Mutagenetix > Incidental Mutation

Incidental Mutation 'R4735:Dock4'

356507

Institutional Source

Beutler Lab

Gene Symbol

Dock4

Ensembl Gene

ENSMUSG00000035954

Gene Name

dedicator of cytokinesis 4

Synonyms

EST N28122, 6330411N01Rik

MMRRC Submission

041962-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.178) question?

Stock #

R4735 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

40445952-40846874 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 40631526 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Isoleucine at position 75 (F75I)

Ref Sequence

ENSEMBL: ENSMUSP00000152420 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037488] [ENSMUST00000220912]

AlphaFold

P59764

Predicted Effect

probably benign
Transcript: ENSMUST00000037488
AA Change: F75I

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)

SMART Domains

Protein: ENSMUSP00000047387
Gene: ENSMUSG00000035954
AA Change: F75I

Domain	Start	End	E-Value	Type
SH3	9	66	7.29e-10	SMART
Pfam:DOCK_N	69	392	8.2e-110	PFAM
Pfam:DOCK-C2	397	583	1.9e-55	PFAM
low complexity region	829	842	N/A	INTRINSIC
Pfam:DHR-2	1092	1596	5e-108	PFAM
low complexity region	1651	1664	N/A	INTRINSIC
low complexity region	1681	1696	N/A	INTRINSIC
low complexity region	1700	1713	N/A	INTRINSIC
low complexity region	1842	1872	N/A	INTRINSIC
low complexity region	1883	1896	N/A	INTRINSIC
low complexity region	1940	1950	N/A	INTRINSIC
low complexity region	1958	1973	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000220912
AA Change: F75I

PolyPhen 2 Score 0.315 (Sensitivity: 0.90; Specificity: 0.89)

