Mutagenetix > Incidental Mutations

Incidental Mutation 'R0402:Olfr1431'

35648

Institutional Source

Beutler Lab

Gene Symbol

Olfr1431

Ensembl Gene

ENSMUSG00000094133

Gene Name

olfactory receptor 1431

Synonyms

GA_x6K02T2RE5P-2573738-2574676, MOR214-5

MMRRC Submission

038607-MU

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

R0402 (G1)

Quality Score

134

Status

Validated

Chromosome

Chromosomal Location

12200634-12212191 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 12209589 bp

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 8 (T8A)

Ref Sequence

ENSEMBL: ENSMUSP00000150967 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000072316] [ENSMUST00000213759]

Predicted Effect

probably damaging
Transcript: ENSMUST00000072316
AA Change: T8A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000072158
Gene: ENSMUSG00000094133
AA Change: T8A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	32	309	8.4e-56	PFAM
Pfam:7tm_1	42	309	2.4e-18	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000213759
AA Change: T8A

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214138

Meta Mutation Damage Score

0.032

Coding Region Coverage

1x: 98.2%
3x: 97.0%
10x: 94.5%
20x: 88.7%

Validation Efficiency

100% (74/74)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700017N19Rik	A	T	10: 100,609,253	K165N	probably damaging	Het
Adam6b	T	A	12: 113,489,995	M144K	probably damaging	Het
Arhgap44	T	C	11: 65,032,077		probably benign	Het
Arl5c	T	A	11: 97,995,113	I21F	probably damaging	Het
Bglap2	C	T	3: 88,378,245	G40D	probably damaging	Het
Bptf	T	C	11: 107,074,114	E1303G	probably damaging	Het
Calhm1	T	C	19: 47,141,457	T209A	probably damaging	Het
Ccr8	A	G	9: 120,094,910		probably null	Het
Chkb	C	T	15: 89,429,407	R65Q	probably benign	Het
Col4a1	T	C	8: 11,199,838		probably benign	Het
Cryzl2	A	G	1: 157,464,444	T98A	probably benign	Het
D430041D05Rik	T	C	2: 104,168,164	T1080A	probably damaging	Het
Dhx8	C	A	11: 101,752,397	T765N	probably damaging	Het
Dicer1	T	C	12: 104,731,064	D78G	probably benign	Het
Drd2	A	G	9: 49,404,971	I344V	probably benign	Het
Edil3	A	T	13: 89,199,451		probably benign	Het
Fam71a	T	C	1: 191,164,440	D2G	probably benign	Het
Fam71f1	A	G	6: 29,323,902	T209A	probably benign	Het
Fbxw19	C	T	9: 109,484,425	G235D	probably benign	Het
Fzd1	T	C	5: 4,755,702	K627E	possibly damaging	Het
Gm10638	A	G	8: 86,746,200		probably benign	Het
Gm14124	T	A	2: 150,269,216	C609S	possibly damaging	Het
H6pd	G	T	4: 149,996,316	A24E	probably damaging	Het
Hectd2	G	T	19: 36,601,529		probably null	Het
Hps5	A	G	7: 46,790,909		probably benign	Het
Irx3	T	C	8: 91,800,668	N136S	possibly damaging	Het
Kcmf1	T	C	6: 72,849,585	M1V	probably null	Het
Klrb1	A	T	6: 128,710,620	F104I	probably benign	Het
Lrfn5	T	C	12: 61,840,017	M197T	probably benign	Het
Mpdz	A	C	4: 81,361,440	M51R	possibly damaging	Het
Mtbp	G	T	15: 55,569,070	E258*	probably null	Het
Mylk3	T	A	8: 85,352,910	H373L	probably damaging	Het
Myrfl	A	G	10: 116,828,977	S383P	probably damaging	Het
Nt5c	T	C	11: 115,490,642	*195W	probably null	Het
Ocstamp	A	G	2: 165,396,264	V360A	possibly damaging	Het
Olfr1180	A	T	2: 88,412,034	V208D	probably damaging	Het
Olfr122	T	A	17: 37,772,393	C247S	probably damaging	Het
Olfr1277	A	G	2: 111,269,863	F168S	probably damaging	Het
Olfr1330	A	T	4: 118,893,229	I49F	possibly damaging	Het
Otop2	T	C	11: 115,326,408		probably benign	Het
Pom121l2	A	T	13: 21,988,479		probably benign	Het
Pon2	T	A	6: 5,272,410	K137*	probably null	Het
Ppip5k2	T	A	1: 97,719,854	Q1049L	probably benign	Het
Ralgapa2	C	T	2: 146,434,809	V504M	probably damaging	Het
Rph3a	G	A	5: 120,942,254	H654Y	probably damaging	Het
Sh2d1b1	T	C	1: 170,279,773		probably benign	Het
Slc15a2	G	A	16: 36,775,598	T154I	probably benign	Het
Slc45a3	T	C	1: 131,977,527	V96A	possibly damaging	Het
Slc7a4	A	G	16: 17,575,633	S101P	probably damaging	Het
Smco2	T	C	6: 146,871,135		probably benign	Het
Spata2	A	T	2: 167,483,660	V413E	probably benign	Het
Specc1l	A	G	10: 75,246,426	E552G	probably damaging	Het
Sstr5	C	T	17: 25,492,034	V74M	probably benign	Het
Timm50	G	A	7: 28,306,855	R274W	probably damaging	Het
Tll2	A	G	19: 41,098,693	V573A	possibly damaging	Het
Tm7sf3	C	A	6: 146,606,187	R459M	possibly damaging	Het
Txk	A	G	5: 72,731,762		probably null	Het
Uroc1	A	G	6: 90,347,302	D436G	probably damaging	Het
Vmn1r13	T	A	6: 57,210,098	Y81N	possibly damaging	Het
Vmn2r19	A	G	6: 123,336,182	E737G	probably damaging	Het
Wfs1	A	G	5: 36,976,980		probably benign	Het
Zfp1	G	A	8: 111,670,243	E285K	probably damaging	Het
Zfp661	G	A	2: 127,577,720	Q167*	probably null	Het
Zswim8	T	C	14: 20,710,766	F36S	probably damaging	Het
Zw10	A	G	9: 49,068,723	T385A	probably benign	Het

