Incidental Mutation 'R4745:Arhgef4'
| ID |
356620 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Arhgef4
|
| Ensembl Gene |
ENSMUSG00000037509 |
| Gene Name |
Rho guanine nucleotide exchange factor 4 |
| Synonyms |
Asef, 9330140K16Rik, C230030N03Rik |
| MMRRC Submission |
042028-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4745 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
34717263-34851819 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 34846356 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Alanine
at position 379
(T379A)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124906
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047664]
[ENSMUST00000159021]
[ENSMUST00000159747]
[ENSMUST00000160855]
[ENSMUST00000162599]
|
| AlphaFold |
Q7TNR9 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000047664
AA Change: T235A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000035980
Gene: ENSMUSG00000037509
AA Change: T235A
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
1 |
45 |
6.97e-7 |
SMART |
|
RhoGEF
|
82 |
261 |
3.86e-56 |
SMART |
|
PH
|
294 |
402 |
2.33e-14 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000159021
|
| SMART Domains |
Protein: ENSMUSP00000124467
Gene: ENSMUSG00000037509
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
1 |
45 |
6.97e-7 |
SMART |
|
Pfam:RhoGEF
|
82 |
190 |
3.4e-29 |
PFAM |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000159059
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159747
AA Change: T1606A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000124213
Gene: ENSMUSG00000037509
AA Change: T1606A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
15 |
28 |
N/A |
INTRINSIC |
|
low complexity region
|
573 |
584 |
N/A |
INTRINSIC |
|
low complexity region
|
686 |
712 |
N/A |
INTRINSIC |
|
low complexity region
|
915 |
926 |
N/A |
INTRINSIC |
|
low complexity region
|
1119 |
1137 |
N/A |
INTRINSIC |
|
low complexity region
|
1240 |
1254 |
N/A |
INTRINSIC |
|
SH3
|
1361 |
1416 |
3.73e-16 |
SMART |
|
RhoGEF
|
1453 |
1632 |
3.86e-56 |
SMART |
|
PH
|
1665 |
1773 |
2.33e-14 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000160855
|
| SMART Domains |
Protein: ENSMUSP00000124207
Gene: ENSMUSG00000037509
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
1 |
45 |
6.97e-7 |
SMART |
|
Pfam:RhoGEF
|
82 |
187 |
1.2e-21 |
PFAM |
|
low complexity region
|
194 |
211 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000162599
AA Change: T379A
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000124906
Gene: ENSMUSG00000037509
AA Change: T379A
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
73 |
87 |
N/A |
INTRINSIC |
|
SH3
|
194 |
249 |
3.73e-16 |
SMART |
|
Pfam:RhoGEF
|
304 |
405 |
1.2e-25 |
PFAM |
|
PH
|
438 |
546 |
2.33e-14 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000162760
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000193040
|
| Meta Mutation Damage Score |
0.7373 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 97.1%
- 20x: 94.8%
|
| Validation Efficiency |
97% (89/92) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The protein encoded by this gene may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jun 2013]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased angiogenesis, vascular endothelial cell migration, tumor growth, and tumor vascularization. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(1) : Targeted, other(1) |
