Mutagenetix > Incidental Mutations

Incidental Mutation 'R0403:Ncor2'

35687

Institutional Source

Beutler Lab

Gene Symbol

Ncor2

Ensembl Gene

ENSMUSG00000029478

Gene Name

nuclear receptor co-repressor 2

Synonyms

SMRT, SMRTe

MMRRC Submission

038608-MU

Accession Numbers

Ncbi RefSeq: NM_011424.3, NM_001253904.1, NM_001253905.1; MGI:1337080

Is this an essential gene?

Essential (E-score: 1.000) question?

Stock #

R0403 (G1)

Quality Score

202

Status

Validated

Chromosome

Chromosomal Location

125017153-125179219 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 125033337 bp

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 868 (S868P)

Ref Sequence

ENSEMBL: ENSMUSP00000121588 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055256] [ENSMUST00000086083] [ENSMUST00000111393] [ENSMUST00000111394] [ENSMUST00000111398] [ENSMUST00000111402] [ENSMUST00000134404]

Predicted Effect

probably benign
Transcript: ENSMUST00000055256
AA Change: S1421P

PolyPhen 2 Score 0.321 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000055954
Gene: ENSMUSG00000029478
AA Change: S1421P

Domain	Start	End	E-Value	Type
low complexity region	147	154	N/A	INTRINSIC
coiled coil region	167	207	N/A	INTRINSIC
SANT	428	476	4.42e-6	SMART
coiled coil region	494	550	N/A	INTRINSIC
SANT	607	655	1.43e-14	SMART
low complexity region	668	686	N/A	INTRINSIC
low complexity region	699	726	N/A	INTRINSIC
low complexity region	768	813	N/A	INTRINSIC
low complexity region	822	828	N/A	INTRINSIC
low complexity region	848	860	N/A	INTRINSIC
low complexity region	867	874	N/A	INTRINSIC
low complexity region	905	919	N/A	INTRINSIC
low complexity region	935	944	N/A	INTRINSIC
low complexity region	989	1000	N/A	INTRINSIC
low complexity region	1011	1025	N/A	INTRINSIC
low complexity region	1027	1043	N/A	INTRINSIC
low complexity region	1086	1096	N/A	INTRINSIC
low complexity region	1100	1116	N/A	INTRINSIC
low complexity region	1366	1380	N/A	INTRINSIC
low complexity region	1481	1497	N/A	INTRINSIC
low complexity region	1616	1622	N/A	INTRINSIC
low complexity region	1709	1726	N/A	INTRINSIC
low complexity region	1737	1754	N/A	INTRINSIC
low complexity region	1764	1776	N/A	INTRINSIC
low complexity region	1800	1807	N/A	INTRINSIC
low complexity region	1921	1939	N/A	INTRINSIC
low complexity region	1959	1975	N/A	INTRINSIC
low complexity region	2062	2076	N/A	INTRINSIC
PDB:2GPV\|I	2293	2314	8e-8	PDB
low complexity region	2324	2336	N/A	INTRINSIC
low complexity region	2433	2453	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000086083
AA Change: S1419P

PolyPhen 2 Score 0.210 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000083250
Gene: ENSMUSG00000029478
AA Change: S1419P