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000221758

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000222287

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000222798

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000222860

Coding Region Coverage

1x: 99.2%
3x: 98.6%
10x: 97.1%
20x: 95.0%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous disruption of this gene leads to complete embryonic lethality. Heterozygotes display altered blood vessel lumen formation. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 133 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2700049A03Rik	T	A	12: 71,216,123	I1410N	possibly damaging	Het
4932411N23Rik	T	A	X: 126,814,594	K296M	probably damaging	Het
4932438A13Rik	T	A	3: 37,004,967	N3267K	possibly damaging	Het
9230106D20Rik	T	C	10: 19,660,253		noncoding transcript	Het
Acsf3	T	A	8: 122,781,479	I238N	probably damaging	Het
Ahctf1	T	C	1: 179,753,399	N1746S	probably benign	Het
Akap3	T	C	6: 126,865,638	S407P	probably damaging	Het
Ankfy1	T	A	11: 72,730,611	M241K	probably benign	Het
Ano7	C	A	1: 93,400,494	T622K	probably benign	Het
App	T	C	16: 85,103,314	T83A	probably damaging	Het
Arhgef28	T	A	13: 97,899,729	E1674V	probably damaging	Het
Asb2	C	A	12: 103,325,058	V489L	probably benign	Het
Atrn	T	C	2: 131,020,990	V1330A	probably benign	Het
Brca1	A	G	11: 101,492,175		probably null	Het
Bspry	G	A	4: 62,486,525	R186Q	probably damaging	Het
Cdkn2d	C	G	9: 21,290,889	V21L	probably benign	Het
Celsr1	T	A	15: 85,906,029		probably null	Het
Ckap4	A	G	10: 84,533,520	V116A	possibly damaging	Het
Crb3	A	G	17: 57,065,207	T85A	probably damaging	Het
Cyld	T	C	8: 88,729,650	S443P	probably damaging	Het
Cyp27a1	T	G	1: 74,737,207	V434G	possibly damaging	Het
Cyp2b13	A	G	7: 26,088,295	T339A	probably benign	Het
Dars	A	T	1: 128,376,234	L252*	probably null	Het
Dcaf10	G	A	4: 45,372,769	R394Q	possibly damaging	Het
Ddx55	T	C	5: 124,566,476	F382S	probably damaging	Het
Dnah7b	G	A	1: 46,066,955	R33Q	unknown	Het
Dnm2	G	T	9: 21,474,587	S302I	probably damaging	Het
Dpp10	T	C	1: 123,398,627	N365S	probably benign	Het
Dpy19l3	G	T	7: 35,722,721	Q236K	probably benign	Het
Dsp	T	C	13: 38,196,040	S1655P	probably damaging	Het
Ebpl	A	T	14: 61,342,118	I117N	probably damaging	Het
Edc4	T	A	8: 105,887,186	V386E	probably damaging	Het
Eif2s2	T	A	2: 154,878,547		probably null	Het
Elob	A	T	17: 23,827,588		probably null	Het
Enox2	T	C	X: 49,069,677	I71V	probably damaging	Het
Fam160b1	A	G	19: 57,371,229	E67G	probably damaging	Het
Fez1	A	T	9: 36,860,845	K149*	probably null	Het
Fign	A	G	2: 63,980,438	Y163H	probably damaging	Het
Flnc	G	A	6: 29,455,813	G2048S	probably damaging	Het
Fras1	A	G	5: 96,588,163	D539G	probably benign	Het
Frmd4b	T	C	6: 97,459,259		probably benign	Het
Gan	C	T	8: 117,194,231	T402M	probably damaging	Het
Ganc	T	A	2: 120,436,623		silent	Het
Ggt6	C	A	11: 72,436,599	R103S	probably benign	Het
Gli2	T	C	1: 118,840,322	D725G	probably damaging	Het
Gm15446	T	A	5: 109,942,952	C357S	probably damaging	Het
Gm44501	A	G	17: 40,578,919	N108S	probably benign	Het
Gm6309	A	T	5: 146,168,244	D286E	probably damaging	Het
Gm6358	G	A	16: 89,140,960	G29E	unknown	Het
Gm8251	A	G	1: 44,061,701	I79T	probably benign	Het
Grik5	A	G	7: 25,058,288	I422T	probably damaging	Het
Grin2c	A	G	11: 115,249,596	I1232T	possibly damaging	Het
Gsg1	C	T	6: 135,237,407	R365H	possibly damaging	Het
H2-M2	A	G	17: 37,483,244	S30P	possibly damaging	Het
Hcfc2	A	G	10: 82,712,080	D302G	probably damaging	Het
Hk2	T	C	6: 82,744,974	D128G	probably benign	Het
Hmcn2	C	A	2: 31,383,775	Q1380K	probably benign	Het
Hsp90b1	G	T	10: 86,693,955	P617T	probably damaging	Het
Htr1d	A	G	4: 136,442,886	E142G	probably benign	Het
Hydin	G	A	8: 110,555,632		probably null	Het
Il1r1	T	A	1: 40,293,295	N81K	probably benign	Het