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca17 |
T |
C |
17: 24,526,427 (GRCm39) |
Y619C |
probably damaging |
Het |
| Adck1 |
A |
G |
12: 88,368,949 (GRCm39) |
|
probably null |
Het |
| Agap3 |
A |
C |
5: 24,656,123 (GRCm39) |
|
probably null |
Het |
| Ankib1 |
A |
T |
5: 3,782,566 (GRCm39) |
H354Q |
probably damaging |
Het |
| Ankrd29 |
T |
G |
18: 12,387,679 (GRCm39) |
N301T |
probably benign |
Het |
| Arid1a |
A |
G |
4: 133,480,417 (GRCm39) |
V169A |
probably benign |
Het |
| Bag2 |
T |
C |
1: 33,787,417 (GRCm39) |
|
probably null |
Het |
| Bmt2 |
A |
C |
6: 13,628,686 (GRCm39) |
Y332* |
probably null |
Het |
| Bpifb1 |
A |
T |
2: 154,053,501 (GRCm39) |
K248* |
probably null |
Het |
| Caap1 |
C |
A |
4: 94,444,751 (GRCm39) |
|
probably null |
Het |
| Calcr |
T |
A |
6: 3,692,576 (GRCm39) |
Y389F |
probably damaging |
Het |
| Capn1 |
C |
T |
19: 6,043,946 (GRCm39) |
V562I |
probably benign |
Het |
| Ccr1 |
T |
A |
9: 123,763,985 (GRCm39) |
T182S |
probably benign |
Het |
| Ceacam15 |
T |
C |
7: 16,407,259 (GRCm39) |
D86G |
probably benign |
Het |
| Cldnd1 |
C |
T |
16: 58,550,006 (GRCm39) |
T63I |
probably benign |
Het |
| Col12a1 |
A |
T |
9: 79,559,368 (GRCm39) |
|
probably null |
Het |
| Cystm1 |
A |
G |
18: 36,526,348 (GRCm39) |
|
probably benign |
Het |
| Ddx55 |
T |
A |
5: 124,705,028 (GRCm39) |
Y428* |
probably null |
Het |
| Ensa |
G |
A |
3: 95,538,745 (GRCm39) |
G118D |
probably benign |
Het |
| Folh1 |
A |
T |
7: 86,372,482 (GRCm39) |
|
probably null |
Het |
| Foxj2 |
C |
A |
6: 122,814,948 (GRCm39) |
P328Q |
probably damaging |
Het |
| Fscn3 |
A |
G |
6: 28,435,627 (GRCm39) |
I417V |
probably damaging |
Het |
| Galnt7 |
T |
C |
8: 57,995,761 (GRCm39) |
|
probably benign |
Het |
| Gm11563 |
T |
A |
11: 99,549,246 (GRCm39) |
*169C |
probably null |
Het |
| Hfm1 |
A |
T |
5: 107,049,709 (GRCm39) |
D417E |
possibly damaging |
Het |
| Ighv15-2 |
A |
G |
12: 114,528,230 (GRCm39) |
S107P |
probably damaging |
Het |
| Itsn2 |
A |
G |
12: 4,711,944 (GRCm39) |
D904G |
probably damaging |
Het |
| Kif1b |
A |
T |
4: 149,322,339 (GRCm39) |
L860* |
probably null |
Het |
| Krt79 |
T |
C |
15: 101,839,119 (GRCm39) |
E450G |
probably damaging |
Het |
| Lama1 |
T |
C |
17: 68,045,775 (GRCm39) |
S227P |
probably damaging |
Het |
| Lamp5 |
C |
A |
2: 135,902,786 (GRCm39) |
H168Q |
probably benign |
Het |
| Lilra5 |
A |
T |
7: 4,245,076 (GRCm39) |
Q240L |
possibly damaging |
Het |
| Lrp1 |
A |
T |
10: 127,385,813 (GRCm39) |
C3521S |
probably benign |
Het |
| Mroh1 |
T |
A |
15: 76,292,730 (GRCm39) |
|
probably null |
Het |
| Nlrp4g |
A |
T |
9: 124,349,515 (GRCm38) |
|
noncoding transcript |
Het |
| Nr2f6 |
A |
T |
8: 71,831,179 (GRCm39) |
I70N |
probably benign |
Het |
| Nr4a2 |
T |
A |
2: 57,000,163 (GRCm39) |
D311V |
probably damaging |
Het |
| Odad2 |
G |
A |
18: 7,286,763 (GRCm39) |
T156M |
probably benign |
Het |
| Or10w1 |
T |
A |
19: 13,632,750 (GRCm39) |
M319K |
probably benign |
Het |
| Or10x4 |
T |
C |
1: 174,219,442 (GRCm39) |
L269P |
probably damaging |
Het |
| Or52n20 |
T |
A |
7: 104,320,711 (GRCm39) |
F267L |
probably damaging |
Het |
| Pcdhb6 |
C |
A |
18: 37,468,426 (GRCm39) |
A449D |
possibly damaging |
Het |
| Pcgf6 |
A |
G |
19: 47,036,545 (GRCm39) |
|
probably null |
Het |
| Prc1 |
C |
A |
7: 79,962,911 (GRCm39) |
H131Q |
probably benign |
Het |
| Ptprq |
C |
A |
10: 107,360,114 (GRCm39) |
R2187L |
probably damaging |
Het |
| Rasl2-9 |