Domain	Start	End	E-Value	Type
low complexity region	147	154	N/A	INTRINSIC
coiled coil region	167	207	N/A	INTRINSIC
SANT	428	476	4.42e-6	SMART
coiled coil region	494	550	N/A	INTRINSIC
SANT	607	655	1.43e-14	SMART
low complexity region	668	686	N/A	INTRINSIC
low complexity region	699	726	N/A	INTRINSIC
low complexity region	768	813	N/A	INTRINSIC
low complexity region	822	828	N/A	INTRINSIC
low complexity region	848	860	N/A	INTRINSIC
low complexity region	867	874	N/A	INTRINSIC
low complexity region	905	919	N/A	INTRINSIC
low complexity region	935	944	N/A	INTRINSIC
low complexity region	988	999	N/A	INTRINSIC
low complexity region	1010	1024	N/A	INTRINSIC
low complexity region	1026	1042	N/A	INTRINSIC
low complexity region	1085	1095	N/A	INTRINSIC
low complexity region	1099	1115	N/A	INTRINSIC
low complexity region	1364	1378	N/A	INTRINSIC
low complexity region	1479	1495	N/A	INTRINSIC
low complexity region	1614	1620	N/A	INTRINSIC
low complexity region	1707	1724	N/A	INTRINSIC
low complexity region	1735	1752	N/A	INTRINSIC
low complexity region	1762	1774	N/A	INTRINSIC
low complexity region	1798	1805	N/A	INTRINSIC
low complexity region	1916	1934	N/A	INTRINSIC
low complexity region	1954	1970	N/A	INTRINSIC
low complexity region	2057	2071	N/A	INTRINSIC
PDB:2GPV\|I	2288	2309	8e-8	PDB
low complexity region	2319	2331	N/A	INTRINSIC
low complexity region	2428	2448	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111393
AA Change: S1280P

PolyPhen 2 Score 0.097 (Sensitivity: 0.93; Specificity: 0.85)

SMART Domains

Protein: ENSMUSP00000107024
Gene: ENSMUSG00000029478
AA Change: S1280P

Domain	Start	End	E-Value	Type
coiled coil region	1	32	N/A	INTRINSIC
SANT	253	301	4.42e-6	SMART
coiled coil region	319	375	N/A	INTRINSIC
SANT	432	480	1.43e-14	SMART
low complexity region	493	511	N/A	INTRINSIC
low complexity region	524	551	N/A	INTRINSIC
low complexity region	593	638	N/A	INTRINSIC
low complexity region	647	653	N/A	INTRINSIC
low complexity region	673	685	N/A	INTRINSIC
low complexity region	692	699	N/A	INTRINSIC
low complexity region	730	744	N/A	INTRINSIC
low complexity region	760	769	N/A	INTRINSIC
low complexity region	813	824	N/A	INTRINSIC
low complexity region	835	849	N/A	INTRINSIC
low complexity region	851	867	N/A	INTRINSIC
low complexity region	910	920	N/A	INTRINSIC
low complexity region	924	940	N/A	INTRINSIC
low complexity region	1225	1239	N/A	INTRINSIC
low complexity region	1340	1356	N/A	INTRINSIC
low complexity region	1475	1481	N/A	INTRINSIC
low complexity region	1568	1585	N/A	INTRINSIC
low complexity region	1596	1613	N/A	INTRINSIC
low complexity region	1623	1635	N/A	INTRINSIC
low complexity region	1659	1666	N/A	INTRINSIC
low complexity region	1780	1798	N/A	INTRINSIC
low complexity region	1818	1834	N/A	INTRINSIC
low complexity region	1921	1935	N/A	INTRINSIC
PDB:2GPV\|I	2152	2173	7e-8	PDB
low complexity region	2183	2195	N/A	INTRINSIC
low complexity region	2292	2312	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111394
AA Change: S1201P

PolyPhen 2 Score 0.113 (Sensitivity: 0.93; Specificity: 0.86)