Inpp5b	T	C	4: 124,783,967	S407P	probably damaging	Het
Itpkb	T	C	1: 180,418,215	Y766H	probably damaging	Het
Lyrm2	T	A	4: 32,801,150	I65N	probably damaging	Het
Mink1	T	A	11: 70,609,260		probably null	Het
Mkrn3	C	T	7: 62,419,704	R113H	probably damaging	Het
Msx3	G	A	7: 140,047,885	A157V	probably damaging	Het
Nrxn2	T	G	19: 6,498,454	V59G	possibly damaging	Het
Nt5c3b	T	C	11: 100,440,906	T12A	probably benign	Het
Nwd2	G	A	5: 63,808,251	R1726Q	probably benign	Het
Nynrin	A	G	14: 55,870,168	T911A	probably benign	Het
Olfr1179	T	C	2: 88,402,923	T4A	probably benign	Het
Olfr266	T	A	3: 106,821,680	Y293F	probably damaging	Het
Olfr490	A	G	7: 108,286,313	M271T	probably benign	Het
Olfr609	C	T	7: 103,492,060	V273M	possibly damaging	Het
Olfr611	A	G	7: 103,517,823	I187T	possibly damaging	Het
Olfr659	C	T	7: 104,670,993	T97I	probably benign	Het
Olfr805	A	G	10: 129,722,923	I207T	probably benign	Het
Patl1	G	T	19: 11,922,505	M220I	probably benign	Het
Pcnx2	A	T	8: 125,828,041		probably null	Het
Pigr	A	T	1: 130,846,554	T424S	probably damaging	Het
Pik3c2b	T	A	1: 133,067,049	D250E	probably benign	Het
Ppa2	G	A	3: 133,370,425	E272K	probably benign	Het
Pramel7	G	A	2: 87,490,843	Q283*	probably null	Het
Prelid3b	A	G	2: 174,465,890	I81T	probably benign	Het
Prpf38a	T	C	4: 108,579,045	I24V	possibly damaging	Het
Ptger2	A	G	14: 45,001,838	D311G	possibly damaging	Het
Rab4b	A	T	7: 27,172,766		probably benign	Het
Rad17	A	C	13: 100,619,129	D581E	probably damaging	Het
Samd11	T	C	4: 156,248,773	T333A	probably benign	Het
Scaf4	C	T	16: 90,252,432	D256N	unknown	Het
Serinc2	A	G	4: 130,263,645	F82L	probably benign	Het
Serpina3g	T	A	12: 104,239,113	V37E	probably damaging	Het
Serpinb9c	T	A	13: 33,150,271	M263L	probably benign	Het
Shbg	A	G	11: 69,617,500	I67T	possibly damaging	Het
Slc25a48	G	A	13: 56,449,074		probably null	Het
Slc25a54	T	C	3: 109,098,607	W144R	probably damaging	Het
Slc34a1	A	T	13: 55,413,584	T621S	probably benign	Het
Slc6a18	A	T	13: 73,666,435	C419S	probably benign	Het
Smc5	A	T	19: 23,242,705	D389E	probably benign	Het
Smco3	T	A	6: 136,831,638	E79D	probably damaging	Het
Sox5	A	G	6: 143,960,835	F298S	probably damaging	Het
Sphkap	A	G	1: 83,279,117	S304P	probably benign	Het
Tcea2	C	T	2: 181,686,721	T211I	probably damaging	Het
Tcf4	G	T	18: 69,564,155	S34I	possibly damaging	Het
Tlr4	C	T	4: 66,841,198	R743C	probably damaging	Het
Tmem183a	T	C	1: 134,360,882	E67G	probably damaging	Het
Tpr	C	T	1: 150,442,196	R2152C	possibly damaging	Het
Trbv15	T	C	6: 41,141,424	I38T	probably benign	Het
Treh	G	A	9: 44,681,552	A125T	probably damaging	Het
Trio	A	T	15: 27,752,789		probably null	Het
Ttn	A	G	2: 76,951,949	V981A	probably damaging	Het
Uap1l1	A	G	2: 25,362,720	L436P	probably damaging	Het
Uba7	A	T	9: 107,976,916	I182F	possibly damaging	Het
Unc13c	A	T	9: 73,693,338	S1375T	probably benign	Het
Usp48	C	CT	4: 137,633,369		probably null	Het
Utp20	A	C	10: 88,816,918	V378G	possibly damaging	Het
Vmn1r69	A	T	7: 10,580,999		probably benign	Het
Vmn1r86	A	T	7: 13,102,294	H218Q	probably damaging	Het
Vmn2r121	T	A	X: 124,128,638	I562L	probably benign	Het
Vmn2r45	A	T	7: 8,483,473	I272N	probably damaging	Het
Wdr90	A	G	17: 25,859,450	V320A	probably benign	Het
Wfikkn1	A	G	17: 25,878,393	V319A	possibly damaging	Het
Whamm	A	G	7: 81,571,374	D18G	probably benign	Het
Wrn	T	A	8: 33,285,222	I605F	probably damaging	Het
Zdhhc18	A	G	4: 133,613,867	F232L	probably damaging	Het
Zfp41	T	C	15: 75,618,760	I187T	probably benign	Het
Zfp418	A	G	7: 7,182,562	Y508C	probably damaging	Het
Zfp560	T	G	9: 20,349,051	I172L	probably benign	Het
Zfp943	A	T	17: 21,992,410	D159V	probably benign	Het
Zfp955a	T	C	17: 33,241,722	I479V	probably benign	Het
Zfpm1	T	A	8: 122,335,480	V426D	probably benign	Het
Zic1	C	T	9: 91,364,505	M171I	possibly damaging	Het