C |
A |
7: 5,128,702 (GRCm39) |
R76L |
possibly damaging |
Het |
| Rdh16f1 |
A |
T |
10: 127,626,685 (GRCm39) |
Y246F |
probably benign |
Het |
| Rit1 |
T |
C |
3: 88,624,982 (GRCm39) |
|
probably benign |
Het |
| Sash1 |
A |
G |
10: 8,605,672 (GRCm39) |
V906A |
probably benign |
Het |
| Scnn1b |
T |
C |
7: 121,501,509 (GRCm39) |
V108A |
probably benign |
Het |
| Sema4f |
A |
T |
6: 82,895,265 (GRCm39) |
I356N |
probably damaging |
Het |
| Shc4 |
A |
T |
2: 125,491,197 (GRCm39) |
L447Q |
probably damaging |
Het |
| Slc24a1 |
T |
C |
9: 64,856,758 (GRCm39) |
M50V |
unknown |
Het |
| Slc28a3 |
T |
A |
13: 58,722,077 (GRCm39) |
D269V |
possibly damaging |
Het |
| Slc35e1 |
A |
G |
8: 73,246,166 (GRCm39) |
S89P |
possibly damaging |
Het |
| Smpd5 |
T |
A |
15: 76,179,008 (GRCm39) |
H125Q |
probably benign |
Het |
| Snapc2 |
A |
G |
8: 4,304,578 (GRCm39) |
T31A |
probably damaging |
Het |
| Sox5 |
G |
C |
6: 143,779,214 (GRCm39) |
H606D |
possibly damaging |
Het |
| Spag6 |
A |
G |
2: 18,742,107 (GRCm39) |
T367A |
possibly damaging |
Het |
| Spag8 |
T |
C |
4: 43,651,636 (GRCm39) |
T413A |
probably damaging |
Het |
| Sptlc3 |
G |
A |
2: 139,389,087 (GRCm39) |
G156R |
probably damaging |
Het |
| Stx19 |
A |
G |
16: 62,642,783 (GRCm39) |
T200A |
probably benign |
Het |
| Tas2r116 |
A |
G |
6: 132,832,668 (GRCm39) |
T90A |
probably benign |
Het |
| Tasor2 |
G |
A |
13: 3,640,069 (GRCm39) |
T356I |
probably benign |
Het |
| Tbl3 |
A |
G |
17: 24,924,304 (GRCm39) |
|
probably benign |
Het |
| Tekt5 |
G |
T |
16: 10,213,058 (GRCm39) |
P76T |
probably damaging |
Het |
| Tjp2 |
C |
T |
19: 24,074,030 (GRCm39) |
E1086K |
possibly damaging |
Het |
| Topbp1 |
T |
C |
9: 103,200,770 (GRCm39) |
L601P |
probably damaging |
Het |
| Trav16 |
T |
A |
14: 53,980,934 (GRCm39) |
M41K |
possibly damaging |
Het |
| Trav6-5 |
C |
A |
14: 53,728,960 (GRCm39) |
N72K |
probably benign |
Het |
| Trpm3 |
C |
G |
19: 22,692,659 (GRCm39) |
T250S |
possibly damaging |
Het |
| Vps35 |
A |
T |
8: 85,987,891 (GRCm39) |
D753E |
probably benign |
Het |
| Vstm2a |
A |
T |
11: 16,213,061 (GRCm39) |
N149Y |
probably damaging |
Het |
| Vwa2 |
G |
T |
19: 56,895,318 (GRCm39) |
M497I |
probably benign |
Het |
| Zfat |
C |
A |
15: 68,052,223 (GRCm39) |
V517L |
probably benign |
Het |
| Zfp169 |
C |
A |
13: 48,643,708 (GRCm39) |
R473L |
possibly damaging |
Het |
| Zfp672 |
T |
C |
11: 58,220,324 (GRCm39) |
|
probably benign |
Het |
| Zranb1 |
T |
C |
7: 132,574,443 (GRCm39) |
V420A |
probably damaging |
Het |
|
| Other mutations in Arhgef4 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00896:Arhgef4
|
APN |
1 |
34,850,777 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02376:Arhgef4
|
APN |
1 |
34,845,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02604:Arhgef4
|
APN |
1 |
34,850,804 (GRCm39) |
nonsense |
probably null |
|
|
IGL03240:Arhgef4
|
APN |
1 |
34,845,107 (GRCm39) |
missense |
probably benign |
0.03 |
|
BB004:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB014:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0095:Arhgef4
|
UTSW |
1 |
34,771,451 (GRCm39) |
nonsense |
probably null |
|
|
R0157:Arhgef4
|
UTSW |
1 |
34,845,475 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0243:Arhgef4
|
UTSW |
1 |
34,846,080 (GRCm39) |
splice site |
probably null |
|
|
R0383:Arhgef4
|
UTSW |
1 |
34,849,614 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0440:Arhgef4
|
UTSW |
1 |
34,784,529 (GRCm39) |