SMART Domains

Protein: ENSMUSP00000107025
Gene: ENSMUSG00000029478
AA Change: S1201P

Domain	Start	End	E-Value	Type
SANT	209	257	4.42e-6	SMART
coiled coil region	275	331	N/A	INTRINSIC
SANT	388	436	1.43e-14	SMART
low complexity region	449	467	N/A	INTRINSIC
low complexity region	480	507	N/A	INTRINSIC
low complexity region	549	594	N/A	INTRINSIC
low complexity region	603	609	N/A	INTRINSIC
low complexity region	629	641	N/A	INTRINSIC
low complexity region	648	655	N/A	INTRINSIC
low complexity region	686	700	N/A	INTRINSIC
low complexity region	716	725	N/A	INTRINSIC
low complexity region	769	780	N/A	INTRINSIC
low complexity region	791	805	N/A	INTRINSIC
low complexity region	807	823	N/A	INTRINSIC
low complexity region	866	876	N/A	INTRINSIC
low complexity region	880	896	N/A	INTRINSIC
low complexity region	1146	1160	N/A	INTRINSIC
low complexity region	1261	1277	N/A	INTRINSIC
low complexity region	1396	1402	N/A	INTRINSIC
low complexity region	1489	1506	N/A	INTRINSIC
low complexity region	1517	1534	N/A	INTRINSIC
low complexity region	1544	1556	N/A	INTRINSIC
low complexity region	1580	1587	N/A	INTRINSIC
low complexity region	1701	1719	N/A	INTRINSIC
low complexity region	1739	1755	N/A	INTRINSIC
low complexity region	1842	1856	N/A	INTRINSIC
PDB:2GPV\|I	2073	2094	7e-8	PDB
low complexity region	2104	2116	N/A	INTRINSIC
low complexity region	2213	2233	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111398
AA Change: S1420P

PolyPhen 2 Score 0.321 (Sensitivity: 0.90; Specificity: 0.89)

SMART Domains

Protein: ENSMUSP00000107029
Gene: ENSMUSG00000029478
AA Change: S1420P

Domain	Start	End	E-Value	Type
low complexity region	147	154	N/A	INTRINSIC
coiled coil region	167	207	N/A	INTRINSIC
SANT	428	476	4.42e-6	SMART
coiled coil region	494	550	N/A	INTRINSIC
SANT	607	655	1.43e-14	SMART
low complexity region	668	686	N/A	INTRINSIC
low complexity region	699	726	N/A	INTRINSIC
low complexity region	768	813	N/A	INTRINSIC
low complexity region	822	828	N/A	INTRINSIC
low complexity region	848	860	N/A	INTRINSIC
low complexity region	867	874	N/A	INTRINSIC
low complexity region	905	919	N/A	INTRINSIC
low complexity region	935	944	N/A	INTRINSIC
low complexity region	988	999	N/A	INTRINSIC
low complexity region	1010	1024	N/A	INTRINSIC
low complexity region	1026	1042	N/A	INTRINSIC
low complexity region	1085	1095	N/A	INTRINSIC
low complexity region	1099	1115	N/A	INTRINSIC
low complexity region	1365	1379	N/A	INTRINSIC
low complexity region	1480	1496	N/A	INTRINSIC
low complexity region	1615	1621	N/A	INTRINSIC
low complexity region	1708	1725	N/A	INTRINSIC
low complexity region	1736	1753	N/A	INTRINSIC
low complexity region	1763	1775	N/A	INTRINSIC
low complexity region	1799	1806	N/A	INTRINSIC
low complexity region	1920	1938	N/A	INTRINSIC
low complexity region	1958	1974	N/A	INTRINSIC
low complexity region	2061	2075	N/A	INTRINSIC
PDB:2GPV\|I	2292	2313	8e-8	PDB
low complexity region	2323	2335	N/A	INTRINSIC
low complexity region	2432	2452	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000111402
AA Change: S1455P

PolyPhen 2 Score 0.210 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000107033
Gene: ENSMUSG00000029478
AA Change: S1455P