Other mutations in Dock4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Dock4	APN	12	40832306	missense	possibly damaging	0.48
IGL00726:Dock4	APN	12	40790068	splice site	probably benign
IGL00790:Dock4	APN	12	40834391	missense	probably damaging	1.00
IGL01061:Dock4	APN	12	40702969	missense	probably benign	0.01
IGL01083:Dock4	APN	12	40788381	splice site	probably benign
IGL01412:Dock4	APN	12	40730041	splice site	probably benign
IGL01583:Dock4	APN	12	40810467	nonsense	probably null
IGL01603:Dock4	APN	12	40693031	missense	probably damaging	1.00
IGL01766:Dock4	APN	12	40446379	nonsense	probably null
IGL02067:Dock4	APN	12	40834385	missense	probably damaging	1.00
IGL02302:Dock4	APN	12	40725777	missense	probably damaging	1.00
IGL02406:Dock4	APN	12	40777207	missense	probably benign	0.01
IGL02547:Dock4	APN	12	40737479	missense	probably benign
IGL02613:Dock4	APN	12	40810466	missense	probably damaging	1.00
IGL02643:Dock4	APN	12	40668430	missense	probably damaging	1.00
IGL02952:Dock4	APN	12	40710903	critical splice donor site	probably null
IGL02994:Dock4	APN	12	40779160	missense	probably damaging	0.99
IGL03096:Dock4	APN	12	40748001	missense	probably benign	0.00
IGL03144:Dock4	APN	12	40692907	splice site	probably benign
IGL03223:Dock4	APN	12	40817594	missense	probably damaging	1.00
IGL03296:Dock4	APN	12	40733257	missense	possibly damaging	0.84
IGL03349:Dock4	APN	12	40733310	missense	probably benign	0.42
IGL03353:Dock4	APN	12	40817758	splice site	probably null
BB005:Dock4	UTSW	12	40788303	missense	probably damaging	0.98
BB015:Dock4	UTSW	12	40788303	missense	probably damaging	0.98
R0046:Dock4	UTSW	12	40737360	splice site	probably benign
R0046:Dock4	UTSW	12	40737360	splice site	probably benign
R0110:Dock4	UTSW	12	40621312	splice site	probably benign
R0238:Dock4	UTSW	12	40737540	missense	probably damaging	0.98
R0238:Dock4	UTSW	12	40737540	missense	probably damaging	0.98
R0239:Dock4	UTSW	12	40737540	missense	probably damaging	0.98
R0239:Dock4	UTSW	12	40737540	missense	probably damaging	0.98
R0472:Dock4	UTSW	12	40838438	intron	probably benign
R0616:Dock4	UTSW	12	40704415	missense	probably benign	0.31
R0647:Dock4	UTSW	12	40710884	missense	probably damaging	1.00
R0706:Dock4	UTSW	12	40702923	missense	probably damaging	0.98
R0791:Dock4	UTSW	12	40704481	missense	probably damaging	1.00
R0940:Dock4	UTSW	12	40631627	splice site	probably benign
R1087:Dock4	UTSW	12	40729938	missense	probably benign	0.40
R1180:Dock4	UTSW	12	40640414	missense	possibly damaging	0.52
R1194:Dock4	UTSW	12	40829616	missense	probably damaging	1.00
R1463:Dock4	UTSW	12	40816325	frame shift	probably null
R1468:Dock4	UTSW	12	40755810	missense	probably benign	0.00
R1468:Dock4	UTSW	12	40755810	missense	probably benign	0.00
R1523:Dock4	UTSW	12	40693025	missense	possibly damaging	0.88
R1616:Dock4	UTSW	12	40669045	missense	probably damaging	0.99
R1682:Dock4	UTSW	12	40725780	missense	probably damaging	1.00
R1691:Dock4	UTSW	12	40725755	missense	probably benign	0.26
