
R7446:Zfp629	UTSW	7	127,210,201 (GRCm39)	missense	probably benign	0.00
R7780:Zfp629	UTSW	7	127,211,601 (GRCm39)	missense	probably benign	0.12
R7871:Zfp629	UTSW	7	127,211,167 (GRCm39)	missense	probably damaging	1.00
R8542:Zfp629	UTSW	7	127,210,364 (GRCm39)	nonsense	probably null
R9095:Zfp629	UTSW	7	127,209,547 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- AGAACATGGGGTCTGGTCTCTC -3'
(R):5'- TTCAGTGCAGGTACAGAGGG -3'

Sequencing Primer
(F):5'- ATGGGGTCTGGTCTCTCTTCCC -3'
(R):5'- TCAGTGCAGGTACAGAGGGTTATG -3'

Posted On

2015-10-28