Domain	Start	End	E-Value	Type
Pfam:GPS2_interact	141	229	4.9e-41	PFAM
SANT	428	476	4.42e-6	SMART
coiled coil region	494	550	N/A	INTRINSIC
SANT	607	655	1.43e-14	SMART
low complexity region	668	686	N/A	INTRINSIC
low complexity region	699	726	N/A	INTRINSIC
low complexity region	768	813	N/A	INTRINSIC
low complexity region	822	828	N/A	INTRINSIC
low complexity region	848	860	N/A	INTRINSIC
low complexity region	867	874	N/A	INTRINSIC
low complexity region	905	919	N/A	INTRINSIC
low complexity region	935	944	N/A	INTRINSIC
low complexity region	988	999	N/A	INTRINSIC
low complexity region	1010	1024	N/A	INTRINSIC
low complexity region	1026	1042	N/A	INTRINSIC
low complexity region	1085	1095	N/A	INTRINSIC
low complexity region	1099	1115	N/A	INTRINSIC
low complexity region	1400	1414	N/A	INTRINSIC
low complexity region	1515	1531	N/A	INTRINSIC
low complexity region	1650	1656	N/A	INTRINSIC
low complexity region	1743	1760	N/A	INTRINSIC
low complexity region	1771	1788	N/A	INTRINSIC
low complexity region	1798	1810	N/A	INTRINSIC
low complexity region	1834	1841	N/A	INTRINSIC
low complexity region	1955	1973	N/A	INTRINSIC
low complexity region	1993	2009	N/A	INTRINSIC
low complexity region	2096	2110	N/A	INTRINSIC
PDB:2GPV\|I	2327	2348	8e-8	PDB
low complexity region	2358	2370	N/A	INTRINSIC
low complexity region	2467	2487	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000125053
AA Change: S502P

SMART Domains

Protein: ENSMUSP00000117098
Gene: ENSMUSG00000029478
AA Change: S502P

Domain	Start	End	E-Value	Type
low complexity region	36	47	N/A	INTRINSIC
low complexity region	58	72	N/A	INTRINSIC
low complexity region	74	90	N/A	INTRINSIC
low complexity region	133	143	N/A	INTRINSIC
low complexity region	147	163	N/A	INTRINSIC
low complexity region	448	462	N/A	INTRINSIC
low complexity region	563	579	N/A	INTRINSIC
low complexity region	698	704	N/A	INTRINSIC
low complexity region	791	808	N/A	INTRINSIC
low complexity region	819	836	N/A	INTRINSIC
low complexity region	846	858	N/A	INTRINSIC
low complexity region	882	889	N/A	INTRINSIC
low complexity region	1000	1018	N/A	INTRINSIC
low complexity region	1038	1054	N/A	INTRINSIC
low complexity region	1141	1155	N/A	INTRINSIC
PDB:2GPV\|I	1372	1393	5e-8	PDB
low complexity region	1403	1415	N/A	INTRINSIC
low complexity region	1512	1532	N/A	INTRINSIC

Predicted Effect

possibly damaging
Transcript: ENSMUST00000134404
AA Change: S868P

PolyPhen 2 Score 0.734 (Sensitivity: 0.85; Specificity: 0.92)

SMART Domains

Protein: ENSMUSP00000121588
Gene: ENSMUSG00000029478
AA Change: S868P

Domain	Start	End	E-Value	Type
SANT	2	49	1.94e-2	SMART
low complexity region	84	100	N/A	INTRINSIC
low complexity region	113	140	N/A	INTRINSIC
low complexity region	182	227	N/A	INTRINSIC
low complexity region	236	242	N/A	INTRINSIC
low complexity region	262	274	N/A	INTRINSIC
low complexity region	281	288	N/A	INTRINSIC
low complexity region	319	333	N/A	INTRINSIC
low complexity region	349	358	N/A	INTRINSIC
low complexity region	402	413	N/A	INTRINSIC
low complexity region	424	438	N/A	INTRINSIC
low complexity region	440	456	N/A	INTRINSIC
low complexity region	499	509	N/A	INTRINSIC
low complexity region	513	529	N/A	INTRINSIC
low complexity region	813	827	N/A	INTRINSIC
low complexity region	928	944	N/A	INTRINSIC

Meta Mutation Damage Score

0.1130

Coding Region Coverage

1x: 98.0%
3x: 96.8%
10x: 93.2%
20x: 83.7%

Validation Efficiency

97% (110/113)

MGI Phenotype

Strain: 3765904; 4329504
Lethality: E1-E16
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011]
PHENOTYPE: Mice homozygous for a null allele die before E16.5 of heart defects and exhibit neural defects. [provided by MGI curators]

Allele List at MGI

All alleles(145) : Targeted(2) Gene trapped(143)