R1693:Dock4	UTSW	12	40834722	missense	probably benign	0.07
R1737:Dock4	UTSW	12	40807001	splice site	probably null
R1802:Dock4	UTSW	12	40794598	missense	possibly damaging	0.90
R1813:Dock4	UTSW	12	40636228	missense	probably damaging	1.00
R1846:Dock4	UTSW	12	40733268	missense	probably benign	0.00
R1959:Dock4	UTSW	12	40710798	missense	probably damaging	1.00
R1975:Dock4	UTSW	12	40779642	splice site	probably benign
R1986:Dock4	UTSW	12	40730063	missense	probably damaging	1.00
R2105:Dock4	UTSW	12	40692989	missense	probably benign	0.00
R2134:Dock4	UTSW	12	40745668	missense	probably benign
R2135:Dock4	UTSW	12	40745668	missense	probably benign
R2154:Dock4	UTSW	12	40820662	missense	probably damaging	1.00
R2154:Dock4	UTSW	12	40844548	small insertion	probably benign
R2864:Dock4	UTSW	12	40730073	missense	probably damaging	1.00
R2890:Dock4	UTSW	12	40623801	critical splice acceptor site	probably null
R3086:Dock4	UTSW	12	40731863	missense	probably benign	0.02
R3808:Dock4	UTSW	12	40672810	missense	probably damaging	0.99
R3811:Dock4	UTSW	12	40779124	missense	possibly damaging	0.87
R3836:Dock4	UTSW	12	40794624	critical splice donor site	probably null
R3838:Dock4	UTSW	12	40794624	critical splice donor site	probably null
R4091:Dock4	UTSW	12	40844267	missense	probably damaging	0.99
R4752:Dock4	UTSW	12	40446365	missense	probably benign	0.04
R4828:Dock4	UTSW	12	40668437	missense	probably damaging	1.00
R5039:Dock4	UTSW	12	40817746	missense	probably damaging	1.00
R5092:Dock4	UTSW	12	40844441	missense	probably benign
R5146:Dock4	UTSW	12	40649492	splice site	probably null
R5213:Dock4	UTSW	12	40676742	missense	probably damaging	1.00
R5214:Dock4	UTSW	12	40704466	missense	probably benign	0.00
R5270:Dock4	UTSW	12	40733271	missense	probably benign	0.02
R5426:Dock4	UTSW	12	40745745	missense	probably damaging	1.00
R5474:Dock4	UTSW	12	40745731	missense	probably benign
R5544:Dock4	UTSW	12	40834702	missense	possibly damaging	0.87
R5615:Dock4	UTSW	12	40649480	missense	probably benign	0.22
R5649:Dock4	UTSW	12	40844540	missense	probably benign	0.03
R5702:Dock4	UTSW	12	40737491	missense	probably benign	0.02
R5846:Dock4	UTSW	12	40817736	missense	probably damaging	1.00
R5847:Dock4	UTSW	12	40621251	missense	probably damaging	0.97
R5895:Dock4	UTSW	12	40755813	missense	probably damaging	1.00
R5997:Dock4	UTSW	12	40755834	missense	probably damaging	0.99
R6011:Dock4	UTSW	12	40817757	critical splice donor site	probably null
R6022:Dock4	UTSW	12	40748110	missense	probably benign	0.04
R6038:Dock4	UTSW	12	40733351	splice site	probably null
R6038:Dock4	UTSW	12	40733351	splice site	probably null
R6179:Dock4	UTSW	12	40731869	missense	probably benign	0.00
R6479:Dock4	UTSW	12	40828955	missense	probably damaging	1.00
R6516:Dock4	UTSW	12	40731899	missense	possibly damaging	0.94
R6748:Dock4	UTSW	12	40704466	missense	probably benign	0.44
R6752:Dock4	UTSW	12	40820617	missense	probably damaging	1.00
R6814:Dock4	UTSW	12	40812326	critical splice donor site	probably null
R6864:Dock4	UTSW	12	40745746	missense	probably damaging	1.00