Other mutations in Olfr1431

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01330:Olfr1431	APN	19	12210040	missense	possibly damaging	0.65
IGL02206:Olfr1431	APN	19	12210460	missense	probably damaging	1.00
IGL02938:Olfr1431	APN	19	12209682	missense	probably benign	0.00
PIT4812001:Olfr1431	UTSW	19	12210253	missense	probably damaging	1.00
R0661:Olfr1431	UTSW	19	12209704	missense	probably damaging	1.00
R1193:Olfr1431	UTSW	19	12210439	missense	probably damaging	1.00
R1483:Olfr1431	UTSW	19	12209750	nonsense	probably null
R4091:Olfr1431	UTSW	19	12209779	missense	probably damaging	1.00
R4280:Olfr1431	UTSW	19	12209938	missense	probably damaging	1.00
R5028:Olfr1431	UTSW	19	12210154	missense	possibly damaging	0.94
R5540:Olfr1431	UTSW	19	12210460	missense	probably damaging	1.00
R6042:Olfr1431	UTSW	19	12209922	missense	probably damaging	0.99
R6045:Olfr1431	UTSW	19	12210295	missense	probably damaging	1.00
R7104:Olfr1431	UTSW	19	12209878	missense	possibly damaging	0.82
Z1088:Olfr1431	UTSW	19	12210490	missense	possibly damaging	0.55

Predicted Primers

PCR Primer
(F):5'- TTGGCATCAAGGAACTACCTGCTTC -3'
(R):5'- GGCAACATTCAGTCAGCCCCATAG -3'

Sequencing Primer
(F):5'- AGGAACTACCTGCTTCCTTCTAAAG -3'
(R):5'- CCCACAAAGCTGATAGTTTGG -3'

Posted On

2013-05-09