Other mutations in this stock

Total: 105 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ace	A	G	11: 105,973,880		probably null	Het
Adgrg3	C	T	8: 95,036,922	L284F	probably benign	Het
Alkbh8	T	A	9: 3,385,469	V587E	probably damaging	Het
Ap4b1	T	A	3: 103,818,839	C244S	probably damaging	Het
Ap4b1	T	A	3: 103,821,396	M590K	probably benign	Het
Arhgap15	C	T	2: 44,063,766	T168I	probably damaging	Het
Arntl2	T	A	6: 146,822,655	H348Q	probably damaging	Het
Atp8b1	A	G	18: 64,540,310	V997A	probably damaging	Het
Atrn	G	A	2: 130,906,859	C100Y	probably damaging	Het
Baiap2l2	C	A	15: 79,271,216	A151S	probably benign	Het
Baz2b	A	T	2: 59,969,377	D199E	possibly damaging	Het
Cblb	A	G	16: 52,152,626	D440G	probably benign	Het
Cdon	T	C	9: 35,473,500	V694A	probably benign	Het
Cep250	A	T	2: 155,992,349	R2065W	probably damaging	Het
Ces2b	G	T	8: 104,833,945	A131S	probably damaging	Het
Chrna9	A	T	5: 65,967,892	T59S	possibly damaging	Het
Cog3	T	A	14: 75,742,327		probably benign	Het
Cpa1	G	A	6: 30,641,857	V227I	probably benign	Het
Cyp3a25	A	T	5: 145,998,513	C98S	probably damaging	Het
D8Ertd738e	C	T	8: 84,249,601		probably null	Het
Ddx60	A	G	8: 61,994,541		probably benign	Het
Dhx16	T	C	17: 35,883,050		probably null	Het
Dnah9	T	A	11: 66,084,789	Q1478L	possibly damaging	Het
Dock10	T	C	1: 80,524,070	Y1434C	possibly damaging	Het
Enpp3	T	A	10: 24,804,436	D325V	probably damaging	Het
Entpd6	C	A	2: 150,760,170	T194K	possibly damaging	Het
Fam208b	A	T	13: 3,582,052	Y816*	probably null	Het
Fat2	A	T	11: 55,270,349	V3185E	probably benign	Het
Flrt1	A	G	19: 7,095,919	L421P	probably benign	Het
Fmn2	A	T	1: 174,694,278	Q1292L	probably damaging	Het
Fndc1	T	C	17: 7,775,588		probably null	Het
Fndc1	T	C	17: 7,753,723	D1459G	probably damaging	Het
Fzr1	A	G	10: 81,369,368	S265P	possibly damaging	Het
Gm13119	A	G	4: 144,362,646	N178S	probably benign	Het
Gm14085	T	C	2: 122,521,854	L364S	probably damaging	Het
Gpr142	G	A	11: 114,806,029	V134M	probably damaging	Het
Grid2ip	G	T	5: 143,357,620	V24L	possibly damaging	Het
Herc2	G	A	7: 56,159,417	R2555H	probably damaging	Het
Hpdl	A	T	4: 116,820,479	Y262N	possibly damaging	Het
Htr3a	A	G	9: 48,908,659	V57A	probably damaging	Het
Igfbp7	T	C	5: 77,355,591	I186V	probably benign	Het
Itga2b	C	T	11: 102,467,326		probably null	Het
Itgae	A	C	11: 73,123,183	D736A	possibly damaging	Het
Itpkc	T	A	7: 27,208,345	M645L	probably benign	Het
Jchain	T	C	5: 88,521,378	R139G	probably benign	Het
Kif13a	A	G	13: 46,791,401	V908A	probably damaging	Het
Kif1b	T	A	4: 149,181,967	K389*	probably null	Het
Klhl12	T	C	1: 134,485,856	Y360H	possibly damaging	Het
Knop1	G	A	7: 118,853,053	R148W	probably damaging	Het
Lpar1	T	A	4: 58,487,191	N27Y	probably damaging	Het
Lpar2	T	A	8: 69,824,152	V197D	probably damaging	Het