R6872:Dock4	UTSW	12	40812326	critical splice donor site	probably null
R6891:Dock4	UTSW	12	40779136	missense	probably damaging	1.00
R6937:Dock4	UTSW	12	40834635	missense	probably benign	0.01
R6950:Dock4	UTSW	12	40733314	missense	possibly damaging	0.80
R7081:Dock4	UTSW	12	40621286	missense	probably damaging	1.00
R7129:Dock4	UTSW	12	40828879	missense	probably damaging	1.00
R7140:Dock4	UTSW	12	40636159	missense	probably benign	0.06
R7241:Dock4	UTSW	12	40794860	missense	probably damaging	1.00
R7378:Dock4	UTSW	12	40788244	missense	possibly damaging	0.94
R7714:Dock4	UTSW	12	40725649	nonsense	probably null
R7720:Dock4	UTSW	12	40806975	missense	probably damaging	0.99
R7756:Dock4	UTSW	12	40710879	missense	probably benign	0.02
R7758:Dock4	UTSW	12	40710879	missense	probably benign	0.02
R7759:Dock4	UTSW	12	40817736	missense	probably damaging	1.00
R7787:Dock4	UTSW	12	40725677	missense	probably benign
R7879:Dock4	UTSW	12	40730084	missense	possibly damaging	0.76
R7928:Dock4	UTSW	12	40788303	missense	probably damaging	0.98
R8000:Dock4	UTSW	12	40833119	missense	probably benign	0.05
R8042:Dock4	UTSW	12	40745760	missense	probably benign	0.01
R8231:Dock4	UTSW	12	40702951	missense	possibly damaging	0.88
R8234:Dock4	UTSW	12	40834838	splice site	probably null
R8758:Dock4	UTSW	12	40788232	missense	probably benign	0.12
R8871:Dock4	UTSW	12	40745731	missense	probably benign
R8873:Dock4	UTSW	12	40676768	nonsense	probably null
R8884:Dock4	UTSW	12	40806885	missense	probably damaging	1.00
R9164:Dock4	UTSW	12	40704338	missense	probably damaging	1.00
R9225:Dock4	UTSW	12	40829670	missense	probably benign	0.02
R9276:Dock4	UTSW	12	40649405	missense	possibly damaging	0.48
R9307:Dock4	UTSW	12	40636156	missense	probably damaging	1.00
R9675:Dock4	UTSW	12	40844380	small insertion	probably benign
R9675:Dock4	UTSW	12	40844394	small insertion	probably benign
R9676:Dock4	UTSW	12	40844380	small insertion	probably benign
R9676:Dock4	UTSW	12	40844388	small insertion	probably benign
R9676:Dock4	UTSW	12	40844398	small insertion	probably benign
R9676:Dock4	UTSW	12	40844402	small insertion	probably benign
R9678:Dock4	UTSW	12	40844380	small insertion	probably benign
R9678:Dock4	UTSW	12	40844388	small insertion	probably benign
R9678:Dock4	UTSW	12	40844397	small insertion	probably benign
R9691:Dock4	UTSW	12	40636098	missense	probably damaging	1.00
RF018:Dock4	UTSW	12	40844399	frame shift	probably null
RF025:Dock4	UTSW	12	40844393	frame shift	probably null
RF063:Dock4	UTSW	12	40844399	frame shift	probably null
X0028:Dock4	UTSW	12	40669047	missense	probably benign	0.25
Z1176:Dock4	UTSW	12	40631614	missense	probably benign	0.01
Z1176:Dock4	UTSW	12	40631616	missense	probably benign	0.16
Z1177:Dock4	UTSW	12	40817641	missense	possibly damaging	0.88

Predicted Primers

PCR Primer
(F):5'- GAAGTGACTGGTCCCTTGAG -3'
(R):5'- AGGCCCAGTGAATTATAGCAAG -3'

Sequencing Primer
(F):5'- TGGTCCCTTGAGCATTGTAC -3'
(R):5'- GCCCAGTGAATTATAGCAAGCTCTC -3'

Posted On

2015-11-11