splice site |
probably null |
|
|
R0452:Arhgef4
|
UTSW |
1 |
34,771,403 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R0893:Arhgef4
|
UTSW |
1 |
34,846,191 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1429:Arhgef4
|
UTSW |
1 |
34,849,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1437:Arhgef4
|
UTSW |
1 |
34,763,026 (GRCm39) |
missense |
unknown |
|
|
R1669:Arhgef4
|
UTSW |
1 |
34,771,239 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1780:Arhgef4
|
UTSW |
1 |
34,763,241 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R1809:Arhgef4
|
UTSW |
1 |
34,849,636 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1879:Arhgef4
|
UTSW |
1 |
34,761,521 (GRCm39) |
missense |
unknown |
|
|
R1908:Arhgef4
|
UTSW |
1 |
34,763,340 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1919:Arhgef4
|
UTSW |
1 |
34,850,221 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2020:Arhgef4
|
UTSW |
1 |
34,762,891 (GRCm39) |
missense |
unknown |
|
|
R2058:Arhgef4
|
UTSW |
1 |
34,761,458 (GRCm39) |
missense |
unknown |
|
|
R2213:Arhgef4
|
UTSW |
1 |
34,846,230 (GRCm39) |
splice site |
probably null |
|
|
R2851:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R2852:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R2853:Arhgef4
|
UTSW |
1 |
34,763,129 (GRCm39) |
missense |
unknown |
|
|
R3697:Arhgef4
|
UTSW |
1 |
34,761,521 (GRCm39) |
missense |
unknown |
|
|
R4012:Arhgef4
|
UTSW |
1 |
34,764,187 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R4118:Arhgef4
|
UTSW |
1 |
34,771,428 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4133:Arhgef4
|
UTSW |
1 |
34,845,185 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4534:Arhgef4
|
UTSW |
1 |
34,762,162 (GRCm39) |
missense |
unknown |
|
|
R4535:Arhgef4
|
UTSW |
1 |
34,762,162 (GRCm39) |
missense |
unknown |
|
|
R4581:Arhgef4
|
UTSW |
1 |
34,771,205 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R4665:Arhgef4
|
UTSW |
1 |
34,845,113 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R4678:Arhgef4
|
UTSW |
1 |
34,761,749 (GRCm39) |
missense |
unknown |
|
|
R4684:Arhgef4
|
UTSW |
1 |
34,850,866 (GRCm39) |
splice site |
probably null |
|
|
R4706:Arhgef4
|
UTSW |
1 |
34,771,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4747:Arhgef4
|
UTSW |
1 |
34,762,355 (GRCm39) |
missense |
unknown |
|
|
R4988:Arhgef4
|
UTSW |
1 |
34,762,535 (GRCm39) |
missense |
unknown |
|
|
R5063:Arhgef4
|
UTSW |
1 |
34,763,296 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5154:Arhgef4
|
UTSW |
1 |
34,771,455 (GRCm39) |
missense |
probably benign |
0.43 |
|
R5156:Arhgef4
|
UTSW |
1 |
34,762,355 (GRCm39) |
missense |
unknown |
|
|
R5263:Arhgef4
|
UTSW |
1 |
34,764,078 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R5450:Arhgef4
|
UTSW |
1 |
34,846,405 (GRCm39) |
intron |
probably benign |
|
|
R5807:Arhgef4
|
UTSW |
1 |
34,846,696 (GRCm39) |
intron |
probably benign |
|
|
R5863:Arhgef4
|
UTSW |
1 |
34,761,926 (GRCm39) |
missense |
unknown |
|
|
R6034:Arhgef4
|
UTSW |
1 |
34,760,984 (GRCm39) |
missense |
unknown |
|
|
R6034:Arhgef4
|
UTSW |
1 |
34,760,984 (GRCm39) |
missense |
unknown |
|
|
R6311:Arhgef4
|
UTSW |
1 |
34,763,062 (GRCm39) |
missense |
unknown |
|
|
R6315:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6316:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6318:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6323:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6324:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6325:Arhgef4