Lrrc74a	A	G	12: 86,740,979	N128S	probably damaging	Het
Lum	G	T	10: 97,572,043	V337F	probably benign	Het
Mag	T	C	7: 30,906,980	D344G	probably damaging	Het
Maip1	G	A	1: 57,407,196	A142T	probably benign	Het
Mlh3	A	G	12: 85,268,968	V148A	possibly damaging	Het
Nav3	A	G	10: 109,767,103	V1195A	probably damaging	Het
Nek1	A	G	8: 61,106,855	E907G	probably damaging	Het
Nfam1	G	A	15: 83,016,379	T134I	probably benign	Het
Nr0b2	T	C	4: 133,553,759	V112A	probably damaging	Het
Nrp1	A	G	8: 128,457,969	N365S	probably damaging	Het
Nrsn2	T	C	2: 152,369,790	Y107C	probably damaging	Het
Ntng1	G	A	3: 109,934,611	A282V	probably damaging	Het
Nxf1	T	C	19: 8,765,028	I337T	probably damaging	Het
Obscn	C	T	11: 59,076,540	G479D	probably damaging	Het
Olfr45	T	C	7: 140,691,309	S135P	possibly damaging	Het
Oprd1	T	A	4: 132,113,768	D293V	probably benign	Het
P3h2	T	G	16: 25,969,950	N586H	possibly damaging	Het
Pcid2	T	C	8: 13,085,367	Y214C	probably damaging	Het
Pkd1l3	C	G	8: 109,623,649	D375E	possibly damaging	Het
Pkd1l3	G	A	8: 109,623,663	S380N	probably benign	Het
Ppic	C	A	18: 53,411,071	G81W	probably damaging	Het
Ppp2r1a	C	A	17: 20,957,041	P246T	probably damaging	Het
Ppp4r4	T	G	12: 103,584,102	S46A	probably benign	Het
Prkce	A	G	17: 86,168,653	T21A	probably damaging	Het
Prkg2	T	C	5: 98,994,645	E210G	possibly damaging	Het
Prss35	A	G	9: 86,756,037	M287V	probably damaging	Het
Psd	G	A	19: 46,320,972		probably benign	Het
Ptch2	A	T	4: 117,110,839	K843*	probably null	Het
Rab44	C	A	17: 29,145,261	T603K	probably damaging	Het
Rasal3	T	A	17: 32,392,790		probably null	Het
Rbbp6	A	G	7: 122,992,296	T526A	probably damaging	Het
Ros1	A	T	10: 52,143,438		probably benign	Het
Sec24b	T	A	3: 129,989,676	L1104F	possibly damaging	Het
Sec24b	A	G	3: 129,999,534	S685P	probably damaging	Het
Sema6a	G	A	18: 47,290,045		probably null	Het
Setmar	A	T	6: 108,075,962	H139L	probably benign	Het
Slc4a7	T	C	14: 14,766,808	V710A	probably benign	Het
Smarcc1	T	A	9: 110,237,808		probably null	Het
Smchd1	G	A	17: 71,394,902	L1032F	probably damaging	Het
Speg	T	C	1: 75,430,784		probably benign	Het
Tcea1	C	G	1: 4,889,503	R134G	probably benign	Het
Tchhl1	C	T	3: 93,471,029	Q347*	probably null	Het
Tecrl	A	T	5: 83,354,758		probably benign	Het
Tepsin	T	C	11: 120,093,682		probably benign	Het
Tmem40	G	A	6: 115,733,985		probably benign	Het
Tpr	G	A	1: 150,407,414		probably benign	Het
Ttll12	A	T	15: 83,580,658		probably benign	Het
Ttn	T	A	2: 76,909,608	D3529V	probably benign	Het
Usp34	T	A	11: 23,333,838	H177Q	possibly damaging	Het
Vsig10	T	A	5: 117,338,461	S327T	probably benign	Het
Zbtb4	T	A	11: 69,777,639	M396K	probably damaging	Het
Zfp352	C	T	4: 90,225,009	T462I	possibly damaging	Het
Zfp385b	T	C	2: 77,476,845	M145V	probably damaging	Het
Zfp780b	C	A	7: 27,971,689	V65F	possibly damaging	Het

Other mutations in Ncor2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00330:Ncor2	APN	5	125042743	critical splice donor site	probably null
IGL00519:Ncor2	APN	5	125084924	missense	unknown
IGL00900:Ncor2	APN	5	125025784	missense	probably damaging	1.00
IGL00950:Ncor2	APN	5	125086890	missense	unknown
IGL01320:Ncor2	APN	5	125109927	missense	probably benign	0.00
IGL01382:Ncor2	APN	5	125055773	missense	probably damaging	0.96
IGL01573:Ncor2	APN	5	125085026	missense	unknown
IGL01721:Ncor2	APN	5	125050937	missense	probably damaging	1.00
IGL01875:Ncor2	APN	5	125065870	missense	unknown
IGL02090:Ncor2	APN	5	125034403	missense	probably damaging	0.99
IGL02192:Ncor2	APN	5	125024237	missense	probably damaging	1.00
IGL02396:Ncor2	APN	5	125037914	missense	probably damaging	1.00
IGL02934:Ncor2	APN	5	125025557	missense	probably benign	0.33
IGL02997:Ncor2	APN	5	125119570	intron	probably benign
R0019:Ncor2	UTSW	5	125119481	critical splice donor site	probably null
R0331:Ncor2	UTSW	5	125084917	missense	unknown
R0333:Ncor2	UTSW	5	125034344	splice site	probably benign
R0557:Ncor2	UTSW	5	125106305	nonsense	probably null
R0562:Ncor2	UTSW	5	125085029	missense	unknown
R0671:Ncor2	UTSW	5	125049387	missense	probably benign	0.13
R0699:Ncor2	UTSW	5	125029112	unclassified	probably benign
R0865:Ncor2	UTSW	5	125038982	missense	probably benign	0.17
R1183:Ncor2	UTSW	5	125023521	missense	possibly damaging	0.65
R1325:Ncor2	UTSW	5	125118780	intron	probably benign
R1344:Ncor2	UTSW	5	125025446	missense	probably damaging	1.00
R1433:Ncor2	UTSW	5	125109975	intron	probably benign
R1481:Ncor2	UTSW	5	125027138	nonsense	probably null
R1539:Ncor2	UTSW	5	125109939	missense	probably benign	0.07
R1558:Ncor2	UTSW	5	125033546	missense	probably damaging	1.00
R1585:Ncor2	UTSW	5	125084998	missense	unknown
R1611:Ncor2	UTSW	5	125110020	intron	probably benign
R1764:Ncor2	UTSW	5	125028615	missense	possibly damaging	0.91
R1789:Ncor2	UTSW	5	125019890	missense	probably damaging	1.00
R1809:Ncor2	UTSW	5	125118793	intron	probably benign
R1901:Ncor2	UTSW	5	125025425	missense	probably benign	0.39
R1946:Ncor2	UTSW	5	125034412	missense	probably damaging	1.00
R1970:Ncor2	UTSW	5	125038918	missense	probably damaging	0.99
R2048:Ncor2	UTSW	5	125084932	missense	unknown
R2137:Ncor2	UTSW	5	125030712	missense	probably damaging	1.00
R2270:Ncor2	UTSW	5	125037955	missense	probably benign	0.33
R2380:Ncor2	UTSW	5	125036080	missense	possibly damaging	0.89
R2570:Ncor2	UTSW	5	125028800	critical splice acceptor site	probably null
R2918:Ncor2	UTSW	5	125025760	missense	probably damaging	0.99
R2921:Ncor2	UTSW	5	125055791	missense	probably damaging	1.00
R2922:Ncor2	UTSW	5	125055791	missense	probably damaging	1.00
R2923:Ncor2	UTSW	5	125055791	missense	probably damaging	1.00