|
UTSW |
1 |
34,762,558 (GRCm39) |
missense |
unknown |
|
|
R6340:Arhgef4
|
UTSW |
1 |
34,771,304 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6835:Arhgef4
|
UTSW |
1 |
34,845,574 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6981:Arhgef4
|
UTSW |
1 |
34,761,533 (GRCm39) |
missense |
unknown |
|
|
R7087:Arhgef4
|
UTSW |
1 |
34,850,767 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7297:Arhgef4
|
UTSW |
1 |
34,846,273 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7525:Arhgef4
|
UTSW |
1 |
34,848,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7614:Arhgef4
|
UTSW |
1 |
34,771,316 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7693:Arhgef4
|
UTSW |
1 |
34,763,222 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7892:Arhgef4
|
UTSW |
1 |
34,760,885 (GRCm39) |
missense |
unknown |
|
|
R7895:Arhgef4
|
UTSW |
1 |
34,845,478 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7927:Arhgef4
|
UTSW |
1 |
34,846,334 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7965:Arhgef4
|
UTSW |
1 |
34,850,762 (GRCm39) |
missense |
probably benign |
|
|
R7973:Arhgef4
|
UTSW |
1 |
34,763,518 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7979:Arhgef4
|
UTSW |
1 |
34,760,978 (GRCm39) |
missense |
unknown |
|
|
R8160:Arhgef4
|
UTSW |
1 |
34,762,655 (GRCm39) |
missense |
unknown |
|
|
R8175:Arhgef4
|
UTSW |
1 |
34,849,455 (GRCm39) |
missense |
probably benign |
|
|
R8178:Arhgef4
|
UTSW |
1 |
34,761,983 (GRCm39) |
missense |
unknown |
|
|
R9046:Arhgef4
|
UTSW |
1 |
34,850,846 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9077:Arhgef4
|
UTSW |
1 |
34,760,824 (GRCm39) |
missense |
unknown |
|
|
R9209:Arhgef4
|
UTSW |
1 |
34,849,576 (GRCm39) |
missense |
probably benign |
|
|
R9209:Arhgef4
|
UTSW |
1 |
34,764,241 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9355:Arhgef4
|
UTSW |
1 |
34,849,630 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9489:Arhgef4
|
UTSW |
1 |
34,761,745 (GRCm39) |
missense |
unknown |
|
|
R9509:Arhgef4
|
UTSW |
1 |
34,762,772 (GRCm39) |
missense |
unknown |
|
|
R9605:Arhgef4
|
UTSW |
1 |
34,761,745 (GRCm39) |
missense |
unknown |
|
|
R9665:Arhgef4
|
UTSW |
1 |
34,849,518 (GRCm39) |
missense |
probably benign |
|
|
R9675:Arhgef4
|
UTSW |
1 |
34,845,108 (GRCm39) |
missense |
probably benign |
|
|
R9790:Arhgef4
|
UTSW |
1 |
34,832,445 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9791:Arhgef4
|
UTSW |
1 |
34,832,445 (GRCm39) |
critical splice donor site |
probably null |
|
|
RF012:Arhgef4
|
UTSW |
1 |
34,763,565 (GRCm39) |
small deletion |
probably benign |
|
|
X0062:Arhgef4
|
UTSW |
1 |
34,763,308 (GRCm39) |
missense |
probably benign |
0.35 |
|
YA93:Arhgef4
|
UTSW |
1 |
34,771,298 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Arhgef4
|
UTSW |
1 |
34,844,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Arhgef4
|
UTSW |
1 |
34,762,810 (GRCm39) |
missense |
unknown |
|
|
Z1177:Arhgef4
|
UTSW |
1 |
34,763,340 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1177:Arhgef4
|
UTSW |
1 |
34,762,447 (GRCm39) |
missense |
unknown |
|
|
Z1177:Arhgef4
|
UTSW |
1 |
34,762,002 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
PCR Primer
(F):5'- GCAAGCAGACTTCCAGATCTATTC -3'
(R):5'- CTCCGGTATAGCTCAAGGTG -3'
Sequencing Primer
(F):5'- GATCTATTCTGAGTACTGCAACAACC -3'
(R):5'- ATAGCTCAAGGTGGTGGCC -3'
|
| Posted On |
2015-11-11 |
Incidental Mutation