R3116:Ncor2	UTSW	5	125024166	missense	probably damaging	1.00
R3768:Ncor2	UTSW	5	125028687	missense	probably damaging	1.00
R3826:Ncor2	UTSW	5	125118692	intron	probably benign
R3829:Ncor2	UTSW	5	125118692	intron	probably benign
R3830:Ncor2	UTSW	5	125118692	intron	probably benign
R3951:Ncor2	UTSW	5	125032256	missense	possibly damaging	0.94
R4175:Ncor2	UTSW	5	125050956	missense	probably damaging	0.99
R4360:Ncor2	UTSW	5	125028972	missense	probably damaging	1.00
R4470:Ncor2	UTSW	5	125102641	critical splice donor site	probably null
R4490:Ncor2	UTSW	5	125036815	splice site	probably null
R4573:Ncor2	UTSW	5	125055825	missense	probably damaging	0.99
R4611:Ncor2	UTSW	5	125030859	missense	probably damaging	1.00
R4799:Ncor2	UTSW	5	125037060	critical splice donor site	probably null
R4851:Ncor2	UTSW	5	125033367	missense	possibly damaging	0.93
R4853:Ncor2	UTSW	5	125025105	missense	probably damaging	0.99
R4853:Ncor2	UTSW	5	125081183	missense	unknown
R4896:Ncor2	UTSW	5	125049340	critical splice donor site	probably null
R4997:Ncor2	UTSW	5	125034010	missense	probably damaging	0.99
R5057:Ncor2	UTSW	5	125048066	missense	possibly damaging	0.86
R5253:Ncor2	UTSW	5	125026930	missense	probably benign	0.44
R5461:Ncor2	UTSW	5	125027113	missense	probably damaging	1.00
R5585:Ncor2	UTSW	5	125067911	nonsense	probably null
R5638:Ncor2	UTSW	5	125048300	missense	probably benign	0.33
R5879:Ncor2	UTSW	5	125026775	unclassified	probably benign
R5967:Ncor2	UTSW	5	125068984	missense	unknown
R5999:Ncor2	UTSW	5	125033441	missense	probably damaging	1.00
R6020:Ncor2	UTSW	5	125020011	missense	probably benign	0.14
R6109:Ncor2	UTSW	5	125055846	missense	probably damaging	1.00
R6423:Ncor2	UTSW	5	125087902	missense	unknown
R6462:Ncor2	UTSW	5	125024172	missense	probably damaging	1.00
R6478:Ncor2	UTSW	5	125110005	intron	probably benign
R7074:Ncor2	UTSW	5	125049366	nonsense	probably null
R7179:Ncor2	UTSW	5	125055783	missense	unknown
R7261:Ncor2	UTSW	5	125110079	splice site	probably null
R7263:Ncor2	UTSW	5	125032132	missense
R7273:Ncor2	UTSW	5	125023623	missense
R7282:Ncor2	UTSW	5	125020040	missense
R7570:Ncor2	UTSW	5	125030089	missense
R7725:Ncor2	UTSW	5	125023566	missense
R7747:Ncor2	UTSW	5	125027038	missense
R7748:Ncor2	UTSW	5	125109967	missense	unknown
R7825:Ncor2	UTSW	5	125037077	missense	possibly damaging	0.53
R8008:Ncor2	UTSW	5	125067919	missense	not run
Z1088:Ncor2	UTSW	5	125067788	missense	unknown
Z1088:Ncor2	UTSW	5	125086840	critical splice donor site	probably null
Z1177:Ncor2	UTSW	5	125036849	missense	not run
Z1177:Ncor2	UTSW	5	125047994	missense	not run

Predicted Primers

PCR Primer
(F):5'- TTGACACATACATGCAGGTGGAGAC -3'
(R):5'- ATTTGTGCTGACCTAGACCGAGCC -3'

Sequencing Primer
(F):5'- CGTGGGGAGCAGTCAAGTG -3'
(R):5'- AGGCCAAGCTCTTGAAGC -3'

Posted On

2013-05-09